Feb 02, 2012 09:38AM

Copy Number Variations on Chromosome 4q26–27 Are Associated with Cantu Syndrome

Dermatology (DOI:10.1159/000333800) (Source: Dermatology)

Feb 02, 2012 09:38AM

Index

(Source: Dermatologic Clinics)

Feb 02, 2012 09:38AM

Clinical Meaning in Skin-specific Quality of Life Instruments: A Comparison of the Dermatology Life Quality Index and Skindex Banding Systems

This article focuses on the anchor-based banding approach and reviews methods to assign clinical meaning to QOL measures, specifically the Dermatology Life Quality Index (DLQI) and Skindex. This article also includes pilot data that compares the DLQI and Skindex using these previously validated banding systems. (Source: Dermatologic Clinics)

Feb 02, 2012 09:38AM

Quality-of-Life Instruments: Evaluation of the Impact of Psoriasis on Patients

The negative impact of psoriasis on a patient's quality of life (QoL) is well documented in the literature. Patients often suffer poor self-esteem, difficulties in social interactions, and significant psychological distress. It is, therefore, critically important that a clinician evaluate the extent to which the disease impacts a patient's QoL. This chapter reviews several validated and reliable generic, dermatology-specific, and disease-specific QoL instruments useful in measuring the impact of psoriasis on patient's QoL. These QoL instruments can be especially helpful in identifying those patients who would most benefit from systemic or biologic therapy. (Source: Dermatologic Clinics)

Feb 02, 2012 09:38AM

Melasma Quality of Life Measures

This article addresses these methods, which could be useful to those desiring to develop the MELASQOL in other languages. (Source: Dermatologic Clinics)

Feb 02, 2012 09:38AM

Health-Related Quality of Life in Dermatology: Introduction and Overview

This article introduces a compendium of articles that address HRQoL in dermatology across a spectrum of diseases and ways that HRQoL can be incorporated in the clinical and research settings. (Source: Dermatologic Clinics)

Feb 02, 2012 09:38AM

Forthcoming Issues

(Source: Dermatologic Clinics)

Feb 02, 2012 09:38AM

Contents

(Source: Dermatologic Clinics)

Feb 02, 2012 09:38AM

Contributors

(Source: Dermatologic Clinics)

Feb 02, 2012 03:18AM

Immunology in clinic review series; focus on autoinflammatory diseases: update on monogenic autoinflammatory diseases: the role of interleukin (IL)‐1 and an emerging role for cytokines beyond IL‐1

OTHER THEMES PUBLISHED IN THIS IMMUNOLOGY IN THE CLINIC REVIEW SERIESAllergy, Host Responses, Cancer, Type 1 diabetes and viruses, Metabolic diseases.SummaryThe disease‐based discovery of the molecular basis for autoinflammatory diseases has led not only to a rapidly growing number of clinically and genetically identifiable disorders, but has unmantled key inflammatory pathways such as the potent role of the alarm cytokine interleukin (IL)‐1 in human disease. Following its initial failures in the treatment of sepsis and the moderate success in the treatment of rheumatoid arthritis, IL‐1 blocking therapies had a renaissance in the treatment of a number of autoinflammatory conditions, and IL‐1 blocking therapies have been Food and Drug Administration (FDA)‐approved for the treatmen...

Feb 01, 2012 09:00PM

Lack of Sunlight May Raise Stroke Risk

Study found those who got less exposure were more likely to suffer an attack (Source: The Doctors Lounge - Dermatology)

Feb 01, 2012 09:00PM

Photostabilization of Ascorbic Acid with Citric Acid, Tartaric Acid and Boric Acid in Cream Formulations

SynopsisThe present study involves the evaluation of the effect of certain stabilizers, i.e. citric acid (CT), tartaric acid (TA) and boric acid (BA) on the degradation of ascorbic acid (AH2) in oil‐in‐water cream formulations exposed to the UV light and stored in the dark. The apparent first‐order rate constants (0.34–0.95×10−3 min−1 in light, 0.38–1.24×10−2 day−1 in dark) for the degradation reactions in the presence of the stabilizers have been determined. These rate constants have been used to derive the second‐order rate constants (0.26–1.45×10−2 M−1 min−1 in light, 3.75–8.50×10−3 M−1 day−1) for the interaction of AH2 and the individual stabilizers. These stabilizers are effective in causing the inhibition of the rate of degradation of AH2 both ...

