Dr. William Ting, Board-Certified Dermatologist
at California Dermatology Care

2262 Camino Ramon, San Ramon, CA 94583
Tel: 925-328-0255
Email: staff@CalDermCare.com


Advanced Care with a Personal Touch

   

 

 

Medical Dermatology    Evidence-based medicine   Customized solution   Personal care

Latest Dermatology Headlines

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(email staff to get your personal passcode)

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MEDICAL DERMATOLOGY

Acne and Acne Scar

Excimer Laser for Psoriasis & Vitiligo

Keloid & Hypertrophic Scar Laser Therapy

Mohs Surgery for Skin Cancers

Nail Fungus GenesisPlus Laser Therapy

Photodynamic Therapy

Psoriasis & NBUVB Phototherapy

RadioTherapy Nonsurgical SRT-100 for Skin Cancer

Skin Allergy Patch Test

Sweating Disorder MiraDry for Hyperhidrosis

Wart Laser Therapy


COSMETIC DERMATOLOGY

Aesthetician Services
Microdermabrasion
 

Botox, Dysport & Xeomin

Cellulaze Cellulite Therapy

new! CoolSculpting

Facial Redness/Vein Laser Therapy

Fillers injection for Wrinkles

Fractional CO2 laser

new! Hair Transplant with Neograft

Laser Surgery Services
Acne/Pore reducing Laser
Collagen Stimulating Laser
Excimer Laser
Facial Veins laser
Hair Laser Removal
IPL Fotofacial
Melasma Laser
Nail Fungus Laser
Resurfacing Laser
Scar revision Laser
Tattoo Removal Lasers
VBeam Pulse Dye Laser
Wart Laser


Latisse

Leg Vein Laser Therapy & Asclera Sclerotherapy

Liposonix + Vaser Shape Nonsurgical Body Sculpting
 

Melasma and Pigmentation

Pore Size Reduction and Laser Rejuvenation

Sculptra Liquid Facelift

SideLaze Lift

Ulthera natural lift & skin tightening of face and neck


Related Websites
FaceUpLifting.com
iCellulaze.com
MoreHair4Me.com
SideLazeLift.com
SonixLipo.com


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925-328-0255

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* Review Dr. Ting's 717+ Q&A on RealSelf

Dr. William Ting has expertise in treating the entire spectrum of medical dermatology, with emphasis in preventive medicine and personalized recommendations. He enjoys taking care of patients with acne, eczema, hair and nail disorders, rashes, psoriasis and skin cancers.

He is at the forefront of medical dermatology and dermatologic research. He continues to publish articles in peer-reviewed dermatology journals. He is an early pioneer of photodynamic therapy (PDT) and one of the most experienced practitioners of PDT in the Bay Area. He is the first dermatologist in the San Francisco Bay Area and Northern California to introduce Lutronic Spectra Laser for melasma, acne, scar revision, pore size reduction as well as the Cutera GenesisPlus laser for advanced nail fungus laser treatment, keloid and hypertrophic scar, warts and scar revision.

Dr. Ting is a fellow of the American Academy of Dermatology (AAD) and American Society of Dermatologic Surgery (ASDS). He is a member of the National Psoriasis Foundation and International Hyperhidrosis Society.

Innovative Therapeutic Approach to Common Skin Conditions

Acne

Eczema (Atopic Dermatitis)

Hair and Nail disorders

  • Maximize therapeutic synergy and efficacy by utilizing both prescription-strength and over-the counter products when available
  • Comprehensive workup including bloodwork and biopsy if necessary
  • Systemic oral hormonal therapy for women and men when indicated

Psoriasis 

Rosacea

  • Multi-prong approach to minimize redness
  • Low-dose 'non-antibiotic' anti-inflammatory oral medication for long-term remission 
  • Emphasis on prevention
  • Fotofacial/IPL laser utilizing Cynosure XPL/Elite MPX
  • Cutera GenesisPlus Laser with or without combination with IPL 
  • Diode laser for facial veins
  • VBeam Pulse Dye Laser, the new gold standard for rosacea and facial redness

Skin Cancer 

  • Emphasis on prophylactic treatments with topical 5-FU, imiquimod, diclofenac, ingenol mebutate and oral chemopreventive therapy such as Soriatane.
  • Reduce future risks of skin cancer with photodynamic therapy, TCA chemical peels and/or fractional CO2 resurfacing laser  
  • Mohs Surgery to achieve highest cure rate and tissue sparing
  • Close colloboration with plastic surgeon(s) as needed  

Sweating Disorder (Hyperhidrosis) 

Vitiligo

Warts 


ABCD of Mole Check

 

 

Common Medical Dermatology Diagnostics and Therapeutics:

Dermatology Links:

American Academy of Dermatology
American Society of Dermatologic Surgery
American Society of Mohs Surgery
International Hyperhidrosis Society
National Psoriasis Foundation

 Latest Dermatology Headlines:

Latest Dermatology Headlines
Thu, 02 Oct 2014 02:39:01 +0100

http://www.medworm.com/rss/index.php/Dermatology/12/

Oct 01, 2014 06:13PM

Purple Urine, Itchy Daughter: What's the Diagnosis?

