Dr. William Ting, Board-Certified Dermatologist
at California Dermatology Care

2262 Camino Ramon, San Ramon, CA 94583
Tel: 925-328-0255
Email: staff@CalDermCare.com


Advanced Care with a Personal Touch

   

 

 

Medical Dermatology    Evidence-based medicine   Customized solution   Personal care

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MEDICAL DERMATOLOGY

Acne and Acne Scar

Excimer Laser for Psoriasis & Vitiligo

Keloid & Hypertrophic Scar Laser Therapy

Mohs Surgery for Skin Cancers

Nail Fungus GenesisPlus Laser Therapy

Photodynamic Therapy

Psoriasis & NBUVB Phototherapy

RadioTherapy Nonsurgical SRT-100 for Skin Cancer

Skin Allergy Patch Test

Sweating Disorder MiraDry for Hyperhidrosis

Wart Laser Therapy


COSMETIC DERMATOLOGY

Aesthetician Services
Microdermabrasion
 

Botox, Dysport & Xeomin

Cellulaze Cellulite Therapy

new! CoolSculpting

Facial Redness/Vein Laser Therapy

Fillers injection for Wrinkles

Fractional CO2 laser

new! Hair Transplant with Neograft

Laser Surgery Services
Acne/Pore reducing Laser
Collagen Stimulating Laser
Excimer Laser
Facial Veins laser
Hair Laser Removal
IPL Fotofacial
Melasma Laser
Nail Fungus Laser
Resurfacing Laser
Scar revision Laser
Tattoo Removal Lasers
VBeam Pulse Dye Laser
Wart Laser


Latisse

Leg Vein Laser Therapy & Asclera Sclerotherapy

Liposonix + Vaser Shape Nonsurgical Body Sculpting
 

Melasma and Pigmentation

Pore Size Reduction and Laser Rejuvenation

Sculptra Liquid Facelift

SideLaze Lift

Ulthera natural lift & skin tightening of face and neck


Related Websites
FaceUpLifting.com
iCellulaze.com
MoreHair4Me.com
SideLazeLift.com
SonixLipo.com


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Dr. William Ting has expertise in treating the entire spectrum of medical dermatology, with emphasis in preventive medicine and personalized recommendations. He enjoys taking care of patients with acne, eczema, hair and nail disorders, rashes, psoriasis and skin cancers.

He is at the forefront of medical dermatology and dermatologic research. He continues to publish articles in peer-reviewed dermatology journals. He is an early pioneer of photodynamic therapy (PDT) and one of the most experienced practitioners of PDT in the Bay Area. He is the first dermatologist in the San Francisco Bay Area and Northern California to introduce Lutronic Spectra Laser for melasma, acne, scar revision, pore size reduction as well as the Cutera GenesisPlus laser for advanced nail fungus laser treatment, keloid and hypertrophic scar, warts and scar revision.

Dr. Ting is a fellow of the American Academy of Dermatology (AAD) and American Society of Dermatologic Surgery (ASDS). He is a member of the National Psoriasis Foundation and International Hyperhidrosis Society.

Innovative Therapeutic Approach to Common Skin Conditions

Acne

Eczema (Atopic Dermatitis)

Hair and Nail disorders

  • Maximize therapeutic synergy and efficacy by utilizing both prescription-strength and over-the counter products when available
  • Comprehensive workup including bloodwork and biopsy if necessary
  • Systemic oral hormonal therapy for women and men when indicated

Psoriasis 

Rosacea

  • Multi-prong approach to minimize redness
  • Low-dose 'non-antibiotic' anti-inflammatory oral medication for long-term remission 
  • Emphasis on prevention
  • Fotofacial/IPL laser utilizing Cynosure XPL/Elite MPX
  • Cutera GenesisPlus Laser with or without combination with IPL 
  • Diode laser for facial veins
  • VBeam Pulse Dye Laser, the new gold standard for rosacea and facial redness

Skin Cancer 

  • Emphasis on prophylactic treatments with topical 5-FU, imiquimod, diclofenac, ingenol mebutate and oral chemopreventive therapy such as Soriatane.
  • Reduce future risks of skin cancer with photodynamic therapy, TCA chemical peels and/or fractional CO2 resurfacing laser  
  • Mohs Surgery to achieve highest cure rate and tissue sparing
  • Close colloboration with plastic surgeon(s) as needed  

Sweating Disorder (Hyperhidrosis) 

Vitiligo

Warts 


ABCD of Mole Check

 

 

Common Medical Dermatology Diagnostics and Therapeutics:

Dermatology Links:

American Academy of Dermatology
American Society of Dermatologic Surgery
American Society of Mohs Surgery
International Hyperhidrosis Society
National Psoriasis Foundation

 Latest Dermatology Headlines:

Latest Dermatology Headlines
Tue, 30 Sep 2014 13:32:34 +0100

http://www.medworm.com/rss/index.php/Dermatology/12/

Sep 30, 2014 05:32AM

Evidence-Based Treatment for Melasma: Expert Opinion and a Review

Conclusion The key therapy recommended is fluorinated steroid containing 2?4% HQ-based triple combination for first line, with additional selective peels if required in second line. Lasers are a last resort. (Source: Dermatology and Therapy)

