Dr. William Ting, Board-Certified Dermatologist
at California Dermatology Care
2262 Camino Ramon, San Ramon, CA 94583
500 Alfred Nobel Drive, Suite #185, Hercules, CA 94547
Tel: 925-328-0255
Email: staff@CalDermCare.com


Advanced Care with a Personal Touch

   

 

 

Medical Dermatology    Evidence-based medicine   Customized solution   Personal care

Latest Dermatology Headlines

Dr. William Ting has expertise in treating the entire spectrum of medical dermatology, with emphasis in preventive medicine and personalized recommendations. He enjoys taking care of patients with acne, eczema, hair and nail disorders, rashes, psoriasis and skin cancers.

He is at the forefront of medical dermatology and dermatologic research. He continues to publish articles in peer-reviewed dermatology journals. He is an early pioneer of photodynamic therapy (PDT) and one of the most experienced practitioners of PDT in the Bay Area. He is the first dermatologist in the San Francisco Bay Area and Northern California to introduce Lutronic Spectra Laser for melasma, acne, scar revision, pore size reduction as well as the Cutera GenesisPlus laser for advanced nail fungus laser treatment, keloid and hypertrophic scar, warts and scar revision.

Dr. Ting is a fellow of the American Academy of Dermatology (AAD) and American Society of Dermatologic Surgery (ASDS). He is a member of the National Psoriasis Foundation and International Hyperhidrosis Society.

Innovative Therapeutic Approach to Common Skin Conditions

Acne

Eczema (Atopic Dermatitis)

Hair and Nail disorders

  • Maximize therapeutic synergy and efficacy by utilizing both prescription-strength and over-the counter products when available
  • Comprehensive workup including bloodwork and biopsy if necessary
  • Systemic oral hormonal therapy for women and men when indicated

Psoriasis 

Rosacea

  • Multi-prong approach to minimize redness
  • Low-dose 'non-antibiotic' anti-inflammatory oral medication for long-term remission 
  • Emphasis on prevention
  • Fotofacial/IPL laser utilizing Cynosure XPL/Elite MPX
  • Cutera GenesisPlus Laser with or without combination with IPL 
  • Diode laser for facial veins
  • VBeam Pulse Dye Laser, the new gold standard for rosacea and facial redness

Skin Cancer 

  • Emphasis on prophylactic treatments with topical 5-FU, imiquimod, diclofenac, ingenol mebutate and oral chemopreventive therapy such as Soriatane.
  • Reduce future risks of skin cancer with photodynamic therapy, TCA chemical peels and/or fractional CO2 resurfacing laser  
  • Mohs Surgery to achieve highest cure rate and tissue sparing
  • Close colloboration with plastic surgeon(s) as needed  

Sweating Disorder (Hyperhidrosis) 

Vitiligo

Warts 


ABCD of Mole Check

 

 

Common Medical Dermatology Diagnostics and Therapeutics:

Dermatology Links:

American Academy of Dermatology
American Society of Dermatologic Surgery
American Society of Mohs Surgery
International Hyperhidrosis Society
National Psoriasis Foundation

 Latest Dermatology Headlines:

Latest Dermatology Headlines
Wed, 29 Jul 2015 13:45:48 +0100

http://www.medworm.com/rss/index.php/Dermatology/12/

Jul 29, 2015 05:32AM

Melanosis of the areola and nipple with an atypical pigment network

(Source: International Journal of Dermatology)

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Jul 29, 2015 05:32AM

Keloid Removal by Shave Excision With Adjuvant External Beam Radiation Therapy

No abstract available (Source: Dermatologic Surgery)

Jul 29, 2015 05:32AM

A Novel Noninvasive Wound Closure Device as the Final Layer in Skin Closure

No abstract available (Source: Dermatologic Surgery)

Jul 29, 2015 05:32AM

Nail Bed Reconstruction With Local Flaps After Full-Thickness Chemical Burn

No abstract available (Source: Dermatologic Surgery)

Jul 29, 2015 05:32AM

Use of the Parell Frontal Sinus T-Stent to Prevent External Auditory Canal Stenosis

No abstract available (Source: Dermatologic Surgery)

Jul 29, 2015 05:32AM

Intraoperative Real-Time Reflectance Confocal Microscopy for Guiding Surgical Margins of Lentigo Maligna Melanoma

No abstract available (Source: Dermatologic Surgery)

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Jul 29, 2015 05:31AM

Transposition?Advancement Flap for the Reconstruction of Segmental Auricular Defects

No abstract available (Source: Dermatologic Surgery)

Jul 29, 2015 05:31AM

A Novel Suture Technique for High-Tension Wound Closure: The Tandem Pulley Stitch

No abstract available (Source: Dermatologic Surgery)

Jul 29, 2015 05:31AM

Book Review: Procedural Dermatology

No abstract available (Source: Dermatologic Surgery)

Jul 29, 2015 05:31AM

Polyotia: A Rare Disorder

No abstract available (Source: Dermatologic Surgery)

Jul 29, 2015 05:31AM

Reconstruction of Defects of the Posterior Pinna

No abstract available (Source: Dermatologic Surgery)

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Jul 29, 2015 05:31AM

Comparison of OnabotulinumtoxinA and RimabotulinumtoxinB for the Treatment of Axillary Hyperhidrosis

CONCLUSION: Both toxins showed comparable anhidrotic effect for the treatment of axillary hyperhidrosis at a conversion ratio of 1:30. (Source: Dermatologic Surgery)

Jul 29, 2015 05:31AM

Subject Satisfaction With OnabotulinumtoxinA Treatment of Glabellar and Lateral Canthal Lines Using a New Patient-Reported Outcome Measure