Feb 01, 2012 09:00PM

Lipocalin‐type prostaglandin D synthase as a marker for the proliferative potential of melanocyte‐lineage cells in the human skin

In conclusion, L‐PGDS expression may contribute to the restricted proliferation of epidermal melanocytes, but conversely its overexpression may reflect the dysregulated proliferation of melanoma cells. (Source: The Journal of Dermatology)

Feb 01, 2012 09:00PM

Femoral head osteonecrosis after long‐term topical corticosteroid treatment in a psoriasis patient

(Source: The Journal of Dermatology)

Feb 01, 2012 09:00PM

Blaschkitis‐like eruptions with hypodontia and low IκB kinase gamma expression

(Source: The Journal of Dermatology)

Feb 01, 2012 09:00PM

Ber‐EP4 is a useful marker for follicular germinative cell differentiation of cutaneous epithelial neoplasms

In this study, we performed immunohistochemical staining of 31 cases of basal cell carcinoma (BCC); 20 cases of trichoblastoma (TB), including ten cases of nodular type, eight cases of cribriform type (trichoepithelioma) and two cases of columnar type (desmoplastic trichoepithelioma); 16 cases of actinic keratosis (AK); and 10 cases each of Bowen’s disease, poroma and seborrheic keratosis. Six cases of BCC and AK were co‐lesions of both neoplasms. In normal skin tissue, Ber‐EP4 reacted positively with the secretory portion of eccrine glands and follicular germinative cells at the lower end of catagen hairs. Neoplastic cells in 97% of cases with BCC reacted positively with Ber‐EP4 in at least 5% of neoplastic cells. Those in 90% with nodular type TB and 50% with trichoepithelioma al...

Feb 01, 2012 09:00PM

Incontinentia pigmenti with NEMO mutation in a Japanese family

(Source: The Journal of Dermatology)

Feb 01, 2012 08:00PM

Topical Treatments for Atopic DermatitisTopical Treatments for Atopic Dermatitis

Proper skin care can improve skin barrier function, reducing susceptibility to triggers of flares, but what skin care regimen works best? Pediatric Nursing (Source: Medscape Today Headlines)

Feb 01, 2012 03:00PM

Eosinophilia during Psoriasis Treatment with TNF Antagonists

Dermatology (DOI:10.1159/000334805) (Source: Dermatology)

Feb 01, 2012 03:00PM

Linear Pitting and Splinter Haemorrhages Are More Commonly Seen in the Nails of Patients with Established Psoriasis in Comparison to Psoriatic Arthritis

Dermatology (DOI:10.1159/000335571) (Source: Dermatology)

Feb 01, 2012 03:00PM

Evaluation of the German Guideline for Chronic Pruritus: Results of a Retrospective Study on 385 Patients

Dermatology (DOI:10.1159/000335782) (Source: Dermatology)

Feb 01, 2012 02:00PM

Tanning Salons Lie About Health Risks Says Congressional Panel

A report compiled by the U.S. House Energy and Commerce Committee slates tanning salons for not making the risks clear to their customers. The committee asked for a thorough investigation to find out whether tanning salons across the country make it clear to their clients the health issues associated with the services they offer. In a sting operation, the committee investigators made enquiries at 300 indoor tanning salons around the United States... (Source: Health News from Medical News Today)

Feb 01, 2012 03:48AM

Effectiveness of the Novel Herbal Medicine, KIOM-MA, and Its Bioconversion Product, KIOM-MA128, on the Treatment of Atopic Dermatitis

This study was conducted to determine if oral administration of the novel herbal medicine, KIOM-MA, and its Lactobacillus acidophilus-fermented product, KIOM-MA128, has therapeutic properties for the treatment of atopic dermatitis (AD). Using AD-induced BALB/c mice by Ovalbumin and aluminum hydroxide, the effectiveness of KIOM-MA and KIOM-MA128 on AD was evaluated. Oral administration of KIOM-MA and KIOM-MA128 reduced major clinical signs of AD including erythema/darkening, edema/papulation, excoriations, lichenification/prurigo, and dryness. Interestingly, KIOM-MA128 more significantly improved AD-related symptoms including decrease of IgE level in the plasma as well as reduction of scratching behavior, skin severity in the AD BALB/c model. HPLC analysis showed the significant changes in ...

