Dr. William Ting, Board-Certified Dermatologist
at California Dermatology Care

2262 Camino Ramon, San Ramon, CA 94583
Tel: 925-328-0255
Email: staff@CalDermCare.com


Advanced Care with a Personal Touch

   

 

 

Medical Dermatology    Evidence-based medicine   Customized solution   Personal care

Latest Dermatology Headlines

Dr. William Ting has expertise in treating the entire spectrum of medical dermatology, with emphasis in preventive medicine and personalized recommendations. He enjoys taking care of patients with acne, eczema, hair and nail disorders, rashes, psoriasis and skin cancers.

He is at the forefront of medical dermatology and dermatologic research. He continues to publish articles in peer-reviewed dermatology journals. He is an early pioneer of photodynamic therapy (PDT) and one of the most experienced practitioners of PDT in the Bay Area. He is the first dermatologist in the San Francisco Bay Area and Northern California to introduce Lutronic Spectra Laser for melasma, acne, scar revision, pore size reduction as well as the Cutera GenesisPlus laser for advanced nail fungus laser treatment, keloid and hypertrophic scar, warts and scar revision.

Dr. Ting is a fellow of the American Academy of Dermatology (AAD) and American Society of Dermatologic Surgery (ASDS). He is a member of the National Psoriasis Foundation and International Hyperhidrosis Society.

Innovative Therapeutic Approach to Common Skin Conditions

Acne

Eczema (Atopic Dermatitis)

Hair and Nail disorders

  • Maximize therapeutic synergy and efficacy by utilizing both prescription-strength and over-the counter products when available
  • Comprehensive workup including bloodwork and biopsy if necessary
  • Systemic oral hormonal therapy for women and men when indicated

Psoriasis 

Rosacea

  • Multi-prong approach to minimize redness
  • Low-dose 'non-antibiotic' anti-inflammatory oral medication for long-term remission 
  • Emphasis on prevention
  • Fotofacial/IPL laser utilizing Cynosure XPL/Elite MPX
  • Cutera GenesisPlus Laser with or without combination with IPL 
  • Diode laser for facial veins
  • VBeam Pulse Dye Laser, the new gold standard for rosacea and facial redness

Skin Cancer 

  • Emphasis on prophylactic treatments with topical 5-FU, imiquimod, diclofenac, ingenol mebutate and oral chemopreventive therapy such as Soriatane.
  • Reduce future risks of skin cancer with photodynamic therapy, TCA chemical peels and/or fractional CO2 resurfacing laser  
  • Mohs Surgery to achieve highest cure rate and tissue sparing
  • Close colloboration with plastic surgeon(s) as needed  

Sweating Disorder (Hyperhidrosis) 

Vitiligo

Warts 


ABCD of Mole Check

 

 

Common Medical Dermatology Diagnostics and Therapeutics:

Dermatology Links:

American Academy of Dermatology
American Society of Dermatologic Surgery
American Society of Mohs Surgery
International Hyperhidrosis Society
National Psoriasis Foundation

 Latest Dermatology Headlines:

Latest Dermatology Headlines
Wed, 25 Mar 2015 04:11:10 +0100

http://www.medworm.com/rss/index.php/Dermatology/12/

Mar 24, 2015 08:09PM

Phenotypical characterization of circulating cell subsets in pyoderma gangrenosum patients: the experience of the Italian immuno?pathology group

ConclusionsThe pattern of chemokine expression argues in favour of a Th1 (CCR5+) and Th17 (CCR6+) polarization with a down?regulation of Th2 (CCR4+). (Source: Journal of the European Academy of Dermatology and Venereology)

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Mar 24, 2015 08:06PM

A review of herbal medicines in wound healing

Abstract Herbs have been integral to both traditional and non?traditional forms of medicine dating back at least 5000 years. The enduring popularity of herbal medicines may be explained by the perception that herbs cause minimal unwanted side effects. More recently, scientists increasingly rely on modern scientific methods and evidence?based medicine to prove efficacy of herbal medicines and focus on better understanding of mechanisms of their action. However, information concerning quantitative human health benefits of herbal medicines is still rare or dispersed, limiting their proper valuation. Preparations from traditional medicinal plants are often used for wound healing purposes covering a broad area of different skin?related diseases. Herbal medicines in wound management invol...

Mar 24, 2015 06:35PM

Psoriasis and Tonsillectomy: A Real Head Scratcher

(MedPage Today) -- Skin disease often improves after surgery but no one knows why. (Source: MedPage Today Dermatology)

Mar 24, 2015 04:00PM

Evaluating the Cosmetic Patient: Understanding which Patients Benefit from Minimally Invasive Procedures versus Those that Require Surgery or Lifting Procedures

Abstract Cosmetic consultations are rising steadily, and the armamentarium available to the treating physician varies widely from minimally invasive procedures to invasive surgery. Due to the diverse age ranges and varied aesthetic presentations of patients, no single approach is possible or suited for everyone. When choosing a particular procedure, a number of factors are taken into consideration such as the age of the patient, expectations, degree and duration of the expected outcome, cost, and overall experience of the treating physician. In this article, the face and neck areas have been divided into three zones and the discussion focuses on the treatment options available, highlighting in particular the scenarios in which surgical intervention is recommended versus non-invasi...