(MedPage Today) -- See how your diagnostic skills measure up to those of our other readers. (Source: MedPage Today Dermatology)

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Oct 01, 2014 02:43AM

RheumShorts: Psoriatic Arthritis and Shingles (CME/CE)

(MedPage Today) -- Combo psoriatic arthritis treatment associated with an increased risk of herpes zoster. (Source: MedPage Today Dermatology)

Oct 01, 2014 02:31AM

Vulvar skin disorders throughout lifetime: about some representative dermatoses.

The objective of this paper is to present general considerations which should be kept in mind by clinicians in charge of women with vulvar diseases. Four representative vulvar dermatoses are described. Lichen simplex chronicus is a pathological condition related to chemical and mechanical irritant agents. Detrimental effects of these irritants, in the presence of other dermatoses, have to be considered when therapeutic responses are unsatisfactory. Lichen sclerosus is the most common vulvar dermatosis in elderly. However, it should be kept in mind that it may be diagnosed at any age. Lichen planus, in spite of sharing a similar range of etiological factors with lichen sclerosus, is a very distinct entity. Finally, Paget's disease, although rare, is also described especially because of the ...

Sep 30, 2014 09:00PM

Sclerosing Disorders of the Skin: An Overview With Focus on Histopathological Features

Abstract:Sclerosing disorders of the skin consist of a heterogeneous spectrum of entities that share in common cutaneous sclerosis with excessive local accumulation of collagen and/or other extracellular matrix components in the dermis, subcutaneous tissue, and/or underlying soft tissues. The clinical course of these diseases varies from benign disease with a localized skin involvement to systemic, life-threatening disorders. Thus, a correct diagnosis is extremely significant as these disorders are very different in terms of pathogenesis, course, treatment, and outcome. Although they have sclerosis as an overlapping feature, other histopathological features, such as sclerosis depth, hyalinization, mucin deposition, sclerotic bodies, and fibroblastic proliferation, may provide clues to a mo...

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Sep 30, 2014 09:00PM

Clonality Assessment of Cutaneous B-Cell Lymphoid Proliferations: A Comparison of Flow Cytometry Immunophenotyping, Molecular Studies, and Immunohistochemistry/In Situ Hybridization and Review of the Literature

Abstract:Cutaneous lymphoid infiltrates are diagnostically challenging. Although ancillary techniques to assess clonality can help distinguish between reactive lymphoid hyperplasia and lymphoma, one of the most widely used techniques in hematopathology, flow cytometry immunophenotyping (FCI), has not been routinely applied to skin specimens. We performed FCI on 73 skin specimens from 67 patients clinically suspected of having a cutaneous B-cell lymphoma (CBCL) and compared the results with those obtained from immunoglobulin heavy chain (IGH) gene molecular studies (58 cases, primarily by polymerase chain reaction) and either immunohistochemistry (IHC) or in situ hybridization to evaluate for light chain restriction (22 and 2 cases, respectively). Sufficient quantity of CD45 (leukocyte comm...

Sep 30, 2014 09:00PM

An Immunohistochemical Study of Angiokeratomas of Children

Conclusions:Angiokeratomas are complex lesions with difficult classification. Angiokeratomas are best considered vascular malformations in children, according to the WT1-negative stain. The lymphatic component of angiokeratoma is demonstrated by positivity and/or focal expression for lymphatic markers (podoplanin and Prox1); however, a blood capillary component within the malformation cannot be excluded. (Source: The American Journal of Dermatopathology)

Sep 30, 2014 09:00PM

Prurigo Pigmentosa: A Clinicopathologic Study of 4 Cases From the Middle East

Abstract:Prurigo pigmentosa (PP) is a rare inflammatory dermatosis originally reported in Japan. Since then, most reports have originated from Asia, and to a lesser extent from Europe. Although the pathogenesis remains unclear, it is now established that PP is linked to ketoacidotic states. Four patients diagnosed with PP were identified from the dermatopathology database at the American University of Beirut Medical Center between January 2009 and December 2013. Clinicopathologic findings in the 4 patients were similar to those previously reported in the literature. The patients were all female with a mean age of 23.5 years. They all presented with itchy erythematous reticulated papulovesicles/plaques leaving variable reticulated brownish patches. Two patients had, in addition, annular les...

Sep 30, 2014 09:00PM

Expression of Insulin-like Growth Factor-1 Receptor in Conventional Cutaneous Squamous Cell Carcinoma With Different Histological Grades of Differentiation

Conclusions:The strong and differential expression of IGF-1R in different histological degrees of CSCC indicates a possible role for IGF-insulin receptor in the carcinogenesis and differentiation of this disease and identifies IGF-1R as an interesting target for prevention and treatment of CSCC that deserves further investigation. (Source: The American Journal of Dermatopathology)

Sep 30, 2014 09:00PM

Histopathological Diagnosis of Atopic Eruption of Pregnancy and Polymorphic Eruption of Pregnancy: A Study on 41 Cases

Abstract:The specific dermatoses of pregnancy represent a recently reclassified heterogeneous group of pruritic inflammatory skin diseases unique to pregnancy that include pemphigoid gestationis, polymorphic eruption of pregnancy (PEP), intrahepatic cholestasis of pregnancy, and atopic eruption of pregnancy (AEP). Among them, PEP and AEP are the most frequent ones. We performed a histopathological study of a series of PEP and AEP patients (n = 41). Twenty-two patients had PEP that started in the third trimester in 16 (73%) patients and postpartum in 6 (27%) patients. Histopathology revealed a superficial or superficial and deep perivascular dermatitis with eosinophils in all biopsies and signs of a lymphocytic vasculitis in 5 (23%) cases. Epidermal changes, including epidermal hyperplasia,...