CONCLUSION: High satisfaction rates are achieved and sustained in subjects treated with onabotulinumtoxinA for GL and CFL combined. (Source: Dermatologic Surgery)

Jul 29, 2015 05:31AM

Duration of Effect by Injection Volume and Facial Subregion for a Volumizing Hyaluronic Acid Filler in Treating Midface Volume Deficit

CONCLUSION: VYC-20L is effective at restoring midface volume, with high subject satisfaction and an acceptable safety profile. (Source: Dermatologic Surgery)

Jul 29, 2015 05:31AM

Delayed-Onset Nodules Secondary to a Smooth Cohesive 20 mg/mL Hyaluronic Acid Filler: Cause and Management

CONCLUSION: Although delayed nodules are uncommon from HA-V (0.5%), it is important to be aware of this adverse effect and have a management protocol in place. It is the authors' opinion from the patients' responses and from the literature that these nodules are immune mediated in nature. (Source: Dermatologic Surgery)

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Jul 29, 2015 05:31AM

Commentary on Laboratory Errors Leading to Nonmelanoma Skin Cancer Recurrence Following Mohs Micrographic Surgery

No abstract available (Source: Dermatologic Surgery)

Jul 29, 2015 05:31AM

Continuous Versus Interrupted Sutures for Facial Surgery Repair: A Randomized Prospective Study

CONCLUSION: Interrupted and continuous 5-0 nylon sutures result in an equivalent final cosmetic appearance of facial MMS scars. Given its advantages, running sutures may be the preferred closure technique for facial repair. (Source: Dermatologic Surgery)

Jul 29, 2015 05:31AM

Laboratory Errors Leading to Nonmelanoma Skin Cancer Recurrence After Mohs Micrographic Surgery

CONCLUSION: Local recurrences after MMS are extremely rare. When recurrences do occur, they can be attributed to errors in histological interpretation or tumor mapping. (Source: Dermatologic Surgery)

Jul 29, 2015 05:31AM

Retention of Mohs Surgeons in Academic Dermatology

CONCLUSION: Opportunities for intellectual stimulation, collaboration, and teaching remain the main draw for academic Mohs surgeons. A supportive environment, strong leadership, and establishing fair compensation are imperative in ensuring their stay. (Source: Dermatologic Surgery)

Jul 29, 2015 05:31AM

Polypodium Leucotomos Supplementation in the Treatment of Scalp Actinic Keratosis: Could It Improve the Efficacy of Photodynamic Therapy?

CONCLUSION: Polypodium leucotomos improves PDT clearance and decreases AK recurrence rate at 6 months, suggesting its use as a complementary agent in the treatment of field cancerization. (Source: Dermatologic Surgery)

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Jul 29, 2015 05:31AM

Mohs Appropriate Use Criteria: Retrospectively Applied to Nonmelanoma Skin Cancers at a Single Academic Center

CONCLUSION: In a 3-month review of all NMSC cases at the academic center, there is a low percentage of cases performed that are inappropriate for MMS by AUC. At the institution, there is a large percentage of NMSC that meet AUC but are treated by other modalities. The use is highly appropriate for MMS, and these data suggest possible underutilization of MMS for certain NMSCs. Further studies are required to determine the effectiveness of other treatment modalities for NMSC that meet Mohs AUC. (Source: Dermatologic Surgery)

Jul 29, 2015 05:31AM

How to Review a Manuscript

CONCLUSION: Reviewing a manuscript for the journal is amenable to a simple algorithmic approach. Encouraging recent graduates and others to review for the journal by clarifying the process can further assist the editorial staff in selecting the best manuscripts and improving these before publication. (Source: Dermatologic Surgery)

Jul 29, 2015 05:31AM

Does Pregnancy After a Diagnosis of Melanoma Affect Prognosis? Systematic Review and Meta-analysis

CONCLUSION: Current evidence does not support the hypothesis that pregnancy subsequent to successful treatment of melanoma worsens prognosis. However, relevant data are sparse, suggesting that a precautionary approach is warranted regarding childbearing advice to melanoma survivors. (Source: Dermatologic Surgery)

Jul 29, 2015 05:29AM

Case of pemphigus with immunoglobulin G and A antibodies, binding to both the intercellular spaces and basement membrane zone

We report a case involving a 62?year?old woman with in vivo?bound immunoglobulin (Ig)G and IgA antibodies in both the intercellular space (ICS) and basement membrane zone (BMZ). Her clinical and histopathological features were identical with those of pemphigus vulgaris, while the immunopathological findings suggested IgG/IgA pemphigus. Direct immunofluorescence (IF) showed in vivo?bound IgG and IgA antibodies in the ICS and BMZ, whereas indirect IF showed circulating IgG but not IgA antibodies in the ICS and BMZ. The anti?ICS IgG bound to desmoglein?3, while the anti?BMZ antibodies bound to the epidermal side of 1 mol/L NaCl?split skin. To the best of our knowledge, only two similar cases have been reported so far. Furthermore, we also examined IgG subclass distribution ...

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Jul 29, 2015 04:35AM

Malignant Melanoma Arising in Red Tattoo Ink.