Mar 24, 2015 12:21PM

Memphis cosmetics company scores $1.5 million in funding

Memphis-based Innova was a key investor in a new round of funding for Memphis-based Silicone Arts Laboratories. Silicone Arts has completed a Series A Round of funding totaling $1.5 million. In addition to Innova, Dallas-based GPG Ventures was involved in the investment. The company manufactures Dermaflage, a cosmetic synthetic skin that includes a topical filler to conceal scars and wrinkles. Silicone Arts will use the funding to grow its direct to consumer site with the use of videos from real? (Source: bizjournals.com Health Care:Biotechnology headlines)

Mar 24, 2015 09:25AM

New bill consolidates SGR fix, CHIP reauthorization

Bipartisan lawmakers have introduced a bill that would repeal the Medicare Sustainable Growth Rate (SGR) formula, this time with language that would reauthorize the Children?s Health Insurance Program (CHIP) for 2 years. Leaders on the House Energy and Commerce and House Ways and Means committees... (Source: Skin and Allergy News)

Mar 24, 2015 07:55AM

Complex ventral hernia repair with a human acellular dermal matrix

Conclusions Hernia recurrences are not uncommon following complex abdominal wall reconstruction. Improved outcomes are seen when a TS-HADM is utilized as reinforcement to primary fascial closure. (Source: Hernia)

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Mar 24, 2015 07:55AM

Outcome in porcine acellular dermal matrix reinforcement of infected abdominal wall defects: a prospective study

Conclusions The utility of biologic prostheses to repair infected abdominal wall defects is controversial; however, currently, they remain the only alternative to a two-staged surgery. Prospective, randomized studies in larger populations of patients are necessary to fully determine the usefulness of biologic prostheses in this setting. (Source: Hernia)

Mar 24, 2015 07:00AM

Fat-Lysing Agent Makes Double Chin Disappear

(MedPage Today) -- Consistent results seen with injection of synthetic deoxycholic acid compound. (Source: MedPage Today Dermatology)

Mar 24, 2015 03:42AM

Ultrasonographic wrist and hand abnormalities in early psoriatic arthritis patients: correlation with clinical, dermatological, serological and genetic indices.

CONCLUSIONS: US abnormalities of hand and wrist were independent of clinical ePsA indices (except erosions), while they correlated to dermatological (except PASI), serological and genetic parameters of disease. PMID: 25797649 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)

Mar 24, 2015 03:42AM

Prospective evaluation of frequency of signs of systemic sclerosis in 76 patients with morphea.

CONCLUSIONS: Signs indicative of SSc are statistically not more frequently present in patients with morphoea than in controls and this study does not support the view that those 2 entities are part of a common disease spectrum. PMID: 25797524 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)

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Mar 24, 2015 01:53AM

Pediatric Atopic Dermatitis: Pimecrolimus Safe, EffectivePediatric Atopic Dermatitis: Pimecrolimus Safe, Effective

Pimecrolimus is a safe and effective alternative to topical corticosteroids for infants and young children with mild to moderate atopic dermatitis. Medscape Medical News (Source: Medscape Medical News Headlines)

Mar 24, 2015 12:18AM

Antiviral Promising in Early HPV TrialAntiviral Promising in Early HPV Trial

The experimental drug ranpirnase has the potential to be the first antiviral treatment for human papillomavirus (HPV). Medscape Medical News (Source: Medscape Infectious Diseases Headlines)

Mar 24, 2015 12:09AM

Clinical Aspects of Syphilis Reinfection in HIV-Infected Patients

Conclusions: We observed a high rate of reinfection, but with less severe skin manifestations during reinfection episodes.Dermatology (Source: Dermatology)

Mar 23, 2015 10:17PM

American Academy of Dermatology (AAD) 73rd Annual MeetingAmerican Academy of Dermatology (AAD) 73rd Annual Meeting

Read clinically focused news coverage of key developments from AAD 2015. Medscape Dermatology (Source: Medscape Dermatology Headlines)

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Mar 23, 2015 07:19PM

Effectiveness of erbium:YAG laser and cryosurgery in seborrheic keratoses: Randomized, prospective intraindividual comparison study

Journal of Dermatological Treatment, Ahead of Print. (Source: Journal of Dermatological Treatment)

Mar 23, 2015 06:35PM

Acne Improves Without Use of Antibiotics

(MedPage Today) -- Topical adapalene/benzoyl peroxide reduced lesion counts up to 75%. (Source: MedPage Today Dermatology)

Mar 23, 2015 04:00PM

Influence of the complex of retinol?vitamin C on skin surface lipids

ConclusionRetinol peel treatments can help to increase the amount of skin surface lipids in women during menopause. (Source: Journal of Cosmetic Dermatology)

Mar 23, 2015 04:00PM

Advancing Survivors’ Knowledge (ASK) about skin cancer study: study protocol for a randomized controlled trial

DiscussionThe current study addresses barriers to screening in this population by providing educational and motivational information for both survivors and physicians regarding the value of periodic skin examinations. It also utilizes innovative mobile health technology to encourage and motivate (that is activate) survivors to conduct skin self-examinations, request physician exams, and obtain treatment when worrisome lesions are found. Finally, as a comparative effectiveness trial, this study isolates the effects of adding specific components to the patient activation intervention to test the most effective intervention for enhancing skin examination vigilance among this high-risk group.Trial registrationClinicaltrials.gov: NCT02046811; Registration date: 22 January 2014. (Source: Trials)

Mar 23, 2015 04:00PM

Prototheca zopfii Genotype 2-induced Nasal Dermatitis in a Cat

This report describes Prototheca zopfii genotype 2-induced inflammation of the nasal skin and cutaneous mucosa of the right nostril in a 14-year-old neutered female domestic shorthair cat. Microscopical examination revealed marked pyogranulomatous inflammation with numerous intralesional algae. These had a round to ovoid shape, were 8?21 ?m in diameter, formed endospores and displayed a positive immunoreaction for Prototheca zopfii antigen. By 18S rRNA gene amplification and sequencing the intralesional algae were confirmed as Prototheca zopfii and further characterized as Prototheca zopfii genotype 2. This case report reveals Prototheca zopfii as an additional Prototheca species associated with feline protothecosis. (Source: Journal of Comparative Pathology)

