Dr. William Ting, Board-Certified Dermatologist
at California Dermatology Care

2262 Camino Ramon, San Ramon, CA 94583
Tel: 925-328-0255
Email: staff@CalDermCare.com


Advanced Care with a Personal Touch

   

 

 

Medical Dermatology    Evidence-based medicine   Customized solution   Personal care

Latest Dermatology Headlines

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MEDICAL DERMATOLOGY

Acne and Acne Scar

Excimer Laser for Psoriasis & Vitiligo

Keloid & Hypertrophic Scar Laser Therapy

Mohs Surgery for Skin Cancers

Nail Fungus GenesisPlus Laser Therapy

Photodynamic Therapy

Psoriasis & NBUVB Phototherapy

RadioTherapy Nonsurgical SRT-100 for Skin Cancer

Skin Allergy Patch Test

Sweating Disorder MiraDry for Hyperhidrosis

Wart Laser Therapy


COSMETIC DERMATOLOGY

Aesthetician Services
Microdermabrasion
 

Botox, Dysport & Xeomin

Cellulaze Cellulite Therapy

new! CoolSculpting

Facial Redness/Vein Laser Therapy

Fillers injection for Wrinkles

Fractional CO2 laser

new! Hair Transplant with Neograft

Laser Surgery Services
Acne/Pore reducing Laser
Collagen Stimulating Laser
Excimer Laser
Facial Veins laser
Hair Laser Removal
IPL Fotofacial
Melasma Laser
Nail Fungus Laser
Resurfacing Laser
Scar revision Laser
Tattoo Removal Lasers
VBeam Pulse Dye Laser
Wart Laser


Latisse

Leg Vein Laser Therapy & Asclera Sclerotherapy

Liposonix + Vaser Shape Nonsurgical Body Sculpting
 

Melasma and Pigmentation

Pore Size Reduction and Laser Rejuvenation

Sculptra Liquid Facelift

SideLaze Lift

Ulthera natural lift & skin tightening of face and neck


Related Websites
FaceUpLifting.com
iCellulaze.com
MoreHair4Me.com
SideLazeLift.com
SonixLipo.com


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925-328-0255

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Dr. William Ting has expertise in treating the entire spectrum of medical dermatology, with emphasis in preventive medicine and personalized recommendations. He enjoys taking care of patients with acne, eczema, hair and nail disorders, rashes, psoriasis and skin cancers.

He is at the forefront of medical dermatology and dermatologic research. He continues to publish articles in peer-reviewed dermatology journals. He is an early pioneer of photodynamic therapy (PDT) and one of the most experienced practitioners of PDT in the Bay Area. He is the first dermatologist in the San Francisco Bay Area and Northern California to introduce Lutronic Spectra Laser for melasma, acne, scar revision, pore size reduction as well as the Cutera GenesisPlus laser for advanced nail fungus laser treatment, keloid and hypertrophic scar, warts and scar revision.

Dr. Ting is a fellow of the American Academy of Dermatology (AAD) and American Society of Dermatologic Surgery (ASDS). He is a member of the National Psoriasis Foundation and International Hyperhidrosis Society.

Innovative Therapeutic Approach to Common Skin Conditions

Acne

Eczema (Atopic Dermatitis)

Hair and Nail disorders

  • Maximize therapeutic synergy and efficacy by utilizing both prescription-strength and over-the counter products when available
  • Comprehensive workup including bloodwork and biopsy if necessary
  • Systemic oral hormonal therapy for women and men when indicated

Psoriasis 

Rosacea

  • Multi-prong approach to minimize redness
  • Low-dose 'non-antibiotic' anti-inflammatory oral medication for long-term remission 
  • Emphasis on prevention
  • Fotofacial/IPL laser utilizing Cynosure XPL/Elite MPX
  • Cutera GenesisPlus Laser with or without combination with IPL 
  • Diode laser for facial veins
  • VBeam Pulse Dye Laser, the new gold standard for rosacea and facial redness

Skin Cancer 

  • Emphasis on prophylactic treatments with topical 5-FU, imiquimod, diclofenac, ingenol mebutate and oral chemopreventive therapy such as Soriatane.
  • Reduce future risks of skin cancer with photodynamic therapy, TCA chemical peels and/or fractional CO2 resurfacing laser  
  • Mohs Surgery to achieve highest cure rate and tissue sparing
  • Close colloboration with plastic surgeon(s) as needed  

Sweating Disorder (Hyperhidrosis) 

Vitiligo

Warts 


ABCD of Mole Check

 

 

Common Medical Dermatology Diagnostics and Therapeutics:

Dermatology Links:

American Academy of Dermatology
American Society of Dermatologic Surgery
American Society of Mohs Surgery
International Hyperhidrosis Society
National Psoriasis Foundation

 Latest Dermatology Headlines:

Latest Dermatology Headlines
Sun, 23 Nov 2014 05:05:01 +0100

http://www.medworm.com/rss/index.php/Dermatology/12/

Nov 22, 2014 08:00AM

Variance components for susceptibility to Mycobacterium bovis infection in dairy and beef cattle.

CONCLUSIONS: Genetic trends for bTB susceptibility observed in this study suggest a slight increase in genetic susceptibility to bTB in recent years. Since bTB is of economic importance and because all animals are routinely tested at least once annually in Ireland and some other countries, the presence of genetic variation for bTB susceptibility suggests that bTB susceptibility should be included in a national breeding program to halt possible deterioration in genetic susceptibility to bTB infection. PMID: 25407624 [PubMed - in process] (Source: Genet Sel Evol)

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Nov 22, 2014 07:53AM

Radiation combined injury models to study the effects of interventions and wound biomechanics - Zawaski JA, Yates CR, Miller DD, Kaffes CC, Sabek OM, Afshar SF, Young DA, Yang Y, Gaber MW.

In the event of a nuclear detonation, a considerable number of projected casualties will suffer from combined radiation exposure and burn and/or wound injury. Countermeasure assessment in the setting of radiation exposure combined with dermal injury is ham... (Source: SafetyLit: All (Unduplicated))

Nov 22, 2014 01:08AM

Cutaneous PEComa: A Rare Entity to Consider in an Unusual Site

We report a case of cutaneous PEComa to raise awareness of the entity occurring at this site and caution against misinterpretation as a primary or metastatic malignancy, for example melanoma or renal cell carcinoma, clear cell type. (Source: The American Journal of Dermatopathology)

Nov 22, 2014 01:08AM

Epidermolysis Bullosa Nevus in a Patient With Recessive Dystrophic Epidermolysis Bullosa: A Case Report

We present a case of a 6-year-old girl with recessive dystrophic epidermolysis bullosa (EB) who presented with a large pigmented lesion clinically concerning for melanoma. After histological examination and fluorescent in situ hybridization analysis, diagnosis of EB nevus was performed. EB nevi are benign melanocytic neoplasms with histological findings similar to recurrent nevi occurring in all types of EB. They often mimic melanoma clinically, dermatoscopically, and histopathologically. The ability to recognize an EB nevus is essential for appropriate management of the patient. Unnecessary surgical excision in patients with already high-risk EB should be avoided. Close monitoring of these lesions is recommended because no cases of transformation to melanoma have been described. (Source: ...

