Dr. William Ting, Board-Certified Dermatologist
at California Dermatology Care

2262 Camino Ramon, San Ramon, CA 94583
Tel: 925-328-0255
Email: staff@CalDermCare.com


Advanced Care with a Personal Touch

   

 

 

Medical Dermatology    Evidence-based medicine   Customized solution   Personal care

Latest Dermatology Headlines

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* Patient Biopsy Results via LabCalls


MEDICAL DERMATOLOGY

Acne and Acne Scar

Excimer Laser for Psoriasis & Vitiligo

Keloid & Hypertrophic Scar Laser Therapy

Mohs Surgery for Skin Cancers

Nail Fungus GenesisPlus Laser Therapy

Photodynamic Therapy

Psoriasis & NBUVB Phototherapy

RadioTherapy Nonsurgical SRT-100 for Skin Cancer and Keloid 

Skin Allergy Patch Test

Sweating Disorder MiraDry for Hyperhidrosis

Wart Laser Therapy


COSMETIC DERMATOLOGY

Aesthetician Services
Microdermabrasion
 

Botox, Dysport & Xeomin

Cellulaze Cellulite Therapy

new! CoolSculpting

Facial Redness/Vein Laser Therapy

Fillers injection for Wrinkles

Fractional CO2 laser

new! Hair Transplant with Neograft

Laser Surgery Services
Acne/Pore reducing Laser
Collagen Stimulating Laser
Excimer Laser
Facial Veins laser
Hair Laser Removal
IPL Fotofacial
Melasma Laser
Nail Fungus Laser
Resurfacing Laser
Scar revision Laser
Tattoo Removal Lasers
VBeam Pulse Dye Laser
Wart Laser


Latisse

Leg Vein Laser Therapy & Asclera Sclerotherapy

Liposonix + Vaser Shape Nonsurgical Body Sculpting
 

Melasma and Pigmentation newly updated!

Pore Size Reduction and Laser Rejuvenation

Sculptra Liquid Facelift

SideLaze Lift

Ulthera natural lift & skin tightening of face and neck


Related Websites
FaceUpLifting.com
iCellulaze.com
MoreHair4Me.com
SideLazeLift.com
SonixLipo.com


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925-328-0255

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* Review Dr. Ting's 717+ Q&A on RealSelf

Dr. William Ting has expertise in treating the entire spectrum of medical dermatology, with emphasis in preventive medicine and personalized recommendations. He enjoys taking care of patients with acne, eczema, hair and nail disorders, rashes, psoriasis and skin cancers.

He is at the forefront of medical dermatology and dermatologic research. He continues to publish articles in peer-reviewed dermatology journals. He is an early pioneer of photodynamic therapy (PDT) and one of the most experienced practitioners of PDT in the Bay Area. He is the first dermatologist in the San Francisco Bay Area and Northern California to introduce Lutronic Spectra Laser for melasma, acne, scar revision, pore size reduction as well as the Cutera GenesisPlus laser for advanced nail fungus laser treatment, keloid and hypertrophic scar, warts and scar revision.

Dr. Ting is a fellow of the American Academy of Dermatology (AAD) and American Society of Dermatologic Surgery (ASDS). He is a member of the National Psoriasis Foundation and International Hyperhidrosis Society.

Innovative Therapeutic Approach to Common Skin Conditions

Acne

Eczema (Atopic Dermatitis)

Hair and Nail disorders

  • Maximize therapeutic synergy and efficacy by utilizing both prescription-strength and over-the counter products when available
  • Comprehensive workup including bloodwork and biopsy if necessary
  • Systemic oral hormonal therapy for women and men when indicated

Psoriasis 

Rosacea

  • Multi-prong approach to minimize redness
  • Low-dose 'non-antibiotic' anti-inflammatory oral medication for long-term remission 
  • Emphasis on prevention
  • Fotofacial/IPL laser utilizing Cynosure XPL/Elite MPX
  • Cutera GenesisPlus Laser with or without combination with IPL 
  • Diode laser for facial veins
  • VBeam Pulse Dye Laser, the new gold standard for rosacea and facial redness

Skin Cancer 

  • Emphasis on prophylactic treatments with topical 5-FU, imiquimod, diclofenac, ingenol mebutate and oral chemopreventive therapy such as Soriatane.
  • Reduce future risks of skin cancer with photodynamic therapy, TCA chemical peels and/or fractional CO2 resurfacing laser  
  • Mohs Surgery to achieve highest cure rate and tissue sparing
  • Close colloboration with plastic surgeon(s) as needed  

Sweating Disorder (Hyperhidrosis) 

Vitiligo

Warts 


ABCD of Mole Check

 

 

Common Medical Dermatology Diagnostics and Therapeutics:

Dermatology Links:

American Academy of Dermatology
American Society of Dermatologic Surgery
American Society of Mohs Surgery
International Hyperhidrosis Society
National Psoriasis Foundation

 Latest Dermatology Headlines:

Latest Dermatology Headlines
Wed, 28 Jan 2015 07:40:10 +0100

http://www.medworm.com/rss/index.php/Dermatology/12/

Jan 27, 2015 11:35PM

Co?existence of psoriasis and melanoma in a large urban academic centre population: a cross?sectional retrospective study

ConclusionOur findings show a statistically significant association between psoriasis and melanoma. After adjusting the OR for phototherapy and age, a statistically significant association remained. Further investigations exploring these associations are warranted in order to establish the relative risk for melanoma in psoriasis patients. (Source: Journal of the European Academy of Dermatology and Venereology)

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Jan 27, 2015 11:32PM

Concomitant Mycosis Fungoides and Vitiligo: How Mycosis Fungoides May Contribute to Melanocyte Destruction

Conclusions: No single feature was common to all of our patients, suggesting that multiple factors may contribute to the development of vitiligo in a patient-specific fashion.Dermatology (Source: Dermatology)

Jan 27, 2015 11:32PM

Development of a Non-Melanoma Skin Cancer Detection Model

Conclusions: Detection or screening models for AK and BCC could be made with a limited number of variables. Nurses also diagnosed skin lesions correctly in a high percentage of cases. Further research is necessary to investigate the robustness of these findings, whether the percentage of correct diagnoses can be improved and how best to implement model-based prediction in the diagnostic process.Dermatology (Source: Dermatology)

Jan 27, 2015 11:32PM

Symptoms in Plasma Cell Vulvitis: First Observational Cohort Study on Type, Frequency and Severity

Conclusions: Symptoms in PCV are frequent and more than often severe. Neither age at onset nor duration of the disease nor the extent of vulvar involvement were associated with symptom severity. Both the delay in diagnosis and the inappropriate previous treatments seem to indicate frequent misdiagnosis.Dermatology (Source: Dermatology)

Jan 27, 2015 11:28PM

Novel missense mutation in the EDA1 gene identified in a family with hypohidrotic ectodermal dysplasia

ConclusionsWe found a novel missense mutation in exon 1 of the EDA1 gene in a putative Mayan family from México with XL?HED. We identified in this population some novel clinical signs of HED. (Source: International Journal of Dermatology)

Jan 27, 2015 04:10PM

A large hyperplastic nodule on the abdomen.