Mar 23, 2015 04:00PM

The Androgenic Alopecia Protective Effects of Forsythiaside?A and the Molecular Regulation in a Mouse Model

This study examined the inhibitory effect of forsythiaside?A, a natural substance derived from Forsythia suspensa (F. suspensa), on entry into catagen induced by dihydrotestosterone (DHT) in an androgenic alopecia mouse model. In vitro experiment comparing finasteride with forsythiaside?A showed that forsythiaside?A treatment resulted in a 30% greater inhibition of DHT?induced apoptosis in human hair dermal papilla cell (HHDPCs) and human keratinocytes (HaCaTs). In vivo experiment showed that mouse hair density and thickness were increased by 50% and 30%, respectively, in the forsythiaside?A?treated group when compared to a DHT group. Tissue histological results revealed that the forsythiaside?A?treated group had an increase in size and shape of the hair follicles and a 1.5...

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Mar 23, 2015 04:00PM

A Randomized 'N-of-1' Single Blinded Clinical Trial of Barbed Dermal Sutures vs. Smooth Sutures in Elective Plastic Surgery shows differences in scar appearance two-years post-operatively

Barbed sutures have unidirectional circumferential shallow barbs, which distribute tension throughout the wound and close wound securely without the need to tie knots. Objectives. We compare two different methods of wound closure in elective plastic surgical cases: barbed 3/0 V-Loc?180 suture and smooth 3/0 Maxon? sutures, both polyglyconate monofilament synthetic absorbable sutures. We assessed the aesthetic long-term results with a minimum two year follow up. Methods. This is a prospective, randomized controlled study with internal control. (Source: Journal of Plastic, Reconstructive and Aesthetic Surgery)

Mar 23, 2015 04:00PM

Long?term remission of primary cutaneous neutrophil?rich CD30+ anaplastic large cell lymphoma treated with topical imiquimod. A case report

(Source: Journal of the European Academy of Dermatology and Venereology)

Mar 23, 2015 04:00PM

Familial hypochondroplasia and acanthosis nigricans with FGFR3 K650T mutation

(Source: Journal of the European Academy of Dermatology and Venereology)

Mar 23, 2015 04:00PM

Familial cutaneous leiomyomatosis in multiple generations with varied morphological presentations

(Source: Journal of the European Academy of Dermatology and Venereology)

Mar 23, 2015 11:49AM

VIDEO: Ask vitiligo patients about autoimmune symptoms

SAN FRANCISCO ? Thyroid disease is known to be more common in patients with vitiligo, but that?s just the tip of the iceberg. In a review of 1,098 patients, researchers at Henry Ford Hospital in Detroit found... (Source: Skin and Allergy News)

Mar 23, 2015 11:27AM

HIV levels fell in HSV-2?seronegative patients taking valacyclovir

HIV levels declined in patients who did not have herpes but took the antiherpes drug valacylovir in a double-blind placebo-controlled crossover trial. The study showed that the drug ?likely reduced HIV levels by interfering directly with HIV?s reproductive machinery and did not require the... (Source: Skin and Allergy News)

Mar 23, 2015 10:37AM

Sun Exposure in Adulthood Can Be RiskySun Exposure in Adulthood Can Be Risky

Too much exposure to the sun as an adult might cause more skin cancer than exposure during childhood, a new study that contradicts conventional thinking has found. Medscape Medical News (Source: Medscape Medical News Headlines)

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Mar 23, 2015 09:43AM

Value-based payment: Time to start getting ready

WASHINGTON? Are physicians ready for the shift toward value-based compensation? A report from the American Medical Association and the RAND Corporation aims to get physicians thinking about what investments they should expect to... (Source: Skin and Allergy News)

Mar 23, 2015 09:15AM

Intravenous human immunoglobulin for treatment of folliculitis decalvans

Journal of Dermatological Treatment, Ahead of Print. (Source: Journal of Dermatological Treatment)

Mar 23, 2015 04:18AM

Does Teno Torque Virus Induce Autoimmunity After Hematopoietic Stem Cell Transplantation? A Case Report

We report here a case of an 11-month-old infant affected by acute myeloid leukemia who underwent hematopoietic stem cell transplantation, and after 6 months had autoimmune hepatitis and atopic dermatitis. Extremely high-cytokine IP-10 and eotaxin levels were found in her sera, and serological tests and RT-PCR for viruses showed positive results exclusively for Teno Torque virus. (Source: Journal of Pediatric Hematology Oncology)

Mar 23, 2015 02:41AM

HPyV6, HPyV7 and TSPyV DNA sequences detection in skin disease patients and healthy subjects

ConclusionOur preliminary data suggest that these three novel human polyomaviruses seem not to play a significant role neither in the pathogenesis of cutaneous malignancies nor in that of inflammatory disorders but, according to literature, can inhabit the skin. On the basis of our data regarding the HPyV6 DNA presence with decreasing percentages in healthy subjects, skin cancer and inflammatory disorders patients, it could be an intriguing matter to study if the activated innate immune response in inflammatory disorders can suppress the virus. Further investigations are needed to better understand their relationship with the human host and its innate immune system. (Source: Journal of the European Academy of Dermatology and Venereology)

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Mar 23, 2015 02:35AM

Helicobacter pylori infection in psoriasis: results of a clinical study and review of the literature