Nov 22, 2014 01:08AM

Syringocystadenocarcinoma Papilliferum With Intraepidermal Pagetoid Spread on an Unusual Location

No abstract available (Source: The American Journal of Dermatopathology)

Nov 22, 2014 01:08AM

Ex Vivo Blister Induction: A More Sensitive Technique for Immunofluorescence Mapping Studies in Inherited Epidermolysis Bullosa

No abstract available (Source: The American Journal of Dermatopathology)

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Nov 22, 2014 01:08AM

IgG/IgA Pemphigus

Abstract:IgG/IgA pemphigus has recently been described in the literature as an overlap of pemphigus vulgaris or pemphigus foliaceus with IgA pemphigus. There has also been some postulation that this IgG/IgA pemphigus may be associated with internal malignancy as well. Our case demonstrates the unique clinical, histopathological, and direct immunofluorescence findings of IgG/IgA pemphigus and further highlights the possibility of association of this disease with internal malignancy. (Source: The American Journal of Dermatopathology)

Nov 22, 2014 01:08AM

A Unique Cutaneous Presentation of Burkitt Lymphoma

Abstract:Few reports of cutaneous Burkitt lymphoma exist in the literature. Here, the authors describe the case of a human immunodeficiency virus?positive individual with the rare diagnosis of cutaneous Burkitt lymphoma. Three weeks before the development of his cutaneous lesions, the patient experienced bilateral lower extremity paralysis, and an epidural mass was found. Bone marrow biopsy findings and serum protein electrophoresis seemed consistent with multiple myeloma. The visible appearance of the skin lesions raised concern for cutaneous involvement by myeloma; however, the skin biopsy showed morphological and immunohistochemical features of Burkitt lymphoma. In this case report, the authors discuss the histopathologic findings of the cutaneous lesions in consideration with the bon...

Nov 22, 2014 01:08AM

Cutaneous Lupus Erythematosus With Histopathologic Changes Restricted to the Acrosyringia

We present the second case of systemic lupus erythematosus (SLE) with histopathologic involvement mostly located in the acrosyringia. The patient was a 37-year-old male with multiorgan failure who, in the context of flare-up of SLE, presented cutaneous lesions consisting of erythematous and edematous macules and plaques on the face, arms, and anterior chest. Histopathologic examination demonstrated necrotic keratinocytes confined to the acrosyringia as the main finding. It was associated with sparse inflammatory infiltrate in the superficial dermis, mostly composed of lymphocytes. The epidermis between the acrosyringia was spared. Our case was clinically almost identical to the one previously described, being a patient with a severe SLE and widespread cutaneous involvement and receiving tr...

Nov 22, 2014 01:08AM

Reading Between the Layers: Early Histopathological Findings in Exogenous Ochronosis

Abstract:Exogenous ochronosis (EO), although rare, is a well-known pigmentary disorder. Being extremely difficult to treat, early identification is very important, with histopathology remaining the gold standard in diagnosis. A 66-year-old woman presented with periocular and lateral neck blue-gray pigmentation, who after workup including history, physical examination, and skin biopsy was diagnosed with EO based on early histopathologic findings. Classically, banana-shaped collagen fibers are considered the pathognomonic histopathologic sign; however, we present this unique case to illustrate the early findings of EO including basophilia of the collagen fibers in the upper dermis, homogenization and swelling of the collagen bundles, and altered texture and arrangement of elastic fibers in t...

Nov 22, 2014 01:08AM

Molluscum-like Lesions in a 12-Year-Old Boy: Answer

No abstract available (Source: The American Journal of Dermatopathology)

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Nov 22, 2014 01:08AM

Signet-Ring Cell Melanoma: A Potential Diagnostic Pitfall

We report a rare case of primary signet-ring cell malignant melanoma in a 62-year-old man. He initially presented with an enlarging nevus on his right flank with surrounding erythema. A biopsy showed atypical epithelioid and signet cells with prominent nucleoli and occasional mitoses. Initial diagnosis favored metastatic signet-cell carcinoma of gastrointestinal origin. Review of the biopsy and immunohistochemical analysis revealed the malignant signet-ring cells stained with S100, vimentin, and melanoma cocktail, in keeping with melanoma. The signet-cell morphology can be found in a variety of other malignancies. To prevent potential misdiagnoses, thorough histological examination should be aided by an appropriate immunohistochemical panel to confirm melanoma and exclude erroneous differe...

Nov 22, 2014 01:08AM

Molluscum-like Lesions in a 12-Year-Old Boy: Challenge

No abstract available (Source: The American Journal of Dermatopathology)

Nov 22, 2014 01:08AM

Vascular Leg Ulcers: Histopathologic Study of 293 Patients

In conclusion, histopathologic and hemodynamic data correlation could provide the basis for future analysis of leg ulcers pathogenesis and may improve treatment protocols. We should underline that this observational study represents a single-institute experience and that larger series are needed to confirm our observations. (Source: The American Journal of Dermatopathology)

Nov 22, 2014 01:08AM

Multiple Distinct T-Cell Clones in Folliculotropic Mycosis Fungoides

Abstract:Multiple distinct T-cell clones have been demonstrated in a subset of mycosis fungoides (MF), but have so far not been documented in folliculotropic MF, a clinical and histological variant of MF. We analyzed T-cell receptor (TCR) gene rearrangements in 8 patients with folliculotropic MF with multiple biopsies (range, 2?5) taken during the course of disease. Two patients had disease stage IA?IIA, 5 stage IIB?IVA, whereas data were not available for 1 patient. TCR ? and ? gene rearrangements were analyzed according to the BIOMED-2 PCR protocol. Multiple clonal TCR gene rearrangements indicating more than 1 T-cell clone were found in 5 patients. Although the number of patients is small, the finding of multiple distinct T-cell clones in 5 out of 8 patients suggests that chroni...

