Dr. William Ting, Board-Certified Dermatologist
at California Dermatology Care

2262 Camino Ramon, San Ramon, CA 94583
Tel: 925-328-0255
Email: staff@CalDermCare.com


Advanced Care with a Personal Touch

   

 

 

Medical Dermatology    Evidence-based medicine   Customized solution   Personal care

Latest Dermatology Headlines

Patient Online Log in
(email staff to get your personal passcode)

* Patient Biopsy Results via LabCalls


MEDICAL DERMATOLOGY

Acne and Acne Scar

Excimer Laser for Psoriasis & Vitiligo

Keloid & Hypertrophic Scar Laser Therapy

Mohs Surgery for Skin Cancers

Nail Fungus GenesisPlus Laser Therapy

Photodynamic Therapy

Psoriasis & NBUVB Phototherapy

RadioTherapy Nonsurgical SRT-100 for Skin Cancer

Skin Allergy Patch Test

Sweating Disorder MiraDry for Hyperhidrosis

Wart Laser Therapy


COSMETIC DERMATOLOGY

Aesthetician Services
Microdermabrasion
 

Botox, Dysport & Xeomin

Cellulaze Cellulite Therapy

new! CoolSculpting

Facial Redness/Vein Laser Therapy

Fillers injection for Wrinkles

Fractional CO2 laser

new! Hair Transplant with Neograft

Laser Surgery Services
Acne/Pore reducing Laser
Collagen Stimulating Laser
Excimer Laser
Facial Veins laser
Hair Laser Removal
IPL Fotofacial
Melasma Laser
Nail Fungus Laser
Resurfacing Laser
Scar revision Laser
SmartLipo Laser
Tattoo Laser
VBeam Pulse Dye Laser
Wart Laser


Latisse

Leg Vein Laser Therapy & Asclera Sclerotherapy

Liposonix + Vaser Shape Nonsurgical Body Sculpting
 

Melasma and Pigmentation

Pore Size Reduction and Laser Rejuvenation

Sculptra Liquid Facelift

new! SideLaze Lift

SmartLipo Laser Tumescent Liposuction

Ulthera natural lift & skin tightening of face and neck


Related Websites
FaceUpLifting.com
iSmartLipo.com
iCellulaze.com
MoreHair4Me.com
SideLazeLift.com
SonixLipo.com


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925-328-0255

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Dr. William Ting has expertise in treating the entire spectrum of medical dermatology, with emphasis in preventive medicine and personalized recommendations. He enjoys taking care of patients with acne, eczema, hair and nail disorders, rashes, psoriasis and skin cancers.

He is at the forefront of medical dermatology and dermatologic research. He continues to publish articles in peer-reviewed dermatology journals. He is an early pioneer of photodynamic therapy (PDT) and one of the most experienced practitioners of PDT in the Bay Area. He is the first dermatologist in the San Francisco Bay Area and Northern California to introduce Lutronic Spectra Laser for melasma, acne, scar revision, pore size reduction as well as the Cutera GenesisPlus laser for advanced nail fungus laser treatment, keloid and hypertrophic scar, warts and scar revision.

Dr. Ting is a fellow of the American Academy of Dermatology (AAD) and American Society of Dermatologic Surgery (ASDS). He is a member of the National Psoriasis Foundation and International Hyperhidrosis Society.

Innovative Therapeutic Approach to Common Skin Conditions

Acne

Eczema (Atopic Dermatitis)

Hair and Nail disorders

  • Maximize therapeutic synergy and efficacy by utilizing both prescription-strength and over-the counter products when available
  • Comprehensive workup including bloodwork and biopsy if necessary
  • Systemic oral hormonal therapy for women and men when indicated

Psoriasis 

Rosacea

  • Multi-prong approach to minimize redness
  • Low-dose 'non-antibiotic' anti-inflammatory oral medication for long-term remission 
  • Emphasis on prevention
  • Fotofacial/IPL laser utilizing Cynosure XPL/Elite MPX
  • Cutera GenesisPlus Laser with or without combination with IPL 
  • Diode laser for facial veins
  • VBeam Pulse Dye Laser, the new gold standard for rosacea and facial redness

Skin Cancer 

  • Emphasis on prophylactic treatments with topical 5-FU, imiquimod, diclofenac, ingenol mebutate and oral chemopreventive therapy such as Soriatane.
  • Reduce future risks of skin cancer with photodynamic therapy, TCA chemical peels and/or fractional CO2 resurfacing laser  
  • Mohs Surgery to achieve highest cure rate and tissue sparing
  • Close colloboration with plastic surgeon(s) as needed  

Sweating Disorder (Hyperhidrosis) 

Vitiligo

Warts 


ABCD of Mole Check

 

 

Common Medical Dermatology Diagnostics and Therapeutics:

Dermatology Links:

American Academy of Dermatology
American Society of Dermatologic Surgery
American Society of Mohs Surgery
International Hyperhidrosis Society
National Psoriasis Foundation

 Latest Dermatology Headlines:

Latest Dermatology Headlines
Wed, 23 Apr 2014 08:11:18 +0100

http://www.medworm.com/rss/index.php/Dermatology/12/

Apr 22, 2014 04:00PM

Risk factors for juvenile dermatomyositis: Exposure to tobacco and air pollutants during pregnancy

Conclusion: Inhaled pollutants and tobacco smoking during fetal development may contribute to JDM. © 2014 American College of Rheumatology. (Source: Arthritis Care and Research)

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Apr 22, 2014 04:00PM

Morus alba L. suppresses the development of atopic dermatitis induced by the house dust mite in NC/Nga mice