We report the case of a 33-year-old male who presented with a malignant melanoma on his anterior chest wall. The lesion was only found in the red ink pigment of the tattoo, as were several in-transit dermal metastases. Possible explanations include a pre-existing lesion which was seeded with red ink or the possibility of the red ink causing an inflammatory reaction leading to malignant transformation. This is the first reported case of a melanoma developing in the red ink pigment of a multi-colored tattoo. PMID: 26217569 [PubMed] (Source: Archives of Plastic Surgery)

Jul 28, 2015 11:28PM

A skin-picking disorder case report: a psychopathological explanation

We describe the case of a 44-year-old woman, without known previous psychiatric history, hospitalized after a significant hemorrhage caused by self-inflicted deep facial dermal lesions (with muscle exposition). Psychopathological possible explanations of this case, as in similar reviewed ones, are related to frustration, aggression, and impulsivity.Descrevemos um caso clínico de uma senhora de 44 anos de idade, sem antecedentes psiquiátricos prévios, internada após hemorragia significante causada por uma lesão facial autoinfligida (com exposição de músculo). Possíveis explicações psicopatológicas deste caso, tal como em casos similares, relacionam-se com frustração, agressividade e impulsividade. (Source: Jornal Brasileiro de Psiquiatria)

Jul 28, 2015 01:31PM

Controversial Oxygen Therapy ZAPS Cancer

Get more oxygen into your blood, and it instantly destroys infections, bacteria, fungi, and viruses. Oxygen can even destroy cancer cells without harming healthy cells. In today’s world, getting oxygen to your cells is not as easy as it used to be. Even simple nutritional deficiencies like a lack of omega-3s can prevent oxygen from reaching your cells. When my new wellness center opens in October, I’m introducing several new oxygen therapies including an overlooked yet powerful technology called ozone therapy. But ozone is controversial. It attracts attention from the Feds because it WORKS. And anything that kills cancer naturally is going to bring heat from Big Pharma and Uncle Sam. Here in the U.S., the FDA has been trying to crush ozone therapy for over 70 years ? with the...

Jul 28, 2015 07:50AM

Occupational contact dermatitis caused by nickel in scratchcards

(Source: Contact Dermatitis)

Jul 28, 2015 07:00AM

Hypereosinophilic syndrome: an indolent rash with a serious cardiac complication

We present a case of idiopathic HES in a 30?year?old woman with asymptomatic multianeurysmal CAD and a sinus of Valsalva aneurysm, and discuss a brief review of the literature and management strategies. (Source: Clinical And Experimental Dermatology)

Jul 28, 2015 05:35AM

An observational study of the real-life management of psoriasis patients treated with etanercept according to the new reimbursement criteria (in Belgium)

Journal of Dermatological Treatment, Ahead of Print. (Source: Journal of Dermatological Treatment)

Jul 28, 2015 04:02AM

Blue Rubber Bleb Nevus Syndrome Showing Vascular Skin Lesions Predominantly on the Face

An 81-year-old Japanese man presented with dark blue papules and nodules on his face. There were multiple soft papules and nodules, dark blue in color, compressive, and ranging in size from 2 to 10 mm. A few similar lesions were seen on the patient's right dorsal second toe and right buccal mucosa. There were no skin lesions on his trunk and upper limbs. The patient's past history did not include gastrointestinal bleeding or anemia. Histopathological examination showed dilated vascular spaces lined by the normal epithelium extending beneath the dermis and into the subcutaneous fat. Endoscopy of the gastrointestinal tract to check for colon involvement was not performed. X-ray images of the limbs revealed no abnormalities in the bones or joints. Laboratory investigations did not show anemia...

Jul 28, 2015 04:02AM

Elderly-Onset Generalized Pustular Psoriasis without a Previous History of Psoriasis Vulgaris

We report an 83-year-old man showing irregularly shaped erythema with pustules on the trunk and extremities. He initially had no fever and came to our clinic a few days after the onset of the skin lesions because of high fever and general malaise. We found an extension and new development of erythema and pustules on the whole body. The patient also manifested night delirium. Histological examination revealed neutrophil infiltration into the upper epidermis, which formed a spongiform pustule of Kogoj. Pustular fluid cultures were negative for bacteria. We diagnosed GPP without preceding psoriasis vulgaris. Mutation analysis revealed no significant mutations in IL36RN and CARD14. Previous reports indicated that onset of GPP at the age of 83 years is definitely rare. In older individuals, gen...

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Jul 28, 2015 03:55AM

Risk of Cutaneous Squamous Cell Carcinoma Development in Renal Transplant Recipients Is Independent of TMC/EVER Alterations

Conclusion: To clarify the correlation between SNPs in both TMC genes and cSCC development in RTRs, integrated investigations of large cohorts including both RTRs and immunocompetent individuals with consideration of cSCC status, SNP genotype and human papillomavirus status might be necessary.Dermatology (Source: Dermatology)

Jul 27, 2015 07:20PM

Effects of Kyunghee Facial Resistance Program (KFRP) on mechanical and elastic properties of skin

Journal of Dermatological Treatment, Ahead of Print. (Source: Journal of Dermatological Treatment)

Jul 27, 2015 04:00PM

An abnormality in glucocorticoid receptor expression differentiates steroid responders from nonresponders in keloid disease

ConclusionsThis is the first demonstration that keloid response to steroids can be measured objectively using noninvasive imaging. FLPI is a potentially reliable tool to stratify KD responsiveness. Altered GR expression may be the mechanism gating therapeutic response. (Source: British Journal of Dermatology)

Jul 27, 2015 04:00PM

Skin imaging modalities quantify progression and stage of infantile haemangiomas

(Source: British Journal of Dermatology)

Jul 27, 2015 04:00PM

N 1 -methylspermidine, a stable spermidine analog, prolongs anagen and regulates epithelial stem cell functions in human hair follicles

Abstract Spermidine (Spd), the prototypic polyamine, has been shown to be essential for hair follicle (HF) growth. However, Spd can be readily converted into other polyamines, and is physiologically unstable. Therefore, to assess its individual functions on HFs, we used the metabolically stable Spd analog N1-methylspermidine (N1-MeSpd). N1-MeSpd was confirmed to be a metabolically stable compound, with a half life of 90 h. 0.5 µM N1-MeSpd strongly prolonged anagen and decreased cell apoptosis in HFs in culture after 6 days, accompanied by specific stimulation of the expression of the epithelial stem cell-associated keratin, K15. N1-MeSpd also reduced lactate dehydrogenase activity in the culture supernatant, a parameter of cell death and cell lysis. N1-MeSpd diminished intrace...

