Dr. William Ting, Board-Certified Dermatologist
at California Dermatology Care

2262 Camino Ramon, San Ramon, CA 94583
Tel: 925-328-0255
Email: staff@CalDermCare.com


Advanced Care with a Personal Touch

   

 

 

Medical Dermatology    Evidence-based medicine   Customized solution   Personal care

Latest Dermatology Headlines

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(email staff to get your personal passcode)

* Patient Biopsy Results via LabCalls


MEDICAL DERMATOLOGY

Acne and Acne Scar

Excimer Laser for Psoriasis & Vitiligo

Keloid & Hypertrophic Scar Laser Therapy

Mohs Surgery for Skin Cancers

Nail Fungus GenesisPlus Laser Therapy

Photodynamic Therapy

Psoriasis & NBUVB Phototherapy

RadioTherapy Nonsurgical SRT-100 for Skin Cancer

Skin Allergy Patch Test

Sweating Disorder MiraDry for Hyperhidrosis

Wart Laser Therapy


COSMETIC DERMATOLOGY

Aesthetician Services
Microdermabrasion
 

Botox, Dysport & Xeomin

Cellulaze Cellulite Therapy

new! CoolSculpting

Facial Redness/Vein Laser Therapy

Fillers injection for Wrinkles

Fractional CO2 laser

new! Hair Transplant with Neograft

Laser Surgery Services
Acne/Pore reducing Laser
Collagen Stimulating Laser
Excimer Laser
Facial Veins laser
Hair Laser Removal
IPL Fotofacial
Melasma Laser
Nail Fungus Laser
Resurfacing Laser
Scar revision Laser
SmartLipo Laser
Tattoo Laser
VBeam Pulse Dye Laser
Wart Laser


Latisse

Leg Vein Laser Therapy & Asclera Sclerotherapy

Liposonix + Vaser Shape Nonsurgical Body Sculpting
 

Melasma and Pigmentation

Pore Size Reduction and Laser Rejuvenation

Sculptra Liquid Facelift

new! SideLaze Lift

SmartLipo Laser Tumescent Liposuction

Ulthera natural lift & skin tightening of face and neck


Related Websites
FaceUpLifting.com
iSmartLipo.com
iCellulaze.com
MoreHair4Me.com
SideLazeLift.com
SonixLipo.com


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Dr. William Ting has expertise in treating the entire spectrum of medical dermatology, with emphasis in preventive medicine and personalized recommendations. He enjoys taking care of patients with acne, eczema, hair and nail disorders, rashes, psoriasis and skin cancers.

He is at the forefront of medical dermatology and dermatologic research. He continues to publish articles in peer-reviewed dermatology journals. He is an early pioneer of photodynamic therapy (PDT) and one of the most experienced practitioners of PDT in the Bay Area. He is the first dermatologist in the San Francisco Bay Area and Northern California to introduce Lutronic Spectra Laser for melasma, acne, scar revision, pore size reduction as well as the Cutera GenesisPlus laser for advanced nail fungus laser treatment, keloid and hypertrophic scar, warts and scar revision.

Dr. Ting is a fellow of the American Academy of Dermatology (AAD) and American Society of Dermatologic Surgery (ASDS). He is a member of the National Psoriasis Foundation and International Hyperhidrosis Society.

Innovative Therapeutic Approach to Common Skin Conditions

Acne

Eczema (Atopic Dermatitis)

Hair and Nail disorders

  • Maximize therapeutic synergy and efficacy by utilizing both prescription-strength and over-the counter products when available
  • Comprehensive workup including bloodwork and biopsy if necessary
  • Systemic oral hormonal therapy for women and men when indicated

Psoriasis 

Rosacea

  • Multi-prong approach to minimize redness
  • Low-dose 'non-antibiotic' anti-inflammatory oral medication for long-term remission 
  • Emphasis on prevention
  • Fotofacial/IPL laser utilizing Cynosure XPL/Elite MPX
  • Cutera GenesisPlus Laser with or without combination with IPL 
  • Diode laser for facial veins
  • VBeam Pulse Dye Laser, the new gold standard for rosacea and facial redness

Skin Cancer 

  • Emphasis on prophylactic treatments with topical 5-FU, imiquimod, diclofenac, ingenol mebutate and oral chemopreventive therapy such as Soriatane.
  • Reduce future risks of skin cancer with photodynamic therapy, TCA chemical peels and/or fractional CO2 resurfacing laser  
  • Mohs Surgery to achieve highest cure rate and tissue sparing
  • Close colloboration with plastic surgeon(s) as needed  

Sweating Disorder (Hyperhidrosis) 

Vitiligo

Warts 


ABCD of Mole Check

 

 

Common Medical Dermatology Diagnostics and Therapeutics:

Dermatology Links:

American Academy of Dermatology
American Society of Dermatologic Surgery
American Society of Mohs Surgery
International Hyperhidrosis Society
National Psoriasis Foundation

 Latest Dermatology Headlines:

Latest Dermatology Headlines
Tue, 29 Jul 2014 08:30:21 +0100

http://www.medworm.com/rss/index.php/Dermatology/12/

Jul 29, 2014 12:29AM

Pyoderma gangrenosum, acne, psoriasis, arthritis and suppurative hidradenitis (PAPASH)?syndrome: a new entity within the spectrum of autoinflammatory syndromes?