Nov 22, 2014 01:08AM

Panfolliculoma and Histopathologic Variants: A Study of 19 Cases

Abstract:Panfolliculoma (PF) is an uncommon benign follicular neoplasm exhibiting differentiation toward all components of a hair follicle. Several pathologic manifestations have been described in a limited number of cases. We studied 19 cases of PF to summarize the clinical parameters and to classify this unique neoplasm histopathologically. A study of the largest sample series of PF has been performed here. The lesions affect both genders after age 20. The head is the most common site of PF of all types. On microscopic examination, all cases demonstrated advanced follicular differentiation by showing cell components of infundibulum, isthmus, stem, bulb, and mesenchymal papilla. Based on the findings and various patterns in histopathology, we classified PF into 3 subtypes: nodular, superf...

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Nov 22, 2014 01:07AM

Immunohistochemical Expression of MCM2 in Nonmelanoma Epithelial Skin Cancers

Abstract:Cutaneous basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) represent 45.5% and 37.02%, respectively, of total malignant skin cancer according to the latest registry of Egyptian National Cancer Institute. Minichromosome maintenance (MCM) proteins are essential replication initiation factors. The current study examined the immunohistochemical expression of MCM2 in normal skin (10 cases), some proliferative skin lesions (6 psoriasis, 2 keratoacanthoma, and 2 seborrheic keratosis), and nonmelanoma epithelial skin cancers (20 BCC and 21 SCC). MCM2 was expressed in basal layer of normal epidermis and upregulated in proliferative skin lesions and nonmelanoma epithelial skin cancers without significant differences between the latter groups (P > 0.05). Mean and median values of...

Nov 22, 2014 01:07AM

Capacity of Dermatologists to Diagnose Oral and Perioral Lesions Compared With Orthodontists, Primary Care Physicians, and Pediatricians

Abstract:Oral pathology is an interdisciplinary field of unclear boundaries. Only a few studies have been previously published comparing the diagnostic capacity among different specialists taking care of the disorders involving oral mucosa and perioral skin. The goal of this study was to assess the capacity for diagnosing dermatologic conditions involving the oral mucosa and perioral skin in children and adults among orthodontists, dermatologists, and primary care physicians. Samples of orthodontists (n = 118), dermatologists (n = 100), pediatricians (n = 75), and family doctors (n = 68) were selected for the study. Two tests of 30 color clinical photographs each were prepared, one containing oral lesions in children and other one in adults. Statistical and comparative analyses of correct ...

Nov 22, 2014 01:07AM

Mycosis Fungoides: An Updated Review of Clinicopathologic Variants

Abstract:Mycosis fungoides (MF) is the most common primary cutaneous T-cell lymphoma. Although it was first described in 1833, our understanding of this disease has continued to evolve. From a diagnostic perspective, the diagnosis of MF can be challenging particularly in the early stages of the disease, because of overlap between the histological features of early MF lesions and many other inflammatory dermatoses. Furthermore, there has been an emergence of numerous clinicopathologic and immunohistochemical variants of MF reported in the literature. Although the prognostic significance of some of the rare variants is still not fully understood, certain variants, such as folliculotropic and bullous MF, have demonstrated less indolent clinical courses compared with classic MF and necessitate...

Nov 21, 2014 06:32PM

?Television alopecia?: a rare cause of pressure alopecia

(Source: Journal of the European Academy of Dermatology and Venereology)

Nov 21, 2014 05:18PM

Intractable Facial Pain and Numb Chin due to Metastatic Esophageal Adenocarcinoma

The etiologies of facial pain are innumerable, thus facial pain misdiagnosis and resultant mismanagement is common. Numb chin syndrome presents with hypoesthesia and/or anesthesia in the dermatomal distribution of the inferior alveolar or the mental nerve. In this case report, we will discuss a case of intractable facial pain in a 57-year-old male with a history of esophageal adenocarcinoma who was initially misdiagnosed and treated as trigeminal neuralgia. During clinical examination, the loss of sensation in the inferior alveolar nerve distribution was identified and led to the diagnosis of mandibular metastasis. The details of the clinical presentation will be discussed in the context of accurate identification and diagnosis. Focal radiation to the metastatic location along with sphenop...

Nov 21, 2014 04:00PM

Autologous implantation of BMP2?expressing dermal fibroblasts to improve bone mineral density and architecture in rabbit long bones

This article is protected by copyright. All rights reserved (Source: Journal of Orthopaedic Research)

Nov 21, 2014 04:00PM

Identification of polycyclic aromatic hydrocarbons in soils in Taizhou, East China

Abstract Polycyclic aromatic hydrocarbons (PAHs) and their hazards in surface soil (n = 92) were investigated in Taizhou, China, which is an area in East China famous for production and exporting of rice. Total concentrations of PAHs in soils ranged from 2.3 × 101 to 7.6 × 102 with a mean of 1.8 × 102 ?g/kg (dry mass; dm). Concentrations of 16 PAHs reported here were less than those observed in most previous studies in China and other countries. Concentrations of individual PAH in fluvo-aquic soils were greater than those in paddy soils except naphthalene. Fluoranthene and pyrene were dominant PAHs, which accounted for 19.7 and 13.3 % of the total mass of PAHs, respectively. Based on ratios of low molecular weight PAHs to high molecular weight PAHs, diagnostic ra...

Nov 21, 2014 04:00PM

Development of a cumulative irritation model for incontinence-associated dermatitis

Abstract Incontinence-associated dermatitis (IAD) is a painful yet preventable form of cumulative skin irritation prevalent amongst those with limited movement. Consequently, it has a significant impact on the quality of life for those affected as well as substantial cost implications. Prevention and intervention is typically through good skin hygiene regimes and regular use of barrier products. In this paper, we describe the development of an in vivo model of IAD in healthy volunteers by occluded application of alkaline synthetic urine to the volar aspect of volunteer?s forearms for 6 h per day over a five-day period to reproduce the moist and irritant conditions causative of IAD. Irritation was assessed and quantified on a daily basis by a series of non-invasive biophysic...

Nov 21, 2014 04:00PM

Epidermal tight junction barrier function is altered by skin inflammation, but not by filaggrin-deficient stratum corneum

The tight junction (TJ) barrier is located in the granular layer of the epidermis. Filaggrin deficiency predisposes patients to atopic dermatitis (AD) by impairing stratum corneum (SC) barrier function. Altered TJ barrier function has been observed in the skin of patients with AD; however, it remains unclear whether TJ function is influenced by filaggrin deficiency directly or secondarily via skin inflammation. (Source: Journal of Dermatological Science)

Nov 21, 2014 04:00PM

Animal models of vitiligo: Matching the model to the question

Publication date: Available online 15 November 2014 Source:Dermatologica Sinica Author(s): Kingsley I. Essien , John E. Harris Vitiligo is an autoimmune disease of the skin that is characterized by patchy depigmentation (i.e., white spots) and results from the loss of melanocytes, which are pigment-producing cells. The pathogenesis of human vitiligo consists of an interaction between intrinsic melanocyte defects, environmental factors, and autoimmune mechanisms that target these cells for destruction. Human clinical and translational studies have outlined pathways that are important in human disease; however, combining human correlative studies with mechanistic studies in representative preclinical animal models is a powerful approach to study disease pathogenesis and develop new treatme...