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Jul 27, 2015 04:00PM

Corrigendum to ?The role of sentinel lymph node biopsy in the management of invasive extramammary Paget?s disease: multi-center, retrospective study of 151 patients? [J. Dermatol. Sci. 79 (2015) 38?42]

The authors regret that affiliation i was incorrect in their paper. The correct affiliation is shown above and the online version has been updated accordingly. (Source: Journal of Dermatological Science)

Jul 27, 2015 04:00PM

A clinico-epidemiological study of herpes zoster

Conclusion This study shows a lower age incidence of herpes zoster HIV positivity and zoster associated pain as compared to other studies. The pattern of segmental involvement in herpes zoster seen in this study was similar to other studies. (Source: Medical Journal Armed Forces India)

Jul 27, 2015 04:00PM

Age-associated reduction of cell spreading induces mitochondrial DNA common deletion by oxidative stress in human skin dermal fibroblasts: implication for human skin connective tissue aging

Conclusion: mtDNA common deletion is highly prevalent in the dermis of both naturally aged and photoaged human skin in vivo. mtDNA common deletion in response to reduced cell spreading is mediated, at least in part, by elevated oxidative stress in human dermal fibroblasts. These data extend current understanding of the mitochondrial theory of aging by identifying the connection between mtDNA common deletion and age-related reduction of cell spreading. (Source: Journal of Biomedical Science)

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Jul 27, 2015 04:00PM

Clinical evaluation of a helicase-dependant amplification (HDA) based commercial assay for the simultaneous detection of HSV-1 and HSV-2

In this study, we evaluate the performance of a commercial assay, the AmpliVue HSV 1+2 Assay (Quidel), that employs HDA for the detection of both HSV-1 and HSV-2. The assay was tested on 307 clinical specimens (genital, oral, dermal). When compared to shell-vial virus culture and immunofluorescence typing of HSV, the positive percent agreement (PPA) and negative percent agreement (NPA) values were 98.2% and 90.9%, respectively. Excellent assay performance was demonstrated. (Source: Diagnostic Microbiology and Infectious Disease)

Jul 27, 2015 04:00PM

Antibody response of definitive hosts against antigens of two life stages of the neuropathogenic schistosome Trichobilharzia regenti

Conclusions: Antigens of cercariae and schistosomula elicited distinct antibody response in ducks, which correlated positively with the age of animals at the time of infection. Several antigens originating in cercariae and fewer in schistosomula were recognized by IgY with diverse sensitivity and specificity; only a few seemed to be common to both stages. Four of them were considered as the most promising candidates for immunodiagnostics. (Source: Parasites and Vectors)

Jul 27, 2015 04:00PM

Lichen scrofulosorum: yet another disease manifesting the Koebner phenomenon?

(Source: International Journal of Dermatology)

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Jul 27, 2015 04:00PM

The clinicopathological spectrum of trichoepitheliomas: a retrospective descriptive study

ConclusionThe current study was confined to a cohort of patients, in the Western Cape Province of South Africa, whose ethnic and geographic origins were not available. The extrapolation of findings from this study to the rest of the South African population may not be valid. A cribriform growth pattern occurs in the majority of cases of multiple TEs. (Source: International Journal of Dermatology)

Jul 27, 2015 04:00PM

Using immunofluorescence (antigen) mapping in the diagnosis and classification of epidermolysis bullosa: a first report from Iran

ConclusionIFM technique is relatively simple to perform, and interpretation of the results is not sophisticated. The proportion of inconclusive results will be decreased if the specimens contain freshly induced blister. (Source: International Journal of Dermatology)

Jul 27, 2015 04:00PM

Identification and functional characterization of a novel transglutaminase 1 gene mutation associated with autosomal recessive congenital ichthyosis

Abstract BackgroundAutosomal recessive congenital ichthyosis (ARCI) is a group of genetically heterogeneous diseases. Mutations in transglutaminase (TGase) 1 gene (TGM1, OMIM 190195) have been implicated in ARCI. However, little is known about TGM1 mutations in the Chinese population, and no functional studies have investigated the biological effect of mutant TGM1 on human epidermal keratinocytes (HaCaT) cells. ObjectivesTo identify the pathogenic mutations of TGM1 gene in two Chinese siblings with ARCI and gain insight into functional consequences of these mutations. MethodsFifteen exons and flanking splice sites of TGM1 gene were amplified by polymerase chain reaction and then underwent bidirectional Sanger sequencing. The HaCaT cells were transfected with lentiviral vectors, which overe...

Jul 27, 2015 04:00PM

Circulating CD4+CD25highFoxP3+ T?regulatory cells in patients with atopic dermatitis after narrowband?ultraviolet B phototherapy

ConclusionsSignificant reduction in AD disease severity is correlated with the change in Tregs% and Tregs/Teffs. (Source: International Journal of Dermatology)

Jul 27, 2015 04:00PM

The bidirectional interactions between psoriasis and obstructive sleep apnea

Abstract Psoriasis is a chronic inflammatory skin disorder which can impair general routine activities and has been closely related to poor quality of life. Pruritus and scratching are frequently observed, occurring mainly during sleep and precipitating nighttime arousals. Indeed, sleep quality has been shown to be negatively affected in psoriatic patients, in a close relationship with stress exposure and immune response. Although psoriasis is known to impair sleep, leading to insomnia, its association with obstructive sleep apnea (OSA) is controversial. Similarly, OSA is considered a multifactorial inflammatory disease, characterized by intermittent hypoxia, sleep fragmentation and autonomic dysfunction, with important outcomes on the cardiovascular and metabolic systems. Importantly, imm...