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Sep 30, 2014 09:00PM

Angioplasmacellular Hyperplasia?A New Histopathologic Clue for Anogenital Herpes Simplex Recidivans in Immunocompromised Patients?

Abstract:Chronic herpes infections in immunocompromised patients exhibit uncommon features both on clinical and histopathologic levels, which can make correct diagnosis challenging. Better defining histopathologic criteria to identify chronic herpes infection in immunocompromised patients would be of great diagnostic value. In a single-center study, clinical and pathological data of herpes infections confirmed by biopsy was collected. We identified 42 cases overall, of which 21 were from immunocompromised patients and performed a detailed histopathologic pattern analysis of all lesions. In immunocompromised patients, vasculitis was seen in 2/21 cases (9.5%). Involvement of the sweat duct epithelium and/or sebaceous glands was observed in none of the HIV-infected patients but in 5/11 (45.4%...

Sep 30, 2014 09:00PM

Targetoid Eruptions: Challenge

No abstract available (Source: The American Journal of Dermatopathology)

Sep 30, 2014 09:00PM

Biopsy Diagnoses of Clinically Atypical Pigmented Lesions of the Head and Neck in Adults

Abstract:A subset of facial melanoma in situ has histological features that overlap with those of ?dysplastic? nevi. The authors evaluated this important diagnostic pitfall by assessing the frequency of melanoma as the final diagnosis in skin biopsies submitted over a 1-year period with a clinical impression of ?atypical? or dysplastic nevus from the head or neck of adults. A total of 1998 biopsies met inclusion criteria. Final diagnoses included both melanocytic and nonmelanocytic processes. Clear trends were noted based on the age of the patient with benign nevi encompassing nearly 70% of specimens in patients aged 21?29 years and (Source: The American Journal of Dermatopathology)

Sep 30, 2014 09:00PM

Noninfectious Cutaneous Granulomas in Primary Immunodeficiency Disorders: Report From a National Registry

In this report, the authors describe these 4 patients with cutaneous granulomas/granulomatous skin reactions associated one each with common variable immunodeficiency, Omenn syndrome, combined immunodeficiency, and Blau syndrome (BS), and briefly review the literature on various clinicopathological patterns of cutaneous granulomas with possible underlying pathogenetic mechanisms responsible for such tissue reactions in patients with PID. (Source: The American Journal of Dermatopathology)

Sep 30, 2014 09:00PM

Targetoid Eruptions: Answer

No abstract available (Source: The American Journal of Dermatopathology)

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Sep 30, 2014 09:00PM

Rapid Progression of Primary Cutaneous Gamma?Delta T-Cell Lymphoma With an Initial Indolent Clinical Presentation

In conclusion, this case demonstrates a case of CGD-TCL presenting as a longstanding indolent disease with a rapid terminal progression. The indolent clinical course and histological heterogeneity make diagnosing this entity during the initial stage extremely challenging. This case underscores a diverse clinical presentations and a need to consider CGD-TCL in patients showing subcutaneous lesions with an indolent clinical course. (Source: The American Journal of Dermatopathology)

Sep 30, 2014 09:00PM

Multiple Low-Grade Sarcomas of Fibroblastic Type in the Setting of HIV and Acquired Epidermodysplasia Verruciformis

Abstract:A 46-year-old white male with a history of HIV (CD4 245), acquired epidermodysplasia verruciformis, anal carcinoma in situ, hepatitis B and C presented with 3 asymptomatic, nontender, firm pink/skin-colored nodules involving the arm, left lateral leg, and right third finger. One year later, he developed a similar lesion on his right medial lower leg. Excisional biopsy of one of the lesions showed an atypical spindle cell neoplasm of the dermis compatible with a low-grade sarcoma of fibroblastic origin. Testing for human herpes virus-8, 23 human papillomavirus types, Epstein?Barr virus, and FUS fusion protein were negative. The patient underwent diagnostic imaging with computed tomography scans of the chest, abdomen, and pelvis along with positron emission tomography scan to ensu...

Sep 30, 2014 09:00PM

Superficial Soft Tissue Biphasic Synovial Sarcoma With Apocrine Differentiation in the Glandular Component: A Report of Two Cases

Abstract:The authors present 2 cases of a subcutaneous biphasic synovial sarcoma with marked apocrine differentiation that potentially may be confused with cutaneous epithelial neoplasms, including malignant apocrine mixed tumor or metaplastic carcinoma with an apocrine glandular component. Microscopically, both neoplasms had a biphasic architecture with the epithelial and spindle cell components. The epithelial component was prominent and consisted of simple glands with round lumina and complex glandular structures with intraluminal bridges forming cribriform areas. The glands were lined by cuboidal to columnar cells with eosinophilic or clear cytoplasm manifesting apical apocrine-like and intraluminal eosinophilic secretions. The spindle cell component was less prominent and was composed...