Jan 31, 2012 11:00PM

First Drug to Target Cause of Cystic Fibrosis Approved

Title: First Drug to Target Cause of Cystic Fibrosis ApprovedCategory: Health NewsCreated: 2/1/2012 11:01:00 AMLast Editorial Review: 2/1/2012 (Source: MedicineNet Skin General)

Jan 31, 2012 11:00PM

fexofenadine, Allegra, Allegra Allergy, Allegra Hives, Children's Allegra

Title: fexofenadine, Allegra, Allegra Allergy, Allegra Hives, Children's AllegraCategory: MedicationsCreated: 12/31/1997Last Editorial Review: 2/1/2012 (Source: MedicineNet Skin General)

Jan 31, 2012 09:00PM

Use of digital infrared imaging in the assessment of childhood psoriasis

(Source: Skin Research and Technology)

Jan 31, 2012 09:00PM

Characterization of the miRNA profile in UVB‐irradiated normal human keratinocytes

AbstractThe aim of this study was to assess the effects of ultraviolet B (UVB) irradiation on microRNA (miRNA) expression in normal human keratinocytes. Global miRNA expression profiles of primary cultures of normal human keratinocytes 4 and 24 hours post‐irradiation were studied using miRNA microarray with further confirmation by real‐time PCR. We found that upon 30 or 60 mJ/cm2 of UVB radiation, the expression of 44 miRNAs were up‐ or downregulated more than 2‐fold compared to non‐irradiated keratinocytes. MiRNAs were either up‐ or downregulated after 4 hours, and then either returned to normal levels or remained affected after 24 hours, resulting in 4 distinct patterns of miRNA expression change. It appears that acute exposure of keratinocytes to UVB radiation results in sev...

Jan 31, 2012 09:00PM

Spectrofluorescence of Skin and Hair

We examined several sources of skin including in vivo human and ex vivo pig, sheep, goat, and cow skin. We also analyzed various types of mature hair characterized by degree of melanin content. These analyses provided us with a fundamental understanding of the effects of melanin distribution in hair fibers and aided with the identification of fluorophores present in hair.© 2012 The Authors ICS © 2012 Society of Cosmetic Scientists and the Société Française de Cosmétologie (Source: International Journal of Cosmetic Science)

Jan 31, 2012 09:00PM

Accuracy of dermoscopic criteria for the diagnosis of psoriasis, dermatitis, lichen planus and pityriasis rosea

Conclusions:  PP, LP, PR and dermatitis show specific dermoscopic patterns that may aid their clinical diagnosis. Certain combinations of dermoscopic features can reliably predict the diagnosis of PP. (Source: British Journal of Dermatology)

Jan 31, 2012 09:00PM

Blaschkoid distribution of cylindromas in a germline CYLD mutation carrier.

(Source: British Journal of Dermatology)

Jan 31, 2012 09:00PM

Fractional Laser Resurfacing for Acne Scars: A Review

AbstractThis review investigates the effectiveness of ablative and non‐ablative Fractional Photothermolysis (FP) lasers for treating facial acne scars. 26 studies (13=ablative FP; 13=non‐ablative FP) published between year‐2003 to January 2011 were reviewed. Quantitative and qualitative data from each article were examined and analysed. 4 studies were split‐face randomised controlled studies (RCTs). Whilst the data analysed where all clinically relevant and significant, there were some methodological differences between the studies. Outcomes included subjective and objective assessment of scar appearance, pre‐ and postoperative treatment, side effects and pain scores. A small number of studies used 3D Optical Profiling Imaging and histology for objective assessment. Even allowing...

Jan 31, 2012 09:00PM

A rare heterozygous TRAF6 variant is associated with hypohidrotic ectodermal dysplasia

AbstractMutation of the genes encoding components of the TNFα‐like (tumour necrosis factor α) pathway involved in signal transduction between the ectoderm and the mesenchyme during embryonic development causes hypohidrotic ectodermal dysplasia (HED), resulting from the abnormal differentiation of tooth buds, hair follicles and eccrine sweat glands. Two phenotypically indistinguishable forms of HED, X‐linked recessive and autosomal (dominant or recessive), have been discerned in mice and humans.1 The X‐linked form (OMIM #305100) is caused by mutations in the ED1 gene, which encodes two principal ectodysplasins. EDA‐A1 is recognized by receptor EDA1R (ectodysplasin A1 receptor), causing the recruitment of an adaptor, EDARADD (EDA1R‐associated death domain), which interacts with T...