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Nov 21, 2014 04:00PM

Portable ultraviolet light A1 light source to treat hypertrophic scar

Conclusion These results support the potential of a portable UV-A1 light device in treating hypertrophic scar. (Source: Dermatologica Sinica)

Nov 21, 2014 04:00PM

Current clinical use of depigmenting agents

Publication date: Available online 11 November 2014 Source:Dermatologica Sinica Author(s): Jung Won Shin , Kyoung Chan Park A variety of topical depigmenting agents have been used clinically, with varying degrees of success. To date, the most effective topical treatment is a triple-combination agent containing hydroquinone (HQ), tretinoin, and fluocinolone acetonide. However, its use is associated with relatively high frequencies of adverse reactions, and therefore there is a necessity to produce effective topical depigmenting agents with fewer adverse effects. Several processes can be targeted for the treatment of hyperpigmentation; specifically, regulation of melanogenesis by inhibiting tyrosinase activity, a key enzyme in melanin synthesis, represents a major therapeutic target. Anoth...

Nov 21, 2014 04:00PM

A global productivity and bibliometric analysis of telemedicine and teledermatology publication trends during 1980?2013

Conclusion Most items have been published from high-income, developed countries. Thus the physicians in undeveloped and developing countries, in which telemedicine and teledermatology applications are crucial to deliver medical care and services, should be encouraged to perform novel studies. (Source: Dermatologica Sinica)

Nov 21, 2014 04:00PM

An updated review of melasma pathogenesis

Publication date: Available online 6 November 2014 Source:Dermatologica Sinica Author(s): Ai-Young Lee Melasma is a pigmentation disorder characterized by common clinical findings. However, the pathogenic mechanisms involved are heterogeneous in different individuals and ethnic groups. We have reviewed the pathophysiological mechanisms involved in melasma. Although the pathogenesis has not entirely been elucidated thus far, new findings are being identified by research groups. Epidemiologic studies may provide clues on the involvement of genetic factor(s), UV irradiation, or hormones in melasma. Some of the mechanisms of altered skin pigmentation, such as UV-induced pigmentation, may also be applicable to the pathogenesis of melasma. In fact, an increase in similar keratinocyte-derived m...

Nov 21, 2014 04:00PM

Ascher syndrome

We report here a case of forme fruste Ascher syndrome in a 29-year-old man. (Source: Dermatologica Sinica)

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Nov 21, 2014 04:00PM

A novel MVK gene mutation in a Chinese patient with disseminated superficial actinic porokeratosis

Publication date: Available online 29 October 2014 Source:Dermatologica Sinica Author(s): Yuanyuan Xu , Xi'an Fu , Baoqi Yang , Hong Liu , Furen Zhang (Source: Dermatologica Sinica)

Nov 21, 2014 04:00PM

Photoprotection in ethnic skin

Publication date: Available online 19 October 2014 Source:Dermatologica Sinica Author(s): Mohammed S. Al-Jamal , James L. Griffith , Henry W. Lim Although cutaneous photodamage is partially mitigated by darker skin pigmentation, sun-induced aging, dyspigmentation, sunburns, and skin cancers are reported worldwide in all skin types and races. The severity of photodamage varies from individual to individual, and is predominantly based upon genetic differences altering the body's response or susceptibility to sun damage. In addition, non-Caucasian patients are less likely to perform skin self-examinations, attend dermatologic follow-ups, and seven times less likely to apply sunscreen than Caucasian patients. Therefore, the remainder of this article will discuss the categories of photoprotec...

Nov 21, 2014 04:00PM

Occurrence of eruptive granuloma annulare before leukemic transformation in a patient with myelodysplastic syndrome

Publication date: Available online 16 October 2014 Source:Dermatologica Sinica Author(s): Wan-Ting Chen , Yu-Hung Wu , Kuo-Ming Chang (Source: Dermatologica Sinica)

Nov 21, 2014 01:24PM

CHMP Backs Secukinumab, Apremilast for PsoriasisCHMP Backs Secukinumab, Apremilast for Psoriasis

The European Medicines Agency committee has recommended secukinumab and apremilast for moderate to severe plaque psoriasis and apremilast for active psoriatic arthritis. International Approvals (Source: Medscape Medical News Headlines)

Nov 21, 2014 11:59AM

Collagen filler succeeds against acne scars

SAN DIEGO ? An injectable collagen-based filler significantly outperformed saline placebo for treating acne scars, with durable effects at 12 months, according to a randomized, double-blind crossover trial of 147 adults. The study ?successfully demonstrates the effectiveness and safety of...googletag.display('div-gpt-ad-cta'); (Source: Skin and Allergy News)

Nov 21, 2014 08:12AM

VIDEO: Biomarker may reveal lymphoma risk in Sjögren?s syndrome

BOSTON ? Low expression of protein A20 in minor salivary gland tissue appears to be associated with lymphomas in patients with primary Sjögren?s syndrome. In an interview after his late-breaker presentation at the annual meeting of the American College of Rheumatology, Dr. Svein Joar A. Johnsen of...googletag.display('div-gpt-ad-cta'); (Source: Skin and Allergy News)

Nov 21, 2014 06:52AM

Insurance commissioners publish first draft of network adequacy model law

Model legislation that aims to ensure the adequacy, accessibility, and quality of health insurers? provider networks does not address a number of concerns voiced by physicians. The <a...googletag.display('div-gpt-ad-cta'); (Source: Skin and Allergy News)

Nov 21, 2014 01:34AM

Severe Primary Ocular Surface Involvement in Behcet Disease

ConclusionsOcular surface lesions should be noted as an uncommon but possible manifestation of BD. Such severe ocular surface lesions without uveitis require a thorough medical history, dermatological examination, and serological testing to arrive at a diagnosis of BD. Accordingly, routine examination of the ocular surface is recommended in patients with BD, and BD should be included in a list of differential diagnoses for patients with ocular surface lesions. (Source: Optometry and Vision Science)

Nov 20, 2014 10:00PM

Improve your skin health and avoid skin cancer naturally

(NaturalNews) For millions of people, around the world, perfect skin seems like a distant dream. The American Academy of Dermatology reveals that acne affects 40 - 50 million Americans, at a cost of over $2 billion per year. Every year, in the United States, 5 million people are treated... (Source: NaturalNews.com)

Nov 20, 2014 09:00PM

BENZEFOAM ULTRA (Benzoyl Peroxide) Aerosol, Foam [Onset Dermatologics LLC]