Conclusion: Our results suggest that MAE has potent inhibitory effects on atopic dermatitis-like lesion and may be a beneficial natural resource for the treatment of atopic dermatitis. (Source: BMC Complementary and Alternative Medicine)

Apr 22, 2014 01:12PM

Dermoscopy and reflectance confocal microscopy of pigmented actinic keratoses: a morphological study

ConclusionLarger case series with adequate control population are warranted to validate these findings and to test their value in clinical setting. (Source: Journal of the European Academy of Dermatology and Venereology)

Apr 22, 2014 12:43PM

Simponi Eases Psoriatic Arthritis Over Long Term

(MedPage Today) -- The efficacy of golimumab (Simponi) for alleviating the joint and skin symptoms of psoriatic arthritis persisted for 5 years in the long-term extension of a randomized study. (Source: MedPage Today Dermatology)

Apr 22, 2014 02:52AM

Pemphigus vulgaris of the epiglottis successfully treated with rituximab

(Source: Journal of the European Academy of Dermatology and Venereology)

Apr 22, 2014 02:51AM

Industry News

No abstract available (Source: Advances in Skin and Wound Care)

Apr 21, 2014 06:31PM

Medical complications and deaths in 21 and 56 km road race runners: a 4-year prospective study in 65 865 runners--SAFER study I - Schwabe K, Schwellnus M, Derman W, Swanevelder S, Jordaan E.

BACKGROUND: Cardiac arrest and sudden death during distance-running events have been reported but other medical complications, including serious life-threatening complications have not been well described. OBJECTIVE: To document the incidence and n... (Source: SafetyLit: All (Unduplicated))

Apr 21, 2014 04:00PM

Hypofractionated Radiation Therapy for Early Stage Breast Cancer: Outcomes, Toxicities, and Cost Analysis

We report our outcomes and a cost analysis. Between 2000 and 2012, 84 patients participated in this IRB?approved study and underwent whole breast radiation to 23 Gy in four fractions. Local control and survival were analyzed using the Kaplan?Meier method. Acute toxicities and overall long?term cosmetic results were assessed. Costs were estimated from 2012 Medicare reimbursement data and compared to costs from standard courses of 25 and 16 fractions. All 84 patients are included in this report. Median age was 83 (range 42?98). Most patients had stage I (80%), hormone receptor positive (90%) breast cancer. Fifty?eight patients (69%) were treated prone and 26 (31%) supine. At a median follow?up of 3 years, one local recurrence has occurred, of ductal carcinoma in situ histology....

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Apr 21, 2014 04:00PM

Forthcoming Events

(Source: Journal of the European Academy of Dermatology and Venereology)

Apr 21, 2014 04:00PM

Announcement

(Source: Journal of the European Academy of Dermatology and Venereology)

Apr 21, 2014 04:00PM

Automatic method for the dermatological diagnosis of selected hand skin features in hyperspectral imaging

Conclusions: The obtained results confirmed the usefulness of the proposed new method of image analysis and processing in dermatology of the hand as it enables reproducible, quantitative assessment of any fragment of this body part. Each image in a sequence was analysed in this way in no more than 100 ms using Intel Core i5 CPU M460 @ 2.5GHz 4GB RAM. (Source: BioMedical Engineering OnLine)

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Apr 21, 2014 04:00PM

Periostin accelerates human malignant melanoma progression by modifying the melanoma microenvironment

Summary Given no reliable therapy for advanced malignant melanoma, it is important to elucidate the molecular mechanisms underlying the disease progression. Using a quantitative proteomics approach, the ?isobaric tags for relative and absolute quantitation (iTRAQ)? method, we identified that the extracellular matrix protein, periostin (POSTN), was highly expressed in invasive melanoma compared with normal skin. An immunohistochemical analysis showed that POSTN was expressed in all invasive melanoma (n = 20) and metastatic lymph node (n = 5) tissue samples, notably restricted in their stroma. In terms of the intercellular regulation of POSTN, we found that there was upregulation of POSTN when melanoma cells and normal human dermal fibroblasts (NHDFs) were cocultured, with restricted...

Apr 21, 2014 04:00PM

Electrochemotherapy as a novel treatment for primary cutaneous marginal zone B?cell lymphomas

Abstract In the present study, we describe the use of electrochemotherapy as alternative therapy for primary cutaneous marginal zone B?cell lymphomas in patients unsuitable for surgery or radiotherapy. Our experience refers to three patients with primary cutaneous marginal zone B?cell lymphomas related to Borrelia burgdorferi infection, treated with specific antimicrobial therapy and electrochemotherapy. (Source: Dermatologic Therapy)

Apr 21, 2014 04:00PM

Both low?dose arotinoid ethylester and acitretin are effective in the treatment of familial erythrokeratodermia variabilis

Abstract We previously reported a large Chinese pedigree of erythrokeratodermia variabilis (EKV). A unique feature was that some of the affected members experienced transitory pustules on the border of classic lesions. Here we prescribed oral arotinoid ethylester and acitretin to two of the affected members in the pedigree, at starting dosage of 0.03?mg/day for arotinoid ethylester and 30?mg/day for acitretin, maintenance dosage of 0.03?mg every other day and 20?mg/day, respectively. Both patients reached complete clearance of the lesions during the treatment period. Side effect was negligible for the case on arotinoid ethylester. The patient on acitretin experienced elevated level of serum triglyceride and alanine aminotransferase that restrained further use. (Source: Dermatologic...