Jan 31, 2012 09:00PM

Serum leptin, adiponectin, resistin and ghrelin levels in psoriatic patients treated with cyclosporin

AbstractCyclosporin has various effects on adipose tissue and glucose metabolism. This situation may lead to changes in serum levels of adipocyte‐derived cytokines which have influence on the pathogenesis of psoriasis. The aim of this study was to evaluate the effect of cyclosporin treatment on some adipocyte‐derived cytokines in psoriatic patients. This case–control study was performed between June 2009 and March 2010, at the Department of Dermatology of Meram School of Medicine. Serum leptin, adiponectin, resistin and ghrelin levels were assessed in 26 patients with psoriasis before and after cyclosporin treatment and body mass index‐matched 26 healthy control subjects. The adipokines levels were compared between the groups. Serum leptin, ghrelin, resistin and adiponectin levels ...

Jan 31, 2012 09:00PM

Kongresskalender

(Source: JDDG)

Jan 31, 2012 09:00PM

Buchbesprechungen

(Source: JDDG)

Jan 31, 2012 09:00PM

Nachruf

(Source: JDDG)

Jan 31, 2012 09:00PM

Laudatio

(Source: JDDG)

Jan 31, 2012 09:00PM

Arbeitsgemeinschaft Dermatologische Onkologie (ADO)

(Source: JDDG)

Jan 31, 2012 09:00PM

Vaskuläre Zwillingsflecken – Wie viele Möglichkeiten gibt es?

(Source: JDDG)

Jan 31, 2012 09:00PM

Vascular twin spotting – how many possibilities exist?

(Source: JDDG)

Jan 31, 2012 09:00PM

Unilaterale nävoide Teleangiektasien mit anämischen Höfen: Warum sind's keine Zwillingsflecken?

(Source: JDDG)

Jan 31, 2012 09:00PM

Unilateral nevoid telangiectasias with anemic halos: why aren't they twin spots?

(Source: JDDG)

Jan 31, 2012 09:00PM

Journal‐Club

(Source: JDDG)

Jan 31, 2012 09:00PM

Digitiforme Hyperkeratosen

(Source: JDDG)

Jan 31, 2012 09:00PM

Spontan aufgetretener, derber, entzündlicher Knoten mit zentral grauschwarzer Färbung im Bereich des Bauchnabels

(Source: JDDG)

Jan 31, 2012 09:00PM

Infantiles Bromoderm unter antikonvulsiver Therapie

(Source: JDDG)

Jan 31, 2012 09:00PM

Disseminierter chronisch‐diskoider Lupus erythematodes mit linearen Effloreszenzen entlang der Blaschko‐Linien an Unterarm und Hand

(Source: JDDG)

Jan 31, 2012 09:00PM

Neoplasien der Lippenregion: Retrospektive Analyse von 181 Fällen

(Source: JDDG)

Jan 31, 2012 09:00PM

Hyperhidrosis plantaris – randomisierter konzentrationsabhängiger Seitenvergleich zur Evaluation der Wirksamkeit und Verträglichkeit eines kosmetischen aluminiumchloridhexahydrathaltigen Antiperspirants

(Source: JDDG)

Jan 31, 2012 09:00PM

Liposuktion – ein operatives Verfahren in der Dermatologie

(Source: JDDG)

Jan 31, 2012 09:00PM

Medizinprodukte in der Dermatologie: Topische halbfeste Formulierungen zur Behandlung von Hauterkrankungen

(Source: JDDG)

Jan 31, 2012 09:00PM

In‐vitro‐Allergiediagnostik aktuell

(Source: JDDG)

Jan 31, 2012 09:00PM

Von Wurzeln und Flügeln

(Source: JDDG)

Jan 31, 2012 09:00PM

Mendelian traits causing susceptibility to mucocutaneous fungal infections in human subjects

Mucocutaneous candidiasis and dermatophyte infections occur either in isolation or alongside other symptoms in patients with various primary immunodeficiency diseases with diverse genetic defects, which result in impaired IL-17 immunity, IL-22 immunity, or both. In patients with chronic mucocutaneous candidiasis, disease-associated polymorphisms in DECTIN1 act on the level of fungal recognition, whereas mutations in caspase recruitment domain–containing protein 9 (CARD9) disturb the subsequent spleen tyrosine kinase 2–CARD9/BCL10/MALT1–driven signaling cascade, impairing nuclear factor κB–mediated maturation of antigen-presenting cells and priming of naive T cells to differentiate into the TH17 cell lineage. TH17-priming cytokines signal through the transcription factor signal tr...