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Sep 30, 2014 05:31AM

Body mass index is negatively associated with acne lesion counts in Taiwanese women with post?adolescent acne

ConclusionInitial findings indicate that BMI is negatively associated with the number of acne lesions in Taiwanese women with moderate to severe post?adolescent acne. (Source: Journal of the European Academy of Dermatology and Venereology)

Sep 30, 2014 05:28AM

In Situ Assessment Of Pi3k And Pten Alterations In Mycosis Fungoides: Correlation With Clinicopathological Features

This article is protected by copyright. All rights reserved. (Source: Experimental Dermatology)

Sep 30, 2014 05:27AM

Melasma treatment using an erbium:YAG laser: a clinical, immunohistochemical, and ultrastructural study

ConclusionsErbium:YAG laser resurfacing effectively improves melasma; however, the almost universal appearance of transient postinflammatory hyperpigmentation necessitates prompt and persistent intervention. (Source: International Journal of Dermatology)

Sep 30, 2014 04:10AM

Radiotherapy for Dermatofibrosarcoma Protuberans

Conclusions:RT may improve local control and reduce the risk of recurrence postoperatively in patients with DFSP. (Source: American Journal of Clinical Oncology - Current Table Of Contents)

Sep 30, 2014 03:44AM

Common Dermatologic Manifestations of Primary Immune Deficiencies

Abstract The skin is the largest organ of our body; it consists of the epidermis, dermis, hair follicles, sweat glands, blood vessels, and connective tissue matrix. Its main function is to act as a barrier to the outside world and protect us from infections. Any component of the skin is subject to insults from the environment and/or from within the body. Primary immune deficiency patients present with recurrent or prolonged infections not frequently seen in healthy individuals. Oftentimes, these infections involve the skin. Primary immune deficiency may also present with noninfectious cutaneous signs, such as eczema; erythroderma; granulomas; dysplasia of the skin, hair, nails, or teeth; pigmentary changes; angioedema; urticaria; vasculitis; or autoimmune skin disease due to immu...

Sep 29, 2014 04:00PM

Tomotherapy concomitant with cetuximab, followed by cetuximab as single-agent therapy for unresectable squamous cell carcinoma of the skin: a case report

Conclusion: The treatment was effective and feasible. Considering these excellent results, further studies about concomitant tomotherapy with Cetuximab for advanced/inoperable SCC of the skin are needed. (Source: BMC Dermatology)

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Sep 29, 2014 04:00PM

Single?nucleotide polymorphisms in pigment genes and nonmelanoma skin cancer predisposition: a systematic review

Summary Nonmelanoma skin cancer (NMSC) is the most common cancer in the U.S.A. The two most common NMSCs are basal cell carcinoma and squamous cell carcinoma. The associations of single?nucleotide polymorphisms (SNPs) in pigmentation pathway genes with NMSC are not well characterized. There is a series of epidemiological studies that have tested these relationships, but there is no recent summary of these findings. To explain overarching trends, we undertook a systematic review of published studies. The summarized data support the concept that specific SNPs in the pigmentation pathway are of importance for the pathogenesis of NMSC. The SNPs with the most promising evidence include MC1R rs1805007(T) (Arg151Cys) and rs1805008(T) (Arg160Trp), and ASIP AH haplotype [rs4911414(T) and rs101536...

Sep 29, 2014 04:00PM

The histamine?synthesizing enzyme histidine decarboxylase is upregulated by keratinocytes in atopic skin

ConclusionsKeratinocytes express abundant HDC protein, and the levels increase in atopic skin. LPS, HDM and cytokines, which are implicated in allergic inflammation, promote the expression of the enzyme and upregulate histamine levels in keratinocytes. Actively produced histamine influences keratinocyte differentiation, suggesting functional relevance of the axis to atopic dermatitis. The findings therefore identify a new point of therapeutic intervention. (Source: British Journal of Dermatology)

Sep 29, 2014 04:00PM

High?frequency ultrasonography but not 930?nm optical coherence tomography reliably evaluates melanoma thickness in vivo: a prospective validation study

ConclusionsHFUS is a reliable and reproducible noninvasive method for assessing melanoma thickness. Routine use of HFUS may allow single?step excision of equivocal melanocytic lesions, with surgical margins determined by in vivo assessment of tumour thickness. (Source: British Journal of Dermatology)

Sep 29, 2014 04:00PM

Regulated genes in psoriatic skin during treatment with fumaric acid esters

ConclusionsFAE treatment induces glutathione and Nrf2 pathway genes in lesional skin of patients with psoriasis. In responders, FAEs specifically regulate the transcription factors PTTG1, NR3C1, GATA3 and NF?BIZ, which are important in normal cutaneous development, and the T?helper (Th)2 and Th17 pathways, respectively. (Source: British Journal of Dermatology)

Sep 29, 2014 04:00PM

Paclitaxel?induced diffuse cutaneous sclerosis: a case with associated esophageal dysmotility, Raynaud's phenomenon, and myositis

(Source: International Journal of Dermatology)

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Sep 29, 2014 04:00PM

A randomized, double?blind, placebo?controlled clinical trial on the efficacy and safety of 3% Rumex occidentalis cream versus 4% hydroquinone cream in the treatment of melasma among Filipinos