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Jul 27, 2015 04:00PM

Issue Information

(Source: Experimental Dermatology)

Jul 27, 2015 04:00PM

Clinical Snippets

(Source: Experimental Dermatology)

Jul 27, 2015 04:00PM

Hematopoietic Stem Cell Transplant for Mycosis Fungoides and Sézary Syndrome

This article reviews the role of HSCT in MF/SS and discusses data regarding conditioning regimens, treatment-related complications, and outcomes. (Source: Dermatologic Clinics)

Jul 27, 2015 04:00PM

Extracorporeal Photopheresis in the Treatment of Mycosis Fungoides and Sézary Syndrome

Extracorporeal photopheresis (ECP) is an immunomodulating procedure that leads to an expansion of peripheral blood dendritic cell populations and an enhanced TH1 immune response in cutaneous T-cell lymphoma (CTCL). Because of its excellent side effect profile and moderate efficacy, ECP is considered first-line therapy for erythrodermic mycosis fungoides (MF) and Sézary syndrome. Patients with a measurable but low blood tumor burden are most likely to respond to ECP, and the addition of adjunctive immunostimulatory agents may also increase response rates. There may be a role for ECP in the treatment of refractory early stage MF, but data are limited. (Source: Dermatologic Clinics)

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Jul 27, 2015 04:00PM

Radiation Therapy for Cutaneous T-Cell Lymphomas

Radiation therapy is an extraordinarily effective skin-directed therapy for cutaneous T-cell lymphomas. Lymphocytes are extremely sensitive to radiation and a complete response is generally achieved even with low doses. Radiation therapy has several important roles in the management of mycosis fungoides. For the rare patient with unilesional disease, radiation therapy alone is potentially curative. For patients with more advanced cutaneous disease, radiation therapy to local lesions or to the entire skin can effectively palliate symptomatic disease and provide local disease control. Compared with other skin-directed therapies, radiation therapy is particularly advantageous because it can effectively penetrate and treat thicker plaques and tumors. (Source: Dermatologic Clinics)

Jul 27, 2015 11:35AM

Recovery of Severe Muscular and Fascial Calcinosis After Treatment With Bisphosphonates in a Child With Juvenile Dermatomyositis

We report a case of a 10-year-old boy with JDM and severe calcification deposits along fasciae and muscle planes. He complained of symptoms associated to JDM with pulmonary involvement since 1 year before receiving medical attention. Three months before consultation, he experienced bilateral leg pain accompanied by progressive hardening of muscles and the presence of small nodules around the elbows and submandibular region. Computed tomography images revealed a severe ?eggshell? calcification pattern of the lower-limb muscular fasciae. Significant clinical and radiological improvement was achieved after 30 months of alendronate therapy. (Source: JCR: Journal of Clinical Rheumatology)

Jul 27, 2015 11:13AM

Red Blood Cells Store and Release Interleukin-33

Abstract: Interleukin-33 (IL-33) is a member of the IL-1 cytokine superfamily that potently drives production of a variety of cytokines and contributes to the pathogenesis of inflammatory diseases. The IL-33 is a nuclear protein and is released from apoptotic or necrotic cells. Serum IL-33 levels are increased in various diseases, such as atopic dermatitis, chronic hepatitis C infection, and asthma. Here, we show that red blood cells (RBCs) are one of the major sources of plasma IL-33. The IL-33 levels are significantly increased in supernatants from lysed RBCs. Plasma IL-33 levels are increased in patients during hemolysis, and plasma IL-33 levels show a positive correlation with degree of hemolysis. The IL-33 protein and messenger RNA levels were detected in the late stages of differenti...

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Jul 27, 2015 07:35AM

Drug manufacturers delayed reporting serious unexpected adverse events

Drug manufacturers did not report about 10% of serious and unexpected adverse events to the U.S. Food and Drug Administration within the required time period, investigators reported online in JAMA Internal Medicine. Moreover, manufacturers were more likely to delay reporting serious and unexpected...googletag.display('div-gpt-ad-cta'); (Source: Skin and Allergy News)

Jul 27, 2015 05:27AM

Bleeding profile in users of an etonogestrel sub-dermal implant: effects of anthropometric variables. An observational uncontrolled preliminary study in Italian population

Gynecological Endocrinology, Volume 31, Issue 6, Page 491-494, June 2015. (Source: Gynecological Endocrinology)

Jul 27, 2015 02:42AM

Association between methylenetetrahydrofolate reductase C677T polymorphism and psoriasis: A meta?analysis

In conclusion, MTHFR C677T polymorphism, qualitatively, is not a genetic factor for the pathogenesis of psoriasis but could quantitatively reflect the severity of psoriasis to some extent. (Source: The Journal of Dermatology)

Jul 26, 2015 08:37PM

Layer-by-Layer Assembly of Inactivated Poliovirus and N-Trimethyl Chitosan on pH-Sensitive Microneedles for Dermal Vaccination

LangmuirDOI: 10.1021/acs.langmuir.5b01262 (Source: Langmuir)

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Jul 26, 2015 08:01PM

Stevens-Johnson syndrome cases differ based on cause

Children with Stevens-Johnson syndrome associated with Mycoplasma pneumoniae were more likely to develop pneumonia, to have fewer affected skin sites, and to have respiratory symptoms prior to the condition, a study found. ?The spectrum of M. pneumoniae?-associated Stevens-Johnson syndrome...googletag.display('div-gpt-ad-cta'); (Source: Skin and Allergy News)