(Source: Journal of the European Academy of Dermatology and Venereology)

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Jul 29, 2014 12:26AM

The first skin cancer screening day at the Italian parliament: a Euromelanoma initiative

ConclusionsThe considerable suspicion rate produced by this screening is justified by the particular demographics of the study population. Italian members of parliament display sun?seeking behaviors similar to those previously described in the general public. Increasing politicians? attention on skin cancer is vital for sufficient resources to be allocated to prevention strategies. Expert medical groups and politicians should cooperate to create a proper, integrated policy on skin cancer. (Source: International Journal of Dermatology)

Jul 28, 2014 04:00PM

Tacrolimus 0.1% ointment in the treatment of allergic contact dermatitis: a new approach

(Source: International Journal of Dermatology)

Jul 28, 2014 04:00PM

Melanoma manifesting as a verrucous lesion in the interdigital toe space

(Source: International Journal of Dermatology)

Jul 28, 2014 04:00PM

The human skin microbiome

(Source: International Journal of Dermatology)

Jul 28, 2014 04:00PM

Diagnostic imaging in paraneoplastic autoimmune multiorgan syndrome: retrospective single site study and literature review of 225 patients

ConclusionDiagnostic imaging is frequently utilized in PAMS with unknown malignancy. Both conventional CT and 18F?FDG PET/CT are likely to detect the typical underlying neoplasms. Relative to conventional CT, 18F?FDG PET/CT may provide additional useful information regarding prognosis for the likely underlying malignancies, although there is a paucity of reports describing the use of this modality for this purpose. (Source: International Journal of Dermatology)

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Jul 28, 2014 04:00PM

The significance of hypersensitivity to autologous sweat and serum in cholinergic urticaria: cholinergic urticaria may have different subtypes

ConclusionsThe frequency of hypersensitivity to autologous sweat and serum was significantly higher in patients with ChU, compared with healthy controls. This suggests that autoimmunity to an unknown serum factor as well as sweat hypersensitivity may be involved in the pathogenesis of ChU. (Source: International Journal of Dermatology)

Jul 28, 2014 04:00PM

Kava dermopathy in Fiji: an acquired ichthyosis?

Summary Kava dermopathy is a common cutaneous effect of regular or heavy use of Kava, a psychoactive beverage consumed widely throughout the Pacific. In Fiji in 2012, over 1000 study participants underwent full skin examination, and kava dermopathy was a common cutaneous finding. The clinical manifestations of kava dermopathy share similarities with the spectrum of autosomal recessive congenital ichthyoses, predominantly lamellar ichthyosis. The pathogenesis of Kava dermopathy may be associated with a functional defect in one or more cytochrome P450 enzymes implicated in epidermal integrity, thus mimicking the genetic defect as seen in lamellar ichthyosis type 3. (Source: International Journal of Dermatology)

Jul 28, 2014 04:00PM

Azathioprine as a therapeutic alternative for refractory chronic urticaria

ConclusionAzathioprine should be considered as a therapeutic option for chronic, steroid?dependent urticaria, refractory to other treatments. (Source: International Journal of Dermatology)

Jul 28, 2014 04:00PM

A time course study about gene expression of post?thermal injury with DNA microarray

ConclusionOur findings are beneficial for understanding the progression of the wound healing response after burn. (Source: International Journal of Dermatology)

Jul 28, 2014 04:00PM

Clinical differences between early? and late?onset psoriasis in Thai patients

ConclusionsThe present study supports the hypothesis that there are clinical differences between EOP and LOP in Asian populations. (Source: International Journal of Dermatology)

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Jul 28, 2014 04:00PM

Superimposed linear lichen planus in a 4?year?old girl

(Source: International Journal of Dermatology)

Jul 28, 2014 04:00PM

Capillary malformation in the lumbosacral region as a clinical sign of occult spinal dysraphism

(Source: International Journal of Dermatology)

Jul 28, 2014 04:00PM

Tunneling hair syndrome: a description of a new entity

(Source: International Journal of Dermatology)

Jul 28, 2014 04:00PM

Facial myiasis and canthariasis associated with systemic lupus panniculitis: a case report

ConclusionThis is the first report on facial canthariasis due to larval stages caused by two species of beetles and recovery of pupal stages of the common green bottle fly. (Source: International Journal of Dermatology)

Jul 28, 2014 04:00PM

Trichomonas vaginalis: unusual presentation with ulcerative lesions

(Source: International Journal of Dermatology)

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Jul 28, 2014 12:52PM

Polysome Profiling Shows the Identity of Human Adipose-Derived Stromal/Stem Cells in Detail and Clearly Distinguishes Them from Dermal Fibroblasts

Stem Cells and Development , Vol. 0, No. 0. (Source: Stem Cells and Development)