ConclusionsRumex occidentalis 3% cream is a safe and effective skin?lightening agent for melasma and is comparable in efficacy with 4% HQ cream. (Source: International Journal of Dermatology)

Sep 29, 2014 04:00PM

Six years' follow?up of multibacillary leprosy patients treated with uniform multi?drug therapy in China

ConclusionsA 6?month administration of UMDT is effective in MB leprosy patients. The changes in BI values and the frequency of leprosy reactions were similar to those cited in reports in the literature of patients treated with 1? or 2?year regimens of MDT. However, further research should be conducted to confirm the present results. (Source: International Journal of Dermatology)

Sep 29, 2014 04:00PM

First reported case of Aspergillus nidulans eumycetoma in a sporotrichoid distribution

ConclusionsAspergillus spp. have emerged as important opportunistic pathogens, especially in immunosuppressed patients. Aspergillus nidulans occurs frequently in soil, decaying vegetation, and water but has very rarely been described as a cause of mycetoma. The infection responds well to treatment with itraconazole, voriconazole, and amphotericin B. The current patient represents the first demonstration of A. nidulans mycetoma presenting in a sporotrichoid distribution. (Source: International Journal of Dermatology)

Sep 29, 2014 04:00PM

Downregulation of involucrin in psoriatic lesions following therapy with propylthiouracil, an anti?thyroid thioureylene: immunohistochemistry and gene expression analysis

ConclusionsIn psoriasis, there is increased expression of involucrin, which leads to abnormal keratinocyte differentiation and hence to the formation of psoriatic plaques. The therapeutic effect of PTU in psoriasis may be attributable to the downregulation of involucrin. Larger trials should further elucidate the mechanism and therapeutic potential of PTU in psoriasis. (Source: International Journal of Dermatology)

Sep 29, 2014 04:00PM

Flagellate erythema in parvovirus B19 infection

(Source: International Journal of Dermatology)

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Sep 29, 2014 04:00PM

Localized vasculitis in newly formed striae: a unique manifestation of systemic lupus erythematosus

(Source: International Journal of Dermatology)

Sep 29, 2014 04:00PM

Quality of life and related factors in a cohort of plaque?type psoriasis patients in La Coruña, Spain

ConclusionsFactors associated with greater impairment of QoL were gender, psoriasis duration, and type of treatment. Patients receiving systemic and biologic therapies reported better QoL. (Source: International Journal of Dermatology)

Sep 29, 2014 04:00PM

Pigmented clear cell acanthoma of the finger simulating pigmented nevus

(Source: International Journal of Dermatology)

Sep 29, 2014 04:00PM

Is there an increased prevalence of Wilms' tumor in incontinentia pigmenti syndrome?

(Source: International Journal of Dermatology)

Sep 29, 2014 04:00PM

Nodular hidradenoma of the wrist with spontaneous regression in a 7?month?old infant

(Source: International Journal of Dermatology)

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Sep 29, 2014 04:00PM

Alteration of dermoscopic features in a juvenile xanthogranuloma during follow?up of 43 months

(Source: International Journal of Dermatology)

Sep 29, 2014 04:00PM

Treatment of pseudoepitheliomatous, keratotic, and micaceous balanitis with topical photodynamic therapy

ConclusionsThis case indicates that ALA?PDT may be an effective treatment option for plaque?stage PKMB and thus warrants further investigation. (Source: International Journal of Dermatology)

Sep 29, 2014 04:00PM

A case of tinea cruris of the amputation stump: an example of an immunocompromised district

(Source: International Journal of Dermatology)

Sep 29, 2014 04:00PM

Membrane and soluble Toll?like receptor 2 in patients with psoriasis treated by Goeckerman therapy

ConclusionsMembrane and soluble TLR2 may be involved in the pathogenesis of psoriasis. Both remained unchanged by GT. (Source: International Journal of Dermatology)

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Sep 29, 2014 04:00PM

Review of accessory tragus with highlights of its associated syndromes

Abstract Accessory tragus is a developmental defect involving malformation of part of the external ear. It is a moderately rare congenital condition reported in 1858 by Birkett for the first time. Histological features of accessory tragus include a thin layer of stratum corneum with a rugated epidermis, presence of eccrine glands, and irregular spatial positioning of vellus hair follicles accompanied by sebaceous glands. Accessory tragus is commonly a limited deformity; however, it can be a sign of associated congenital syndromes. It has been shown to be associated with Goldenhar syndrome, Townes?Brocks syndrome, Treacher?Collins syndrome, VACTERL syndrome, and Wolf?Hirschhron syndrome. Surgical excision, the most common form of management of accessory tragus lesions, typically leads...