Updated Date: Nov 21, 2014 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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Nov 20, 2014 09:00PM

AURSTAT () Gel [Onset Dermatologics LLC]

Updated Date: Nov 21, 2014 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Nov 20, 2014 09:00PM

HYLATOPICPLUS EMOLLIENT () Aerosol, Foam [Onset Dermatologics LLC]

Updated Date: Nov 21, 2014 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Nov 20, 2014 08:12PM

Ipilimumab, not just another anti-cancer therapy: hypophysitis as side effect illustrated by four case-reports

We describe four cases of involvement of the pituitary gland during treatment with ipilimumab. When managed with vigilant monitoring and high-dose corticosteroids, the acute symptoms resolve, but lifelong hormone substitution therapy can be necessary. Involvement of the pituitary axes is a severe side effect of treatment with ipilimumab with an urgent need for the correct medical intervention. (Source: Endocrine)

Nov 20, 2014 07:30PM

A Case of Dermatomyositis with Esophageal Fistula in Whom Blind Mucosal Biopsy Detected Occult Oropharyngeal Carcinoma

We present a case of anti-transcription intermediary factor 1 (anti-TIF-1) antibody-positive dermatomyositis with concomitant esophageal fistula and extensive truncal erythema. The characteristic cutaneous features and presence of anti-TIF-1 antibodies were predictive for internal malignancy. However, repeated examinations for internal malignancy showed none, and blind mucosal biopsy was needed to diagnose oropharyngeal carcinoma. We should note the possibility of occult nasopharyngeal carcinoma and consider performing blind mucosal biopsy in dermatomyositis with esophageal fistula, especially with extensive truncal erythema.Case Rep Dermatol 2014;6:268-273 (Source: Case Reports in Dermatology)

Nov 20, 2014 07:28PM

Multiple pigmented clear cell acanthoma in an African patient

(Source: Journal of the European Academy of Dermatology and Venereology)

Nov 20, 2014 07:27PM

Viruses and Pemphigus: An Intriguing Never-Ending Story

Virus infections and autoimmunity have long been linked. As to pemphigus, many studies have been directed to prove or rule out the possibility of viral induction. Herpesviruses have often been related to the onset or reactivation of pemphigus. The association may be (i) casual, (ii) due to the iatrogenic immunosuppression facilitating opportunistic viral infections or (iii) based on a pathogenic link between the viral presence and the host's dysregulated immune response leading to autoimmunity. Japanese researchers, using real-time polymerase chain reaction, lately detected herpes simplex virus DNA in the saliva from pemphigus patients at the earliest stage of the disease and with no signs or history of herpetic infection, thus confirming the possible existence of cases of pemphigus induce...

Nov 20, 2014 07:27PM

ILDS Newsletter No. 32

Dermatology 2014;229:275-278 (Source: Dermatology)

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Nov 20, 2014 07:27PM

Ten Years On: The Impact of Biologics on the Practice of Dermatology

This review delivers a commentary on the first decade of biologics? use in psoriasis and provides a glimpse of the pipeline of therapies currently in development for psoriasis that will enhance the therapeutic armamentarium available to the dermatologist. In addition, the authors revisit the rationale for the development of biological therapies, inventory the available therapies of today, and retrospectively assess their impact on the dermatology practice as it relates to the management of patients with psoriasis. (Source: Dermatologic Clinics)

Nov 20, 2014 07:27PM

Psoriatic Arthritis for the Dermatologist

Psoriatic arthritis (PsA) is a chronic, progressive, inflammatory spondyloarthropathy that affects approximately one-third of patients with all types of psoriasis. Dermatologists are in a unique position to recognize early symptoms of PsA, initiate appropriate therapy, and prevent development of further disability. The course of PsA can be modulated by immunosuppressive therapy; patients with moderate-to-severe disease require aggressive management with medications proven to halt disease progression. It is essential for the dermatologist to understand the safety, tolerability, efficacy, cost, and potential to halt disease progression with available medications for this relatively common and potentially disabling disease. (Source: Dermatologic Clinics)

Nov 20, 2014 07:27PM

Pharmacogenomics and the Resulting Impact on Psoriasis Therapies

Psoriasis is a model disease for the development of pharmacogenomic markers of treatment response, with ready access to diseased tissue and objective validated outcome measures. With the application of state-of-the-art technologies and investment in careful experimental design, the goal of stratified medicine in psoriasis may be possible. Current pharmacogenomic studies in psoriasis show excellence in many areas, including the investigation of a broad range of psoriasis therapies. To facilitate the advent of stratified medicine in psoriasis, uniformity of study design is required, with high quality, consistent phenotyping strategies for participants; definitions of outcome; and the publication of reproducible methodologies. (Source: Dermatologic Clinics)

Nov 20, 2014 07:27PM

Psoriasis: The Future

The umbrella term psoriasis is now understood to incorporate several distinct phenotypes or endotypes along the disease spectrum that in turn will dictate different therapies. A stratified medicine approach to psoriasis using this clinical information coupled with pharmacogenomic and immunologic data will become more widely acceptable in the future. Comorbidities associated with psoriasis, such as diabetes, depression, and Crohn disease, and the debate about the interdependence of psoriasis and cardiovascular disease will also dictate future research and holistic and management plans for this complex disease. (Source: Dermatologic Clinics)

Nov 20, 2014 07:27PM

Index

Note: Page numbers of article titles are in boldface type. Acitretin (Source: Dermatologic Clinics)

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Nov 20, 2014 07:27PM

Assessing Psoriasis Severity and Outcomes for Clinical Trials and Routine Clinical Practice

Psoriasis is a complex disease. Dermatologists have not documented psoriasis severity, except in clinical trials; doing so requires tools for assessing psoriasis and an understanding of what changes in those assessments mean in terms of outcome. Two psoriasis assessment tools have dominated: The Psoriasis Area and Severity Index and the Dermatology Life Quality Index. There are advantages and disadvantages to each. Newer instruments may not be more suitable for documenting psoriasis. There may be benefits in terms of patient ownership of disease management from using self-assessment tools for documenting severity, for example, the Self-assessment version of the Simplified Psoriasis Index. (Source: Dermatologic Clinics)

Nov 20, 2014 07:27PM

An Update on Topical Therapies for Mild-Moderate Psoriasis

Topical therapies are the mainstream treatment of psoriasis because most patients have mild disease. First-line treatments are vitamin D derivatives and corticosteroids. These treatments are usually given in combination schedules. For topical treatments the selection of the most appropriate vehicle is of major importance, thus improving adherence to the treatment, which frequently is impaired by the complexities of topical therapeutic choices. Evidence for efficacy and safety of topical treatments is readily available for vitamin D treatments and short-term treatment with corticosteroids. However, the scientific evidence for longer-term treatments is limited. Multiple new small molecules are in various stages of development and are reviewed. (Source: Dermatologic Clinics)