Jul 28, 2014 10:57AM

Autoantibodies against TIF?1?? and CADM?140 in Spanish patients with clinically amyopathic dermatomyositis (CADM): clinical significance and diagnostic utility

ConclusionThere is an association between cancer?associated myositis and interstitial lung diseases and their hallmark autoantibodies in our cohort. In addition, the combined determination of myositis?specific autoantibodies and SSA autoantibodies may help to accurately discriminate SCLE from CADM. (Source: Journal of the European Academy of Dermatology and Venereology)

Jul 28, 2014 10:55AM

Comparative study of maximum likelihood and spectral angle mapper algorithms used for automated detection of melanoma

BackgroundMelanoma is a leading fatal illness responsible for 80% of deaths from skin cancer. It originates in the pigment?producing melanocytes in the basal layer of the epidermis. Melanocytes produce the melanin (the dark pigment), which is responsible for the color of skin. As all cancers, melanoma is caused by damage to the DNA of the cells, which causes the cell to grow out of control, leading to a tumor, which is much more dangerous if it cannot be found or detected early. Only biopsy can determine exact malformation diagnosis, although it can rise metastasizing. When a melanoma is suspected, the usual standard procedure is to perform a biopsy and to subsequently analyze the suspicious tissue under the microscope. MethodsIn this paper, we provide a new approach using methods known ...

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Jul 28, 2014 10:55AM

Coexistence effect of UVA absorbers to increase their solubility and stability of supersaturation

This article is protected by copyright. All rights reserved. (Source: International Journal of Cosmetic Science)

Jul 28, 2014 03:55AM

Bazex syndrome (acrokeratosis paraneoplastica)

(Source: Clinical And Experimental Dermatology)

Jul 27, 2014 10:04PM

Omalizumab Effective for Chronic Hives up to 24 WeeksOmalizumab Effective for Chronic Hives up to 24 Weeks

The 300-mg dose of omalizumab was most effective compared with placebo, but symptoms recur after treatment is discontinued. Medscape Medical News (Source: Medscape Medical News Headlines)

Jul 27, 2014 04:00PM

From experimental design to functional gene networks: DNA microarray contribution to skin aging research

This article is protected by copyright. All rights reserved. (Source: International Journal of Cosmetic Science)

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Jul 27, 2014 04:00PM

Evaluation of Soy?Based Surface Active Copolymers as Surfactant Ingredients in Model Shampoo Formulations

ConclusionSBPS?based formulations meet major requirements of multifunctional shampoos ? mild detergency, foaming, good conditioning, and aesthetic appeal, which are comparable to commercially available shampoos.In addition, examination of SBPS/SLS mixtures in model shampoos showed that the presence of the SBPS enables the concentration of SLS to be significantly reduced without sacrificing shampoo performance.This article is protected by copyright. All rights reserved. (Source: International Journal of Cosmetic Science)

Jul 27, 2014 04:00PM

American Board of Dermatology Examination Dates

(Source: Journal of Cutaneous Pathology)

Jul 27, 2014 04:00PM

Correlation of CXCL10, Tumor Necrosis Factor Receptor Type II, and Galectin 9 With Disease Activity in Juvenile Dermatomyositis

ConclusionOur findings indicate that CXCL10, TNFRII, and galectin 9 correspond to disease status in juvenile DM and thus could be helpful in monitoring disease activity and guiding treatment. Furthermore, they might provide new knowledge about the pathogenesis of this autoimmune disease. (Source: Arthritis and Rheumatism)

Jul 27, 2014 04:00PM

Human T-cell leukemia virus type 1 and Foxp3 expression: viral strategy in vivo

Human T-cell leukemia virus type 1 (HTLV-1) is the causal agent of adult T-cell leukemia (ATL) and inflammatory diseases, including HTLV-1-associated myelopathy/tropical spastic paraparesis, uveitis and infective dermatitis. However, it remains to be elucidated how HTLV-1 induces both neoplastic and inflammatory diseases. A critical component in the Treg-cell machinery is the transcription factor Forkhead box P3 (Foxp3), which is expressed in ~5% of CD4+ T cells of healthy individuals. Foxp3 is expressed in around 80% of ATL cases. Recent studies point to the capacity of Treg cells to convert to other cell types, even to those with an inflammatory phenotype. These characteristics might indicate that Treg cells might be playing a critical role in HTLV-1 infection, either by being targeted b...