Sep 29, 2014 04:00PM

Immunohistochemical expression of Bcl?2 and Ki?67 in oral lichen planus and leukoplakia with different degrees of dysplasia

ConclusionsExpression of Bcl?2 may play a dual role in tumor development and progression. Increased cell proliferation in the epithelium may present a predisposition to cancer in OLP. The expression of Ki?67 can be considered as an adjunct marker for proliferative activity in lesions with malignant potential. The prognostic value of these immunomarkers in the evaluation of precancerous oral lesions requires further investigation. (Source: International Journal of Dermatology)

Sep 29, 2014 04:00PM

Cutaneous sarcoidosis: clinicopathologic study of 76 patients from Lebanon

ConclusionsThe clinical and histopathologic features of cutaneous sarcoidosis patients in the present series are generally comparable with those published in the literature, with minor differences. Clinically, the most commonly seen lesion was plaque. Microscopically, cutaneous sarcoidosis may exhibit a grenz zone and may show perineural inflammation and foreign bodies. (Source: International Journal of Dermatology)

Sep 29, 2014 04:00PM

Age?related morphometric changes of inner structures of the skin assessed by in vivo reflectance confocal microscopy

ConclusionsSkin aging may be reflected in the size of granular and prickle cells and dermal papillae, and the extent varies in each sun?exposed or sun?protected skin site. (Source: International Journal of Dermatology)

Sep 29, 2014 04:00PM

Characteristic ?pebbling? skin eruption as a presenting sign of Hunter syndrome

(Source: International Journal of Dermatology)

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Sep 29, 2014 04:00PM

Evaluation of body composition parameters in patients with psoriasis

ConclusionsThe present study provides evidence of a relationship between some body composition parameters and the occurrence of psoriasis. We suggest that body composition parameters should be analyzed not only in obese psoriasis patients but in all psoriasis patients upon their first diagnosis. Systemic therapy does not appear to cause any changes in body composition parameters. (Source: International Journal of Dermatology)

Sep 29, 2014 04:00PM

Clinical and epidemiological analysis of keloids in Chinese patients

Abstract Keloids are common abnormally raised fibroproliferative lesions that can occur following even minor cutaneous trauma. There are limited data on Chinese patients with keloids, and the purpose of our study was to investigate the clinical and epidemiological features of keloids in Chinese patients. Assessment was performed by unified, designed questionnaires. A total of 715 patients were enrolled and statistical analysis and heritability were performed using EPI INFO 6.0, SPSS13.0 and Falconer?s method. Keloids occurred typically between the ages of 10 and 30 years, and the mean age of initial onset was 21.14 ± 13.45 years in females and 22.55 ± 11.36 years in males. The difference in the mean age of onset was not significant between males and females (p > 0....

Sep 29, 2014 04:00PM

Dermoscopy of adamantinoid trichoblastoma

(Source: Journal of the European Academy of Dermatology and Venereology)

Sep 29, 2014 04:00PM

A novel INDEL mutation in the EDA gene resulting in a distinct X? linked hypohidrotic ectodermal dysplasia phenotype in an Italian family

(Source: Journal of the European Academy of Dermatology and Venereology)

Sep 29, 2014 04:00PM

Recurrent cold?induced pruritic flush caused by small?fibre neuropathy in skin grafts

(Source: Journal of the European Academy of Dermatology and Venereology)

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Sep 29, 2014 04:00PM

An improved Peltier effect?based instrument for critical temperature threshold measurement in cold? and heat?induced urticaria

ConclusionThe TempTest® 4 is a simple, easy to use, licensed, commercially available and affordable instrument for the determination of CTTs in both cold? and heat?induced urticaria. (Source: Journal of the European Academy of Dermatology and Venereology)

Sep 29, 2014 04:00PM

Consensus on performing skin biopsies, laboratory workup, evaluation of tissue samples and reporting of the results in patients with suspected cutaneous graft?versus?host disease

ConclusionWhile a consensus on the need for biopsies in cGvHD was reached the value of skin biopsies in aGvHD and subsequent biopsies during therapy requires further evaluation. (Source: Journal of the European Academy of Dermatology and Venereology)

Sep 29, 2014 01:01PM

Nicolau syndrome secondary to subcutaneous Bortezomib injection

(Source: Journal of the European Academy of Dermatology and Venereology)

Sep 29, 2014 12:59PM

Malassezia yeasts activate the NLRP3 inflammasome in antigen?presenting cells via Syk?kinase signaling

This article is protected by copyright. All rights reserved. (Source: Experimental Dermatology)

Sep 29, 2014 12:00PM

BRAF mutation status in primary and metastatic melanomas in two regions with differing potential ultraviolet radiation exposure

ConclusionsWe have documented the rate of different BRAF mutation types in a Lebanese and Pakistani cohort, and assessed correlations with prognostic markers and potential UVR exposure. (Source: Clinical And Experimental Dermatology)

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Sep 28, 2014 04:00PM

Improvement of polyphenol properties upon glucosylation in a UV?induced skin cell ageing model

ConclusionOur results demonstrated that enzymatic glucosylation of CA and EGCG led to an improved or preserved antioxidant activity in a cellular model of UV?induced skin ageing, despite the decrease in instantaneous antioxidant properties observed for Glc?CA. Glc?EGCG is specifically more active on keratinocytes, suggesting a specific targeting. Such glucosylated polyphenols displaying improved physicochemical and biological properties should be better candidates than natural ones for use in food additives and cosmetics. Résumé ObjectifsLes polyphénols sont des molécules ayant un fort pouvoir antioxydant permettant de prévenir les dommages dus au photovieillissement de la peau mais leur utilisation est limitée de par leur faible solubilité et leur toxicité envers les cellul...