Authors: Zhang Y, Li Z, Xiao S, Feng Y Abstract A 65-year-old man presented with a slowly enlarging, hyperplastic cutaneous nodule on the abdomen that developed over a period of 20 years. Based on the clinical manifestation and typical histopathology, the patient received a diagnosis of giant basal cell carcinoma. PMID: 25612134 [PubMed - in process] (Source: Dermatol Online J)

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Jan 27, 2015 04:10PM

Danazol-induced Stevens-Johnson syndrome in a patient with systemic lupus erythematosus.

Authors: Koh W, Tay Y, Koh M Abstract A patient with Stevens-Johnson syndrome related to danazol is presented. PMID: 25612133 [PubMed - in process] (Source: Dermatol Online J)

Jan 27, 2015 04:10PM

Pulmonary sarcoidosis and latent tuberculosis in a patient with psoriasis treated with adalimumab.

We report the case of a 54-year old man with plaque psoriasis who developed a positive TB test and pulmonary sarcoidosis after 12 months of adalimumab treatment. After stopping adalimumab, his psoriasis worsened and he was started on ustekinumab and narrowband UVB, with improvement in symptoms. We provide a review of the literature and discuss treatment challenges. PMID: 25612132 [PubMed - in process] (Source: Dermatol Online J)

Jan 27, 2015 04:10PM

Worn down nails after acrylic nail removal.

We present a previously undescribed source of worn-down nail syndrome caused by trauma from nail filing after acrylic nail removal. PMID: 25612131 [PubMed - in process] (Source: Dermatol Online J)

Jan 27, 2015 04:10PM

A case of cutaneous larva migrans presenting in a pregnant patient.

We present a case of CLM in a 31-year-old pregnant woman. The treatment of CLM relies on antihelminthic agents, such as thiabendazole, albendazole, and ivermectin. This case was interesting in that the standard treatment options previously mentioned were contraindicated owing to the patient's pregnancy. Cryotherapy with liquid nitrogen resulted in complete resolution of her lesion and symptoms. PMID: 25612130 [PubMed - in process] (Source: Dermatol Online J)

Jan 27, 2015 04:10PM

Recurrent, pruritic papules on the legs.

We present a patient with recurrent, pruritic, erythematous papules to the legs. PMID: 25612129 [PubMed - in process] (Source: Dermatol Online J)

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Jan 27, 2015 04:10PM

A case of primary cutaneous mucormycosis caused by minor trauma.

We present the case of a 66-year-old neutropenic man with mantle-cell lymphoma who presented for evaluation of a rapidly expanding necrotic eschar after a minor cutaneous injury. Histopathology revealed infection with Rhizopus indicating primary cutaneous mucormycosis. Our case reviews the presentation and management of this condition as well highlights the potential for minor cutaneous injuries in the hospital to lead to this dangerous infection. PMID: 25612128 [PubMed - in process] (Source: Dermatol Online J)

Jan 27, 2015 04:10PM

Dermatology on pinterest.

CONCLUSIONS: Our study contributes to a growing body of data that dermatology organizations are relatively absent from new social media sites, and Pinterest represents a potential outlet for targeted intervention in high-risk groups for skin disease. PMID: 25612127 [PubMed - in process] (Source: Dermatol Online J)

Jan 27, 2015 04:10PM

Impact of a dermatology wiki website on dermatology education.

CONCLUSIONS: Overall, addition of the dermwiki website to the dermatology elective curriculum has improved medical student and resident satisfaction scores. The improvement is greater among students planning to enter the field of dermatology. This study serves as a model for the incorporation of internet-based interactive tools to transform and supplement the learning environment. PMID: 25612126 [PubMed - in process] (Source: Dermatol Online J)

Jan 27, 2015 04:10PM

Comparing burden of dermatologic disease to search interest on google trends.

This study provides further insight into what may be the most burdensome skin diseases because those with more burdensome diseases likely sought out information on their condition. PMID: 25612125 [PubMed - in process] (Source: Dermatol Online J)

Jan 27, 2015 04:10PM

Gout nodulosis: report of a rare case and brief review.

Authors: Kumar P, Das A, Savant SS, Mandal RK, Hassan S Abstract The development of tophi in the absence of prior episodes of gouty arthritis is unusual. We hereby present a case of a non-alcoholic, normoglycemic, and normotensive middle-aged man, who presented with multiple nodules distributed bilaterally over the dorsum of hands, feet, and elbow joints without any prior history of arthritis. Serum uric acid level was found to be normal. Histology was consistent with features of tophi. On the basis of clinical and histological findings, the nodules were diagnosed as gouty tophi and the patient was diagnosed with gouty nodulosis. Gouty nodulosis is a very rare presentation of gout and only a few reports exist in the medical literature. PMID: 25612124 [PubMed - in process] (Sou...

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Jan 27, 2015 04:10PM

Unusual manifestations of ectodermal dysplasia-syndactyly syndrome type I in two Yemeni siblings.

We report 2 Yemeni siblings with typical EDSS manifestations, including bilateral, partial cutaneous syndactyly of the fingers and toes; sparse, coarse, brittle scalp hair, eyebrows, and eyelashes; and conical, widely spaced teeth with enamel notches. In addition, the siblings presented with other features hitherto not described for this syndrome, such as adermatoglyphia, onychogryphosis, hypoplastic widely spaced nipples, hypoplastic thumbs, and red scalp hair. PMID: 25612123 [PubMed - in process] (Source: Dermatol Online J)

Jan 27, 2015 04:10PM

Diffuse lichenplanopilaris and multiple squamous neoplasms.

We report a case of new onset lichen planopilaris with multiple squamous cell neoplasms. PMID: 25612122 [PubMed - in process] (Source: Dermatol Online J)

Jan 27, 2015 04:10PM

Pancreatic panniculitis.