Jan 31, 2012 03:00PM

Coriandrum sativum L. Protects Human Keratinocytes from Oxidative Stress by Regulating Oxidative Defense Systems

Skin Pharmacol Physiol 2012;25:93–99 (DOI:10.1159/000335257) (Source: Skin Pharmacology and Physiology)

Jan 31, 2012 03:00PM

Comparison of the Antiseptic Efficacy of Tissue-Tolerable Plasma and an Octenidine Hydrochloride-Based Wound Antiseptic on Human Skin

Skin Pharmacol Physiol 2012;25:100–106 (DOI:10.1159/000335558) (Source: Skin Pharmacology and Physiology)

Jan 31, 2012 09:00AM

Are All Itches The Same? - Probably Not

Gil Yosipovitch, M.D., Ph.D., professor of dermatology at Wake Forest Baptist Medical Center and a world-famous itch expert, who has proven the pleasure ability of itching in his previous studies, has now published a new study online in the British Journal of Dermatology ,in which he analyses itch relief at different sites on the body and the associated pleasure, showing that how good scratching an itch feels is related to the itch's location. Yosipovitch explained: "The goal of this study was to examine the role of the pleasurability of scratching in providing relief for itch... (Source: Health News from Medical News Today)

Jan 31, 2012 09:00AM

Children With Severe Burn Injuries Are At A Much Higher Risk Of Health Complications And Death

A study published Online First by The Lancet has found that children with burn injuries covering 60% or more of their total body surface area (TBSA) are at a much higher risk of experiencing severe complications or death. The authors urge the need for more attention to be given to such patients, with more vigilant and improved forms of therapy... (Source: Health News from Medical News Today)

Jan 31, 2012 06:49AM

Production of human tissue‐engineered skin trilayer on a plasma‐based hypodermis

In conclusion, we engineered a fully differentiated human skin trilayer that could present multiple applications such as use for in vitro drug absorption tests and regenerative therapies. Copyright © 2012 John Wiley & Sons, Ltd. (Source: Journal of Tissue Engineering and Regenerative Medicine)

Jan 31, 2012 05:15AM

Telemedicine boosting dermatology care

A study of nearly 1,500 patients who had teledermatology consultations shows improved clinical outcomes, with better diagnosis and disease management. (Source: American Medical News - PROFESSION)

Jan 31, 2012 05:00AM

Health Tip: Wash Skin Properly

To keep it clean and help prevent acne (Source: The Doctors Lounge - Dermatology)

Jan 31, 2012 12:01AM

Hidradenitis suppurativa and immune dysregulation.

Authors: Jemec GB PMID: 22268854 [PubMed - in process] (Source: The British Journal of Dermatology)

Jan 31, 2012 12:01AM

Retracing an old journey in variegate porphyria.

Authors: Badminton MN PMID: 22268855 [PubMed - in process] (Source: The British Journal of Dermatology)

Jan 31, 2012 12:00AM

Maintaining vitamin D status in winter with ultraviolet B.

Authors: Rhodes LE PMID: 22268856 [PubMed - in process] (Source: The British Journal of Dermatology)

Jan 31, 2012 12:00AM

Psoriasis: an evidence-based update. Report of the 9th Evidenced Based Update Meeting, 12 May 2011, Loughborough, U.K.

Authors: De Mozzi P, Johnston GA, Alexandroff AB Abstract The Centre of Evidence Based Dermatology, University of Nottingham, U.K. holds an annual Evidence Based Update (EBU) Meeting focused on important dermatological topics, which have in the past included eczema, urticaria, blistering disorders, skin infections, skin cancer and hair disorders. These one-day meetings aim to summarize the most recent evidence in the form of systematic reviews and recently completed clinical trials. This year, the 9th EBU meeting took place in Loughborough, U.K. on 12 May 2011 and was devoted to psoriasis. The latest updates on topical treatments, nail psoriasis, genetics and clinical implications, rational use of biologics, new and unpublished studies on combination of phototherapy and biologics f...