ConclusionsPatients with mild to severe psoriasis do not show a greater prevalence of H. pylori infection; however, H. pylori seems able to affect the clinical severity of psoriasis. (Source: International Journal of Dermatology)

Mar 22, 2015 11:53PM

The natural product transforming the lives of cancer patients after surgery

A pioineering treatment helped cellist Caroline Brown to treat a rare form of cancer, and she aims to be playing again soon, says Cherril Hicks (Source: Telegraph Health)

Mar 22, 2015 11:00PM

Many Acne Patients Don't Take Their Meds, Survey Shows

Title: Many Acne Patients Don't Take Their Meds, Survey ShowsCategory: Health NewsCreated: 3/20/2015 12:00:00 AMLast Editorial Review: 3/23/2015 12:00:00 AM (Source: MedicineNet Skin General)

Mar 22, 2015 09:00PM

KC OTO-PACK (Hydrocortisone, Ketoconazole) Gel [DermaZoo, LLC]

Updated Date: Mar 23, 2015 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Mar 22, 2015 08:01PM

Pimecrolimus cream safe, effective for atopic dermatitis in young children

Using pimecrolimus cream as a first-line treatment for atopic dermatitis in infants spares the need for topical corticosteroids as frequently and appears safe over the long term, according to a study published online March 23 in Pediatrics. ?The efficacy results suggest that pimecrolimus has... (Source: Skin and Allergy News)

Mar 22, 2015 07:38PM

Acute pancreatitis as initial presentation of cocaine-induced vasculitis: a case report.

CONCLUSION: Internists should recognize that acute pancreatitis can present as an atypical and rare initial systemic manifestation of cocaine-induced vasculitis. PMID: 25791555 [PubMed - in process] (Source: JOP)

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Mar 22, 2015 06:35PM

IL-17 Inhibitor Clears Psoriasis More Often

(MedPage Today) -- Brodalumab twice as likely to clear all lesions as ustekinumab. (Source: MedPage Today Dermatology)

Mar 22, 2015 04:20PM

Genotoxicity Assessment of Reactive and Disperse Textile Dyes Using Human Dermal Equivalent (3D Cell Culture System)

(Source: Journal of Toxicology and Environmental Health Part A)

Mar 22, 2015 04:00PM

Evaluation of autoimmune thyroid disease in melasma

This study suggests that there is a relationship between thyroid autoimmunity and melasma. However, to make recommendations on screening for thyroid disease in patients with melasma, future research of good methodological quality is needed. (Source: Journal of Cosmetic Dermatology)

Mar 22, 2015 04:00PM

Efficacy and tolerance assessment of a new type of dermocosmetic in infants and children with moderate atopic dermatitis

ConclusionThe new emollient dermocosmetic SBT complex applied adjunctively or alternately with topical AD treatments significantly improved AD without any safety concerns. SBT complex may play an important role in the restoration of the natural skin barrier. (Source: Journal of Cosmetic Dermatology)

Mar 22, 2015 04:00PM

A mild case of hyaline fibromatosis syndrome, presenting in an adult

(Source: Journal of the European Academy of Dermatology and Venereology)

Mar 22, 2015 04:00PM

Conventional vs. daylight methyl aminolevulinate photodynamic therapy for actinic keratosis of the face and scalp: an intra?patient, prospective, comparison study in Italy

ConclusionMAL DL?PDT showed similar efficacy to c?PDT in the treatment of AK I of the face/scalp but was less effective than c?PDT for AKs II and III. DL?PDT was better tolerated being associated with lower pain and occurrence of fewer adverse events. Clinical response to DL?PDT was significantly moderated by outdoor temperature, increasing at higher temperatures. (Source: Journal of the European Academy of Dermatology and Venereology)

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Mar 22, 2015 04:00PM

Anatomic relationship of the proximal nail matrix to the extensor hallucis longus tendon insertion

ConclusionsWe have found that the extensor tendon is between the matrix and the phalanx and extends dorsally to the distal aspect of the distal phalanx. The nail matrix of the great toe is not attached to the periosteum of the dorsal aspect of the base of distal phalanx as is the case in fingers, because the extensor hallucis tendon is plantar or directly underneath the nail matrix and the tendon is dorsal to the bone. Our anatomic study demonstrates that the proximal limit of the matrix and nail bed of the human great toe are dorsal and overlapping the terminal extensor hallucis longus tendon until its distal bony insertion in all specimens. (Source: Journal of the European Academy of Dermatology and Venereology)

Mar 22, 2015 04:00PM

Genital melanocytic naevus on lichen sclerosus: an uncommon occurrence and a management proposal

ConclusionsThe evaluation of genital naevi should take into account the presence of inflammatory disorders, not uncommon in such location. Treatment of the latter and short follow?up of the patients, can avoid over?diagnosis of malignancies and extensive surgical procedures. (Source: Journal of the European Academy of Dermatology and Venereology)

Mar 22, 2015 04:00PM

Stage?specific direct health care costs in patients with cutaneous malignant melanoma

ConclusionsThe direct health care costs for CMM patients were significantly higher than in the general population independent of clinical stage. CMM patients diagnosed in clinical stage III?IV were associated with particularly high costs and the health care system may save resources by finding CMM patients in earlier stages. (Source: Journal of the European Academy of Dermatology and Venereology)

Mar 22, 2015 04:00PM

Antiviral gene expression in psoriasis

ConclusionOur findings highlight psoriasis as an inflammatory disease with cutaneous but not systemic immune activation against viral pathogens. (Source: Journal of the European Academy of Dermatology and Venereology)