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Jul 27, 2014 04:00PM

Langerhans cells promote early germinal center formation in response to Leishmania?derived cutaneous antigens

In conclusion this study reveals an indispensable role for LCs in promoting GC B?cell differentiation following cutaneous infection with L. major parasites. We propose that LCs are key regulators of GC formation and therefore have broader implications for the development of allergies and autoimmunity as well as for future vaccination strategies. This article is protected by copyright. All rights reserved (Source: European Journal of Immunology)

Jul 27, 2014 04:00PM

Immunofluorescence mapping (IFM) in inherited epidermolysis bullosa ? A study of eighty?six cases from India

ConclusionThis is the first large study of immunofluorescence mapping in the subtypes of EB in Indian patients. The study provides a framework for better understanding of EB in Indian patients and for a better diagnosis and management particularly in the infantile period.This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)

Jul 27, 2014 04:00PM

Treatment monitoring of topical ingenol mebutate in actinic keratoses with the combination of optical coherence tomography and reflectance confocal microscopy: a case series

This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)

Jul 27, 2014 04:00PM

Treatment of recalcitrant warts with intralesional measles, mumps, and rubella vaccine: a promising approach

ConclusionsIntralesional immunotherapy by MMR vaccine is a promising, effective, and safe treatment modality for recalcitrant warts. (Source: International Journal of Dermatology)

Jul 27, 2014 04:00PM

Primary cutaneous balloon cell melanoma: a very rare variant

(Source: International Journal of Dermatology)

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Jul 27, 2014 04:00PM

Metastatic gastric signet ring cell carcinoma clinically mimicking radiation recall dermatitis

(Source: International Journal of Dermatology)

Jul 27, 2014 04:00PM

Prevalence and risk factors for skin diseases among antiretroviral?naïve HIV?infected pregnant women in Dar es Salaam, Tanzania

ConclusionThe burden of skin diseases was relatively low. Advanced HIV stage was associated with a range of skin conditions. CD4+ cell count was not related to skin infection prevalence. (Source: International Journal of Dermatology)

Jul 27, 2014 04:00PM

Treatment of lower extremity telangiectasias in women by foam sclerotherapy vs. Nd:YAG laser: a prospective, comparative, randomized, open?label trial

ConclusionTelangiectasias of the lower extremities can be successfully treated with either synchronized long?pulsed Nd:YAG laser or sclerotherapy. The 1064?nm long?pulsed Nd:YAG laser is associated with more pain and is suitable especially in case of needle phobia, allergy to sclerosants and in presence of small veins with telangiectatic matting, while sclerotherapy can also treat the feeder veins. (Source: Journal of the European Academy of Dermatology and Venereology)

Jul 27, 2014 03:00PM

Reata begins patient enrolment in Phase II radiation dermatitis trial of RTA 408

US-based biopharmaceutical firm Reata Pharmaceuticals has enrolled the first patient in a Phase II dose-ranging trial of RTA 408 Lotion in breast cancer patients at risk for radiation dermatitis. (Source: Drug Development Technology)

Jul 26, 2014 04:00PM

ABCC6- a new player in cellular cholesterol and lipoprotein metabolism?

Conclusion: Increased cholesterol biosynthesis, elevated PCSK9 levels and reduced APOE mRNA expression newly found in PXE fibroblasts could enforce atherogenesis and cardiovascular risk in PXE patients. Moreover, the increase in ABCC6 expression accompanied by the induction of cholesterol biosynthesis supposes a functional role for ABCC6 in human lipoprotein and cholesterol homeostasis. (Source: Lipids in Health and Disease)

Jul 26, 2014 04:00PM

Cole disease: a case report and literature review

(Source: Journal of the European Academy of Dermatology and Venereology)

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Jul 26, 2014 04:00PM

Physician perceptions and experience of current treatment in actinic keratosis

ConclusionsThe research clarifies the challenges associated with prescribing topical AK therapy and highlights that short treatment duration and rapid clearance of skin reactions are key considerations for physicians. This provides a basis for the generation of recommendations for improving the real?world efficacy of topical therapy. (Source: Journal of the European Academy of Dermatology and Venereology)

Jul 26, 2014 04:00PM

Contact allergy to biguanides might explain cases of unresolved eyelid dermatitis

(Source: Journal of the European Academy of Dermatology and Venereology)

Jul 26, 2014 04:00PM

Defective basement membrane in atopic dermatitis and possible role of IL?13

(Source: Journal of the European Academy of Dermatology and Venereology)

Jul 26, 2014 04:00PM

Pigmentary demarcation lines of pregnancy in two Caucasian women

(Source: Journal of the European Academy of Dermatology and Venereology)

Jul 26, 2014 03:31PM

Monthly changes in hair growth parameters of Chinese subjects, observed along a full year

ConclusionData confirm that Chinese hairs present characteristics of the most developed and fast growing terminal fibres, as compared to other non Asian ethnics.This article is protected by copyright. All rights reserved. (Source: International Journal of Cosmetic Science)

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Jul 26, 2014 06:49AM

Chronic Hand Infections

Chronic infections of the hand are uncommon, and a high index of suspension is required for their early diagnosis. These can be grouped based on the microorganism. Mycobacterial infections include tuberculosis, atypical mycobacterial infections, and leprosy. Other bacterial infections include actinomycosis, cat-scratch disease, syphilis, tularemia, bacillary angiomatosis, and actinomycetoma. Fungal infections may be classified as cutaneous (affecting the skin, the paronychia or nail plate), subcutaneous (mainly lymphocutaneous sporotrichosis and dermatiaceous infections), and deep fungal infections. (Source: The Journal of Hand Surgery)

Jul 26, 2014 05:14AM

Denver's a top 10 city for people to look younger longer

Sure, Forbes recently ranked Denver as one of the top five cities in the nation for businesses, but did you know Denverites are also lucky enough to live in one of the best places to stay looking younger longer? Yep, according to RealSelf, an online community that consolidates and shares information about cosmetic surgery, dermatology, dentistry and other elective treatments, the Mile High City is the No. 5 best city to thwart those pesky wrinkles and other effects of aging. Click the image? (Source: bizjournals.com Health Care:Pharmaceuticals headlines)

Jul 26, 2014 03:51AM

6:2 Fluorotelomer iodide in vitro metabolism by rat liver microsomes: Comparison with [1,2-(14)C] 6:2 fluorotelomer alcohol.