Sep 28, 2014 04:00PM

Polidocanol inhibits cowhage? but not histamine?induced itch in humans

This study has compared the antipruritic efficacy of topical polidocanol in histamine?induced itch and a histamine?independent, cowhage?induced model of pruritus. Polidocanol (3%) or vehicle was applied topically under occlusion for one hour to the forearms of 45 healthy volunteers before itch was provoked by rubbing in 40?45 spicules of cowhage or skin prick testing (SPT) with 10 mg/ml histamine. Itch was recorded at 1?minute intervals for 30 minutes on a 100 mm visual analogue scale (VAS). Polidocanol significantly reduced the area under the curve for cowhage?induced itch by 58% (P<0.05), but had no significant effect on histamine?induced itch. This result underlines the importance of histamine?independent itch models in the development of topical antipruritic agents. ...

Sep 28, 2014 04:00PM

Aspirin?exacerbated cutaneous disease (AECD) is a distinct subphenotype of chronic spontaneous urticaria

ConclusionsAECD is a distinct phenotype that should be considered for inclusion as a separate subtype of chronic spontaneous urticaria. (Source: Journal of the European Academy of Dermatology and Venereology)

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Sep 28, 2014 04:00PM

Lba35 * overall survival and biomarker results from a phase 2 study of mek1/2 inhibitor binimetinib (mek162) in patients with advanced nras-mutant melanoma

Conclusions: Binimetinib 45mg bid is active in NRAS-mutant melanoma with an acceptable safety profile. A pivotal phase 3 study (NEMO) evaluating binimetinib in NRAS-mutant melanoma is ongoing. Understanding of the genetic landscape will be further refined from data collected in the NEMO study.Disclosure: C. van Herpen: has been on a board of directors and/or advisory board for Merck and has received research funding for Novartis and Merck; A. Hauschild: has received trial grants for Amgen, BMS, Celgene, Eisai, GSK, MelaSciences, Merck Serono, MSD, Novartis, Oncosec, Roche. He has also consulted for and received honoraria from these companies and MedImmune; R. Dummer: has received research funding and consulted for Novartis; C. Berking: has consulted for Novartis, Roche, GSK, MSD, BMS, Astr...

Sep 28, 2014 11:05AM

Analysis of perioperative factors associated with increased cost following abdominal wall reconstruction (AWR)

Conclusion We present a critical assessment of cost in AWR at a major academic teaching hospital and quantify the impact of reconstruction in the setting of medical morbidities and reconstructive complexities. The data from this study can be used to adjust reimbursement schemes and to critically assess the cost?benefit of performing AWR. (Source: Hernia)

Sep 28, 2014 11:05AM

Onlay ventral hernia repairs using porcine non-cross-linked dermal biologic mesh

Conclusions Porcine non-cross-linked biologic mesh overlay has excellent short-term results in patients at increased risk for mesh infection. No patient required mesh removal, and there have been no recurrent hernias in patients with primary fascial closure. Biologic bridging is not effective for long-term abdominal wall reconstruction. (Source: Hernia)

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Sep 27, 2014 04:00PM

Myeloid?derived suppressor cells in malignant melanoma

Summary Melanoma is known for its rapid progression, metastasis to distant organs and therapeutic resistance. Despite high melanoma immunogenicity, the results of immunotherapeutic clinical studies are mostly unsatisfactory. One explanation is the development of strong immunosuppression mediated by highly immunosuppressive regulatory leukocytes, in particular, myeloid?derived suppressor cells (MDSCs). These cells were found to be enriched and activated in the melanoma microenvironment, inducing a profound impairment of anti?tumor immune responses and leading to the tumor progression. Therefore, understanding the mechanisms of MDSC generation, migration to the tumor site and activation as well as their targeting is important for the development of novel strategies for effective melanoma...

Sep 27, 2014 04:00PM

The immunohistochemical profile of granular cell (Abrikossoff) tumor suggests an endomesenchymal origin

Abstract Granular cell tumor (GCT) is an uncommon soft tissue neoplasm which has an unclear histogenesis. The aim of this study was to analyze its immunophenotype and hypothesize on the histogenesis of GCT. A database of 2,250 soft tissue tumors was examined to identify and characterize the particularities of GCTs. A large panel of antibodies was used. Of the 2,250 tumors, only 15 were GCTs (0.66 %); these were diagnosed in patients whose average age was 37 years. Among them, 5 had malignant potential, the remaining 10 were benign. One of these benign tumors was associated with a metachronous chondrosarcoma with metastases in the lungs. No recurrences were reported in these cases. The benign tumors displayed positivity for S-100, neuron-specific enolase (NSE), CD56, epithelial m...

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Sep 27, 2014 12:57PM

Focus on Clinical Decision Support Functionality:: A CMS Update

No abstract available (Source: Advances in Skin and Wound Care)

Sep 27, 2014 12:13PM

PodMed: A Medical News Roundup From Johns Hopkins (with audio)

(MedPage Today) -- This weeks topics include the effect of education on prenatal testing, Ebola estimates, varicose vein therapy, and PET scanning to diagnose lung cancer. (Source: MedPage Today Dermatology)

Sep 26, 2014 05:00PM

Locoregional Therapies in Melanoma.