Mar 22, 2015 04:00PM

Homocysteine plasma levels in psoriasis patients: our experience and review of the literature

ConclusionOur results confirm that psoriasis patients with more severe disease, can have hyperhomocysteinaemia, without regard to disease duration or joint involvement. Hyperhomocysteinaemia is not influenced by a target therapy for psoriasis and it is as greater as psoriasis severity. However, limitation of our study is the relatively small number of cases. Homocysteine plasmatic levels should be advisable as a further independent risk factor for cardiovascular disease in psoriasis patients. (Source: Journal of the European Academy of Dermatology and Venereology)

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Mar 22, 2015 04:00PM

Forthcoming Events

(Source: Journal of the European Academy of Dermatology and Venereology)

Mar 22, 2015 04:00PM

Announcement

(Source: Journal of the European Academy of Dermatology and Venereology)

Mar 22, 2015 04:00PM

Multiplex cytokine analysis of dermal interstitial blister fluid defines local disease mechanisms in systemic sclerosis

Conclusions: Our data confirm that an immuno-inflammatory environment and aberrant vascular repair are intimately linked to fibroblast activation in lesional skin in SSc. This non-invasive method could be used to profile disease activity in the clinic, and identifies key inflammatory or pro-fibrotic proteins that might be targeted therapeutically. Distinct subgroups of SSc may be defined that show innate or adaptive immune cytokine signatures. (Source: BioMed Central)

Mar 22, 2015 04:00PM

Corrigendum

Clark-Greuel, J .N., Helmes, C. T., Lawrence, A., Odio, M., and White, J. C. Setting the record straight on diaper rash and disposable diapers. Clin Pediatr. 2014; 53(9S): 23S-26S. Original DOI: 10.1177/0009922814540380 In this article, published in the August 2014 supplement issue, Figures 1, 2, 5, and 6 are missing the copyright attribution. The copyright information should be as listed below: Used with permission of the American Academy of Pediatrics, Pediatric Dermatology: A Quick Reference Guide, 2nd Edition, Copyright © 2011 American Academy of Pediatrics. (Source: Clinical Pediatrics)

Mar 22, 2015 04:00PM

Young Women Taking Spironolactone for Acne Don't Have Increased Rate of Hyperkalemia (FREE)

By Kelly Young Edited by Susan Sadoughi, MD, and André Sofair, MD, MPH Regular potassium monitoring may not be required in young women prescribed spironolactone for acne, according to a study in JAMA Dermatology that was presented at the ? (Source: Physician's First Watch current issue)

Mar 22, 2015 04:00PM

Metals in cosmetics: implications for human health

Abstract Cosmetics, preparations repeatedly applied directly to the human skin, mucous membranes, hair and nails, should be safe for health, however, recently there has been increasing concern about their safety. Unfortunately, using these products in some cases is related to the occurrence of unfavourable effects resulting from intentional or the accidental presence of chemical substances, including toxic metals. Heavy metals such as lead, mercury, cadmium, arsenic and nickel, as well as aluminium, classified as a light metal, are detected in various types of cosmetics (colour cosmetics, face and body care products, hair cosmetics, herbal cosmetics, etc.). In addition, necessary, but harmful when they occur in excessive amounts, elements such as copper, iron, chromium and cobalt are also ...

Mar 22, 2015 04:00PM

CCR8 regulates contact hypersensitivity by restricting cutaneous dendritic cell migration to the draining lymph nodes

In this study, we found that Ccr8 –/– mice developed severer contact hypersensitivity (CHS) responses to 2,4-dinitrofluorobenzene, a murine model of ACD, compared with wild-type mice. T cells from Ccr8 –/– mice showed enhanced proliferative recall responses and Th1 and Th17 cell populations were expanded in these mice. However, CHS responses were similar between SCID mice adoptively transferred with Ccr8 –/– and wild-type T cells, suggesting that CCR8 in T cells is not responsible for the exacerbation of CHS. Notably, skin-resident dendritic cells (DCs), such as Langerhans cells and dermal DCs, and inflammatory DCs were highly accumulated in lymph nodes (LNs) of Ccr8 –/– mice after sensitization. Consistent with this, Ccr8 –/– ant...

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Mar 22, 2015 04:00PM

Update on ultraviolet A and B radiation generated by the sun and artificial lamps and their effects on skin

Synopsis Solar radiation, especially ultraviolet A (UVA) and ultraviolet B (UVB), can cause damage to the human body, and exposure to the radiation may vary according to the geographical location, time of year and other factors. The effects of UVA and UVB radiation on organisms range from erythema formation, through tanning and reduced synthesis of macromolecules such as collagen and elastin, to carcinogenic DNA mutations. Some studies suggest that, in addition to the radiation emitted by the sun, artificial sources of radiation, such as commercial lamps, can also generate small amounts of UVA and UVB radiation. Depending on the source intensity and on the distance from the source, this radiation can be harmful to photosensitive individuals. In healthy subjects, the evidence on the danger ...