Jan 31, 2012 12:00AM

All Itches Are Not Equal

New research from Gil Yosipovitch, M.D., Ph.D., professor of dermatology at Wake Forest Baptist Medical Center and a world-renowned itch expert, shows that how good scratching an itch feels is related to the itch's location. While previous studies by Yosipovitch have shown the pleasurability of itching, analysis of itch relief at different body sites and related pleasurability had not been performed until now. The study was published online this month by the British Journal of Dermatology... (Source: Health News from Medical News Today)

Jan 30, 2012 11:00PM

Health Tip: Most Teens Don't Get Enough Sleep

Title: Health Tip: Most Teens Don't Get Enough SleepCategory: Health NewsCreated: 1/31/2012 8:05:00 AMLast Editorial Review: 1/31/2012 (Source: MedicineNet Skin General)

Jan 30, 2012 11:00PM

Health Tip: Wash Skin Properly

Title: Health Tip: Wash Skin ProperlyCategory: Health NewsCreated: 1/31/2012 8:05:00 AMLast Editorial Review: 1/31/2012 (Source: MedicineNet Skin General)

Jan 30, 2012 11:00PM

Erivedge Approved to Treat Basal Cell Carcinoma

Title: Erivedge Approved to Treat Basal Cell CarcinomaCategory: Health NewsCreated: 1/30/2012 4:06:00 PMLast Editorial Review: 1/31/2012 (Source: MedicineNet Skin General)

Jan 30, 2012 11:00PM

Rheumatoid Arthritis - When Do I Call the Doctor?

Title: Rheumatoid Arthritis - When Do I Call the Doctor?Category: Doctor's ViewsCreated: 7/7/2001 12:46:00 PMLast Editorial Review: 1/31/2012 (Source: MedicineNet Skin General)

Jan 30, 2012 09:00PM

Detection of a rare CDKN2A intronic mutation in a Hungarian melanoma‐prone family and its role in splicing regulation

AbstractThe genetic predisposition to melanoma is quite heterogeneous. The major locus for melanoma predisposition is the cell cycle regulatory CDKN2A gene on chromosome 9p21 though alterations in it have been detected in only 20 40% of melanoma prone families. However, with regard to the frequency of melanoma‐prone families linked to 9p21, the frequency of germline coding mutations of the CDKN2A gene is lower than expected. We set out to investigate whether the rare IVS1+37 G/C intronic mutation of the CDKN2A gene recently identified in a Hungarian melanoma prone family, influences mRNA splicing regulation. To this end, CDKN2A minigenes containing the wild type and the mutant intronic sequence were created and transfected into HeLa cells with the aim of study of the mRNA transcripts. Th...

Jan 30, 2012 09:00PM

Twenty Top Tips To Totally Triumph in Dermatology

(Source: British Journal of Dermatology)

Jan 30, 2012 09:00PM

The use of a hand held mirror to reduce litigation and improve communication in dermatological surgery

(Source: British Journal of Dermatology)

Jan 30, 2012 09:00PM

Aberrant Hypermethylation in Primary and Sentinel Lymph Node Metastases in Pediatric Cutaneous Melanoma Patients

Conclusions:  Differences in the methylation status of these TRGs in the SLN(+) pediatric and adult melanoma patients may account for why SLN(+) pediatric patients have different clinical outcomes. SLN biopsy should continue to be performed; within SLN(+) pediatric melanoma patients, hypermethylation of TRGs can be used to identify a subpopulation at highest risk for poor outcomes who warrant vigilant clinical follow‐up. (Source: British Journal of Dermatology)

Jan 30, 2012 08:00PM

Biologics in the Treatment of Moderate to Severe PsoriasisBiologics in the Treatment of Moderate to Severe Psoriasis

This study assessed the comparative effectiveness of five biologic agents currently approved in Europe for the treatment of moderate to severe psoriasis. How do they rank? The British Journal of Dermatology (Source: Medscape Today Headlines)

Jan 30, 2012 03:00PM

Alopecia Areata during Treatment of Psoriasis with Adalimumab and Leflunomide: A Case and Review of the Literature