Nov 20, 2014 07:27PM

Phototherapy and Photochemotherapy for Psoriasis

Phototherapy is a first-line option for the treatment of moderate to severe psoriasis. Systematic reviews indicate near comparable efficacy of the different forms of phototherapy. Localized phototherapy can be an adjunctive treatment of recalcitrant plaques during systemic treatment of psoriasis. More than 200 psoralen?UV-A therapy treatment sessions is associated with an increased risk of keratinocytic cancers, whereas no increased risk has been demonstrated for narrow-band UV-B therapy. The mechanism of action of phototherapy in psoriasis is via inhibition of keratinocyte proliferation; induction of apoptosis in keratinocytes, dendritic, and T cells; and inhibition of Th1 and Th17 pathways, but activation of Th2. (Source: Dermatologic Clinics)

Nov 20, 2014 07:27PM

Current and Future Oral Systemic Therapies for Psoriasis

For patients with moderate to severe psoriasis, there is a large range of variably effective and safe oral, systemic medications. With appropriate monitoring, these therapies may be used as either monotherapy or in combination with other therapies. Newer drugs in the research pipeline hold significant promise. (Source: Dermatologic Clinics)

Nov 20, 2014 07:27PM

Genetics of Psoriasis

This article focuses on the results of genetic association studies, which provide evidence that psoriasis susceptibility genes are involved in innate and adaptive immunity and skin barrier functions. The potential for disease stratification and the development of more effective treatments with fewer side effects using genetic data are highlighted. (Source: Dermatologic Clinics)

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Nov 20, 2014 07:27PM

The Immunopathogenesis of Psoriasis

Psoriasis vulgaris is a chronic inflammatory skin disease that results from the complex interplay between keratinocytes, dendritic cells, and T cells. Keratinocytes trigger innate and adaptive immune responses. Dermal myeloid dendritic cells regulate T cell activation and production of cytokines and chemokines that amplify inflammation. Most of the psoriatic T cells discretely produce interferon-?, interleukin (IL)-17, and IL-22. The initiation phase of psoriasis involves Toll-like receptors, antimicrobial peptide LL37, and plasmacytoid dendritic cells. Keratinocytes are the main cutaneous cell type expressing IL-17 receptors and hence the immune circuit is amplified by keratinocytes upregulating mRNAs for a range of inflammatory products. (Source: Dermatologic Clinics)

Nov 20, 2014 07:27PM

Psoriasis and the Life Cycle of Persistent Life Effects

Psoriasis is associated with significant physical, social, and behavioral comorbidities that create a substantial burden. We outline herein that these comorbidities start early in life and persist for decades, ultimately impacting the entire life course of patients with psoriasis. By highlighting the ages that psoriasis patients are affected with physical, social, behavioral and emotional comorbidities, we demonstrate the age-appropriate considerations for psoriasis patients. (Source: Dermatologic Clinics)

Nov 20, 2014 07:27PM

Psoriasis Is a Systemic Disease with Multiple Cardiovascular and Metabolic Comorbidities

This article summarizes the current literature on cardiovascular and metabolic comorbidities in psoriasis, identifies research gaps, and suggests management strategies to reduce cardiovascular risk in patients with moderate to severe psoriasis. (Source: Dermatologic Clinics)

Nov 20, 2014 07:27PM

Contributors

BRUCE H. THIERS, MD Professor and Chairman, Department of Dermatology and Dermatologic Surgery, Medical University of South Carolina, Charleston, South Carolina (Source: Dermatologic Clinics)

Nov 20, 2014 07:27PM

Contents

M. Alan Menter and Christopher E. M. Griffiths Satveer K. Mahil, Francesca Capon, and Jonathan N. Barker (Source: Dermatologic Clinics)

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Nov 20, 2014 07:27PM

Forthcoming Issues

Nail Disorders: Practical Tips for Diagnosis and Treatment Antonella Tosti, Editor (Source: Dermatologic Clinics)

Nov 20, 2014 07:27PM

The International Psoriasis Council: Advancing Knowledge, Enhancing Care

Founded in 2004, the International Psoriasis Council (IPC) is a dermatology-led, voluntary, global nonprofit organization dedicated to innovation across the full spectrum of psoriasis through research, education, and patient care. The IPC?s mission is to empower our network of global key opinion leaders to advance knowledge about psoriasis and its associated comorbidities, thereby enhancing the care of patients worldwide. The IPC provides a forum for education, collaboration, and innovation among physicians, researchers, and other professionals working on the physical, economic, and social aspects of psoriasis and its associated comorbidities (www.psoriasiscouncil.org). (Source: Dermatologic Clinics)

Nov 20, 2014 06:13PM

Standard Drugs Alter Gene Expression in PsA

(MedPage Today) -- Cellular housekeeping and immune pathways the most commonly affected. (Source: MedPage Today Dermatology)

Nov 20, 2014 04:10PM

The Evolving Spectrum of Polymyositis and Dermatomyositis?Moving Towards Clinicoserological Syndromes: A Critical Review

Abstract The idiopathic inflammatory myopathies: polymyositis (PM) and dermatomyositis (DM) have been historically defined by broad clinical and pathological criteria. These conditions affect both adults and children with clinical features including muscle weakness, skin disease and internal organ involvement. Over the last few years, it has become increasingly apparent that using a clinico-serological approach, both DM and PM can be defined into more homogeneous subsets. A large number of antibodies are directed against cytoplasmic or nuclear components involved in key regulatory intra-cellular processes including protein synthesis, translocation and gene transcription within this disease spectrum. In addition, these autoantibodies are found in patients with clinical features ot...

Nov 20, 2014 04:10PM

Immunoglobulin E-Binding Epitopes of Mite Allergens: From Characterization to Immunotherapy

Abstract House dust mites and storage mites produce a number of allergens that can induce hypersensitivity reactions in humans and result in allergic diseases like asthma, rhinitis, and dermatitis. Recent advances in identifying and characterizing these allergens?and, in particular, their immunoglobulin E (IgE)-binding epitopes?have produced a wealth of knowledge. Here, methods for identifying IgE-binding epitopes, from immunoassays to in silico approaches, are summarized and placed in context with the identification of epitopes of mite allergens, particularly from the Dermatophagoides spp. major allergen groups 1 and 2. Finally, the transfer of this information to the clinical development and application of new diagnostic and immunotherapeutic approaches is discussed. While ...