We describe a rare case of a patient with pancreatic adenocarcinoma who presented initially with a rash on her lower legs. Skin biopsy showed lobular panniculitis and characteristic "ghost" adipocytes consistent with pancreatitic panniculitis. This clinical case is an interesting example where a seemingly innocuous skin condition heralds an underlying malignant disease process. PMID: 25612121 [PubMed - in process] (Source: Dermatol Online J)

Jan 27, 2015 04:10PM

Severe cutaneous adverse reaction to telaprevir.

Authors: Shuster M, Do D, Nambudiri V Abstract A 50-year-old woman presented with diffuse, intensely pruritic pink-red papules on her trunk and extremities three weeks after starting combination therapy with ribavirin, telaprevir, and interferon. She also had cervical lymphadenopathy, fever, eosinophilia, and transaminitis consistent with a severe drug reaction to telaprevir. She was started on high potency topical steroids under inpatient observation and recovered within two weeks. Severe cutaneous eruptions secondary to telaprevir have resulted in black-box warnings for potentially fatal skin reactions, including Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) and Stevens-Johnson Syndrome (SJS), and Toxic Epidermal Necrolysis (TEN). Because these reactions carry acu...

Jan 27, 2015 04:10PM

Idiopathic perniosis of the buttocks and thighs - clinical report.

We report a rare case of perniosis of the buttocks and thighs in a 34-year-old healthy woman without a previous history of horse riding or other high-risk activities. In this case, the use of thin and tight clothes is believed to have been enough for the development of perniosis in this susceptible subject. PMID: 25612119 [PubMed - in process] (Source: Dermatol Online J)

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Jan 27, 2015 04:10PM

Multifocal tuberculosis verrucosa cutis.

Authors: Chahar M, Dhali TK, D'souza P Abstract Tuberculosis Verrucosa Cutis (TBVC), a verrucous form of cutaneous tuberculosis, occurs from inoculation of tubercle bacilli into the skin of a previously sensitized patient with moderate to high degree of immunity. This disease is now rare in western countries and in India; the incidence of cutaneous tuberculosis has fallen from 2% to 0.15%. However two recent studies from the Indian subcontinent have reported the prevalence of cutaneous tuebrculosis as 0.7% (Varshney et al) and 0.26% (Patra et al) This case is reported to demonstrate the indolent and extensive nature of tuberculosis verrucosa cutis in an immunocompetent individual and to highlight the importance of histopathology and empirical antitubercular therapy as an adjunct di...

Jan 27, 2015 04:10PM

The use of photodynamic therapy to treat hidradenitis suppurativa a review and critical analysis.

In conclusion, PDT is not a first line treatment for HS but in some cases could be added as an adjuvant to therapies such as clindamycin and rifampin. PMID: 25612117 [PubMed - in process] (Source: Dermatol Online J)

Jan 27, 2015 04:00PM

Allergic Sensitization and Rhinitis in Children: What Is New?

Opinion statement In children with nasal symptoms during several months, oftentimes with a chronically relapsing course, allergic rhinitis is one of the most probable diagnoses. This is often complicated with recurrent respiratory infections, as there is a circular causal loop between allergic rhinitis that increases the frequency of respiratory infections and the infections that exacerbate the allergic disease. As a consequence, in these children, the physician should intentionally search for allergic sensitization, in serologic specific IgE testing and/or with skin prick testing. If a possible allergic diathesis is further suspected because of a personal (atopic dermatitis) or a family history of allergic diseases, the search for allergic sensitization should begin at an even ea...

Jan 27, 2015 12:00PM

Airborne allergic contact dermatitis caused by chamomile tea

(Source: Contact Dermatitis)

Jan 27, 2015 11:17AM

How the mollusc got its scales: convergent evolution of the molluscan scleritome

Radiation of dramatically disparate forms among the phylum Mollusca remains a key question in metazoan evolution, and requires careful evaluation of homology of hard parts throughout the deep fossil record. Enigmatic early Cambrian taxa such as Halkieria and Wiwaxia (in the clade Halwaxiida) have been proposed to represent stem?group aculiferan molluscs (Caudofoveata?+?Solenogastres?+?Polyplacophora), as complex scleritomes were considered to be unique to aculiferans among extant molluscs. The ?scaly?foot gastropod? (Neomphalina: Peltospiridae) from hydrothermal vents of the Indian Ocean, however, also carries dermal sclerites and thus challenges this inferred homology. Despite superficial similarities to various mollusc sclerites, the scaly?foot gastropod sclerites are s...

Jan 27, 2015 10:55AM

Evaluation of internal consistency of the epidermolysis bullosa oropharyngeal severity score (EBOS).

Conclusions. The EBOS turned out to have a strong and reliable internal consistency, as the majority of the EBOS' items were consistent with each other. PMID: 25598172 [PubMed - in process] (Source: Acta Odontologica Scandinavica)

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Jan 27, 2015 04:21AM

Sequelae in 145 patients with drug?induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms: Survey conducted by the Asian Research Committee on Severe Cutaneous Adverse Reactions (ASCAR)

Abstract Drug?induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms (DIHS/DRESS) is a severe adverse drug reaction caused by specific drug. It is characterized by visceral organ involvement and reactivation of various human herpesviruses. Although sporadic reports have documented certain conditions that appear after the resolution of DIHS/DRESS, little information is available on sequelae after resolution of DIHS/DRESS in a large patient population. The Asian Research Committee on Severe Cutaneous Adverse Reactions, comprised of doctors from Japan and Taiwan, conducted a survey on sequelae and deterioration of the underlying disease in patients with DIHS/DRESS. This was achieved by directly interviewing patients who had been followed?up by experts or t...