Apr 21, 2014 04:00PM

Management of a pemphigus with IgA and IgG antibodies and coexistent lung cancer

We report a rare case of a patient, who developed atypical pemphigus with both IgA and IgG autoantibodies and an underlying lung cancer, successfully treated with corticosteroids and dapsone. (Source: Dermatologic Therapy)

Apr 21, 2014 04:00PM

Dermatological conditions presenting at the Emergency Department in Siena University Hospital from 2006 to 2011

ConclusionThis is the first long?term retrospective analysis of a large series of dermatology emergency patients. It provides useful quantitative and qualitative information on cases for physicians and the national health system for the purposes of improving patient care and cost?effectiveness. (Source: Journal of the European Academy of Dermatology and Venereology)

Apr 21, 2014 04:00PM

A multicentre, randomized, placebo?controlled trial establishing the treatment effect of TDT 068, a topical formulation containing drug?free ultra?deformable phospholipid vesicles, on the primary features of erythematotelangiectatic rosacea

ConclusionThese data, based on investigator assessment, provide evidence for the good tolerability of drug?free TDT 068 as well as modest improvements in the symptoms of erythematotelangiectatic rosacea. (Source: Journal of the European Academy of Dermatology and Venereology)

Apr 21, 2014 04:00PM

Sleep disturbances, anxiety and depression in patients with oral lichen planus: a case?control study

ConclusionWe suggest to screen sleep disturbances in patients with oral lichen planus because they could be considered a prodromal symptoms of mood disorders. (Source: Journal of the European Academy of Dermatology and Venereology)

Apr 21, 2014 04:00PM

Eccrine angiomatous hamartoma: multiple, symmetrical swellings on forearms of a 10?year?old girl

(Source: Journal of the European Academy of Dermatology and Venereology)

Apr 21, 2014 04:00PM

Primary mucinous carcinoma of the skin with in?transit metastasis

(Source: Journal of the European Academy of Dermatology and Venereology)

Apr 21, 2014 04:00PM

CXCL10, TNFR2 and Galectin?9 correlate with disease activity in Juvenile Dermatomyositis

Conclusion: This study shows that CXCL10, TNFR2 and galectin?9 correspond to the disease status in JDM and thus could be helpful in monitoring disease activity and guiding treatment. Furthermore, they might provide new knowledge about the pathogenesis of this autoimmune disease. © 2014 American College of Rheumatology. (Source: Arthritis and Rheumatism)

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Apr 21, 2014 04:00PM

Clinical characteristics and treatment outcomes of autoimmune?associated hemophagocytic syndrome in adults

Conclusion. AAHS is potentially fatal. Corticosteroids are the mainstay of initial treatment. For corticosteroids?refractory cases, IVCY may be beneficial as compared with cyclosporine or IVIG. Proceeding directly from corticosteroids to biologics is promising. © 2014 American College of Rheumatology. (Source: Arthritis and Rheumatism)

Apr 21, 2014 04:00PM

Pilot Study of Etanercept in Patients With Refractory Juvenile Dermatomyositis

ConclusionIn this trial of patients with refractory juvenile DM, etanercept did not demonstrate appreciable improvement and some patients noted worsening of disease. Caution should be taken when recommending TNF receptor inhibitors to patients with active symptoms of juvenile DM, and close followup is warranted. Further investigation of the interaction of the TNF??308A polymorphism and type I interferon is needed to define the mechanism of TNF blockade in juvenile DM. (Source: Arthritis Care and Research)

Apr 21, 2014 02:37PM

Adverse reaction to silicone simulating orofacial granulomatosis

ConclusionWe describe and illustrate a new type of adverse reaction to injected silicone simulating orofacial granulomatosis. The reaction presents as recurrent, unilateral, asymmetric facial edema of the cheek in patients who have been injected with silicone in the face. Familiarity with this adverse reaction will help to prevent erroneous diagnoses such as idiopathic angioedema, Melkersson Rosenthal syndrome, and orofacial granulomatosis. (Source: Journal of the European Academy of Dermatology and Venereology)

Apr 21, 2014 02:37PM

Influence of Smoking on Wound Healing in Patients Undergoing Nail Matrix Phenolization: A Prospective Randomized Clinical Study

PURPOSE:To enhance the learner?s competence with knowledge of the effect of smoking on wound healing in patients undergoing nail matrix phenolization. TARGET AUDIENCE:This continuing education activity is intended for physicians and nurses with an interest in skin and wound care. OBJECTIVES:After participating in this educational activity, the participant should be better able to:1. Summarize factors that affect wound cicatrization and pathophysiologic mechanisms of impaired healing from smoking as found in prior studies from review of the literature.2. Analyze components and findings of this research study on how healing from phenol ablation is influenced by smoking. (Source: Advances in Skin and Wound Care)

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Apr 20, 2014 11:00PM

Health Tip: Protect Your Skin

Title: Health Tip: Protect Your SkinCategory: Health NewsCreated: 4/21/2014 7:35:00 AMLast Editorial Review: 4/21/2014 12:00:00 AM (Source: MedicineNet Skin General)

Apr 20, 2014 04:33PM

What Treatment is Available for Lymphatic Malformations?

Discussion Vascular malformations including those of the arterial, venous and lymphatic systems are due to an arrest of the normal process of angiogenesis, vasculogenesis and remodeling of the vessels. They are not tumors and need to be differentiated from benign and malignant vascular lesions. They occur in 1.5% of the population with 90% present at birth. The nomenclature of congenital lymphatic malformations can be confusing. They can be present in any location and may have mixed elements within them (i.e. lymphatic and venous, lymphatic and arterial, etc.) and different structural components such as dilatation or hyperplasia. Thus people will use different wording that can be ambiguous or incorrect. Lymphatic malformations and problems can be acquired also usually secondary to trauma ...