Authors: Ruan T, Sulecki LM, Wolstenholme BW, Jiang G, Wang N, Buck RC Abstract 6:2 Fluorotelomer iodide [6:2 FTI, F(CF2)6CH2CH2I] is the industrial raw material used to manufacture 6:2 fluorotelomer alcohol [6:2 FTOH, F(CF2)6CH2CH2OH] and 6:2 FTOH-based products. During its manufacture and industrial use, workers may be exposed to via oral, dermal or inhalation of 6:2 FTI. Therefore it is useful to understand how 6:2 FTI may be metabolized and into what transformation products. 6:2 FTI in vitro rat liver microsomal metabolism was explored for the first time to compare its biotransformation potential with that of [1,2-(14)C] 6:2 FTOH [F(CF2)6(14)CH2(14)CH2OH]. 6:2 FTI and 6:2 FTOH metabolite yields were determined in closed-bottle systems using Sprague Dawley and Wistar Han rat mic...

Jul 26, 2014 03:50AM

Cancer risk of polycyclic aromatic hydrocarbons (PAHs) in the soils from Jiaozhou Bay wetland.

This study provides a comprehensive risk assessment on carcinogenic PAHs in Jiaozhou Bay wetland soils, and might be useful in providing potential strategies of cancer risk prevention and controlling. PMID: 25048918 [PubMed - in process] (Source: Chemosphere)

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Jul 26, 2014 12:34AM

Acute UVB?induced epidermal changes assessed by multiphoton laser tomography

ConclusionThus, the study has shown that typical epidermal changes induced by acute UVB irradiation can be evaluated by MPT. (Source: Skin Research and Technology)

Jul 25, 2014 04:00PM

The effects of water exposure on biophysical properties of normal skin

ConclusionWater exposure increases the TEWL and pH of normal skin. Future studies evaluating the durability of the increased TEWL through monitoring the time course of events following skin immersion in water and susceptibility of skin to chemical irritants are required. (Source: Skin Research and Technology)

Jul 25, 2014 04:00PM

Identification of a soft tissue filler by ex vivo confocal microscopy and Raman spectroscopy in a case of adverse reaction to the filler

ConclusionThese results suggest that ex vivo RCM and RS are additional tools to conventional histopathologic examination to characterize soft tissue fillers in case of adverse reaction. RCM has the advantage compared with the histopathologic examination that can be extemporaneously performed on a fresh surgical specimen. RS allow a precise chemical identification of the filler. (Source: Skin Research and Technology)

Jul 25, 2014 04:00PM

Non?invasive assessment of cutaneous wound healing using fluorescent imaging

ConclusionAn in vivo optical system is a very useful tool for the detection of genes, proteins, and small?molecule drugs inside living animals, and this imaging modality can also be adopted for real?time visualization of cancer cell metastasis in live animals. (Source: Skin Research and Technology)

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Jul 25, 2014 04:00PM

Patients with tattoo reactions have reduced quality of life and suffer from itch

Conclusion/DiscussionSufferers of tattoo reactions have reduced quality of life and are often burdened by itching attaining the level of other cumbersome afflictions recognized as dermatological diseases associated with itch. Tattoo reactions warrant diagnosis and treatment with same professional intent shared with other skin diseases. (Source: Skin Research and Technology)

Jul 25, 2014 04:00PM

Imaging wavelength and light penetration depth for water content distribution measurement of skin

Background/purposeWe investigate the measurement sensitivity for the water content distribution in Near?infrared (NIR) imaging ranging up to 2 ?m. MethodsTo evaluate the sensitivity, our attention is focused to the light penetration depth in the skin tissue because the thickness of a layer where the water content can be varied is very thin and deep light penetration decreases the signal variation. The light penetration depths in the wavelengths of 1300, 1450, and 1920 nm are calculated theoretically based on the Monte Carlo light transport simulation. ResultsIt is clarified that the wavelength of 1920 nm gives the smallest penetration depth. A NIR imaging experiment is demonstrated to verify the difference of imaging sensitivity. The experiment result shows that the NIR image taken a...