Jan 27, 2015 01:18AM

Chronic Idiopathic Urticaria: Treatment With OmalizumabChronic Idiopathic Urticaria: Treatment With Omalizumab

Learn more about omalizumab, a fully humanized monoclonal antibody which shows promise as a new third-line option for chronic spontaneous urticaria, a common autoimmune skin condition. Skin Therapy Letter (Source: Medscape Allergy Headlines)

Jan 26, 2015 05:25PM

Levels of bisphenol-A in different paper products in Guangzhou, China and assessment of human exposure via dermal contact

Environ. Sci.: Processes Impacts, 2015, Accepted ManuscriptDOI: 10.1039/C4EM00621F, PaperRuifang Fan, Biyan Zeng, Chao Chen, Qinwei Zhuang, Yongjun Wang, Zhi Yuan (William) Lin, Yuanxiu Zhou, Junnan Li, Yanshan Lv, Mingli Hu, Xiaosu LiuBisphenol A (BPA) is a chemical widely used both in plastics production as food and beverage containers and in thermal papers as a color developer. Dietary consumption is the main...The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - J. Environ. Monit. latest articles)

Jan 26, 2015 04:00PM

Role of Mast Cells and C-Sensory Fibers in Concanavalin A-Induced Paw Edema in Two Rat Strains

This study investigated a putative contribution of mast cells and C-sensory fibers to differences in the development of inflammatory edema following the injection of concanavalin A (Con A) into the hind paws of Dark Agouti (DA) and Albino Oxford (AO) rats. The treatment of adult rats with mast cell-depletor compound 48/80 and neonatal depletion of C-sensory fibers independently revealed that leukocyte composition of the inflamed paws and lymph nodes during local inflammatory response to Con A was generally regulated in a similar way in DA and AO rat strains. However, in DA and AO rats, the decrease and the increase of Con A-induced plasma extravasation were associated with mast cell depletion and activation, respectively, whereas neonatal capsaicin treatment activated dermal mast cells and...

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Jan 26, 2015 04:00PM

Guide for medical professionals (i.e. dermatologists) for the management of Rhododenol?induced leukoderma

Abstract Because some users develop depigmentation after the use of melanogenesis?inhibiting products containing the quasi?drug ingredient Rhododenol, Japanese Dermatological Association (JDA) established a Special Committee on the Safety of Cosmetics Containing Rhododenol on July 17, 2013 and management guide for dermatologists has been updated on the website in order to delineate the diagnostic criteria for Rhododenol?induced leukoderma and provides a broad guide for standard treatment based on current knowledge. This guide is produced on the basis of the guide (version 7) updated on June 20, 2014 in the website. Rhododenol?induced leukoderma refers to depigmentation of varying severity that develops after the use of cosmetics containing Rhododenol, mainly at the site of use. In ...

Jan 26, 2015 04:00PM

Interferon?alpha for the treatment of severe entero? and neuro?Behçet's disease

(Source: The Journal of Dermatology)

Jan 26, 2015 04:00PM

Reply to Dr Chroni

(Source: The Journal of Dermatology)

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Jan 26, 2015 04:00PM

American Board of Dermatology Examination Dates

(Source: Journal of Cutaneous Pathology)

Jan 26, 2015 04:00PM

Abstracts presented at the 51st Annual Meeting of the American Society of Dermatopathology

(Source: Journal of Cutaneous Pathology)

Jan 26, 2015 04:00PM

What's new in atopic eczema? An analysis of systematic reviews published in 2012 and 2013. Part 1. Epidemiology, mechanisms of disease and methodological issues

Summary This review provides a summary of key findings from nine systematic reviews on atopic eczema (AE) published over the 2?year period from January 2012 to 31 December 2013, focusing on epidemiology, mechanisms of disease and methodological issues. There is now reasonable evidence to suggest that antibiotic exposure in early life is associated with increased incidence of AE, but delivery by caesarean section is not. The prevalence of AE is increasing in Africa, eastern Asia, western Europe and parts of northern Europe. Autoimmunity may play a part in the development and subsequent severity of AE. For researchers conducting clinical trials and other prospective studies involving patients with AE, the two best?validated scales for capturing objective clinical signs of AE are the Ecze...

Jan 26, 2015 04:00PM

A simple and rapid model for hair?follicle regeneration in the nude mouse

ConclusionsThe time required for hair regeneration is considerably shortened with IFM. We speculate that this is due to increased blood supply at the transplantation sites. (Source: Clinical And Experimental Dermatology)

Jan 26, 2015 04:00PM

An unusual presentation of generalized essential telangiectasia

We report a case of a 39?year?old man who presented to the ophthalmology department with reduced vision, and was diagnosed with generalized essential telangiectasia by indocyanine green and fluorescein angiography of his eyes. The patient was noted to have corneal neovascularization (which was responsible for his reduced visual acuity) and conjunctival telangiectases seen by angiography. Further examination by the dermatology department identified widespread telangiectases on the patient's legs and trunk. Systemic causes and alternative diagnoses were excluded by further investigations, and the patient was eventually diagnosed with GET. Following discharge from the dermatology department, the patient presented with chest pain and required emergency surgery for a type A thoracic aortic ...

Jan 26, 2015 04:00PM

Failure of rapamycin in the treatment of multiple haemangiomas associated with Maffucci syndrome

(Source: Clinical And Experimental Dermatology)

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Jan 26, 2015 04:00PM

Adverse drug reactions in dermatology

Summary Adverse drug reactions (ADRs) ? that is, unintended and harmful responses to medicines ? are important to dermatologists because many present with cutaneous signs and because dermatological treatments can cause serious ADRs. The detection of ADRs to new drugs is often delayed because they have a long latency or are rare or unexpected. This means that ADRs to newer agents emerge only slowly after marketing. ADRs are part of the differential diagnosis of unusual rashes. A good drug history that includes details of drug dose, time?course of the reaction and factors that may make the patient more susceptible, will help. For example, Stevens?Johnson syndrome with abacavir is much commoner in patients with HLA?B*5701, and has a characteristic time course. Newer agents have brou...

Jan 26, 2015 04:00PM

A serious side effect of a potentially widely used cosmetic product

(Source: Clinical And Experimental Dermatology)

Jan 26, 2015 04:00PM

Eosinophilic follicular reaction induced by Demodex folliculorum mite: a different disease from eosinophilic folliculitis

We present an immunocompetent 65?year?old white man with a 5?year history of recurrent pruritic erythematous and oedematous lesions on his face, neck and scalp. Histopathologically, an eosinophilic microabcess with Demodex folliculorum mite within a pilosebaceous follicle was seen, and considered the causal agent. There were also accumulations of eosinophil granules on collagen bundles, and flame figure formations in the dermis. We believe that ?eosinophilic follicular reaction? is an appropriate term to describe this case of EF induced by D. folliculorum and thus distinguish it from the idiopathic form of EF. Moreover, this case suggests that D. folliculorum can sometimes induce an eosinophilic immune reaction. (Source: Clinical And Experimental Dermatology)

Jan 26, 2015 04:00PM

Nodular fasciitis of the lip mucosa: a rare but clinically important entity

We describe the clinical, histological and immunohistochemistry findings of NF in a 51?year?old woman, and discuss its differential diagnosis. (Source: Clinical And Experimental Dermatology)

Jan 26, 2015 04:00PM

Systematic skin examination in an acute geriatric unit: skin cancer prevalence

ConclusionsThe prevalence of skin cancer is high in frail elderly patients. The association of severe geriatric syndromes suggests that close collaboration between geriatricians and dermatologists is essential to optimize the treatment of skin carcinoma in elderly patients. (Source: Clinical And Experimental Dermatology)

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Jan 26, 2015 04:00PM

The role of acrylic acid impurity as a sensitizing component in electrocardiogram electrodes

ConclusionThe sensitization resulting from direct contact with ECG electrodes was caused by acrylic acid, present as an impurity in ECG electrodes. Positive reactions to 2?HEMA, 2?HPMA and EGDMA are considered to be cross?reactions. (Source: Contact Dermatitis)

Jan 26, 2015 04:00PM

Air?oxidized linalyl acetate???an emerging fragrance allergen?