Mar 22, 2015 04:00PM

A case?control study of MC1R variants in Greek patients with basal cell carcinoma: Increased risk independently of pigmentary characteristics

This article is protected by copyright. All rights reserved. (Source: Experimental Dermatology)

Mar 22, 2015 04:00PM

Androgens, hair loss and eugenics: a tale of discovery and American social history

This article is protected by copyright. All rights reserved. (Source: Experimental Dermatology)

Mar 22, 2015 04:00PM

Ablation of human skin mast cells in situ by lysosomotropic agents

This article is protected by copyright. All rights reserved. (Source: Experimental Dermatology)

Mar 22, 2015 04:00PM

Mapping the expression of epithelial hair follicle stem and progenitor cell?related transcription factors LHX2 and SOX9 in the human hair follicle

This article is protected by copyright. All rights reserved. (Source: Experimental Dermatology)

Mar 22, 2015 04:00PM

Senescent dermal fibroblasts enhance stem cell migration through CCL2/CCR2 axis

This article is protected by copyright. All rights reserved. (Source: Experimental Dermatology)

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Mar 22, 2015 04:00PM

Anti?angiogenic activity of thienopyridine derivative LCB03?0110 by targeting VEGFR?2 and JAK/STAT3 Signaling

This article is protected by copyright. All rights reserved. (Source: Experimental Dermatology)

Mar 22, 2015 04:00PM

Xenobiotic Metabolizing Enzymes in Human Skin and SkinEthic Reconstructed Human Skin Models

This article is protected by copyright. All rights reserved. (Source: Experimental Dermatology)

Mar 22, 2015 04:00PM

Inhibition of Retinoic Acid Catabolism by Minocycline: Evidence for a Novel Mode of Action?

This article is protected by copyright. All rights reserved. (Source: Experimental Dermatology)

Mar 22, 2015 04:00PM

Erythematotelangiectatic Rosacea and Telangiectatic Photoaging Same, Separate, and/or Sequential?

In 1994, I described rosacea as a cutaneous and ocular vascular disease, which was based on premises the most compelling of which was that patients with severe flushing due to systemic disease often had rapidly progressive rosacea, including ocular rosacea, facial telangiectasia, and phymatous changes. The earliest stages of rosacea were proposed to have an inflamed superficial vasculature and low-grade sterile superficial dermal cellulitis due to recognized provocative factors, such as local irritants, temperature extremes, wind, and flushing reactions. Subsequently, I have sought articles adding molecular details to my mental picture of this vascular pathogenesis of rosacea, and the evidentiary harvest has been abundant. (Source: JAMA Dermatology)

Mar 22, 2015 04:00PM

Clinical, Histologic, and Molecular Analysis of Differences Between Erythematotelangiectatic Rosacea and Telangiectatic Photoaging

ImportanceFacial erythema and telangiectasia are commonly associated with the erythematotelangiectatic subtype of rosacea (ETR). It is important for clinicians to recognize that these findings can also be associated with a subtype of photoaging, which we term telangiectatic photoaging (TP).ObjectiveTo demonstrate that ETR and TP are distinct dermatologic disorders.DesignA case-control observational study comparing clinical, histologic, and gene expression features of 26 participants with ETR, 20 with TP, and 11 age- and sex-matched controls in the Program for Clinical Research in Dermatology at University of Michigan.Main Outcomes and MeasuresFindings of clinical history and examination, light and electron microscopy, immunohistochemical analyses, and real-time quantitative reverse-transcr...

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Mar 22, 2015 02:50PM

Methotrexate and biologics linked to higher zoster risk in psoriasis

The combination of methotrexate and biologics for the treatment of psoriasis may increase the risk of herpes zoster infection, according to a large, database cohort study published in JAMA Dermatology. Analysis of medical records for 95,941 patients with psoriasis showed treatment with both... (Source: Skin and Allergy News)

Mar 22, 2015 12:00PM

No increased rate of hyperkalemia in healthy women taking spironolactone for acne

Young women taking spironolactone for hormonally mediated acne do not need to be monitored for hyperkalemia, say the authors of a study that showed no significant increase in the risk of the condition. The retrospective study in 974 otherwise healthy women taking spironolactone found the rate of... (Source: Skin and Allergy News)

Mar 22, 2015 11:56AM

Exfoliative toxin A staphylococcal scalded skin syndrome in preterm infants

Conclusion: The presence of anti-ETA antibodies below a particular cutoff level might be associated with SSSS onset in preterm infants. (Source: European Journal of Pediatrics)

Mar 22, 2015 11:24AM

Dupilumab improves moderate to severe atopic dermatitis in adults

SAN FRANCISCO? Dupilumab met its safety endpoints and significantly outperformed placebo for adults with moderate to severe atopic dermatitis, according to final results of a multicenter, international phase IIb study. At all five doses tested, the biologic significantly improved atopic dermatitis... (Source: Skin and Allergy News)

Mar 22, 2015 11:19AM

VIDEO: Finesse is key to avoiding exfoliation mistakes

SAN FRANCISCO ? Sometimes, salicylic acid is the right call for exfoliation, but sometimes not. Other times microdermabrasion or glycolic acid make sense, or maybe mandelic acid, or something else entirely. In other words, dermatologists have a lot of options for exfoliation, including not to do... (Source: Skin and Allergy News)

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Mar 22, 2015 08:14AM

Ultrasound might improve type 1 rosacea

SAN FRANCISCO ? Micro-focused ultrasound therapy led to measurable improvements in erythematotelangiectatic (type 1) rosacea, and patients reported no serious adverse effects, according to interim results from a small, multicenter, single-blinded randomized study. Thus far, two high-density... (Source: Skin and Allergy News)

Mar 22, 2015 08:08AM

Boron-based cream shows promise for pediatric atopic dermatitis

SAN FRANCISCO? An investigational topical ointment met its safety endpoints and showed signs of efficacy in children and adolescents with mild to moderate atopic dermatitis, according to a small phase II study. Four weeks of twice-daily treatment with the AN2728 agent yielded an average 78%... (Source: Skin and Allergy News)

Mar 22, 2015 06:02AM

VIDEO: Ask gay and bisexual men about tanning bed use

SAN FRANCISCO ? Gay and bisexual men are about six times more likely to use tanning beds than straight men, and have about twice the risk of skin cancer, according to a review of California Health Interview... (Source: Skin and Allergy News)