Jul 25, 2014 04:00PM

Optical coherence tomography applied to tests of skin care products in humans ? a case study

ConclusionBy using the OCT technique, it was possible to quantify changes in skin roughness and in the distribution of depths of skin wrinkles, with adequate sensitivity. OCT imaging allows the direct visualization of the skin topography with resolution of micrometers, a reliable and interactive tool for clinical use. Therefore, for the first time, we demonstrated the use of OCT technique to verify the efficacy of cosmetic products in real time. (Source: Skin Research and Technology)

Jul 25, 2014 04:00PM

Phased?array of microcoils allows MR microscopy of ex vivo human skin samples at 9.4 T

ConclusionThis study demonstrates that MR microscopy on skin biopsies can be applied at low cost on a standard animal MR imaging system. The successful imaging of different skin structures ex vivo is a prerequisite for non?invasive, in vivo application of skin MR microscopy for accurate complementary disease diagnosis in dermatology. (Source: Skin Research and Technology)

Jul 25, 2014 04:00PM

CD271 is expressed in melanoma with more aggressive behavior with correlation of characteristic morphology in in vivo reflectance confocal microscopy.

ConclusionIn the hypothesis that dedifferentiated cells would be strongly responsible for initiation of tumor development and progression, we propose that CD271 detection could be associated with RCM evaluation in order to detect more aggressive melanoma subtypes.This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)

Jul 25, 2014 04:00PM

Vemurafenib skin phototoxicity is indirectly linked to UVA?MED decrease

Conclusionsour study confirms that photosensitivity under vemurafenib was a UVA?phototoxicity reaction, and our results suggest that a metabolite of vemurafenib rather than the parent molecule is involved in this phototoxicity.This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)

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Jul 25, 2014 04:00PM

Photodynamic therapy versus topical imiquimod for treatment of superficial basal cell carcinoma: a subgroup analysis within a non?inferiority randomised controlled trial

ConclusionsImiquimod remains the first choice treatment for sBCC in terms of effectiveness. In older patients with sBCC on the lower extremities MAL?PDT might be preferred. Results should be interpreted carefully as subgroup analyses were exploratory and not driven by prior hypotheses.This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)

Jul 25, 2014 04:00PM

Blistering Time as a Parameter for the Strength of Dermal? Epidermal Adhesion: A Systematic Review and Meta? Analysis

This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)

Jul 25, 2014 04:00PM

Pyodermatitis?pyostomatitis vegetans and anti?BP180 autoantibodies: a casual association?

This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)

Jul 25, 2014 04:00PM

IgG4?related skin disease

This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)

Jul 25, 2014 04:00PM

Mechanisms of tumour vascularization in cutaneous malignant melanoma: clinical implications

Summary Malignant melanoma represents < 10% of all skin cancers but is responsible for the majority of skin?cancer?related deaths. Metastatic melanoma has historically been considered as one of the most therapeutically challenging malignancies. Fortunately, for the first time after decades of basic research and clinical investigation, new drugs have produced major clinical responses. Angiogenesis has been considered an important target for cancer treatment. Initial efforts have focused primarily on targeting endothelial and tumour?related vascular endothelial growth factor signalling. Here, we review different mechanisms of tumour vascularization described in melanoma and discuss the potential clinical implications. (Source: British Journal of Dermatology)

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Jul 25, 2014 04:00PM

Allergy to oxidized limonene and linalool is frequent in the U.K.

ConclusionsThis large, multicentre U.K. audit shows a significant rate of allergy to the hydroperoxides of limonene and linalool plus a high rate of irritant reactions. Testing to the oxidized forms alone captures the majority (97·0%; 411 of 422) of positive reactions; testing to nonoxidized terpenes appears to be less useful. We recommend that the hydroperoxides of limonene and linalool be added to an extended baseline patch test series. (Source: British Journal of Dermatology)

Jul 25, 2014 04:00PM

Factors Affecting Formulation Characteristics and Stability of Ascorbic Acid in Water?in?Oil Creams

ConclusionAmong all the formulations, the creams containing castor oil as emollient and glycerin as humectant showed minimum degradation as compared to the creams containing other excipients. FTIR studies indicated that there is no significant interaction between AA and CT in physical mixtures.This article is protected by copyright. All rights reserved. (Source: International Journal of Cosmetic Science)

Jul 25, 2014 04:00PM

Characterisation of a human epidermis model reconstructed from hair follicle keratinocytes and comparison with two commercially models and native skin

ConclusionORS cell?based reconstructed epidermis is a valid and reproducible model for human epidermis and it may be used to evaluate the effects of active substances and cosmetic formulations.This article is protected by copyright. All rights reserved. (Source: International Journal of Cosmetic Science)

Jul 25, 2014 04:00PM

The anti?inflammatory effect of cherry blossom extract (Prunus yedoensis) used in soothing skin care product

ConclusionCBE shows good anti?inflammatory effect in vitro and in vivo, and represents a promising functional ingredient in soothing skin care product by reducing skin inflammation.This article is protected by copyright. All rights reserved. (Source: International Journal of Cosmetic Science)

Jul 25, 2014 11:07AM

Comparative study on topical immunomodulatory and anti?inflammatory treatments for plasma cell vulvitis: long?term efficacy and safety

ConclusionsCP, FA/BM and TC are effective and safe in treating PCV, inducing both a rapid improvement of the disease, notably of symptoms, and stabilizing its control. (Source: Journal of the European Academy of Dermatology and Venereology)