Authors: Abbott AM, Zager JS Abstract In-transit disease is defined as any dermal or subcutaneous metastases that arise between the primary melanoma but not beyond the draining regional nodal basin. Patients who develop in-transit disease are at further risk to develop additional locoregional and distant disease. Treatment must be individualized and take into consideration the extent of disease, tumor characteristics, and patient characteristics including age, comorbidities, previous therapies, and site of recurrence. Surgery, regional perfusions and intralesional injections all play a role in management options. These patients should be discussed and managed by a multidisciplinary team whenever possible. PMID: 25245964 [PubMed - as supplied by publisher] (Source: The Surgical ...

Sep 26, 2014 04:00PM

Skin disorders in diabetes mellitus

Summary Diabetes mellitus is one of the most common diseases in industrialized Western countries with about 300 million affected patients worldwide. The hyperglycemic state of diabetes mellitus leads to changes in almost every human cell type and organ. Skin changes are considered the most common manifestations of diabetes mellitus. As skin changes can manifest before onset of diabetes mellitus, they may have a diagnostic relevance. Other cutaneous manifestations develop during the course of diabetes mellitus and may be associated with complications in internal organs or may occur as an adverse effect of antidiabetic therapy. In particular, the presence of the diabetic foot syndrome is associated with significantly increased morbidity and mortality of diabetes patients as well as with mark...

Sep 26, 2014 04:00PM

Hauterkrankungen bei Diabetes mellitus

Zusammenfassung Diabetes mellitus ist eine der häufigsten Erkrankungen der westlichen Industrienationen mit weltweit circa 300 Millionen Betroffenen. Die diabetische Stoffwechsellage führt zu Veränderungen praktisch aller Zelltypen und Organe des Körpers. Komplikationen an der Haut zählen hierbei zu den häufigsten Veränderungen. Da Hauterscheinungen einem Diabetes mellitus vorangehen können, besitzen sie eine diagnostische Relevanz. Andere Hautveränderungen und ?erkrankungen entwickeln sich erst im Laufe eines Diabetes mellitus, sind mitunter mit Komplikationen innerer Organe assoziiert oder treten als unerwünschte Wirkung einer antidiabetischen Therapie auf. Besonders das Auftreten eines diabetischen Fußsyndroms geht mit einer signifikant erhöhten Morbidität und Mortalität...

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Sep 26, 2014 04:00PM

Xeroderma pigmentosum: Diagnostic procedures, interdisciplinary patient care, and novel therapeutic approaches

Summary Xeroderma pigmentosum (XP) is an autosomal recessive disease, caused by a gene defect in the nucleotide?excision?repair (NER) pathway or in translesional DNA synthesis. At the age of eight, patients already develop their first skin cancers due to this DNA repair defect. In contrast, in the Caucasian population the first tumor formation in UV exposed skin regions occurs at a mean age of 60. The clinical picture among patients suffering from XP is highly diverse and includes signs of accelerated skin aging, and UV?induced skin cancers, as well as ophthalmologic and neurological symptoms. Patients should therefore receive interdisciplinary care. This includes dermatologists, ophthalmologists, ENT specialists, neurologists, and human geneticists. Patients with XP are clinically d...

Sep 26, 2014 04:00PM

Xeroderma pigmentosum: diagnostisches Vorgehen, interdisziplinäre Patientenversorgung und neue Therapieansätze

Zusammenfassung Xeroderma pigmentosum (XP) ist eine autosomal?rezessiv vererbte Erkrankung, welche durch einen Defekt in der Nukleotid?Exzisions?Reparatur oder der transläsionalen DNA?Synthese gekennzeichnet ist. Bereits mit acht Jahren entwickeln Patienten, die an XP leiden, aufgrund ihres DNA?Reparaturdefekts den ersten Hautkrebs. Dies steht im Gegensatz zur mitteleuropäischen Allgemeinbevölkerung, bei der die ersten Hauttumoren in UV?exponierten Hautarealen mit durchschnittlich 60 Jahren auftreten. Das klinische Bild von Patienten mit XP ist hochgradig divers und schließt Zeichen der vorzeitigen Hautalterung, alle Arten UV?induzierter Hauttumoren, ophthalmologische und neurologische Symptome ein. Betroffene sollten daher interdisziplinär von verschiedenen Fachbereiche...

Sep 26, 2014 04:00PM

The role of human 6?sulfo LacNAc dendritic cells (slanDCs) in autoimmunity and tumor diseases

Summary Dendritic cells play a central role in the regulation of immunological reactivity. The existence of functionally specialized populations of dendritic cells in the skin is a consequence of qualitatively different attacks on our organism. slanDCs are human inflammatory dendritic cells that are characterized by the specific expression of the carbohydrate 6?sulfo LacNAc (slan). After phenotypic maturation, slanDCs are capable of producing very high amounts of proinflammatory mediators such as IL?12, TNF??, IL?1? and IL?23. Recent data describe a potential role of slanDCs in a number of different diseases like psoriasis, lupus erythematosus, and tumors, thus opening up new areas of research on their respective pathogenesis. Furthermore, a slanDC?specific targeting system h...