Jul 26, 2015 08:00PM

Summary Information for: Restylane Lyft with Lidocaine Injectable Gel Injectable Dermal Filler

Labeling, Approval Order, and Summary of Safety and Effectiveness for Restylane Lyft with Lidocaine Injectable Gel Injectable Dermal Filler (P040024S073). (Source: Food and Drug Adminstration (FDA): CDRHNew)

Jul 26, 2015 08:00PM

Consumer Information on: Restylane Lyft with Lidocaine Injectable Gel Injectable Dermal Filler - P040024S073

Restylane Lyft with Lidocaine is a hyaluronic acid gel that is injected into moderate to severe facial folds and wrinkles. It may also be injected into the check to temporarily correct age-related volume loss in patients over the age of 21. (Source: Food and Drug Adminstration (FDA): CDRHNew)

Jul 26, 2015 04:55PM

What Are Common Drug Eruptions in Children?

Discussion Drug reactions unfortunately are common in children and adults. These reactions have different but often overlapping appearances. Viral exanthams also often cloud the picture as these rashes can be because of the drug, the virus or both. Patients with urticaria multiforme present with an acute rash that appears as urticaria plaques that have a hemorrhagic or dusky discoloration. It occurs 1-3 days after viral symptoms (including cough, rhinorrhea, diarrhea) and may also present with fever. Morbilliform drug eruptions one of the most common drug reactions in children and usually occur 7-14 days after the onset of the medication, often amoxicillin. The rash is small, pink or red macules and papules that are diffuse and may coalesce. The rash can get worse with viral syndrome and...

Jul 26, 2015 04:00PM

Oral Nadolol for the Treatment of Infantile Hemangiomas: A Single?Institution Retrospective Cohort Study

ConclusionsOral nadolol is efficacious in patients with problematic IHs. Further large?scale prospective comparative studies are warranted to compare nadolol with other beta?blockers. (Source: Pediatric Dermatology)

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Jul 26, 2015 04:00PM

Aplasia Cutis Congenita Associated with Fetus Papyraceus

We present six new cases of neonates born with symmetric ACC associated with intrauterine fetal demise of co?twins during the late first or early second trimester. (Source: Pediatric Dermatology)

Jul 26, 2015 04:00PM

Nickel Allergy and Our Children's Health: A Review of Indexed Cases and a View of Future Prevention

Abstract Nickel is the leading cause of allergic contact dermatitis (ACD) from early childhood through adolescence. Studies have shown that skin piercings and other nickel?laden exposures can trigger the onset of nickel ACD in those who are susceptible. Nickel ACD causes a vast amount of cutaneous disease in children. Cases of nickel ACD in children have been reported in peer?reviewed literature from 28 states. Common items that contain inciting nickel include jewelry, coins, zippers, belts, tools, toys, chair studs, cases for cell phones and tablets, and dental appliances. The diagnosis of nickel ACD has been routinely confirmed by patch testing in children older than 6 months suspected of ACD from nickel. Unlike in Europe, there are no mandatory restrictions legislated for nickel ex...

Jul 26, 2015 04:00PM

Transplacental Transmission of Pemphigus Herpetiformis in the Setting of Maternal Lymphoma

We describe a healthy boy born with acral crateriform erosions of the hands and feet whose 35?year?old mother had similar lesions. Biopsies from both patients were most consistent with PH. The mother was diagnosed with high?grade B?cell non?Hodgkin lymphoma and began chemotherapy with dexamethasone, and her lesions quickly improved. The infant had no additional lesions after 3 weeks of age and his acral erosions healed. To our knowledge, this is the first report of a diagnosis of PH in an infant and the first case of transplacental transmission of PH. This is also the first report of paraneoplastic PH in lymphoma. This case adds to the growing differential diagnosis of skin disease in postpartum women and their neonates. (Source: Pediatric Dermatology)

Jul 26, 2015 04:00PM

Clinical profiles and treatment outcomes of systemic corticosteroids for toxic epidermal necrolysis: A retrospective study

In conclusion, in addition to withdrawal of the suspected agent and intensive supportive care, the administration of short?term dexamethasone pulse therapy, particularly during the initial phase, may be beneficial in reducing the mortality rate. (Source: The Journal of Dermatology)

Jul 26, 2015 04:00PM

Possible enhancement of BP180 autoantibody production by herpes zoster

We report a case of herpes zoster (HZ) having anti?BP180 serum antibodies. The patient developed sudden?onset, tense blisters and edematous erythema on the right anterior chest, shoulder and upper back. Histopathology showed remarkable degeneration of keratinocytes, acantholysis and blister formation with ballooning cells, indicating herpes virus infection. A polymerase chain reaction analysis of varicella zoster virus (VZV) was positive in crusts and effusions from the skin lesions, confirming the definitive diagnosis of HZ. Notably, we found that the patient had anti?BP180 serum antibodies in association with the occurrence of HZ. After successful treatment with valacyclovir hydrochloride for 7 days, the serum levels of anti?BP180 antibodies decreased in accordance with the impr...