ConclusionsThe frequency of positive reactions to oxidized linalyl acetate is comparable to that of previously studied oxidized fragrance terpenes. Oxidized linalyl acetate could thus be a common fragrance contact allergen. (Source: Contact Dermatitis)

Jan 26, 2015 04:00PM

IJERPH, Vol. 12, Pages 1397-1411: Exposure to the Riot Control Agent CS and Potential Health Effects: A Systematic Review of the Evidence

o-Chlorobenzylidene malononitrile (CS) is one of the most extensively used riot control agents. Our aim was to conduct a systematic review of the potential health effects related to CS exposure. We searched for papers in English between 1991 and 2014. Thirty five (35) studies (25 case reports, seven descriptive studies and three analytical studies) were included in the review. In the twenty five case reports/series 90 cases of exposure to CS and their clinical effects are presented. Their mean age was 25.7 years and 62.0% were males. In addition, 61% of the cases described dermal, 40% respiratory, 57% ocular clinical effects. Life threatening situations as well as long-term health effects were found and were related with exposure to confined/enclosed space. Descriptive and analytical studi...

Jan 26, 2015 04:00PM

Dermatophyte Infections in Environmental Contexts

Publication date: Available online 26 January 2015 Source:Research in Microbiology Author(s): Esther Segal , Michael Frenkel Fungal dermal diseases caused by the molds of the Dermatophyte family are among the most frequent infectious diseases affecting quality of life. There are 3 attributed sources of infection by Dermatophytes:1) humans; 2) animals and 3) soil. Dermatophytes posses the ability to utilize keratin from human and animal tissues, or debris from dead animal sources found in soil, such as feathers, skin or nails. Hence, Dermatophytes are abundant in different ecological niches. All 3 groups can infect humans, causing dermatophytoses manifested in different clinical entities involving skin, hair or nails. The mode of infection of the Dermatophytes is via direct or indirect co...

Jan 26, 2015 04:00PM

Guidance for the management of patients with latent tuberculosis infection requiring biologic therapy in rheumatology and dermatology clinical practice

Publication date: Available online 21 January 2015 Source:Autoimmunity Reviews Author(s): Fabrizio Cantini , Carlotta Nannini , Laura Niccoli , Florenzo Iannone , Giovanni Delogu , Giacomo Garlaschi , Alessandro Sanduzzi Zamparelli , Andrea Matucci , Francesca Prignano , Michele Conversano , Delia Goletti Since the introduction of biologics for the treatment of rheumatoid arthritis (RA), psoriatic arthritis (PsA), ankylosing spondylitis (AS), and psoriasis (Pso) an increased risk of tuberculosis (TB) reactivation in patients with latent tuberculosis infection (LTBI) has been recorded for anti-TNF agents, while a low or absent risk is associated with the non-anti-TNF targeted biologics. To reduce this risk several recommendation sets have been published over time, but in most of them the ...

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Jan 26, 2015 04:00PM

Atypical presentations of bullous pemphigoid: Clinical and immunopathological aspects

Publication date: Available online 21 January 2015 Source:Autoimmunity Reviews Author(s): Emanuele Cozzani , Giulia Gasparini , Martina Burlando , Francesco Drago , Aurora Parodi Bullous pemphigoid may occur in extremely variegated manners, misleading even experienced dermatologists. Indeed the type and/or distribution of lesions may be unusual. Furthermore, there may be an atypical demographic profile of patients, a different clinical course and a different responsiveness to therapy. Up to 20% of the cases the onset is characterized by a non-bullous phase, lasting weeks, months or in particular cases remaining the only manifestation of the disease. During this early phase lesions are generally pruritic erythematous, eczematous or urticarial; however, lesions may also resemble polycyclic...

Jan 26, 2015 04:00PM

Does upper blepharoplasty affect frontalis tonicity?

Frontalis hypertonicity has long been implicated in patients with significant dermatochalasia or blepharoptosis, as evidenced by eyebrow changes that occur after resection of redundant skin or after blepharoptosis operation. However, whether upper blepharoplasty affects the forehead muscle has not been reported. Thus, this study investigated electrophysiology of the frontalis muscle and eyebrow morphology in a population of patients undergoing double eyelid blepharoplasty. (Source: Journal of Plastic, Reconstructive and Aesthetic Surgery)

Jan 26, 2015 04:00PM

Guidelines for diagnosis, prevention and treatment of hand eczema

Summary The guidelines aim to provide advice on the management of hand eczema (HE), using an evidence? and consensus?based approach. The guidelines consider a systematic Cochrane review on interventions for HE, which is based on a systematic search of the published literature (including hand?searching). In addition to the evidence? and consensus?based recommendation on the treatment of HE, the guidelines cover mainly consensus?based diagnostic aspects and preventive measures (primary and secondary prevention). Treatment recommendations include non?pharmacological interventions, topical, physical and systemic treatments. Topical corticosteroids are recommended as first line treatment in the management of HE, however continuous long?term treatment beyond six weeks only when n...

Jan 26, 2015 04:00PM

Issue Information

(Source: Experimental Dermatology)

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Jan 26, 2015 04:00PM

Kerr's coining of ?Apoptosis? and its relevance in skin wound healing and fibrosis

(Source: Experimental Dermatology)

Jan 26, 2015 04:00PM

p63?dependent and independent mechanisms of nectin?1 and nectin?4 regulation in the epidermis

Abstract Nectins are immunoglobulin?like cell adhesion molecules mainly localized in adherens junctions. The transcription factor p63 is a master regulator of gene expression in stratified epithelia and controls several molecular processes. As mutations in the Pvrl1 and Pvrl4 genes encoding for nectins cause genetic disorders with phenotypes similar to p63?related syndromes, we investigated whether these proteins might be under p63 transcriptional control. Here, we show that in p63?null skin, Pvrl1 gene expression is strongly reduced, whereas Pvrl4 expression is unaffected. In human and mouse primary keratinocytes p63 depletion leads to a specific downregulation of the Pvrl1 gene. Consistent with a direct regulation, chromatin immunoprecipitation experiments (ChIP) indicate that p63 ...