Nov 20, 2014 04:00PM

Association of FCER1A genetic polymorphisms with risk for chronic spontaneous urticaria and efficacy of nonsedating H1-antihistamines in Chinese patients

Abstract Antihistamines are the first-line treatment for chronic urticaria (CU). However, some CU patients are relatively refractory to antihistamines. The mechanism underlying the interindividual variation is still unknown. The ?-chain of the high-affinity IgE receptor is crucial to the IgE-mediated allergic response. The present study is to investigate whether FCER1A polymorphisms are associated with the risk of CSU, and to determine whether these polymorphisms influence the therapeutic efficacy of nonsedating H1-antihistamines. 191 CSU patients treated by nonsedating H1-antihistamines monotherapy (including desloratadine, mizolastine or fexofenadine) were prospectively enrolled in this study. The response to antihistamines monotherapy was assessed by urticaria activity score (...

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Nov 20, 2014 04:00PM

[Special Issue Review] Mammalian skin cell biology: At the interface between laboratory and clinic

Mammalian skin research represents the convergence of three complementary disciplines: cell biology, mouse genetics, and dermatology. The skin provides a paradigm for current research in cell adhesion, inflammation, and tissue stem cells. Here, I discuss recent insights into the cell biology of skin. Single-cell analysis has revealed that human epidermal stem cells are heterogeneous and differentiate in response to multiple extrinsic signals. Live-cell imaging, optogenetics, and cell ablation experiments show skin cells to be remarkably dynamic. High-throughput, genome-wide approaches have yielded unprecedented insights into the circuitry that controls epidermal stem cell fate. Last, integrative biological analysis of human skin disorders has revealed unexpected functions for elements of t...

Nov 20, 2014 04:00PM

Tofacitinib withdrawal and re?treatment in moderate?to?severe chronic plaque psoriasis: a randomised controlled trial

ConclusionsContinuously treated patients maintained responses better than placebo recipients. Safety profiles were comparable among continuous and re?treatment groups. Among relapsers, up to 60% recaptured response with tofacitinib.This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)

Nov 20, 2014 04:00PM

A pilot trial of mobile, patient?performed teledermoscopy

ConclusionsSSE plus mobile teledermoscopy is promising for surveillance of particular lesions even without provision of detailed SSE instructions, but in the format tested in this study, consumers may overlook lesions and send many non?pigmented lesions. This investigation demonstrates that high quality dermoscopic images can be taken by patients at home and for those sent, telediagnosis is highly accurate.This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)

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Nov 20, 2014 04:00PM

Differential expression and functionality of ATP binding cassette transporters in the human hair follicle

This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)

Nov 20, 2014 04:00PM

Epithelioid cell histiocytoma of the skin with clonal ALK gene rearrangement resulting in VCL?ALK and SQSTM1?ALK gene fusions

This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)

Nov 20, 2014 04:00PM

Comparing cold?air analgesia, systemically administered analgesia, and scalp nerve blocks for pain management during photodynamic therapy of actinic keratosis of the scalp presenting as field cancerization: a randomized controlled trial

ConclusionsScalp nerve blocks provide an effective method for pain relief during PDT for patients with extensive AK.This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)

Nov 20, 2014 04:00PM

Reflectance Confocal Microscopy correlates of dermoscopic patterns of facial lesions helps to discriminate lentigo maligna from pigmented non?melanocytic macules

ConclusionsRCM is useful for identifying the histologic substrate of dermoscopic features in pigmented lesions of the face, helping in a better definition of the lesion areas for an adequate diagnostic approach.This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)

Nov 20, 2014 04:00PM

Cutaneous adverse events in patients treated with BRAF inhibitor?based therapies for metastatic melanoma for longer than 52 weeks

ConclusionsPatients on BRAF inhibitor?based therapies need to continue to have regular dermatological follow?up independent of the duration of their therapy. (Source: British Journal of Dermatology)

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Nov 20, 2014 04:00PM

Clinical epidemiology of hand eczema in patients accessing dermatological reference centres: results from Italy

ConclusionsChronic hand eczema is frequent among patients with hand eczema accessing dermatology centres. Many patients were severe and refractory to standard therapy. The appropriate identification of hand eczema is the first step in implementing effective and efficient treatments. (Source: British Journal of Dermatology)

Nov 20, 2014 04:00PM

Shared medical appointments for the preoperative consultation visit of Mohs micrographic surgery

Shared medical appointments (SMAs) allow patients with similar diagnoses to be simultaneously educated and cared for by 1 provider. SMAs appear well suited for Mohs micrographic surgery because all patients receive similar information about skin cancer pathophysiology, prognosis, prevention, treatment, reconstructive options, and wound care. (Source: Journal of the American Academy of Dermatology)

Nov 20, 2014 04:00PM

First experience with therapy of severe forms of psoriasis with biosimilar infliximab

(Source: Journal of the European Academy of Dermatology and Venereology)

Nov 20, 2014 04:00PM

A case of chronic radiodermatitis after transjugular intrahepatic portosystemic shunt

(Source: Journal of the European Academy of Dermatology and Venereology)

Nov 20, 2014 04:00PM

Laser therapy for the treatment of Hailey?Hailey disease: a systematic review with focus on carbon dioxide laser resurfacing

Abstract Benign familial chronic pemphigus, or Hailey?Hailey disease (HHD), is a recurrent bullous dermatitis that tends to have a chronic course with frequent relapses. Long?term treatment options include surgery with skin grafting or dermabrasion. Both are highly invasive and carry significant risks and complications. More recently, ?laser?abrasion? has been described as a less invasive option with a better side?effect profile. In this article, we systematically review the safety and efficacy of carbon dioxide laser therapy as a long?term treatment option for HHD, as well as provide a review of other lasers that have been reported with this goal. A total of 23 patients who had been treated with a carbon dioxide laser were identified. After treatment, 10 patients (43%) had h...

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Nov 20, 2014 04:00PM

Risk of non?alcoholic fatty liver disease in patients with psoriasis: a systematic review and meta?analysis

ConclusionCase?control studies support an association between psoriasis and NAFLD. Screening of NAFLD in this group of patients may be warranted. (Source: Journal of the European Academy of Dermatology and Venereology)

Nov 20, 2014 04:00PM

The prevalence of culture?confirmed toenail onychomycosis in at?risk patient populations

Abstract Onychomycosis is a fungal infection of the nail and is the most common nail affliction in the general population. Certain patient populations are at greater risk of infection and the prevalence of onychomycosis reported in the literature has yet to be summarized across these at?risk groups. We performed a systematic review of the literature and calculated pooled prevalence estimates of onychomycosis in at?risk patient populations. The prevalence of dermatophyte toenail onychomycosis was as follows: general population 3.22% (3.07, 3.38), children 0.14% (0.11, 0.18), the elderly 10.28% (8.63, 12.18), diabetic patients 8.75% (7.48, 10.21), psoriatic patients 10.22% (8.61, 12.09), HIV positive patients 10.40% (8.02, 13.38), dialysis patients 11.93% (7.11, 19.35) and renal transpla...