Sep 30, 2014 09:00PM

Chromhidrosis: A Rare Diagnosis Requiring Clinicopathologic Correlation

Abstract:Chromhidrosis is a rare idiopathic disorder characterized by colored secretions most typically from the malar cheeks, axilla, or areolar regions. Histologically, chromhidrosis is notable for glandular structures with decapitation secretion indicating ectopic apocrine glands in the dermis, and the presence of lipofuscin pigments under ultraviolet fluorescence and in cytology smears. This case report describes a 26-year-old man who presented with a 2- to 3-year history of black-colored secretions on the bilateral malar cheeks, present on exertion or with squeezing of the cheeks. A 3-mm punch biopsy of the left cheek demonstrated histopathologic findings characteristic of chromhidrosis under hematoxylin and eosin staining and ultraviolet fluorescence. To our best knowledge, this is t...

Sep 30, 2014 09:00PM

Acantholysis in Mammary Paget Disease

No abstract available (Source: The American Journal of Dermatopathology)

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Sep 30, 2014 09:00PM

Erratum

No abstract available (Source: The American Journal of Dermatopathology)

Sep 30, 2014 09:00PM

Sweet Syndrome?Like Neutrophilic Infiltrate as Initial Presentation of Acute Myelogenous Leukemia

We describe the case of a 53-year-old woman with a clinical presentation suggestive of SS, accompanied by pancytopenia and a hypercellular marrow with signs of myelodysplasia. The histopathological findings were characterized as an SS-like cutaneous neutrophilic infiltrate with atypical myeloid cells, myeloperoxidase, and BCR-ABL+, which were absent in peripheral blood and bone marrow aspirate. The patient was treated with systemic corticosteroids with resolution of symptoms and relapse 3 months later when we tried drug withdrawal. Eight months later, the patient was admitted to hematology for a mature acute myelogenous leukemia with an FLT3 mutation. The patient successfully underwent medullar allotransplant and is now asymptomatic (5-month follow-up). This case describes a patient with a...

Sep 30, 2014 09:00PM

A Composite Neoplastic Lesion of the Vulva With Mixed Features of Fibroadenoma and Hidradenoma Papilliferum Combined With Pseudoangiomatous Stromal Hyperplasia Containing Multinucleated Giant Cells

We present a case of a complex neoplastic lesion of the AGMLG with mixed features of fibroadenoma and hidradenoma papilliferum combined with pseudoangiomatous stromal hyperplasia. Multinucleated cells were detected in the pseudoangiomatous stromal hyperplasia areas as seen in some patients with neurofibromatosis type 1. The neoplasm is similar to rare mammary composite neoplasms that feature simultaneously patterns of a fibroepithelial neoplasms and intraductal papilloma. (Source: The American Journal of Dermatopathology)

Sep 30, 2014 09:00PM

Case Report: Differential Diagnosis Between Primary Cutaneous Apocrine Adenocarcinoma Versus Extramammary or Metastatic Breast Adenocarcinoma

We describe a case of a 33-year-old man who had a short-evolution small nodule in the right axilla with local lymph node metastases. The immunohistochemical characterization was closer to that of breast adenocarcinoma than to an adnexal neoplasm. This was established as the main differential diagnosis. Diagnosis of cutaneous apocrine adenocarcinoma may be difficult and immunomarkers are not specific. The anatomical criteria and systemic investigation are mandatory to establish the correct diagnosis. (Source: The American Journal of Dermatopathology)

Sep 30, 2014 09:00PM

The use of biologicals in cutaneous allergies ? present and future

In conclusion, although currently only one biological is approved in chronic urticaria, there is hope that a rapid better understanding of individual disease factors will support the development of other novel drugs in this field. (Source: Current Opinion in Allergy and Clinical Immunology)

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Sep 30, 2014 09:00PM

Recent developments in atopic dermatitis

Purpose of reviewResearch on atopic dermatitis is actively growing and continuously completing our knowledge on the pathophysiology of this complex disease. Recent findingsGenome-wide association studies revealed new susceptibility loci for atopic dermatitis. In addition, different tissue-specific patterns of DNA methylation have been identified as first evidence for the relevance of epigenetic modifications in atopic dermatitis. Moreover, interest is emerging on the role of the skin and gut microbiome in atopic dermatitis. Signals mediated via pattern recognition receptors of the innate immune system have been analyzed in more detail, and the role of cytokines, such as IL-22, IL-25, IL-31 and IL-33 as well as innate lymphoid cells, has been studied. SummaryTaken together, better knowledge...

Sep 30, 2014 09:00PM

The association between atopic dermatitis and food allergy in adults

Purpose of reviewWe conducted a systematic literature search for studies investigating the link between atopic dermatitis and food sensitization or clinically significant allergy (FA) in adults, to assess the strength of the association between the two diseases in both general and selected populations. Recent findingsAround 10% of adults with FA have concomitant atopic dermatitis at the population level. Adult atopic dermatitis patients show much higher rates of sensitization to foods than healthy individuals, in particular to food proteins cross-reactive with airborne allergens, rather than the food allergens that typically predominate amongst children with atopic dermatitis. When food challenges have been performed, rather than relying on questionnaire information and specific IgE testin...