Jul 25, 2014 11:06AM

The sweat matrix: a new perspective for drugs analysis

(Source: Skin Research and Technology)

Jul 25, 2014 09:20AM

Toxicity of Silver Nanoparticles to Human Dermal Fibroblasts on MicroRNA Level

(Source: Journal of Biomedical Nanotechnology)

Jul 24, 2014 10:42PM

Xerese for the Treatment of Herpes LabialisXerese for the Treatment of Herpes Labialis

What you need to know about Xerese, a topical combination acyclovir-hydrocortisone product for treating herpes labialis, commonly known as cold sores. What other therapies have proven effective? Skin Therapy Letter (Source: Medscape Today Headlines)

Jul 24, 2014 07:13PM

Gross Anatomy: Manicure by Gun Saves Nail

(MedPage Today) -- A BB gun accident turned out to be lucky for a 52-year-old man with treatment-related complications of polycythemia vera. (Source: MedPage Today Dermatology)

Jul 24, 2014 07:00PM

Fc? Receptors III and IV Mediate Tissue Destruction in a Novel Adult Mouse Model of Bullous Pemphigoid.

Authors: Schulze FS, Beckmann T, Nimmerjahn F, Ishiko A, Collin M, Köhl J, Goletz S, Zillikens D, Ludwig R, Schmidt E Abstract Bullous pemphigoid (BP) and epidermolysis bullosa acquisita are subepidermal autoimmune blistering diseases mediated by autoantibodies against type XVII collagen (Col17) and Col7, respectively. For blister formation, Fc-mediated events, such as infiltration of inflammatory cells in the skin, complement activation, and release of proteases at the dermal-epidermal junction, are essential. Although in the neonatal passive transfer mouse model of BP, tissue destruction is mediated by Fc? receptors (Fc?Rs) I and III, the passive transfer model of epidermolysis bullosa acquisita completely depends on Fc?RIV. To clarify this discrepancy, we developed a novel e...

Jul 24, 2014 04:00PM

Issue Information

(Source: Dermatologic Therapy)

Jul 24, 2014 04:00PM

Erratum

(Source: Dermatologic Therapy)

Jul 24, 2014 04:00PM

The utility of ancillary tests in monitoring cutaneous melanoma patients to detect visceral metastasis

(Source: Journal of the European Academy of Dermatology and Venereology)

Jul 24, 2014 04:00PM

Development and psychometric validation of the REFlective evaLuation of psoriasis Efficacy of Treatment and Severity (REFLETS) questionnaire: a common measure of plaque?type psoriasis severity and treatment efficacy for patients and clinicians

ConclusionREFlective evaLuation of psoriasis Efficacy of Treatment and Severity is a promising tool for assessing plaque?type psoriasis severity and treatment efficacy from patient and clinician perspectives. It may help to improve patient and clinician communication in treatment decision making. (Source: Journal of the European Academy of Dermatology and Venereology)

Jul 24, 2014 04:00PM

Pachydermoperiostosis genetic screening in Lebanese families uncovers a novel SLCO2A1mutation

(Source: Journal of the European Academy of Dermatology and Venereology)

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Jul 24, 2014 04:00PM

Scrotal cutaneous toxicity: an uncommon but important side?effect of sunitinib

(Source: Journal of the European Academy of Dermatology and Venereology)

Jul 24, 2014 04:00PM

Declarative titles in original research papers in dermatologic journals 1974?2014

(Source: Journal of the European Academy of Dermatology and Venereology)

Jul 24, 2014 04:00PM

Insulin?transferrin?selenium as an alternative to foetal serum for epidermal equivalents

ConclusionWe show that culture using the ITS medium appears as a viable replacement for FBS in the construction of epidermal equivalents, opening the way to signal transduction studies. Résumé ObjectifLes modèles de peaux reconstruites sont des outils performants pour l'étude des mécanismes mis en jeu au cours du développement, du vieillissement et de pathologies. Ces modèles ont connu diverses adaptations et perfectionnements avec notamment l'implémentation de plusieurs types cellulaires. Pour répondre aux contraintes du développement d'une peau reconstruite in vitro, le milieu de culture nécessite d'être réfléchi avec soin. Le facteur le plus répandu est le sérum de veau f?tal (SVF) qui présente la composition la plus complète et permet d'apporter en une fois les fact...

Jul 24, 2014 04:00PM

Sun protection and hydration of stratum corneum: a study by 2?D differential method

ConclusionWe modelled sunscreens on different substrates using electromagnetic simulations. To compare these results with measurements, we have to carefully hydrate or dehydrate the SC: the simulations did not take into account modifications of the surface (water on the surface for example) or any change in the characteristics of the stratum corneum other than the modification of the corneocytes thickness. Résumé ObjectifLa stratum corneum est la couche la plus externe de la peau. Ses composants et sa morphologie (comme la taille de ses cellules) jouent un rôle dans la protection solaire. Il a ainsi été noté que l'hydratation de cette couche change ses propriétés de protection. Les crèmes solaires, appliquées sur la peau, peuvent être plus ou moins efficaces selon les caractér...