Apr 20, 2014 04:00PM

Global transcriptional analysis reveals surface remodeling of Anaplasma marginale in the tick vector

Anaplasma marginale undergoes surface remodeling when grown in tick cell culture as compared to bovine blood. The A. marginale transcriptional profile from tick salivary glands after acquisition feeding most closely resembles that seen in cell culture. Image: Tick cell culture and Dermacentor andersoni tick. (Source: Parasites and Vectors)

Apr 20, 2014 04:00PM

Dermoscopic criteria associated with BRAF and NRAS mutation status in primary cutaneous melanoma

ConclusionsThis study showed a correlation between BRAF and NRAS status and dermoscopic findings of ?peppering? as an expression of regression and melanophages in dermis, suggesting a morphological consequence of immune behavior in BRAF mutated melanomas.This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)

Apr 20, 2014 04:00PM

Demographic, behavioural and physician?related determinants of early melanoma detection in a low incidence population

ConclusionsSSE was shown to be an important factor in the detection of thin melanoma, in contrast to partial or full body PSE which did not show any statistically significant effect on tumour thickness.This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)

Apr 20, 2014 04:00PM

Providing lifestyle behaviour change support for patients with psoriasis: an assessment of the existing training competencies across medical and nursing health professionals

ConclusionsDevelopment of post?qualification curricula would ensure health professionals are equipped with the necessary knowledge, skills and attitudes to support LBC for psoriasis patients. This is of particular relevance, given the evidence linking unhealthy lifestyles with psoriasis outcomes.This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)

Apr 20, 2014 04:00PM

Cost?effectiveness of topical imiquimod and fluorouracil versus photodynamic therapy for treatment of superficial basal?cell carcinoma

ConclusionBased on the 12 months follow?up results of this economic evaluation, imiquimod and topical fluorouracil cream are cost?effective therapies, i.e. they are more effective and less expensive compared to MAL?PDT for treatment of superficial BCC. Hence, substituting MAL?PDT with either imiquimod or topical fluorouracil results in cost savings although these savings will be larger for topical fluorouracil than for imiquimod. Long?term follow?up effectiveness data are necessary to achieve more conclusive results regarding the cost?effectiveness of imiquimod versus topical 5?fluorouracil cream.This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)

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Apr 20, 2014 04:00PM

Understanding the relationship between disease severity and health?related quality of life: Itching is a significant mediator and problem for patients with psoriasis

ConclusionsPruritus appears to be an important mediator of the association between improvements in disease severity and HRQOL in patients with moderate?to?severe psoriasis.This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)

Apr 20, 2014 04:00PM

Distinct protein expression and activity of transglutaminases found in different epidermal tumors

This article is protected by copyright. All rights reserved. (Source: Experimental Dermatology)

Apr 20, 2014 04:00PM

Distinct melanoma types based on reflectance confocal microscopy

ConclusionsIntegration of confocal microscopy with clinical and histologic aspects may help in identifying and managing distinct tumors.This article is protected by copyright. All rights reserved. (Source: Experimental Dermatology)

Apr 20, 2014 04:00PM

Modulating hair follicle size with Wnt10b/DKK1 during hair regeneration

This article is protected by copyright. All rights reserved. (Source: Experimental Dermatology)

Apr 20, 2014 04:00PM

Non?equilibrium atmospheric pressure plasmas modulate cell cycle?related gene expressions in melanocytic tumors of RET?transgenic mice

This article is protected by copyright. All rights reserved. (Source: Experimental Dermatology)

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Apr 20, 2014 04:00PM

Cannabinoid 1 receptors in keratinocytes attenuate FITC?induced mouse atopic?like dermatitis

This article is protected by copyright. All rights reserved. (Source: Experimental Dermatology)

Apr 20, 2014 04:00PM

Wnt5a ? a potential factor linking psoriasis to metabolic complications

This article is protected by copyright. All rights reserved. (Source: Experimental Dermatology)

Apr 20, 2014 04:00PM

Necrotizing fasciitis of the thigh revealing a Crohn's disease

(Source: Journal of the European Academy of Dermatology and Venereology)

Apr 20, 2014 04:00PM

Fast?growing ?giant? clear cell acanthoma detected by dermoscopy during treatment with infliximab in a psoriatic patient

(Source: Journal of the European Academy of Dermatology and Venereology)

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Apr 20, 2014 04:00PM

Epicardial adipose tissue and coronary artery calcification in psoriasis patients

ConclusionThis study showed that psoriasis was associated with increased EAT volume independently of visceral abdominal fat and with subclinical atherosclerosis. Within psoriasis patients EAT volume was independently associated with CAC. EAT may be another important contributor to the higher cardiovascular risk observed in psoriasis. (Source: Journal of the European Academy of Dermatology and Venereology)

Apr 20, 2014 04:00PM

Role of obesity on the thickness of primary cutaneous melanoma

ConclusionsObesity is a clinical independent risk factor of thick PCM. For health policies, governments should pay greater attention to detect melanoma in obese patients. Our results encourage the basic research on tumoural growth mechanisms due to obesity in melanoma. (Source: Journal of the European Academy of Dermatology and Venereology)

Apr 19, 2014 03:00PM

Direct analysis of airborne mite allergen (Der f1) in the residential atmosphere by chemifluorescent immunoassay using bioaerosol sampler.