Skin Pharmacol Physiol 2012;25:107–110 (DOI:10.1159/000335264) (Source: Skin Pharmacology and Physiology)

Jan 30, 2012 05:25AM

Immature muscle precursors are a source of interferon‐β in myositis: Role of Toll‐like receptor 3 activation and contribution to HLA class I up‐regulation

ConclusionImmature muscle precursors may represent a local source of IFNβ and the target of an immune response involving activated DCs associated with the expression of CLRs and of IL‐12 and IL‐23, which are implicated in T cell polarization. In turn, such local production of IFNβ after TLR‐3 activation in the presence of the Th1 cytokine IFNγ may explain HLA class I overexpression in myositis. (Source: Arthritis and Rheumatism)

Jan 30, 2012 05:25AM

Myositis‐specific anti‐155/140 autoantibodies target transcription intermediary factor 1 family proteins

ConclusionAnti‐155/140 antibodies target TIF‐1 family proteins, TIF‐1α and TIF‐1β, in addition to TIF‐1γ. Since TIF‐1 proteins have significant roles in oncogenesis, these antibodies may be produced during misdirected antitumor immunity. (Source: Arthritis and Rheumatism)

Jan 30, 2012 05:24AM

Autoantibodies to transcription intermediary factor 1 in dermatomyositis shed insight into the cancer–myositis connection

(Source: Arthritis and Rheumatism)

Jan 30, 2012 05:00AM

Health Tip: How to Protect Toddlers From Burns

Precautions include keeping child out of kitchen while you're cooking (Source: The Doctors Lounge - Dermatology)

Jan 30, 2012 12:00AM

New Findings On Aging Pediatric Bruises Published By Notre Dame Researchers

A multi-university research group which includes several University of Notre Dame faculty and graduate students, has recently published a paper detailing new work on the analysis and dating of human bruises. The research, which is funded by the Gerber Foundation, will have particular application to pediatric medicine, as bruise age is often key evidence in child abuse cases... (Source: Health News from Medical News Today)

Jan 29, 2012 11:00PM

Health Tip: How to Protect Toddlers From Burns

Title: Health Tip: How to Protect Toddlers From BurnsCategory: Health NewsCreated: 1/30/2012 8:05:00 AMLast Editorial Review: 1/30/2012 (Source: MedicineNet Skin General)

Jan 29, 2012 10:28PM

Desmoplastic trichoepithelioma with perineural involvement: a series of seven cases.

We present a series of seven desmoplastic trichoepitheliomas with otherwise typical presentation and morphology, nevertheless demonstrating epithelium present in the perineural spaces of adjacent small dermal nerves. Patients ranged in age from 14 to 66 years (mean 44 years). All seven tumors were restricted to dermis, showed strands of basaloid epithelium in desmoplastic stroma, and contained CK20‐positive cells. Additionally, five of five examined tumors displayed diffuse expression of p75 neurotrophin receptor. Five patients were followed‐up clinically (follow‐up time range: 2 months ‐ 4 years). No tumor recurrence was observed in any of these patients. We postulate that perineural involvement is an unusual feature of desmoplastic trichoepithelioma that should not be equated wit...

Jan 29, 2012 09:00PM

Compartment Syndrome of the Lower Leg After Punch Biopsy

(Source: Dermatologic Surgery)

Jan 29, 2012 09:00PM

A Randomized, Blinded Clinical Evaluation of a Novel Microwave Device for Treating Axillary Hyperhidrosis: The Dermatologic Reduction in Underarm Perspiration Study

ConclusionsThe procedure demonstrated statistically significant, long‐term efficacy in sweat reduction. As with any new procedure, findings from this first investigational device study identified optimization strategies for the future. (Source: Dermatologic Surgery)

Jan 29, 2012 09:00PM

Staged Trilobe Pedicle Flap to Repair a Large Cutaneous Lip and Nasal Vestibule Defect

(Source: Dermatologic Surgery)

Jan 29, 2012 09:00PM

Dermatofibrosarcoma Protuberans: A Review of the Literature

ConclusionFor DFSP, MMS is associated with a lower rate of recurrence than WLE and is particularly useful for tumors on the head and neck. Imatinib is used in advanced disease and may take on a larger role in the treatment of DFSP in the future. (Source: Dermatologic Surgery)

Jan 29, 2012 09:00PM

Platelet‐Rich Plasma Combined with Fractional Laser Therapy for Skin Rejuvenation

ConclusionPRP with fractional laser treatment is a good combination therapy for skin rejuvenation. Keratinocyte and fibroblast proliferation and collagen production can explain the capacity of PRP to increase dermal elasticity. (Source: Dermatologic Surgery)

Jan 29, 2012 09:00PM

Which Type of Earring and Which Piercing Point Is Safest with Regard to Tearing Through the Ear by an External Force?