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Sep 26, 2014 04:00PM

Die Bedeutung von humanen 6?sulfo LacNAc dendritischen Zellen (slanDCs) bei Autoimmunität und Tumorerkrankungen

Zusammenfassung Dendritische Zellen spielen eine wichtige Rolle bei der Regulation immunologischer Reaktivität. Die Existenz funktionell spezialisierter Populationen dendritischer Zellen der Haut ist eine Konsequenz der unterschiedlichen Qualität von Angriffen auf unseren Organismus. Als slanDCs werden inflammatorische dendritische Zellen des Menschen bezeichnet, die sich durch die spezifische Expression des Zuckers 6?sulfo LacNAc (slan) auszeichnen. Nach phänotypischer Maturation besitzen slanDCs die Fähigkeit zur Produktion großer Mengen proinflammatorischer Mediatoren wie IL?12, TNF??, IL?1? und IL?23. Aktuelle Daten beschreiben eine mögliche Bedeutung dieser proinflammatorischen Zellen bei so unterschiedlichen Erkrankungen wie der Psoriasis, dem Lupus erythematodes ab...

Sep 26, 2014 04:00PM

Local recurrence and survival in acral lentiginous melanoma comparing 3D histology and conventional histology

ConclusionsExcision with small margins followed by 3D histology is not inferior to conventional surgery with wide margins in terms of the rate of local and has no negative impact on prognosis or the further course of the disease. Local recurrences are rare and do not influence patient survival. (Source: JDDG)

Sep 26, 2014 04:00PM

Lokalrezidivraten und Überlebenswahrscheinlichkeit nach 3D?Histologie und konventioneller Histologie beim akrolentiginösen Melanom

Zusammenfassung HintergrundDie Exzision akrolentiginöser Melanome (ALM) unter Berücksichtigung der empfohlenen Sicherheitsabstände führt oft zur Teilamputation der Akren. Ziel war es, zu prüfen, ob reduzierte Sicherheitsabstände in Verbindung mit Schnittrandhistologie (3D?Histologie) zu einer Prognoseverschlechterung führen. Patienten und Methodik304 Patienten mit ALM wurden retrospektiv ausgewertet. 192 Patienten mit reduziertem Resektionsabstand und nachfolgender 3D?Histologie (Gruppe A) wurden hinsichtlich Prognose und Lokalrezidivrate verglichen mit 112 Patienten, die eine Chirurgie mit definierten Sicherheitsabständen erhalten hatten (Gruppe B). ErgebnisseDie Tumordicke war bei der Gruppe A größer (p = 0,022) und Ulzerationen in dieser Gruppe häufiger (p = 0,017). Der m...

Sep 26, 2014 04:00PM

Seafood allergy in cooks: a case series and review of the literature

ConclusionsSeafood allergy in cooks is mostly characterized by a quick progressive course of disease, generally at the start of the cooking career. The prognosis for continuance in occupation is poor and an occupational disease must be considered at an early stage. An emergency kit with an epinephrine auto?injector should be provided for life by the responsible accident insurer. (Source: JDDG)

Sep 26, 2014 04:00PM

Allergie gegen Meeresfrüchte bei Köchen: Fallserie und Literaturübersicht

Zusammenfassung HintergrundMeeresfrüchte sind sehr potente Allergene. Epidemiologische Studien über Meeresfruchtallergien bei Köchen, der herausragend exponierten Berufsgruppe, existieren bislang nicht. Ziel der Arbeit war es anhand einer ersten größeren Fallserie die hohe Relevanz und Konsequenzen einer Meeresfrüchteallergie bei Köchen aufzuzeigen. Patienten und MethodikRetrospektive Auswertung aller zugesandten Feststellungsverfahrensakten zur Frage des Vorliegens einer Berufskrankheit nach Nr. 5101 der Anlage zur Berufskrankheitenverordnung. ErgebnisseZwischen Januar 2008 und April 2014 wurden 30 Köche (Männeranteil 70 %) mit einer berufsbedingten Meeresfrüchteallergie begutachtet. Es handelte sich mehrheitlich um recht junge Versicherte (Altersmedian 24,7 J.) mit einer frühe...

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Sep 26, 2014 04:00PM

Erosives und mitotisch aktives juveniles Xanthogranulom am Hals eines Säuglings

(Source: JDDG)

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Sep 26, 2014 04:00PM

Fleckförmiger Haarausfall am Hinterkopf

(Source: JDDG)

Sep 26, 2014 04:00PM

Unilaterales schmerzloses Ulkus des Nasenflügels

(Source: JDDG)

Sep 26, 2014 04:00PM

Early takedown of paramedian forehead flap

(Source: JDDG)

Sep 26, 2014 04:00PM

Vorzeitige Durchtrennung des paramedianen Stirnlappens

(Source: JDDG)

Sep 26, 2014 04:00PM

Journal?Club

(Source: JDDG)

Sep 26, 2014 04:00PM

Nachbericht über den 12. ESPD?Kongress in Kiel vom 12.?14. Juni 2014

(Source: JDDG)

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Sep 26, 2014 04:00PM

Alfred?Marchionini?Preis

(Source: JDDG)

Sep 26, 2014 04:00PM

Personalia

(Source: JDDG)

Sep 26, 2014 04:00PM

Kongresskalender

(Source: JDDG)

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Sep 26, 2014 04:00PM

Issue Information

(Source: Experimental Dermatology)

Sep 26, 2014 04:00PM

Launch of the new letter category: ?Mouse Mutants with Absent/Minimal Skin Phenotype?