Mar 22, 2015 04:24AM

VIDEO: Once-yearly skin cancer screening might not be enough after organ transplants

SAN FRANCISCO ? Older white men are most at risk to die from skin cancer after organ transplants, especially if they?ve had a heart or lung transplant, according to a review of more than a half million U.S. organ transplants from 1987-2013. It?s long been known that skin cancer is far more likely... (Source: Skin and Allergy News)

Mar 21, 2015 04:00PM

Breed, gender and age pattern of diagnosis for veterinary care in insured dogs in Japan during fiscal year 2010

Publication date: 1 April 2015 Source:Preventive Veterinary Medicine, Volume 119, Issues 1?2 Author(s): Mai Inoue , A. Hasegawa , Y. Hosoi , K. Sugiura We calculated the annual prevalence of diseases of 18 diagnostic categories in the insured dog population in Japan, using data from 299,555 dogs insured between April 2010 and March 2011. The prevalence was highest for dermatological disorders (22.6% for females and 23.3% for males), followed by otic diseases (16.4% for females and 17.2% for males) and digestive system disorders (15.7% for females and 16.4% for males). The prevalence of cardiovascular, urinary, neoplasia and endocrine disorders, increased with age; infectious diseases and injuries showed a high prevalence at young ages, and the prevalence of musculoskeletal and respirat...

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Mar 21, 2015 04:00PM

Liver injury in patients with DRESS: A clinical study of 72 cases

Drug reaction with eosinophilia and systemic symptoms (DRESS) is a syndrome involving multiple systems. Liver injury is the most common visceral manifestation. (Source: Journal of the American Academy of Dermatology)

Mar 21, 2015 04:00PM

Foraminal decompression of acute calcified disc herniation in an adult

A 50 year old female reported 3 months of thoraco-lumbar back pain with had acutely worsened over the last two weeks and radiated into the left thigh. She was otherwise fit and well with no co-morbidities. Neurologically she demonstrated reduced sensation in the left L1 dermatome. Plain radiographs (Fig. 1) and CT imaging (Fig.2) demonstrated calcific deposits within the T11/12 and T12/L1 disc spaces, and left T12/L1 intervertebral foramen. (Source: The Spine Journal)

Mar 21, 2015 04:00PM

Identification and molecular characterization of Orf virus in Argentina

In this study, we described the sequencing and analysis of five ORFV molecular markers: a partial B2L gene (ORF011), VIR (ORF020), an envelope mature protein (ORF109), vIL10 (ORF127), and GIF (ORF117) from two particular Argentinian outbreaks of CE. (Source: Virus Genes)

Mar 21, 2015 04:00PM

A simple surgical treatment for bovine digital dermatitis-associated white line lesions and sole ulcers

Publication date: Available online 20 March 2015 Source:The Veterinary Journal Author(s): J. Kofler , J. Glonegger-Reichert , J. Dietrich , S. Sykora , A. Tichy , S. Brandt Non-healing white line disease (nhWLD) and sole ulcers (nhSU) are seen increasingly in herds endemically affected with bovine digital dermatitis (BDD). In 35 cows with 42 nhWLD or nhSU lesions, the healing process was monitored for up to 28 or 38 days following extensive debridement of loose horn and infected corium under regional anaesthesia, and topical application of tetracycline spray with bandaging. By 28 days, 27/42 (64%) nhWLD and nhSU were completely covered by a new horn layer and this increased to 30/42 (71%) that had healed by 38 days. Lesion sizes on day 0 correlated with clinical healing within the study ...

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Mar 21, 2015 04:00PM

Psoriasis and obesity in French children: a case?control, multicentre study

ConclusionsThis study shows that being overweight with abdominal obesity and being obese is more common in children with psoriasis than in controls. The risk factors are the same as those that affect the French general population, i.e. female sex and having a parent who was overweight. The severity and clinical type of psoriasis do not affect overweight and obesity. (Source: British Journal of Dermatology)

Mar 21, 2015 04:00PM

Real?time supervised detection of pink areas in dermoscopic images of melanoma: importance of color shades, texture and location

ConclusionTexture, color, and lesion location analysis applied to multiple shades of pink can assist in melanoma detection. When any of these three details: color location, shade analysis, or texture analysis were omitted from the model, accuracy in separating melanoma from benign lesions was lowered. Separation of colors into shades and further details that enhance the characterization of these color shades are needed for optimal discrimination of melanoma from benign lesions. (Source: Skin Research and Technology)

Mar 21, 2015 04:00PM

Brain discriminative cognition on the perception of touching different fabric using fingers Actively

ConclusionIt is suggested that the functional regions involved in the macrogeometric properties of fabric (such as pliability) is in SI, and the perception of microgeometry of fabric surface (such as roughness and glutinousness) in SII, especially in the sub?region OP1 of the OP. Besides, activation in motor cortex can be a reference for the characterization of the brain cognition on the tactile stimulation of fabric. (Source: Skin Research and Technology)

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Mar 21, 2015 04:00PM

K + larity for Spironolactone At Last!

Spironolactone was approved by the US Food and Drug Administration (FDA) 30 years ago for several noncutaneous conditions, such as congestive heart failure. It acts as an aldosterone antagonist and thereby promotes diuresis, reduces blood pressure, and retains potassium. Aside from these mechanisms of action, spironolactone also exerts several antiandrogenic effects in the skin. Spironolactone decreases sebum production by competing with both dihydrotestosterone (DHT) and testosterone for the androgen receptors and also halts the conversion of testosterone to the more potent sebum producer DHT. In addition, spironolactone decreases type 2 17?-hydroxysteroid dehydrogenase and thereby inhibits androgen synthesis. These antiandrogenic actions make spironolactone well suited to treat androgen...