Jan 26, 2015 04:00PM

Next?generation sequencing detection and characterization of a heterozygous novel splice junction mutation in the 2B domain of KRT1 in a family with diffuse palmoplantar keratoderma

This study also demonstrates the value of next?generation sequencing in the identification of novel disease?causing mutations. (Source: Experimental Dermatology)

Jan 26, 2015 04:00PM

Clinical Snippets

(Source: Experimental Dermatology)

Jan 26, 2015 04:00PM

Correction

Connolly SM, Baker DR, Coldiron BM, et al. AAD/ACMS/ASDSA/ASMS 2012 appropriate use criteria for Mohs micrographic surgery: A report of the American Academy of Dermatology, American College of Mohs Surgery, American Society for Dermatologic Surgery Association, and the American Society for Mohs Surgery. J Am Acad Dermatol. 2012;67:531-50. (Source: Journal of the American Academy of Dermatology)

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Jan 26, 2015 04:00PM

Incidence and risk of xerosis with targeted anticancer therapies

Many targeted therapies used in the treatment of cancer can lead to the development of xerosis, but the incidence and relative risk of xerosis have not been ascertained. (Source: Journal of the American Academy of Dermatology)

Jan 26, 2015 04:00PM

A mouse model of skin aging: Fragmentation of dermal collagen fibrils and reduced fibroblast spreading due to expression of human matrix metalloproteinase-1

Fragmentation of dermal collagen fibrils, the major structural proteins in skin, is a prominent feature of human skin aging [1,2]. Elevated collagenase (MMP-1) is largely responsible for initiation of collagen fragmentation in aging human skin [1,3,4]. We previously reported that expression of mutant human MMP-1 (hMMP-1/V94G), which undergoes auto-activation in either young human skin in organ culture or fibroblasts cultured in 3D collagen lattices, causes collagen fibril fragmentation similar to that in aged human skin [5]. (Source: Journal of Dermatological Science)

Jan 26, 2015 04:00PM

Atopic dermatitis-like dermatitis emerges unevenly on different sites in flaky tail mice

Flaky tail mice (FTM; ma/ma, Flgft/ft) have two pathogenic genetic abnormalities related to cutaneous permeability barrier homeostasis, namely, gene mutations in filaggrin (Flgft) and matted (ma), and are known to exhibit atopic dermatitis (AD)-like dermatitis ?spontaneously? and the spontaneous emergence is mainly attributed to the matted mutation [1?4]. Although FTM has been used as one of the murine AD models, whether such spontaneous emergence is consistent with the pathogenesis of human AD, in which genetic abnormalities are not the sole determinant but the combination of genetic abnormalities and environmental factors is the most important characteristic, remains questionable. (Source: Journal of Dermatological Science)

Jan 26, 2015 04:00PM

4-(4-hydroroxyphenyl)-2-butanol (rhododendrol) activates the autophagy-lysosome pathway in melanocytes: insights into the mechanisms of rhododendrol-induced leukoderma

Rhododendrol [4-(4-hydroxyphenyl)-2-butanol, Rhododenol®] was first developed 5 years ago as a skin-whitening cosmetic that contained a 2% (w/w) formulation. It is also a natural ingredient present in many plants, such as the Nikko maple tree [1]. It competes with tyrosine for hydroxylation by tyrosinase and effectively inhibits melanin biosynthesis [2,3]. However, these cosmetics were withdrawn from the market in 2013 after rhododendrol reportedly caused a depigmentation disorder. It was reported that partial depigmentation appeared on the neck, the hands, and the face at sites of repeated application of these cosmetics, and the symptoms in 79% of affected patients disappear or begin to improve within 6 months after ceasing product use? [The Japanese Dermatological Association Special ...

Jan 26, 2015 04:00PM

Erythrodermic psoriasis treated with ustekinumab: an italian multicenter retrospective analysis

Erythrodermic psoriasis (EP) is one of the most severe cutaneous conditions which may lead to serious morbidity and even mortality. This condition is often difficult to manage and, due to its rarity(estimated prevalence 1-2.25% of psoriatic patients) there is a lack of high-quality medical literature examining treatment options [1]. (Source: Journal of Dermatological Science)

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Jan 26, 2015 04:00PM

The genetics of alopecia areata: new approaches, new findings, new treatments

(Source: Journal of Dermatological Science)

Jan 26, 2015 04:00PM

Are baths desirable in atopic dermatitis?

ConclusionsWe found no evidence of an effect of 1?month tap water bathing on skin changes in AD. Only 29 percent of AD patients were favourable to baths. Use of baths in AD should be decided together with the patient. (Source: Journal of the European Academy of Dermatology and Venereology)

Jan 26, 2015 03:32PM

7 Reasons Women Lose Their Hair -- And 7 Treatments

Your ponytail is shrinking...or your part's getting wider...or there's more hair in the shower drain. Take heart -- you're not alone. According to New York City dermatologist Neil Sadick, MD, up to 80 percent of women will have some hair thinning in their lifetime, even if only temporarily. It's normal to shed 50 to 100 hairs a day, says NYC dermatologist Doris Day, MD. If you're losing more than that, a doctor's visit is in order. Here are some common causes and treatments. Cause: Genetics (the most likely culprit) Treatment: Minoxidil, the only topical ingredient that's FDA approved to regrow hair in women. Rogaine has just launched a 5 percent minoxidil foam for women ($30; drugstores). (Previously, the only option for women was 2 percent.) Sadick also suggests in-office red-light la...

Jan 26, 2015 02:46PM

Nailfold capillaroscopic changes in dermatomyositis and polymyositis

Abstract Inflammatory myopathies (IM) are a group of muscle diseases occurring both in children and adults. Nailfold videocapillaroscopy (NVC) alterations are described in IM, but available data are discordant, including differences between polymyositis (PM) and dermatomyositis (DM). The aim of this study was to describe the capillaroscopic differences between PM and DM patients and possible correlation with clinical and serological features. We analyzed 52 unselected patients with IM in a cross-sectional study in a 6-month period. NVC findings of 29 DM and 23 PM patients were compared with those of 52 patients with primary Raynaud?s phenomenon. Tortuosities, capillary loss, enlarged and giant capillaries, microhemorrhages, and ramified capillaries were scored by a semiquantita...