Sep 30, 2014 09:00PM

New findings in allergic contact dermatitis

Purpose of reviewContact allergies are complex diseases and an important challenge for public health. The purpose of this review is to discuss new developments in the field, including epidemiology and molecular mechanisms of contact allergy. Recent findingsUnderstanding how contact allergens promote allergic reactions is important for preventing the disease. According to the latest knowledge, contact allergens are sensed by toll-like receptors and the inflammasome, and possibly the activation of these pathways is a trait shared by all sensitizing compounds. Allergies to nickel, fragrances and preservatives are still frequent, despite regulations aimed at reducing the exposure to potential allergens. Significant numbers of people are exposed, likely due to insufficient protection. Further, ...

Sep 30, 2014 09:00PM

Comparison of the Effect of Diode Laser Versus Intense Pulsed Light in Axillary Hair Removal

CONCLUSION: Both diode laser and the IPL are effective, safe, and able to produce lasting results in axillary hair removal. (Source: Dermatologic Surgery)

Sep 30, 2014 09:00PM

The Anatomical Origin and Course of the Angular Artery Regarding Its Clinical Implications

CONCLUSION: The findings of this study will contribute toward improved outcomes for cosmetic surgery involving the injection of facial filler by enhancing the understanding of AA anatomy. (Source: Dermatologic Surgery)

Sep 30, 2014 09:00PM

To Scoop or Not to Scoop: The Diagnostic and Therapeutic Utility of the Scoop-Shave Biopsy for Pigmented Lesions

CONCLUSION: The scoop-shave is a safe and effective technique for diagnosis and treatment of melanocytic lesions. (Source: Dermatologic Surgery)

Sep 30, 2014 09:00PM

Periorbital Mohs Reconstruction: Characterization of Tumor Histology, Anatomic Location, and Factors Influencing Postoperative Complications

CONCLUSION: Our results indicate that FTSG and lid graft, in particular, result in a higher overall rate of complications when controlling for defect size. (Source: Dermatologic Surgery)

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Sep 30, 2014 09:00PM

Temperature-Modulated Photodynamic Therapy for the Treatment of Actinic Keratosis on the Extremities: A Pilot Study

CONCLUSION: Warming the skin during incubation of ALA seems to improve the efficacy of PDT in the treatment of AKs on the extremities and is well tolerated when heat application is controlled within the limits of safety. (Source: Dermatologic Surgery)

Sep 30, 2014 09:00PM

Skin Sterility After Application of a Vapocoolant Spray

CONCLUSION: The topical antiseptic povidone?iodine significantly reduces skin colonization when compared with unprepared skin (p < .001). The vapocoolant 1,1,1,3,3 pentafluoropropane and 1,1,1,2-tetrafluoroethane is sprayed on skin prepared with povidone?iodine; there is no statistically significant increase in bacterial colonization. (Source: Dermatologic Surgery)

Sep 30, 2014 09:00PM

Complications Using Intense Ultrasound Therapy to Treat Deep Dermal Facial Skin and Subcutaneous Tissues

CONCLUSION: Although most of the complications were transient in nature, 1 patient developed persistent facial edema that became a scar and another developed pseudomelolabial fat atrophy. Furthermore, 3 patients experienced previously unrecognized transient lip and/or brow paralysis. All patients tolerated concurrent neck ultrasound and ablative fractionated CO2 laser resurfacing well. (Source: Dermatologic Surgery)

Sep 30, 2014 09:00PM

Safety and Efficacy of Microfocused Ultrasound to Lift, Tighten, and Smooth the Buttocks

CONCLUSION: Although microfocused ultrasound clearly can be used to safely lift, tighten, and smooth the buttocks, better subject selection and newer developed transducers may lead to greater overall acceptance of this technique. (Source: Dermatologic Surgery)

Sep 30, 2014 09:00PM

A Retrospective Review and Observational Study of Outcomes and Safety of Bimatoprost Ophthalmic Solution 0.03% for Treating Eyelash Hypotrichosis

CONCLUSION: Treatment with bimatoprost 0.03% for at least 12 months is safe, and long-term use is associated with a high degree of satisfaction. (Source: Dermatologic Surgery)

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Sep 30, 2014 09:00PM

Hair Transplantation in the Surgical Treatment of Central Centrifugal Cicatricial Alopecia

CONCLUSION: Hair transplantation is a safe well-tolerated procedure to improve hair loss in African American women with end-stage CCCA who histologically display a lack of inflammation on scalp biopsy. (Source: Dermatologic Surgery)

Sep 30, 2014 09:00PM

Partial Matricectomy With Curettage and Electrocautery: A Comparison of Two Surgical Methods in the Treatment of Ingrown Toenails

CONCLUSION: Both surgical methods are safe treatment modalities with a high success rate. Partial matricectomy, which is achieved using curettage, seems to be superior to electrocautery in respect of reduced inflammation and duration of pain. (Source: Dermatologic Surgery)

Sep 30, 2014 09:00PM

Nasal Tip Revision Using a Dermal Graft

No abstract available (Source: Dermatologic Surgery)

Sep 30, 2014 09:00PM

On the Shoulders of Giants

No abstract available (Source: Dermatologic Surgery)

Sep 30, 2014 09:00PM

Use of Hyaluronidase in Patients With Bee Allergy

No abstract available (Source: Dermatologic Surgery)