Jul 24, 2014 04:00PM

Chlorpyrifos and Cypermethrin Induce Apoptosis in Human Neuroblastoma Cell Line SH?SY5Y

Abstract Our previous in vivo studies showed that chlorpyrifos (CPF) and cypermethrin (CM) in a mixture dermally administered, strongly inhibited cholinesterase activity in plasma and the brain and were very toxic to the rat central nervous system. In this work, the mechanisms of neurotoxicity have not been elucidated. We used human undifferentiated SH?SY5Y cells to study mechanisms of pesticide?induced neuronal cell death. It was found that chlorpyrifos (CPF) and its mixture with cypermethrin (CPF+CM) induced cell death of SH?SY5Y cells in a dose? and time?dependent manner, as shown by MTT assays. Pesticide?induced SH?SY5Y cell death was characterized by concentration?dependent down?regulation of Bcl?2 and Bcl?xL as well as an increase in the caspase 3 activation. Pa...

Jul 24, 2014 04:00PM

Intracranial pathway for dermal lymphatic drainage

(Source: ANZ Journal of Surgery)

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Jul 24, 2014 04:00PM

Reflections on how wound healing?promoting effects of the hair follicle can be translated into clinical practice

This article is protected by copyright. All rights reserved. (Source: Experimental Dermatology)

Jul 24, 2014 04:00PM

Association of promoter polymorphism ?765G>C in the PTGS2 gene with malignant melanoma in Italian patients and its correlation to gene expression in dermal fibroblasts

This article is protected by copyright. All rights reserved. (Source: Experimental Dermatology)

Jul 24, 2014 07:38AM

Make the Diagnosis: Irritable Rash

(MedPage Today) -- A 40-year-old woman presents for a pruritic eruption in her scalp, around her eyes, on her chest, shoulders, and hands. She has had the rash for approximately two months. She notes generalized fatigue. ? She reports difficulty going up two flights of stairs to her apartment ? She is otherwise healthy, and takes no medications. (Source: MedPage Today Dermatology)

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Jul 24, 2014 03:32AM

Why Can't I Stop?

Dermatillomania, an extreme and compulsive grooming habit, can be debilitating for those who suffer from it. However, help is available for those who seek it. read more (Source: Psychology Today Addiction Center)

Jul 24, 2014 02:00AM

Histological spectrum of cutaneous herpes infections.

Authors: Hoyt B, Bhawan J Abstract : Herpes simplex virus and varicella zoster virus are double-stranded DNA viruses that commonly infect humans, resulting in cutaneous manifestations. Diagnosis is generally made based on clinical findings; however, when the presentation is atypical, biopsy can aid in making a correct diagnosis. The classic histopathological findings of herpetic infection are well established (acantholysis, ballooning degeneration, intranuclear inclusions, multinucleation, necrosis, and formation of vesicles or ulcers). Herpes infection can also cause histopathological changes in many dermal structures. Furthermore, herpes can masquerade as a variety of hematologic malignancies or benign cutaneous conditions. The histopathological spectrum of herpes infections is r...

Jul 23, 2014 04:00PM

Hypotrichosis associated with capillary malformation?arteriovenous malformation syndrome

ConclusionsRed punctate spots with pale halos or small telangiectasias are frequent findings in CM?AVM syndrome. Hypotrichosis on the CMs suggests that RASA1 gene mutations could be involved in the hair follicle proliferation and cell cycle.This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)

Jul 23, 2014 04:00PM

High prevalence of circulating autoantibodies against thyroid hormones in vitiligo and correlation with clinical and historical parameters of patients

ConclusionsThe surprisingly high prevalence of THAb in vitiligo patients and their associations suggests a possible pathogenetic role in the disease and stresses the tight link between vitiligo and ATD. Further evaluation in a larger group of patients and an adequate follow?up are needed to define in future their potential predictive role.This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)

Jul 23, 2014 04:00PM

Steroid treatment can improve the impaired quality of life of patients with acquired idiopathic generalized anhidrosis

This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)

Jul 23, 2014 04:00PM

Topical corticosteroid reduces inflammation without compromising efficacy of photodynamic therapy for actinic keratoses a randomised clinical trial

ConclusionsSuper potent corticosteroid before and just after PDT reduced the erythema 24h after treatment of multiple AK in the face and scalp.The use of topical corticosteroid did not affect the efficacy of PDT and may be an easy way to make PDT treatment of large visible areas more acceptable.This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)

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Jul 23, 2014 04:00PM

Nano?TiO2 modulates the dermal sensitization potency of dinitrochlorobenzene after topical exposure

ConclusionIn conclusion, we have demonstrated that topical exposure to TiO2 ENPs increases the chemical?induced dermal sensitization.This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)

Jul 23, 2014 04:00PM

Founder mutation in dystonin?e underlying autosomal recessive epidermolysis bullosa simplex in Kuwait

This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)

Jul 23, 2014 04:00PM

Three difficult cases: the challenge of autoimmunity, immunodeficiency and recurrent infections in patients with Good's syndrome

This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)