Authors: Miyajima K, Suzuki Y, Miki D, Arai M, Arakawa T, Shimomura H, Shiba K, Mitsubayashi K Abstract Dermatophagoides farinae allergen (Der f1) is one of the most important indoor allergens associated with allergic diseases in humans. Mite allergen Der f1 is usually associated with particles of high molecular weight; thus, Der f1 is generally present in settled dust. However, a small quantity of Der f1 can be aerosolized and become an airborne component. Until now, a reliable method of detecting airborne Der f1 has not been developed. The aim of this study was to develop a fiber-optic chemifluorescent immunoassay for the detection of airborne Der f1. In this method, the Der f1 concentration measured on the basis of the intensity of fluorescence amplified by an enzymatic reaction...

Apr 19, 2014 12:23AM

Free Dermatological Drug Samples Increase Prescription CostsFree Dermatological Drug Samples Increase Prescription Costs

A new study has shown that free drug samples given to dermatologists can increase overall prescribing costs. Medscape Medical News (Source: Medscape Business of Medicine Headlines)

Apr 18, 2014 04:00PM

Mouse bone marrow?derived dendritic cells can phagocytize the Sporothrix schenckii, and mature and activate the immune response by secreting interleukin?12 and presenting antigens to T lymphocytes

Abstract In sporotrichosis, dermal dendritic cells were considered to participate in induction of the immune responses against Sporothrix schenckii infection. However, it is still unclear whether and how dermal dendritic cells were involved in the progress. To clarify the pathogenic role of dermal dendritic cells (DC) in sporotrichosis, we examined the phagocytosis, maturation stages, cytokine production and antigen?presenting ability of mouse bone marrow?derived DC after stimulation with S. schenckii. By analysis of flow cytometry, electron microscope and confocal microscope, mouse bone marrow?derived DC were proved to be able to phagocytize the S. schenckii. The increased expression of CD40, CD80 and CD86 on the surface of S. schenckii?pulsed mouse bone marrow?derived DC was...

Apr 18, 2014 04:00PM

Entero?Behçet's disease coexisting with long?term epilepsy and schizophrenia?like symptoms

Abstract Entero?Behçet's disease coexisting with long?term epilepsy and schizophrenia?like symptoms is presented. A 43?year?old woman presented with repeatedly occurring aphthous stomatitis for several years. She had been treated for absence seizures, epilepsy and schizophrenia since she was 9 years old. She presented with multiple aphthous stomatitis on her gingiva, erythema nodosum?like symptoms on the right lateral aspect of her leg and genital ulcers on her perianal area. She also showed polyarthritis. Laboratory examinations revealed elevated C?reactive protein, elevated neutrophil counts, decreased serum Fe and elevated serum Cu. Histological examination showed perivascular neutrophil and mononuclear cell infiltrates and eosinophilic change of the vessel wall in the l...

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Apr 18, 2014 04:00PM

Case of trichomycosis axillaris caused by Corynebacterium propinquum

(Source: The Journal of Dermatology)

Apr 18, 2014 04:00PM

Post?herpes zoster sarcoidosis

(Source: The Journal of Dermatology)

Apr 18, 2014 04:00PM

Calcitriol inhibits keratinocyte proliferation by upregulating leukocyte elastase inhibitor (serpin B1)

Abstract Calcitriol had been proved to be effective for treatment of psoriasis vulgaris. However, the molecular events leading to the normalization of keratinocyte differentiation had not been fully explored. The aim of the study was to evaluate the role of calcitriol and serpin B1 in human keratinocyte cell line (HaCaT) proliferation. Proteins extracted from calcitriol?treated and untreated HaCaT were separated by 2?D differential gel electrophoresis (2DE). Then, the 2DE profiles were analyzed to screen for differentially expressed proteins, which were identified by matrix?assisted laser desorption/ionization time of flight mass spectrometry. The upregulation of serpin B1 was confirmed by quantitative reverse transcription polymerase chain reaction (qRT?PCR) and western blot analy...

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Apr 18, 2014 04:00PM

Bullous morphea arising at the site of a healed herpes zoster

(Source: The Journal of Dermatology)

Apr 18, 2014 04:00PM

Unusual case of linear anetoderma in children

(Source: The Journal of Dermatology)

Apr 18, 2014 04:00PM

Lymphomatoid Papulosis in children: A Series of 25 Cases

ConclusionPaediatric LyP belongs to CD30?positive CTLPD including C?ALCL. Children have to be carefully life?long followed?up even if the prognosis appears good. The high frequency of an associated viral infection, atopic dermatitis, marked eosinophilic infiltrate and a good outcome suggests that paediatric LyP could be considered as a reactional disease rather than a malignant disorder.This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)

Apr 18, 2014 04:00PM

Safety of biologic therapies for psoriasis on reproductive potential and outcomes in males and females

This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)

Apr 18, 2014 04:00PM

Risk factors for facial melasma in women: a case?control study

ConclusionsFacial melasma is independently associated to elements linked to pigmentation capacity, family ancestry, chronic sun exposure, sexual hormone stimuli, psychotropics and anxiety traits.This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)

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Apr 18, 2014 04:00PM

First report of a ipilimumab?induced Grover's disease

This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)

Apr 18, 2014 04:00PM

Weekly radiotherapy for basal cell carcinomas in .the frail and elderly

This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)

Apr 18, 2014 01:36PM

Common Dermatologic Conditions

This review discusses common dermatologic presentations as they would appear in a primary care office, exploring the differential diagnoses for each. Tips are provided on choosing an appropriate topical drug and vehicle and advising patients on its use. Etiology, differential diagnosis, and treatment options are discussed for the following: alopecias including androgenetic alopecia, female pattern hair loss, alopecia areata, and telogen effluvium; facial rashes including acne vulgaris, acne rosacea, periorificial dermatitis, seborrheic dermatitis, erysipelas/cellulitis, and systemic lupus erythematosus; intertriginous rashes including infections, intertrigo, and inverse psoriasis; and the inflamed leg including cellulitis and erysipelas, stasis dermatitis, and contact dermatitis. (Source: ...