Jan 26, 2015 12:15PM

Wong-Type Dermatomyositis Showing Porokeratosis-Like Changes (Columnar Dyskeratosis): A Case Report and Review of the Literature

Conclusion: Wong-type DM is a clinicopathologic DM-PRP hybrid that can also exhibit porokeratosis-like features best described as columnar dyskeratosis. Recognizing these types of lesions in DM is warranted in order to make an accurate assessment of their prognostic significance.Dermatopathology 2015;2:1-8 (Source: Dermatopathology)

Jan 26, 2015 10:20AM

Traumatic injuries after mechanical cardiopulmonary resuscitation (LUCAS?2): a forensic autopsy study

Conclusion LUCAS?2-CPR is associated with more rib fractures than standard CPR. Typical round concentric skin lesions were observed in cases of mechanical reanimation. No life-threatening injuries were reported. Petechiae were common findings. (Source: International Journal of Legal Medicine)

Jan 26, 2015 07:28AM

Rosai?Dorfman disease presenting as panniculitis?like

(Source: Journal of the European Academy of Dermatology and Venereology)

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Jan 26, 2015 07:27AM

Association between Skin and Joint Involvement in Patients with Psoriatic Arthritis Treated with Adalimumab: Analysis of Data from a German Non-Interventional Study

Conclusion: The severity of skin manifestations does not correlate with the severity of joint disease in PsA patients; even patients with mild skin disease may have extensive musculoskeletal involvement.Dermatology (Source: Dermatology)

Jan 26, 2015 04:00AM

Global Climate Anomalies and Potential Infectious Disease Risks: 2014-2015

Conclusions Based on current global climate anomaly conditions and forecasts, El Niño is likely to develop during late 2014 and persist into early 2015. The expected effects on regional weather patterns include persistent high temperatures and drought in some areas, and heavy rainfall and flooding in others. This may enhance populations of particular vectors and the transmission of various infectious diseases in human and animal populations. Although local weather conditions mediate part of ENSO?s influence on infectious disease transmission (?teleconnections?), incorporating ENSO indicators into disease risk predictions offers advantages. ENSO forecasts typically can anticipate local weather effects several months before they manifest, providing lead-time for public health risk com...

Jan 25, 2015 04:55PM

Editorial board members and reviewers.

Authors: Foster A PMID: 25611091 [PubMed - in process] (Source: Veterinary Dermatology)

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Jan 25, 2015 04:00PM

Whole?exome sequencing solves diagnostic dilemma in a rare case of sporadic acrokeratosis verruciformis

(Source: Journal of the European Academy of Dermatology and Venereology)

Jan 25, 2015 04:00PM

Cutaneous endometrial cancer arising from heterotopic endometriosis in an abdominal caesarean section scar

(Source: Journal of the European Academy of Dermatology and Venereology)

Jan 25, 2015 04:00PM

Identification of macrolide?resistant Mycoplasma genitalium using real?time PCR

ConclusionOur TaqMan assay detects common genotypes associated with macrolide?resistant M. genitalium, namely, A2058G, A2059G and A2058C. We show association between the presence of resistant M. genitalium and treatment failure, thereby confirming the validity of testing for these mutants to prevent further spread of antimicrobial resistance and to allow informed choice of antibiotics for treatment. (Source: Journal of the European Academy of Dermatology and Venereology)

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Jan 25, 2015 04:00PM

Cutaneous Epstein?Barr virus?associated lymphoproliferative polymorphic disease ? AIDS presenting manifestation

(Source: Journal of the European Academy of Dermatology and Venereology)

Jan 25, 2015 04:00PM

Elevated prevalence of Type D (distressed) personality in moderate to severe psoriasis is associated with mood status and quality of life impairment: a comparative pilot study

ConclusionBecause Type D personality could represent a frequent type of personality among individuals with moderate to severe psoriasis, it could serve as a ?marker? of more psychologically vulnerable patients, probably related to dysfunctional coping strategies. The Type D personality could represent a profile more frequently encountered among patients with psoriasis, and might therefore help identify subjects physiologically more vulnerable to disease, most likely due to inadequate adaptation mechanisms. (Source: Journal of the European Academy of Dermatology and Venereology)

Jan 25, 2015 04:00PM

Piano glissando purpura: another cutaneous curiosity in musicians

(Source: Journal of the European Academy of Dermatology and Venereology)

Jan 25, 2015 04:00PM

Dermoscopy of periungual pigmented Bowen's disease: its usefulness in differentiation from malignant melanoma

(Source: Journal of the European Academy of Dermatology and Venereology)

Jan 25, 2015 04:00PM

Early non?ablative fractional laser improves the appearance of punch biopsy scars ? a clinical report

(Source: Journal of the European Academy of Dermatology and Venereology)

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Jan 25, 2015 04:00PM

Prevalence of methylchloroisothiazolinone and methylisothiazolinone contact allergy in facial dermatitis: a single centre Irish study

ConclusionsContact allergies to MCI/MI and MI are commoner than what was reported before and is an emerging cause of facial dermatitis. The detection rate of this allergen was increased by 5% in our cohort since the inclusion of MI (0.2%) in the standard series. (Source: Journal of the European Academy of Dermatology and Venereology)

Jan 25, 2015 04:00PM

Resolution of septic shock in a patient with myelomeningocele (spina bifida) complicated with deforming Elephantiasis Nostras Verrucosa

(Source: Journal of the European Academy of Dermatology and Venereology)

Jan 25, 2015 04:00PM

Prognostic and predictive values of oncogenic BRAF, NRAS, c?KIT and MITF in cutaneous and mucous melanoma

ConclusionClinical and pathological characteristics of the primary melanoma differed between wild?type and BRAF? or NRAS?mutated tumours. Patients with BRAF?mutated tumours were younger at diagnosis of primary melanoma. Patients carrying mutations showed better responses better to specific kinase inhibitors and interestingly also to systemic cytotoxic chemotherapy. (Source: Journal of the European Academy of Dermatology and Venereology)

Jan 25, 2015 04:00PM

Phenolic composition and effects on allergic contact dermatitis of phenolic extracts Sapium sebiferum (L.) Roxb. leaves

Conclusion The present study demonstrated that the bioactivity of Sapium sebiferum leaves may be due to the existence of the identified phenolic components, and several high polarity compounds were also active. The beneficial effect of Sapium sebiferum leaves on skin diseases is based on its antioxidant activity or effects on antioxidant defense system. Graphical abstract (Source: Journal of Ethnopharmacology)