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Jul 26, 2015 04:00PM

Clinical remission of pityriasis rubra pilaris with adalimumab in an adolescent patient

(Source: The Journal of Dermatology)

Jul 26, 2015 04:00PM

Case of basosquamous carcinoma: Dermoscopic and immunohistochemical findings

(Source: The Journal of Dermatology)

Jul 26, 2015 04:00PM

Lymphatic transit rate as a novel predictive parameter for nodal metastasis in primary truncal skin cancers

Abstract Prediction of nodal metastasis in skin cancer before sentinel lymph node (SLN) biopsies is ideal to avoid unnecessary SLN biopsy performance. Primary truncal skin cancers are characterized by the lymphatic flow that drains from the primary lesion, occasionally to plural nodal basins. The scintigraphic appearance time (SAT), defined as the time between radionuclide injection and first SLN visualization, can potentially predict nodal metastasis, and a short SAT is a predictive parameter for metastasis. We recently introduced a novel method to measure the lymphatic flow rate using dynamic lymphoscintigraphy exhibiting a time?activity curve in the SLN. The time at which the count reaches a plateau in the SLN is termed the scintigraphic saturation time (SST) and can be a good alterna...

Jul 26, 2015 04:00PM

Characteristic dermoscopic features of verruciform xanthoma: Report of three cases

(Source: The Journal of Dermatology)

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Jul 26, 2015 04:00PM

Dermoscopy of idiopathic guttate hypomelanosis

(Source: The Journal of Dermatology)

Jul 26, 2015 04:00PM

Primary cutaneous nocardiosis caused by Nocardia concava

(Source: The Journal of Dermatology)

Jul 26, 2015 04:00PM

Comparative study between intralesional injection of bleomycin and 5-fluorouracil in treatment of keloids and hypertrophic scars

Publication date: Available online 26 July 2015 Source:Journal of Dermatology & Dermatologic Surgery Author(s): Ahmed M. Kabel, Hanan H. Sabry, Neveen E. Sorour, Fatma M. Moharm The aim of this work was to evaluate the efficacy and safety of intralesional injection of 5- fluorouracil and bleomycin in treatment of keloids and hypertrophic scars. One hundred and twenty patients were divided into the following groups: group IA was injected intralesionally with 5-fluorouracil; group IB was injected intralesionally with a combination of triamcinolone acetonide and 5-fluorouracil; Group II was injected intralesionally with bleomycin. Patients underwent follow up by photographing and Vancouver scar scale system. There was significant improvement in the Vancouver scar scale in group ...

Jul 26, 2015 04:00PM

Bullous cutaneous larva migrans ? A case report

Publication date: Available online 15 July 2015 Source:Journal of Dermatology & Dermatologic Surgery Author(s): Mrinal Gupta Cutaneous larva migrans (CLM) is a skin infestation commonly seen in tropical and subtropical geographic areas, caused by nematode larvae, usually of animal hookworms. Clinically it is characterized by erythematous serpiginous lesions, which are associated with severe itching which may lead to excoriations and secondary bacterial infection. Rarely, it may manifest as vesicobullous lesions or folliculitis. Herein, we present a case of bullous cutaneous larva migrans in a 60-year old farmer who was successfully treated with albendazole and ivermectin. (Source: Journal of Dermatology and Dermatologic Surgery)

Jul 26, 2015 04:00PM

AAP to FDA: Include children early in clinical trials of systemic medications for atopic dermatitis [FOCUS ON SUBSPECIALTIES]

(Source: AAP News)

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Jul 26, 2015 04:00PM

Cryptococcose disséminée chez un patient immunocompétent

We report the case of a patient apparently immunocompetent who had a disseminated cryptococcosis. The disease started with the multiple purplish skin lesions, large umbilicated on the face, groin, forearm and leg with progressively increasing volume. This symptomatology had evolved in the context of weight loss and poor general condition. The diagnosis was established by the presence of cryptococcal at the skin biopsy and cerebrospinal fluid. Research of immunosuppression common pathologies were negative. Treatment was initiated based on amphotericin B for 40 days. The patient's condition deteriorates onset of paraplegia and swallowing disorders causing death in an array of cachexia. This observation points out that disseminated cryptococcosis can occur in an immunocompetent patient. The s...

Jul 26, 2015 04:00PM

No association between vitamin D and atopy, asthma, lung function or atopic dermatitis: a prospective study in adults

This article is protected by copyright. All rights reserved. (Source: Allergy)

Jul 26, 2015 04:00PM

Predictive factors of persistent infantile atopic dermatitis up to 6 years old in Taiwan: a prospective birth cohort study

ConclusionEgg white sensitization and the initial involvement of two or more areas at six months of age were associated with the persistent infantile atopic dermatitis. Patients with persistent infantile atopic dermatitis are more likely to develop asthma by 6 years of age.This article is protected by copyright. All rights reserved. (Source: Allergy)

Jul 26, 2015 04:00PM

Komplementärmedizin in der Dermatologie

(Source: JDDG)

Jul 26, 2015 04:00PM

Allergy ? current insights into prevention and diagnostic workup of immediate?type allergy and treatment of allergic rhinoconjunctivitis

Summary In recent decades, the incidence of allergic diseases has dramatically increased, by now affecting a large percentage of the population. For a long time, allergen avoidance was considered the most crucial measure in primary allergy prevention. However, studies have increasingly shown that exposure to allergens is an essential prerequisite for the development of immunological tolerance. Diagnostic workup is based on patient history, skin tests, and measurement of specific IgE antibodies. The introduction of component?based diagnostic workup offer an option to differentiate between primary sensitization and cross?reactivity caused by sensitization to panallergens or sensitization to cross?reactive carbohydrate epitopes. Symptomatic treatment only leads to temporary relief of al...