Apr 17, 2014 04:00PM

Understanding the dandruff scalp before and after treatment: an in vivo Raman spectroscopic study

ConclusionThe in vivo Raman probe has allowed the direct measurement of dandruff?affected skin in situ for the first time. It has been shown that the dandruff SC is different from that of the non? dandruff scalp and that it is changed by treatment with shampoo containing ZnPTO and brought towards the characteristics of non? dandruff scalp. It offers novel insights into how the nature of a healthy scalp should be defined.This article is protected by copyright. All rights reserved. (Source: International Journal of Cosmetic Science)

Apr 17, 2014 04:00PM

Aqueous dispersions of organogel nanoparticles ? potential systems for cosmetic and dermo?cosmetic applications

ConclusionThe obtained results demonstrate the interest of these gelled nanoparticles and their aqueous dispersion for the preparation of new formulations for cosmetic and dermo?cosmetic applications.This article is protected by copyright. All rights reserved. (Source: International Journal of Cosmetic Science)

Apr 17, 2014 04:00PM

Evaluation Of The Content ? Containing Interaction In Cosmetics Products Using Gas Chromatography ? Mass Spectrometry

This article is protected by copyright. All rights reserved. (Source: International Journal of Cosmetic Science)

Apr 17, 2014 04:00PM

Influence of pH, concentration of sodium lactate as an additive, and ultrasonic treatment on synthesis of zinc phosphate white pigments

This article is protected by copyright. All rights reserved. (Source: International Journal of Cosmetic Science)

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Apr 17, 2014 04:00PM

Histopathological analysis of the progression pattern of subungual melanoma: late tendency of dermal invasion in the nail matrix area

Authors: Hyun-Tae Shin, Kee-Taek Jang, Goo-Hyun Mun, Dong-Youn Lee & Jason B Lee (Source: Modern Pathology AOP)

Apr 17, 2014 01:12PM

Table of Contents

(Source: Journal of the American Academy of Dermatology)

Apr 17, 2014 01:12PM

Information for Readers

(Source: Journal of the American Academy of Dermatology)

Apr 17, 2014 01:12PM

Dermatology Calendar

(Source: Journal of the American Academy of Dermatology)

Apr 17, 2014 01:12PM

Localized bullous fixed drug eruption following yellow fever vaccine

To the Editor: Yellow fever is a potentially fatal, mosquito-borne disease endemic to areas of South America and Africa. The yellow fever vaccine is recommended to those traveling to high-risk areas and is considered one of the safest and most effective vaccines ever developed. The vaccine is a live attenuated version of the 17D strain grown in egg embryos and imparts durable immunity for 10 years. Reported dermatologic side effects of the vaccine include mild injection site reactions, urticaria, and anaphylaxis. (Source: Journal of the American Academy of Dermatology)

Apr 17, 2014 01:12PM

Iotaderma #244

(Source: Journal of the American Academy of Dermatology)

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Apr 17, 2014 01:12PM

April iotaderma (#243)

(Source: Journal of the American Academy of Dermatology)

Apr 17, 2014 01:12PM

Editorial Board

(Source: Journal of the American Academy of Dermatology)

Apr 17, 2014 01:12PM

Treatment of molluscum contagiosum with ingenol mebutate

Molluscum contagiosum (MC) is a common and benign contagious viral skin condition of childhood that accounts for approximately 1% of all diagnoses of skin disorders and up to 10% of skin disorder diagnoses in the pediatric population (Source: Journal of the American Academy of Dermatology)

Apr 17, 2014 01:12PM

A unique protective bandage for preauricular surgery

Creating a pressure dressing for preauricular surgery can be difficult because of the anatomy of the ear and nearby hair. This dressing is indicated for scars located in the preauricular region, between the apex of the helix and ear lobe, 3 cm from the pinna?s anterior implantation (tragus; , A). After covering the surgical scar with ointment and sterile gauze (, B), the bandage is fixed in a vertical direction with hypoallergenic adhesive tape (25 × 12 mm; , C). (Source: Journal of the American Academy of Dermatology)

Apr 17, 2014 01:12PM

Brimonidine effective but may lead to significant rebound erythema

We report a case of facial erythema of rosacea that responded well to this medication, however, rebounded with significantly greater erythema than baseline for the patient. (Source: Journal of the American Academy of Dermatology)

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Apr 17, 2014 01:12PM

Trigeminal trophic syndrome secondary to recurrent meningioma

To the Editor: A 45-year-old man with a history of childhood acute lymphocytic leukemia and radiation-induced bilateral recurrent meningiomas requiring resection in 2001 and resection and Gamma-Knife in 2010 presented with a 4-week history of unexplained facial ulcerations followed by the development of headaches. He reported waking with ?bloody lesions? on his face, which were preceded by facial pain he rated on a scale of 1 to 10 as an 8. He denied pruritus and picking his face. His headaches were associated with left-sided photophobia and facial numbness. Physical exam revealed a red, ulcerated, indurated left tragus. Scattered 5- to 10-mm annular pink atrophic scars with peripheral hyperpigmentation were seen on the left cheek, forehead, and nose (). A 2- x 1-cm superficial ulcerat...