(Source: Experimental Dermatology)

Sep 26, 2014 04:00PM

?Upgrading? psoriasis responsibly

Abstract Psoriasis is a ?pacemaker? in dermatology. Substantial progress has been made regarding our understanding of its pathophysiology and genetic background, fuelling developments in cutaneous biology in general. Besides, the clinical perspective on psoriasis is currently changing, taking into consideration comorbidity and the systemic dimensions of this seemingly organ?specific inflammation. The availability of drugs exhibiting fewer contraindications and improved long?term safety opened a discussion around replacing a relatively limited (regarding both objectives and duration) ?therapeutic? by a much broader ?management? approach when it comes to treating psoriasis as a systemic disease. The question arises whether this ?upgrade? is warranted. (Source: Experimenta...

Sep 26, 2014 04:00PM

Association of promoter polymorphism ?765G>C in the PTGS2 gene with malignant melanoma in Italian patients and its correlation to gene expression in dermal fibroblasts

Abstract Prostaglandins, especially prostaglandin E synthetase (PGE2), influence carcinogenesis by promoting cell proliferation, inhibiting apoptosis, stimulating angiogenesis and mediating immune suppression. Cyclooxygenase?2, coded by the PTGS2 gene, is the key enzyme in the production of prostaglandins. In melanoma, Cox?2 is over expressed in primary malignant melanoma (MM) and in their corresponding metastases. Polymorphisms in the promoter region of PTGS2 gene can modulate gene expression and could modify individual susceptibility to MM. Two hundred and forty melanoma patients and 342 controls were genotyped for polymorphisms ?765G>C (rs20417) and ?1195A>G (rs689466). Allele ?765C frequency was significantly higher in melanoma patients. No allele frequency differences ...

Sep 26, 2014 04:00PM

Analysis of protein?protein interaction between late cornified envelope proteins and corneodesmosin

Abstract Deletion of two members of the late cornified envelope (LCE) family, LCE3B and LCE3C (LCE3C_LCE3B?del), has been identified as risk factor for psoriasis with a possible role in skin barrier function. Moreover, genetic interaction between LCE3C_LCE3B?del and HLA?C*06, located in the psoriasis susceptibility regions 4 and 1 (PSORS4 and 1), has been reported in several populations. Because of high linkage disequilibrium between the PSORS1 genes HLA?C*06 and corneodesmosin (CDSN), both genes are potentially involved in psoriasis. As corneodesmosin and LCE proteins are both constituents of the stratum corneum, we investigated potential direct protein?protein interactions between six LCE proteins and two corneodesmosin sequence variants. Partial colocalization of LCE2 and CDSN...

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Sep 26, 2014 04:00PM

FRT ? Fondation Rene Touraine

(Source: Experimental Dermatology)

Sep 26, 2014 04:00PM

Clinical Snippets

(Source: Experimental Dermatology)

Sep 26, 2014 03:51PM

Cutaneous basal cell carcinoma with endobronchial metastasis.

We present a rare case of metastatic basal cell carcinoma manifested as a bronchial tumour. This case highlights the fact that despite basal cell carcinoma's local invasive potential, the possibility of distant metastasis still exists and clinicians should therefore be cautious about interpreting extracutaneous symptoms. Chest physicians should always consider the possibility of this rare tumour in the lungs in patients with a history of large basal cell carcinomas in the head and neck region. PMID: 25245718 [PubMed - in process] (Source: Annals of the Royal College of Surgeons of England)

Sep 26, 2014 03:50PM

A timesaving technique for shaping of acellular dermal matrix in primary breast reconstruction.

Authors: Siddique K, Azmy I PMID: 25245748 [PubMed - in process] (Source: Annals of the Royal College of Surgeons of England)

Sep 26, 2014 03:05PM

Expression and integrity of dermatopontin in chronic cutaneous wounds: a crucial factor in impaired wound healing

In conclusion, the susceptibility of DPT protein to specific proteases present at high levels in the wound milieu resulted in the degradation of DPT, thus leading to impaired healing response in CCW. (Source: Cell and Tissue Research)

Sep 26, 2014 09:55AM

Treatment of severe poison ivy: a randomized, controlled trial of long versus short course oral prednisone.

CONCLUSIONS: This study suggests that a longer course prescription may save patients' time and exposure to excess medication in the treatment of severe poison ivy. Application of this information to clinical practice will save return visits and reduce excess non-prescription medication administration to individual patients. PMID: 25247016 [PubMed] (Source: Clin Med Res)

Sep 26, 2014 09:55AM

Demographical and Clinical Characteristics of Behcet's Disease in Southeastern Turkey.

CONCLUSION: Demographic and clinical features of BD may vary according to geographical region, gender and ethnicity. We hope that this study will contribute to the epidemiologic data of BD which may exhibit different clinical and demographic features in different parts of the world. PMID: 25247023 [PubMed] (Source: Clin Med Res)

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