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Sep 30, 2014 09:00PM

Google Glass: Dermatologic and Cosmetic Surgery Applications

No abstract available (Source: Dermatologic Surgery)

Sep 30, 2014 09:00PM

Previous Nail Surgery Is a Risk Factor for Recurrence of Ingrown Nails

No abstract available (Source: Dermatologic Surgery)

Sep 30, 2014 09:00PM

Controversies Over Subungual Tumors in Incontinentia Pigmenti

No abstract available (Source: Dermatologic Surgery)

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Sep 30, 2014 09:00PM

Multiple Subungual Squamous Cell Carcinomas in a Patient With Incontinentia Pigmenti

No abstract available (Source: Dermatologic Surgery)

Sep 30, 2014 09:00PM

From the editor?s desk

No abstract available (Source: Advances in Skin and Wound Care)

Sep 30, 2014 09:00PM

Industry news

No abstract available (Source: Advances in Skin and Wound Care)

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Sep 30, 2014 09:00PM

The New School Year Has Started: Reimbursement Subjects Wound Care Professionals Should Study

No abstract available (Source: Advances in Skin and Wound Care)

Sep 30, 2014 09:00PM

The Search for the Missing 50-Year-Old Gold

ABSTRACTIntramuscular and subcutaneous injections of foreign bodies have been used for a number of years for a variety of reasons, including medical and cosmetic purposes. The author describes a case of chronic wound complications secondary to intramuscular gold injections for the treatment of rheumatoid arthritis. The lesions were completely excised, the defect first treated with negative-pressure wound therapy, and, ultimately, split-thickness skin grafting with excellent functional result. (Source: Advances in Skin and Wound Care)

Sep 30, 2014 09:00PM

Leg Ulcer Treatment Outcomes with New Ovine Collagen Extracellular Matrix Dressing: A Retrospective Case Series

ABSTRACTThe purpose of this study was to describe the rate of closure observed in venous leg ulcers during treatment with ovine collagen extracellular matrix dressings and compression. Fourteen patients with 23 wounds were retrospectively evaluated with respect to healing rates, time to closure, and weekly facility charge fees. (Source: Advances in Skin and Wound Care)

Sep 30, 2014 09:00PM

A Novel Epidermal Growth Factor?Containing Wound Dressing for the Treatment of Hard-to-Heal Venous Leg Ulcers

CONCLUSION:The authors? results demonstrate that the novel EGF-containing wound dressing was generally well tolerated and safe. Combined with the significant wound surface reduction, it can be regarded as an adequate novel treatment option for patients with hard-to-heal venous leg ulcers. (Source: Advances in Skin and Wound Care)

Sep 30, 2014 09:00PM

Arterial Disease Ulcers, Part 2: Treatment

No abstract available (Source: Advances in Skin and Wound Care)

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Sep 30, 2014 04:00PM

Tumor?to?bone distance of invasive subungual melanoma: An analysis of 30 cases

Abstract Subungual melanoma (SUM) is rare and represents approximately 2?3% and 20% of all cutaneous melanomas in Caucasians and Asians, respectively. Amputation has usually been performed for invasive SUM; however, not all invasive SUMs invade or attach to the distal phalanx. To investigate the possibility of non?amputative surgery for patients with invasive SUM, the distances between the deepest base of the melanoma cells and the bony surface in the surgical specimens of invasive SUM were measured. Thirty surgical specimens of invasive SUM were retrospectively reviewed. The contents of the specimens were as follows: 14 first toes, 10 thumbs, three second fingers, two third fingers, and one fifth finger. Four specimens showed bone invasion, and the tumor was attached to the bone in fo...

Sep 30, 2014 04:00PM

Expression studies of a novel splice site mutation in the LIPH gene identified in a Japanese patient with autosomal recessive woolly hair

In this study, we analyzed a Japanese patient with ARWH, and identified compound heterozygous mutations in the LIPH gene, c.736T>A (p.Cys246Ser) and c.982+5G>T. The latter one was a novel splice site mutation in intron 7. Expression studies using blood?derived RNA from the patient detected the LIPH transcript from the c.736T>A mutant allele, but not from the c.982+5G>T mutant allele. Furthermore, in vitro transcription assay in cultured cells showed that the mutation c.982+5G>T caused an aberrant splicing event, leading to a frame?shift and a premature termination codon (p.Met328Serfs*41). To the best of our knowledge, this is the second splice site mutation in the LIPH gene, and our findings further expand the spectrum of the LIPH mutations underlying ARWH. (Source: The...