Apr 17, 2014 01:12PM

Striking leflunomide efficacy against refractory cutaneous sarcoidosis

We describe leflunomide efficacy in 2 patients whose cutaneous sarcoidoses were refractory to conventional therapies. (Source: Journal of the American Academy of Dermatology)

Apr 17, 2014 01:12PM

Painless papules on the hands

A 56-year-old man presented with a 6-month history of a progressive asymptomatic papular eruption that began on the dorsal surfaces of his thumbs (, A). The physical examination revealed hundreds of monomorphic firm, clustered 1- to 2-mm skin-colored papules that were symmetrically distributed on the dorsal surfaces of his hands, arms, upper back, neck, and forehead (, B). The hands were notable for skin thickening over the proximal interphalangeal joints (, C). A skin biopsy specimen obtained from a papule on the dorsal surface of one of his hands revealed marked fibroblast proliferation and increased collagen with separation of fibers in the papillary dermis (, A, hematoxylin and eosin stain) caused by diffuse dermal mucin (, B, alcian blue stain). Serum thyroid studies were within norma...

Apr 17, 2014 01:12PM

A woman with pruritic papules in her tattoo

A 46-year-old woman presented with a 3-month history of pruritic, burning papules within a 10-year-old tattoo. The physical examination revealed a large, multicolored tattoo across her back with discrete papules in the black portion (). Tender, red subcutaneous nodules were present on the anterior aspect of the lower legs. The patient developed systemic symptoms, including low-grade fevers, fatigue, chest pain, arthralgias, shortness of breath, and cough. A computed tomography scan of the chest was performed, and it revealed bilateral hilar lymphadenopathy. Pertinent laboratory tests include an elevated serum angiotensin-converting enzyme titer at 80 U/L (reference range, 8-53 U/L). Punch biopsy specimens were obtained from the mid-back tattoo and a left dorsal thumb papule (). (Source: Jo...

Apr 17, 2014 01:12PM

Uncovering a hidden basal cell carcinoma

The routine clinical examination of a 63-year-old man with a 3-year history of plaque psoriasis (PP) revealed numerous erythematous scaly papules and plaques on the trunk and extremities (). (Source: Journal of the American Academy of Dermatology)

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Apr 17, 2014 01:12PM

Adhesive tape technique to enhance potassium hydroxide diagnosis of occult fungal infections

Most potassium hydroxide (KOH) preparations are readily executed and interpreted. Occasionally, hyphae are few or none. When the lesion is clinically suspect of fungal disease and KOH negative, we use adhesive tape not to take a specimen for direct examination but to produce a moist environment under occlusion. Fungal infections generally occur in moist or warm areas because fungi can easily flourish under such conditions. We apply plastic tape to the active outer border of their lesion and request that the patient reattach this tape with additional tape whenever it loosens (). Fungi therefore flourish under the tape. After 2 to 3 days, there will be a high quality sample for examination, which enables a physician to identify mycelia and spores. This simple technique provides a satisfacto...

Apr 17, 2014 01:12PM

Vacation dermatoses

A 6-year-old boy presented with an intensely pruritic rash on his left lower extremity after vacationing in Costa Rica (). He was seen in a local urgent care center, and over the course of 2 weeks was treated with multiple antibiotic ointments and oral antibiotics with no improvement. His mother reported that the patient frequented the beach while in Costa Rica, and that there were often stray dogs on the beach. (Source: Journal of the American Academy of Dermatology)

Apr 17, 2014 01:12PM

Important Notice Regarding JAAD Grand Rounds

(Source: Journal of the American Academy of Dermatology)

Apr 17, 2014 01:12PM

JAAD Grand Rounds quiz? Adult with vesicles and bullae

Learning objectives: At the conclusion of this learning activity, physician participants should be able to assess their own diagnostic and patient management skills and use the results of this exercise to help determine personal learning needs.Instructions: In answering each question, refer to the specific directions provided. Because it is often necessary to provide information occurring later in a series that give away answers to earlier questions, please answer the questions in each series in sequence. (Source: Journal of the American Academy of Dermatology)

Apr 17, 2014 01:12PM

Necrotic plaques in a traveler

A 76-year-old man presented to the emergency department with a 5-day history of severe supraorbital headaches, significant muscle weakness, continuous fevers, and nonpainful ulcers on his right leg. His symptoms began 2 days after returning from a hunting trip to the rural area between Durban and Port Elizabeth, South Africa. The patient?s travel partner also had been having fevers since their return. The physical examination revealed 2 purpuric plaques with a central ulceration and black eschar involving the right medial aspect of the upper thigh and the right popliteal fossa (). There was palpable lymphadenopathy in the right groin. A punch biopsy specimen obtained from the right popliteal fossa lesion was bisected and sent for both routine histology () and culture. A histopathologic e...

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Apr 17, 2014 01:12PM

Expression of programmed death receptor ligand 1 in melanoma may indicate tumor progression and poor patient survival

To the Editor: Melanoma is characterized by a high potential to metastasize at low primary tumor volumes and by a high resistance to conventional therapies. One reason for this is that the tumor microenvironment can protect tumor cells from immune surveillance by a mechanism called ?tumor evasion.? Programmed death receptor ligand 1 (PD-L1) plays an important role in this mechanism by negatively regulating T-cell function. Aberrant PD-L1 expression has been described in melanoma, but its prognostic relevance remains controversial. Therefore, we aimed to analyze PD-L1 expression in melanoma and evaluate its relationship with prognosis. (Source: Journal of the American Academy of Dermatology)

Apr 17, 2014 01:12PM

Change of Address

(Source: Journal of the American Academy of Dermatology)

Apr 17, 2014 01:12PM

Ductal hypoxia in acne: Is it the missing link between comedogenesis and inflammation?