Mar 21, 2015 04:00PM

Low Usefulness of Potassium Monitoring Among Healthy Young Women Taking Spironolactone for Acne

Conclusions and RelevanceThe rate of hyperkalemia in healthy young women taking spironolactone for acne is equivalent to the baseline rate of hyperkalemia in this population. Routine potassium monitoring is unnecessary for healthy women taking spironolactone for acne. (Source: JAMA Dermatology)

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Mar 21, 2015 10:27AM

Contact allergen of 2015: Formaldehyde

SAN FRANCISCO ? Formaldehyde has been named the American Contact Dermatitis Society Contact Allergen of the Year for 2015, Dr. David E. Cohen said in the hot topics session at the annual meeting of the American Academy of Dermatology. Formaldehyde has been a factor in contact dermatitis for a... (Source: Skin and Allergy News)

Mar 21, 2015 06:48AM

Secukinumab beat ustekinumab for psoriasis, with difference by week four

SAN FRANCISCO? Secukinumab met its primary endpoint in a head-to-head trial, achieving 21% more PASI 90 responses than ustekinumab in patients with moderate to severe plaque psoriasis, according to interim, week 16 results from the phase IIIb CLEAR trial. Patients? responses to the two biologic... (Source: Skin and Allergy News)

Mar 21, 2015 06:46AM

Brodalumab achieved primary endpoints for moderate to severe psoriasis at 52 weeks

SAN FRANCISCO? Significantly more psoriasis patients who received the investigational biologic agent brodalumab achieved a PASI 100 response compared with those who received ustekinumab, and clinical responses persisted through 52 weeks, according to data from the pivotal phase III AMAGINE-2... (Source: Skin and Allergy News)

Mar 20, 2015 10:10PM

Dermatopathologists' opinions about the quality of clinical information in the skin biopsy requisition form and the skin biopsy care process: a semiqualitative assessment.

CONCLUSIONS: Dermatopathologists communicated that missing clinical information in the RF and inadequate specimens are common and adversely affect the quality of care. Multiple provider- and practice-related factors contribute to communication failures and deserve further investigation. PMID: 25780013 [PubMed - in process] (Source: American Journal of Clinical Pathology)

Mar 20, 2015 08:43PM

The development and validation of a disease-specific quality of life measure in hyperhidrosis: the Hyperhidrosis Quality of Life Index (HidroQOL©)

Conclusion This study has provided the initial evidence supporting measurement properties and the use of the HidroQoL instrument in both routine clinical practice and in research, for assessing quality of life impacts in hyperhidrosis. (Source: Quality of Life Research)

Mar 20, 2015 04:22PM

Erratum

No abstract available (Source: The American Journal of Dermatopathology)

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Mar 20, 2015 04:22PM

A Unique Case of a Cutaneous Lesion Resembling Mammary Analog Secretory Carcinoma: A Case Report and Review of the Literature

Abstract: Mammary analog secretory carcinoma (MASC) is a rare type of salivary gland tumor named for its morphological and genetic similarity to secretory carcinoma of the breast. These tumors are most often found in the parotid gland but have been described in several other mucosal locations of the head and neck. In this case report, a cutaneous lesion most closely resembling MASC was found in a neck mass of a 64-year-old male patient without evidence of a primary salivary gland or oral tumor. The lesion was excised, and the patient remains disease free to date. This case depicts a rare tumor in the skin most closely mimicking MASC and brings additional awareness to dermatopathologists of this tumor. (Source: The American Journal of Dermatopathology)

Mar 20, 2015 04:22PM

Steroid-Responsive Atypical Marginal Zone Hyperplasia of the Lip in a Child

Abstract: Atypical marginal zone hyperplasia (AMZH) is a recently described disease entity seen mainly in children. AMZH most commonly affects tonsils and appendices. Cutaneous AMZH is rare. The authors report here a recurrent AMZH in the lip of a 9-year-old child who presented originally with a lip swelling for approximately 3 months. The lip lesion recurred after each incomplete excision for 4 times. Pathologically, the lesion demonstrated marginal zone B-cell hyperplasia with kappa monoclonality by flow cytometry and immunohistochemistry studies. Lymphoepithelial lesions were noted with involvement of minor salivary glands. Polymerase chain reaction for immunoglobulin heavy-chain gene rearrangement has been repeatedly negative. Polymerase chain reaction for Borrelia species DNA was nega...

Mar 20, 2015 04:22PM

Multiple Localized Epidermolytic Acanthomas of the Vulva Associated With Vulvar Pruritus: A Case Report

We describe the case of multiple localized EAs occurring on the vulva of a 31-year-old woman presenting with the chief complaint of vulvar pruritus. Although rare to occur in the vulvar area, EAs should be included in the differential diagnosis of multiple vulvar papules. (Source: The American Journal of Dermatopathology)

Mar 20, 2015 04:22PM

Primary Cutaneous Malignant Granular Cell Tumor: An Immunohistochemical Study and Review of the Literature

We report the immunophenotype of this primary cutaneous MGCT, which was studied with an ample panel of antibodies and compare our results with those of the few previously reported cases in the skin and subcutaneous soft tissues. (Source: The American Journal of Dermatopathology)

Mar 20, 2015 04:22PM

Enlarging Ulcers in the Mouth and on the Back

No abstract available (Source: The American Journal of Dermatopathology)

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