Jul 26, 2015 04:00PM

Allergologie ? Aktuelles zur Prävention und Diagnostik von Soforttyp?Allergien und zur Therapie der allergischen Rhinokonjunktivitis

Zusammenfassung Die Inzidenz allergischer Erkrankungen ist in den letzten Jahrzehnten dramatisch gestiegen, so dass diese Erkrankungen jetzt zu den ?Volkskrankheiten? gezählt werden müssen. Allergenexpositionsmeidung galt früher als wichtigste Maßnahme der primären Prävention. Zunehmend zeigen Studien, dass für die Entwicklung immunologischer Toleranz die Auseinandersetzung des Immunsystems mit Allergenen notwendig ist. Die Diagnostik basiert auf Anamnese, Hauttests und Bestimmung von spezifischen IgE?Antikörpern. Durch Komponenten?basierte Diagnostik kann eine primäre Sensibilisierung gegen eine Allergenquelle von Kreuzreaktionen durch Sensibilisierung gegen Panallergene oder kreuzreagierende Kohlenhydratepitope abgegrenzt werden. Die symptomatische Behandlung führt nur ...

Jul 26, 2015 04:00PM

Grüner Tee in der Dermatologie ? Mythen und Fakten

Zusammenfassung Der Genuss von grünem Tee hat in asiatischen Ländern ? vor allem in China ? eine lange Tradition. Die epidemiologisch und experimentell beobachteten antikarzinogenen und antiinflammatorischen Effekte von grünem Tee haben zum Einsatz von Grüntee?Extrakten bei verschiedenen therapeutischen Anwendungen geführt ? sowohl in dermatologischen als auch in kosmetischen Präparaten, wobei die umfangreichsten Untersuchungen für die antikarzinogene und chemopräventive Wirkung von grünem Tee bzw. seines Hauptbestandteils Epigallocatechin?3?gallat vorliegen. Fast ebenso gut nachgewiesen ist die Wirkung bei Infektionskrankheiten wie kutanen Virusinfektionen. Zur topischen Behandlung von Genitalwarzen wurde eine Salbe mit Grüntee?Extrakten 2010 in den USA und kürzli...

Jul 26, 2015 04:00PM

Nebenwirkungen ästhetischer Eingriffe an der Haut

Zusammenfassung In den letzten Jahren sind im Gebiet der ästhetischen Dermatologie eine Vielzahl von neuartigen therapeutischen Ansätzen zur Bekämpfung von Alterserscheinungen und zur Beeinflussung des äußeren Körpererscheinungsbildes verfügbar geworden. Umfangreiche Forschung auf diesem Gebiet hat zu einem erweiterten Verständnis der Anatomie und Physiologie des alternden Gesichtes geführt. Um die komplizierten altersbedingen Veränderungen anzugehen, erfordert die Anti?Aging?Behandlung heutzutage eine multidimensionale Herangehensweise. Zu den häufigsten ästhetischen Eingriffen gehören die Verwendung von Botulinumtoxin, eine Vielzahl von Füll materialien, Microneedling (Kollageninduktionstherapie), chemische Peelings, Laserbehandlung, Radiofrequenzbehandlung, Faden?Fac...

Jul 26, 2015 04:00PM

Incidence trends of nonmelanoma skin cancer in Germany from 1998 to 2010

ConclusionsResults are consistent with national and international observations. The heterogeneity of incidence rates and their changes among federal states indicate that incidence changes are most likely related to improved case registration practices in German cancer registries. (Source: JDDG)

Jul 26, 2015 04:00PM

Inzidenztrends bei nicht?melanozytärem Hautkrebs in Deutschland von 1998 bis 2010

Zusammenfassung Hintergrund und StudienzieleNicht?melanozytärer Hautkrebs (NMSC = nonmelanoma skin cancer) ist die häufigste Krebserkrankung in Deutschland. Allerdings herrscht weitgehende Unklarheit über Inzidenztrends des NMSC und dessen häufigste Untertypen, Basalzellkarzinom (BCC) und Plattenepithelkarzinom (SCC), in Deutschland. Material und MethodenDie Daten aus Krebsregistern von 14 deutschen Bundesländern wurden herangezogen, um altersstandardisierte Inzidenzraten nach histologischen Untertypen zu ermitteln. Anhand von Joinpoint?Regressionsmodellen wurden jährliche prozentuale Veränderungen berechnet, um Trendänderungen in den Jahren 1998 bis 2010 zu erkennen. ErgebnisseDie Inzidenz von NMSC in Deutschland erhöhte sich signifikant von 43,1 Fällen/100 000 im Jahr 1998...

Jul 26, 2015 04:00PM

Wiederholte Injektionen von Botulinumtoxin Typ A steigern kontinuierlich die Wirkdauer bei primärer axillärer Hyperhidrose: Eine retrospektive Analyse von 101 Patienten

Zusammenfassung Hintergrund und ZielsetzungBotulinumtoxin Typ A ist eine wirksame, gut verträgliche, wenn auch temporäre Therapieoption gegen primäre axilläre Hyperhidrose. Über den Einfluss von wiederholten Injektionen auf die Wirkdauer ist jedoch wenig bekannt. Patienten und Methoden139 Patienten mit primärer axillärer Hyperhidrose wurden 50 Botulinumtoxin?Einheiten je Axilla injiziert. Die Wirkdauer wurde bei 101 Patienten, die mindestens 3 Behandlungen erhalten hatten, nach der ersten, zweiten, und letzten Behandlung untersucht. ErgebnisseDie Wirkung hielt im Durchschnitt nach der ersten, zweiten, und letzten Injektion jeweils 4,0 Monate, 4,5 Monate, und 5,0 Monate an. Insgesamt war die Wirkdauer nach der letzten Injektion signifikant länger als nach der ersten Injektion (p =...

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Jul 26, 2015 04:00PM

Pannikulitis bei Pankreatitis

(Source: JDDG)

Jul 26, 2015 04:00PM

Waiting time and practice organization in dermatology

(Source: JDDG)