Sep 30, 2014 04:00PM

CD109 expression is increased in cutaneous squamous cell carcinoma

(Source: The Journal of Dermatology)

Sep 30, 2014 04:00PM

New vascular classification of port?wine stains: improving prediction of Sturge?Weber risk

ConclusionsFacial PWS distribution appears to follow the embryonic vasculature of the face, rather than the trigeminal nerve. We propose that children with a PWS on any part of the ?forehead? should have an urgent ophthalmology review and a brain MRI. A prospective study has been established to test the validity of these guidelines. (Source: British Journal of Dermatology)

Sep 30, 2014 04:00PM

Viewpoint: Amyloids, Melanins and Oxidative Stress in Melanomagenesis

This article is protected by copyright. All rights reserved. (Source: Experimental Dermatology)

Sep 30, 2014 04:00PM

Skin mast cells develop non?synchronized changes in typical lineage characteristics upon culture

This article is protected by copyright. All rights reserved. (Source: Experimental Dermatology)

Sep 30, 2014 04:00PM

Cardio-Facio-Cutaneous Syndrome: Clinical Features, Diagnosis, and Management Guidelines

Cardio-facio-cutaneous syndrome (CFC) is one of the RASopathies that bears many clinical features in common with the other syndromes in this group, most notably Noonan syndrome and Costello syndrome. CFC is genetically heterogeneous and caused by gene mutations in the Ras/mitogen-activated protein kinase pathway. The major features of CFC include characteristic craniofacial dysmorphology, congenital heart disease, dermatologic abnormalities, growth retardation, and intellectual disability. It is essential that this condition be differentiated from other RASopathies, as a correct diagnosis is important for appropriate medical management and determining recurrence risk. Children and adults with CFC require multidisciplinary care from specialists, and the need for comprehensive management has...

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Sep 30, 2014 04:00PM

Type of MRI contrast, tissue gadolinium, and fibrosis

It has been presupposed that the thermodynamic stability constant (Ktherm) of gadolinium-based MRI chelates relate to the risk of precipitating nephrogenic systemic fibrosis. The present study compared low-Ktherm gadodiamide with high-Ktherm gadoteridol in cultured fibroblasts and rats with uninephrectomies. Gadolinium content was assessed using scanning electron microscopy equipped with energy-dispersive X-ray spectroscopy in paraffin-embedded tissues. In vitro, fibroblasts demonstrated dose-dependent fibronectin generation, transforming growth factor-β production, and expression of activated myofibroblast stress fiber protein α-smooth muscle actin. There were negligible differences with respect to toxicity or proliferation between the two contrast agents. In the rodent model, ...

Sep 30, 2014 04:00PM

Migration and determinants of health: clinical epidemiological characteristics of migrants in Malta (2010-11)

Conclusions Immigrants have a lower morbidity burden compared with their fellow countrymen living in the origin country. However, living conditions during the journey, in transit countries and after arrival can influence their health status. The present study provides a comprehensive picture of this growing population that is in need for health promotion, mental health services and fair policy planning. (Source: Journal of Public Health)

Sep 30, 2014 04:00PM

Phase II Evaluation of VDC?1101 in Canine Cutaneous T?Cell Lymphoma

Conclusions and Clinical ImportanceVDC?1101 has activity against canine CTCL and could provide another treatment option in a disease process with a poor prognosis. (Source: Journal of Veterinary Internal Medicine)

Sep 30, 2014 04:00PM

The Editors' Choice

Recent studies have suggested that epidermal barrier dysfunction contributes to the development of atopic dermatitis and other allergic diseases. Horimukai et al (p 824) report the results of a randomized controlled trial investigating whether protecting the skin barrier with a moisturizer during the neonatal period prevents development of atopic dermatitis and allergic sensitization. Approximately 32% fewer neonates who received the moisturizer had atopic dermatitis by week 32 than control subjects (see Figure; P = .012, log-rank test). (Source: Journal of Allergy and Clinical Immunology)

Sep 30, 2014 04:00PM

Peeling off the genetics of atopic dermatitis?like congenital disorders

The epidermis forms during the course of a complex differentiation process known as cornification, which culminates with the formation of the epidermal barrier. The epidermal barrier serves as a vital line of defense against the environment and mainly consists of 3 elements: intracellular keratin filaments, intercellular lipids, and the cornified cell envelope. Adequate epidermal barrier function is also critically dependent on normal shedding of terminally differentiated keratinocytes, a process termed desquamation, which requires the dissolution of cell-cell junctions in the upper granular layers. (Source: Journal of Allergy and Clinical Immunology)

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Sep 30, 2014 04:00PM

Deciphering the complexities of atopic dermatitis: Shifting paradigms in treatment approaches

(Source: Journal of Allergy and Clinical Immunology)

Sep 30, 2014 04:00PM

Application of moisturizer to neonates prevents development of atopic dermatitis

Recent studies have suggested that epidermal barrier dysfunction contributes to the development of atopic dermatitis (AD) and other allergic diseases. (Source: Journal of Allergy and Clinical Immunology)

Sep 30, 2014 04:00PM

Deciphering the complexities of atopic dermatitis: Shifting paradigms in treatment approaches

Atopic dermatitis (AD) is the most common chronic inflammatory skin disease. It often precedes the development of food allergy and asthma. Recent insights into AD reveal abnormalities in terminal differentiation of the epidermal epithelium leading to a defective stratum corneum, which allows enhanced allergen penetration and systemic IgE sensitization. Atopic skin is also predisposed to colonization or infection by pathogenic microbes, most notably Staphylococcus aureus and herpes simplex virus. (Source: Journal of Allergy and Clinical Immunology)

Sep 30, 2014 04:00PM

Eczematous sensitization, a novel pathway for allergic sensitization, can occur in an early stage of eczema

One of the most significant recent advances in the field of food allergy is a paradigm shift in our understanding of allergen sensitization, namely the dual-allergen exposure hypothesis: oral intake of food proteins tends to induce tolerance, whereas epicutaneous exposure to food proteins tends to induce allergic sensitization.1 (Source: Journal of Allergy and Clinical Immunology)