Jan 25, 2015 04:00PM

Effects of Er-Miao-San extracts on TNF-alpha-induced MMP-1 expression in human dermal fibroblasts

Conclusions: Taken together, our data suggest that EMS could potentially be used as an anti-inflammatory and anti-aging treatment. (Source: BioMed Central)

Jan 25, 2015 04:00PM

High Chlamydia burden promotes TNF?dependent reactive arthritis in SKG mice

Conclusion: In the susceptible SKG strain, Chlamydia?induced reactive arthritis develops as a result of deficient intracellular pathogen control, with antigen?specific TNF production upon dissemination of antigen, and TNF?dependent inflammatory disease. This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)

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Jan 25, 2015 04:00PM

Molecular Mechanisms of Acrolein Toxicity: Relevance to Human Disease

Acrolein, a highly reactive unsaturated aldehyde, is a ubiquitous environmental pollutant and its potential as a serious environmental health threat is beginning to be recognized. Humans are exposed to acrolein per oral (food and water), respiratory (cigarette smoke, automobile exhaust, and biocide use) and dermal routes, in addition to endogenous generation (metabolism and lipid peroxidation). Acrolein has been suggested to play a role in several disease states including spinal cord injury, multiple sclerosis, Alzheimer’s disease, cardiovascular disease, diabetes mellitus, and neuro-, hepato-, and nephro-toxicity. On the cellular level, acrolein exposure has diverse toxic effects, including DNA and protein adduction, oxidative stress, mitochondrial disruption, membrane damage, endop...

Jan 25, 2015 03:25AM

Intracellular signaling of the aging suppressor protein klotho.

Authors: Sopjani M, Rinnerthaler M, Kruja J, Dermaku-Sopjani M Abstract The Klotho protein deficiency is known to participate in premature aging. As an aging suppressor, Klotho is an important molecule in aging processes and its overexpression results in longevity. Due to many reasons, the insulin/insulin-like growth factor-1 (IGF-1) has been considered as a key pathway in aging research. The Klotho gene is closely related to this pathway. The Klotho gene encodes a transmembrane protein that after cleavage is also found as a secreted protein. Importantly, its overexpression suppresses insulin/IGF-1 signaling and thus extends the lifespan. In addition, Klotho participates in the regulation of several other intracellular signaling pathways, including regulation of FGF23 signaling, cA...

Jan 24, 2015 04:03PM

Sporotrichosis: an overview and therapeutic options.

Authors: Mahajan VK Abstract Sporotrichosis is a chronic granulomatous mycotic infection caused by Sporothrix schenckii, a common saprophyte of soil, decaying wood, hay, and sphagnum moss, that is endemic in tropical/subtropical areas. The recent phylogenetic studies have delineated the geographic distribution of multiple distinct Sporothrix species causing sporotrichosis. It characteristically involves the skin and subcutaneous tissue following traumatic inoculation of the pathogen. After a variable incubation period, progressively enlarging papulo-nodule at the inoculation site develops that may ulcerate (fixed cutaneous sporotrichosis) or multiple nodules appear proximally along lymphatics (lymphocutaneous sporotrichosis). Osteoarticular sporotrichosis or primary pulmonary sporo...

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Jan 24, 2015 04:00PM

Juvenile Dermatomyositis: A 20-year Retrospective Analysis of Treatment and Clinical Outcomes

Conclusion Factors such as male sex and Gowers' sign were unlikely to favor the achievement of complete clinical remission in juvenile dermatomyositis. Certain complications cannot be avoided, and thus more effective treatments and monitoring strategies are needed for better control of juvenile dermatomyositis. (Source: Pediatrics and Neonatology)

Jan 24, 2015 04:00PM

Dalbergia odorifera Extract Ameliorates UVB?Induced Wrinkle Formation by Modulating Expression of Extracellular Matrix Proteins

This study examined the antiwrinkle effects of ethanol extracts of D. odorifera in UVB?irradiated human skin cells. Ethanol extracts of D. odorifera and thier constituents, dalbergin and sativanone, induced expression of collagen type I and transforming growth factor (TGF)??1 in human dermal fibroblasts. In HR?1 hairless mice exposed to UVB, the ethanol extract reduced wrinkle formation and skin thickness. This inhibitory effect of ethanol extract was associated with the restoration of collagen type I, TGF??1, and elastin to levels approaching those in skin tissues not exposed to UVB, which was accompanied by the reduction of matrix metalloproteinase?2 and upregulation of tissue inhibitors of metalloproteinase (TIMP)?2 and TIMP?3 in skin tissue exposed to UVB. These results...

Jan 24, 2015 04:00PM

Estimated cost efficacy of systemic treatments that are approved by the US Food and Drug Administration for the treatment of moderate to severe psoriasis

Newer psoriasis treatments tout higher efficacy but are generally more expensive. (Source: Journal of the American Academy of Dermatology)

Jan 24, 2015 04:00PM

Rosiglitazone Ameliorates Senescence-like Phenotypes in a Cellular Photoaging Model

(Source: Journal of Dermatological Science)

Jan 24, 2015 04:00PM

Epileptic seizures in neuro-behcet disease: why some patients develops seizure and others not?

Behcet's disease (BD) is a chronic relapsing inflammatory disease of unknown etiopathogenesis [1?3]. It is a disorder of young adults with male predominance. There is a geographical variation in prevalence [4]. Hulusi Behcet, Turkish dermatologist, first described it [2]. BD is mainly characterized by oral and genital ulcerations, ocular manifestations and by involvement of the gastrointestinal, cardiovascular, pulmonary, skeletal and central nervous system [1]. Recurrent oral ulceration is prerequisite with any two of genital ulcerations, skin lesions, uveitis and hyperactivity of skin to nonspecific physical insult (Patergy test) according to the diagnostic criteria formed by the International Study Group [5] (Source: Seizure: European Journal of Epilepsy)

Jan 24, 2015 12:32PM

Adult acne: how to treat it?

A Mayo Clinic dermatologist gives tips on how adults can prevent and treat acne. Treatment options include over the counter medications as well as prescription medications.Acne has 3 stages that can be remembered by the mnemonic "CIN":Comedonal - black/whitehead, open/closedInflammatory - pimples/zitsNodulocysticUse Topical Treatment such as Differin gel as on CCC-F: Cheek, Chin, Cheek, Forehead Posted at Clinical Cases and Images. Stay updated and subscribe, follow us on Twitter and connect on Facebook. (Source: Clinical Cases and Images)