ConclusionThe 4‐mm point is recommended for hoops, buckles, and studs, and the 8‐mm point or higher is recommended for screws and hooks. (Source: Dermatologic Surgery)

Jan 29, 2012 09:00PM

Novel Approach to Decreasing Tension When Approximating Wound Edges in Advancement Flaps: The ImPli Stitch

(Source: Dermatologic Surgery)

Jan 29, 2012 09:00PM

Advanced Treatment Modalities for Vitiligo

ConclusionOur ability to treat vitiligo may be imperfect, but through appropriate patient selection and careful application of one or more of these advanced therapies, successful treatment of vitiligo, even in patients refractory to treatment, can be achieved. (Source: Dermatologic Surgery)

Jan 29, 2012 09:00PM

Comparison of V-Loc™ 180 wound closure device and Quill™ PDO knotless tissue-closure device for intradermal closure in a porcine in vivo model: Evaluation of biomechanical wound strength.

CONCLUSIONS: In this study, V-Loc™ 180 device was significantly stronger than Quill™ PDO device during the critical phases of wound healing in skin. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2012. PMID: 22287058 [PubMed - as supplied by publisher] (Source: Biomed Res)

Jan 29, 2012 09:00PM

Appropriate Time for Test-of-Cure when Diagnosing Gonorrhoea with a Nucleic Acid Amplification Test.

Authors: Hjelmevoll SO, Olsen ME, U J, Haaheim H, Melby KK, Moi H, Unemo M, Skogen V Abstract Culture is commonly regarded as the gold standard for diagnosis of Neisseria gonorrhoeae. However, nucleic acid amplification tests (NAATs) have rapidly replaced culture for diagnostics in many settings. The aim of the present study was to investigate the appropriate time for test-of-cure (TOC) when NAATs are used for diagnosis of gonorrhoea. In total, 30 patients (28 men and 2 women) provided urethral, cervical, rectal or pharyngeal specimens for TOC. All included patients, except one who did not return for second TOC before day 19, tested negative within 2 weeks after treatment with cefixime 400 mg × 1. Antimicrobial susceptibility testing showed that 68% of the culture-positive str...

Jan 29, 2012 08:00PM

How Effective Is Melanoma Screening?How Effective Is Melanoma Screening?

In this large study, melanoma mortality dropped significantly in one German state after a population-wide screening project, while mortality rates remained stable in the rest of the country. Journal Watch (Source: Medscape Today Headlines)

Jan 29, 2012 03:00PM

Erratum

Skin Pharmacol Physiol 2012;25:110 (DOI:10.1159/000336502) (Source: Skin Pharmacology and Physiology)

Jan 29, 2012 10:41AM

Neuropathy Dermatitis following Surgical Nerve Injury

Conclusions. Neuropathy dermatitis is apparently a new variant of dermatitis that follows nerve cut during surgery. (Source: Advances in Pharmacological Sciences)

Jan 29, 2012 10:00AM

Stealthy leprosy pathogen evades critical vitamin D-dependent immune response

A team of UCLA scientists has found that the pathogen that causes leprosy has a remarkable ability to avoid the human immune system by inhibiting the antimicrobial responses important to our defenses.   In one of the first laboratory studies of its kind, researchers discovered that the leprosy pathogen Mycobacterium leprae was able to reduce and evade immune activity that is dependent on vitamin D, a natural hormone that plays an essential role in the body's fight against infections.    The pathogen manipulated micro-RNAs, tiny molecules made of ribonucleic acids that carry information and that help regulate genes to direct cell activity, including immune system defenses. Micro-RNAs are short RNAs that do not code information for proteins, which carry out all cell activity; ...

Jan 29, 2012 09:57AM

Announcement

(Source: Journal of the European Academy of Dermatology and Venereology)

Jan 29, 2012 09:57AM

Announcements

(Source: Journal of the European Academy of Dermatology and Venereology)