Two visions of the etiopathogenesis of acne vulgaris and acne inversa exist. The traditional considers the main driver of acne to be androgens, causing excess proliferation of sebocytes and ductal keratinocytes. The impact of androgens on the components of the folliculopilosebaceous unit (FPSU) has been known for decades. Androgens induce the proliferation of the ductal keratinocytes in the follicular canal. This expanding plug of compact keratin stretches the duct to its maximal circumference, anoxia occurs, the duct leaks and ruptures, keratin and other stimuli are released into the dermis, the toll-like receptors of the innate immune system are activated, and inflammation follows. (Source: Journal of the American Academy of Dermatology)

Apr 17, 2014 01:12PM

Maintenance of certification in dermatology?what we know, what we don't

To the Editor: The Federation of State Medical Boards (FSMB) appreciates the article about the value of lifelong learning and the overview of the FSMB's Maintenance of Licensure (MOL) initiative. As several state medical boards begin to study the implementation of MOL, it is important to recognize that our recommendations do not include, as the article suggests, a ?proctored examination.? The MOL framework adopted in 2010 by FSMB's member boards does not require physicians to take examinations to comply with MOL. While an exam may be an option that some physicians wish to utilize to demonstrate their knowledge and skills in their area of practice, we do not believe such an exam should be mandatory to renew a state medical license. (Source: Journal of the American Academy of Dermatology...

Apr 17, 2014 01:12PM

Comment on ?A double-blind, randomized, placebo-controlled trial of adalimumab in the treatment of cutaneous sarcoidosis?

To the Editor: Recently, the University of Ottawa?s Division of Dermatology (Canada) reviewed ?A double-blind, randomized, placebo-controlled trial of adalimumab in the treatment of cutaneous sarcoidosis? by Pariser et al during our monthly journal club. While we commend the authors on several fronts, the conclusion of the article seems disconnected from the data presented. (Source: Journal of the American Academy of Dermatology)

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Apr 17, 2014 01:12PM

A response to "Comment on ?A double-blind, randomized, placebo-controlled trial of adalimumab in the treatment of cutaneous sarcoidosis?"

To the Editor: The letter of Drs Sauder, Beecker, and Ramsay makes some points with which I agree. This small trial was an attempt to address the lack of controlled clinical data for cutaneous sarcoidosis. The choice of adalimumab was based on a believable pathophysiologic rationale and on anecdotal reports. The concern that adalimumab has been associated with the onset of sarcoidosis seems questionable. Do we avoid adalimumab in patients with psoriasis because it has been associated with the onset of pustular psoriasis in some individuals with rheumatoid arthritis? (Source: Journal of the American Academy of Dermatology)

Apr 17, 2014 01:12PM

Robotic teledermatopathology from an African dermatology clinic

In this study, we summarize our experience with nearly 300 cases seen via the robotic telepathology system in Gaborone, Botswana (in which the microscope is controlled and slides are viewed remotely by the consulting pathologist) and attempt to gauge its impact on the care of patients with dermatologic conditions in that country. (Source: Journal of the American Academy of Dermatology)

Apr 17, 2014 01:12PM

The ethical implications of ?more than one way to skin a cat? Increasing use of radiation therapy to treat nonmelanoma skin cancers by dermatologists

Dr Will B. Rich (Dr R) runs a successful dermatology practice but is intrigued by the possibility of increasing his profits in an environment of declining reimbursements. A representative from a company visits his office and introduces him to a novel way to treat skin cancer with a relatively new Food and Drug Administration (FDA)-approved radiation device. The company representative advises Dr R that this technology will allow him to retain patients rather than refer them to a Mohs surgeon for the treatment of nonmelanoma skin cancers (NMSCs). The actual treatment will be performed by a radiation oncologist whose fee is much less than the code the company suggests Dr R use for reimbursement. Dr R realizes that this procedure has the potential to significantly diversify his practice and to...

Apr 17, 2014 01:12PM

American Board of Dermatology Examination Dates

(Source: Journal of the American Academy of Dermatology)

Apr 17, 2014 01:12PM

Answers to CME examination

(Source: Journal of the American Academy of Dermatology)

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Apr 17, 2014 01:12PM

CME examination

(Source: Journal of the American Academy of Dermatology)

Apr 17, 2014 01:12PM

The spectrum of oculocutaneous disease: Part II. Neoplastic and drug-related causes of oculocutaneous disease

There are a multitude of diseases that commonly affect both the skin and the eye. Part II of this 2-part series reviews the oculocutaneous manifestations of neoplasms, both benign and malignant, and adverse drug reactions affecting the skin and the eye. Though rare, a number of neoplasms that primarily involve the skin, such as melanoma and basal cell carcinoma, can metastasize to the eye, leading to permanent damage if not properly treated. In addition, periocular neoplasms can irritate the conjunctiva and lid, reducing a patient's ability to see clearly. Neoplastic diseases, such as xeroderma pigmentosum, Sturge?Weber syndrome, and multiple myeloma, can also lead to permanent changes in the eye if not discovered and managed promptly. Furthermore, there are a multitude of drugs, includi...