Nov 20, 2014 04:00PM

Inadvertent pregnancy during ustekinumab therapy in a patient with plaque psoriasis and impetigo herpetiformis

(Source: Journal of the European Academy of Dermatology and Venereology)

Nov 20, 2014 04:00PM

Pre?surgical basal cell carcinoma margin definition: the SMART approach

(Source: Journal of the European Academy of Dermatology and Venereology)

Nov 20, 2014 04:00PM

Hemolytic activity of dermatophytes species isolated from clinical specimens

In this study, 66 dermatophytes strains were isolated from clinical specimens and were identified by six different species: 43 (65.1%) Trichophyton rubrum, 7 (10.7%) Trichophyton mentagrophytes, 5 (7.6%) Microsporum canis, 5 (7.6%) Trichophyton tonsurans, 4 (6.0%) Epidermophyton floccosum and 2 (3.0%) Trichophyton violaceum. Twenty-one T. rubrum strains showed incomplete (alpha) hemolysis and nine T. rubrum strains showed complete (beta) hemolysis, whereas hemolysis was absent in 13 T. rubrum strains. Four T. mentagrophytes strains showed complete hemolysis and three T. tonsurans strains showed incomplete hemolysis. However, M. canis, E. floccosum and T. violaceum species had no hemolytic activity. Hemolytic activity is pronounced in dermatophytes and may play an important role a...

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Nov 20, 2014 04:00PM

The anti-dermatophyte activity of Allium hirtifolium Boiss aqueous extract

Publication date: Available online 20 November 2014 Source:Journal de Mycologie Médicale / Journal of Medical Mycology Author(s): M. Mahboubi , N. Kazempour In an attempt at demonstrating the efficacy of Allium hirtifolium aqueous extract in control of skin fungal infections as traditional use, we evaluated the anti-dermatophyte activities of A. hirtifolium aqueous extract from bulbs and of ketoconazole against Trichophyton rubrum, Trichophyton mentagrophytes, Microsporum canis, M. gypseum, Trichophyton schoenleinii and Trichophyton verrucosum var. album by food poisoning technique, disc diffusion and micro broth dilution assays. The anti-fungal activity of A. hirtifolium was excellent when it was compared with ketoconazole. The anti-fungal evaluation by food poisoning method showed...

Nov 20, 2014 04:00PM

Les onychomycoses à moisissures

Publication date: Available online 20 November 2014 Source:Journal de Mycologie Médicale / Journal of Medical Mycology Author(s): D. Chabasse , M. Pihet Les onychomycoses représentent environ 30 % des mycoses superficielles rencontrées en consultation de dermatologie, et près de 50 % des étiologies d?onychopathies. Les champignons en cause sont essentiellement les dermatophytes, habituellement rencontrés au niveau des ongles des pieds, suivis par les levures qui prédominent au niveau des mains. Beaucoup plus rarement, des moisissures peuvent être impliquées. Ces dernières ne représenteraient que 2 à 17 % des étiologies d?onychomycoses. Il convient, dans cette dernière catégorie, de distinguer les onychomycoses à pseudodermatophytes dues aux Neoscytalidium (ex-Scyta...

Nov 20, 2014 04:00PM

Traitement des onychomycoses

Publication date: Available online 20 November 2014 Source:Journal de Mycologie Médicale / Journal of Medical Mycology Author(s): M. Feuilhade de Chauvin Le traitement d?une onychomycose ne se discute qu?après confirmation par un examen mycologique. Les onychomycoses à dermatophytes les plus fréquentes relèvent d?une contagion, compliquant une dermatophytose cutanée du pied ou de la main. L?onychomycose à Candida, plus rares, est une pathologie opportuniste, et l?onychomycose à moisissure un « accident de parcours ». Le traitement d?une onychomycose à dermatophyte prend en compte les différentes parties infectées de l?appareil unguéal. Un traitement topique en monothérapie est réservé aux atteintes mineures ou modérées. Pour les atteintes sévères, un ...

Nov 20, 2014 04:00PM

Regeneron and Sanofi?s dupilumab gets FDA breakthrough therapy status for atopic dermatitis

Regeneron Pharmaceuticals and Sanofi's dupilumab has received breakthrough therapy designation from US Food and Drug Administration (FDA) to treat adults with moderate-to-severe atopic dermatitis (AD). (Source: Pharmaceutical Technology)

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Nov 20, 2014 04:00PM

Cytokine profiles in polymyositis and dermatomyositis complicated by rapidly progressive or chronic interstitial lung disease

Conclusion. IL-6, IL-8, TNF-α and IP-10 are associated with global disease activity in PM/DM. These cytokine levels were high, especially in the ILD subset. Serum IL-8 levels and the balance between IL-4 and IFN- may contribute to the differences in pathophysiology between anti-ARS-ILD and anti-MDA5-ILD. (Source: Rheumatology)

Nov 20, 2014 04:00PM

Calcinosis in juvenile dermatomyositis is influenced by both anti-NXP2 autoantibody status and age at disease onset

Conclusion. Children diagnosed at a young age have a high risk of calcinosis regardless of autoantibody status. However, the presence of anti-NXP2 autoantibodies substantially increases the risk of calcinosis across all ages and is associated with disease severity. (Source: Rheumatology)

Nov 20, 2014 04:00PM

In active juvenile dermatomyositis, elevated eotaxin and MCP-1 and cholesterol levels in the upper normal range are associated with cardiac dysfunction

Conclusion. In the active disease state of JDM, eotaxin and MCP-1 were associated with cardiac dysfunction, possibly through sustained inflammation. In those with active disease and cholesterol levels in the upper normal range, eotaxin and MCP-1 might enhance susceptibility to cardiac dysfunction. (Source: Rheumatology)

Nov 20, 2014 12:30PM

Eczema May Hike Lupus Risk in Kids

(MedPage Today) -- SLE incidence rate tied to severity of atopic dermatitis. (Source: MedPage Today Dermatology)

Nov 20, 2014 11:24AM

ACR: PsA Another Win for Secukinumab

(MedPage Today) -- The anti-IL-17A monoclonal antibody shines in psoriatic arthritis. (Source: MedPage Today Dermatology)

Nov 20, 2014 11:24AM

PsA Another Win for Secukinumab

(MedPage Today) -- The anti-IL-17A monoclonal antibody shines in psoriatic arthritis. (Source: MedPage Today Dermatology)