Sep 30, 2014 04:00PM

Emollient enhancement of the skin barrier from birth offers effective atopic dermatitis prevention

Atopic dermatitis (atopic eczema) is a chronic inflammatory skin disease that has reached epidemic proportions in children worldwide and is increasing in prevalence. Because of the significant socioeconomic effect of atopic dermatitis and its effect on the quality of life of children and families, there have been decades of research focused on disease prevention, with limited success. Recent advances in cutaneous biology suggest skin barrier defects might be key initiators of atopic dermatitis and possibly allergic sensitization. (Source: Journal of Allergy and Clinical Immunology)

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Sep 30, 2014 04:00PM

Randomized trial of vitamin D supplementation for winter-related atopic dermatitis in children

Epidemiologic and preclinical data, and a small randomized trial in Boston, suggest that vitamin D supplementation may improve winter-related atopic dermatitis (AD). (Source: Journal of Allergy and Clinical Immunology)

Sep 30, 2014 04:00PM

Distinct behavior of human Langerhans cells and inflammatory dendritic epidermal cells at tight junctions in patients with atopic dermatitis

The stratum corneum and tight junctions (TJs) form physical barriers in the epidermis. Dendrites of activated Langerhans cells (LCs) extend beyond the TJs to capture external antigens in mice. LCs and inflammatory dendritic epidermal cells (IDECs) are observed in the skin of patients with atopic dermatitis (AD). (Source: Journal of Allergy and Clinical Immunology)

Sep 30, 2014 04:00PM

Proteome analysis of stratum corneum from atopic dermatitis patients by hybrid quadrupole-orbitrap mass spectrometer

The significance of stratum corneum (SC) barrier has been strengthened especially since 2006, when filaggrin (FLG) mutations and very low expression of profilaggrin/filaggrin monomer were found in patients with atopic dermatitis (AD) as well as ichthyosis vulgaris (IV).1 Many other SC constituents and proteases are also known to be involved in the barrier, as new susceptibility loci for AD were found by genomewide association study2 and proteome analysis.3 Although the SC barrier condition is crucial for the assessment of AD, comprehensive evaluation of its abnormalities in individuals remains to be addressed. (Source: Journal of Allergy and Clinical Immunology)

Sep 30, 2014 04:00PM

Breast pathology second review identifies clinically significant discrepancies in over 10% of patients

ConclusionsOur results confirm the value and utility of obtaining a second opinion to optimize patient care. Changes in diagnoses obtained after second review should be interpreted and reported in a collaborative fashion, noting the benefit of a review from second pair of experienced eyes. Our results support the use of second review to ensure inclusion of CAP?required data elements in pathology reports. J. Surg. Oncol. © 2014 Wiley Periodicals, Inc. (Source: Journal of Surgical Oncology)

Sep 30, 2014 04:00PM

Urticaria

Summary Urticaria is a very common skin disease which was already described in the ancient world. Questions still remain about its pathogenesis and management remain open. Compared to other common skin diseases, the published evidence is rather low. The clinical symptoms with pruritic transient wheals and/or angioedema are caused by mediators (particularly histamine) released by activated mast cells and basophils. The mechanism of target cell activation has not been clarified in detail for most urticaria subtypes. Different urticaria subtypes should be distinguished. Spontaneous forms are more common than inducible forms. Chronic urticaria and urticaria in certain age groups (children, pregnancy) can be difficult to manage. Therefore, international consensus resulting in the regular update...

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Sep 30, 2014 04:00PM

Painful erythematous plaque with vesicles and pustules

(Source: JDDG)

Sep 30, 2014 04:00PM

British Association of Dermatologists' guidelines for the management of cutaneous warts 2014

(Source: British Journal of Dermatology)

Sep 30, 2014 04:00PM

Fumaderm® in daily practice for psoriasis: dosing, efficacy and quality of life

ConclusionsThis is the first field study analysing the use of Fumaderm and the improvement of quality of life in patients with psoriasis under daily outpatient conditions. The improvement of DLQI obtained with Fumaderm was comparable with the improvement observed in patients with psoriasis treated with modern biologics. Importantly, in most patients with good clinical response, the treatment dose was one to three tablets daily. (Source: British Journal of Dermatology)

Sep 30, 2014 04:00PM

Profile of skin barrier proteins (filaggrin, claudins 1 and 4) and Th1/Th2/Th17 cytokines in adults with atopic dermatitis

ConclusionOur data reinforce the role of an altered skin barrier in the pathogenesis of AD. Our results show not only reduced expression of filaggrin and claudin 1 in lesional atopic skin but also inverse correlation of filaggrin expression and disease severity. Moreover, elevation of in situ IL?17 and of circulating interleukin levels in AD emphasize the systemic, inflammatory profile of this defective skin barrier dermatosis. (Source: Journal of the European Academy of Dermatology and Venereology)

Sep 30, 2014 08:05AM

Antioxidant found in grapes uncorks new targets for acne treatment

This study demonstrates that combining an oxidant and an antioxidant may enhance each other and help sustain bacteria-fighting activity over a longer period of time.? The team grew colonies of the bacteria that causes acne and then added various concentrations of resveratrol and benzoyl peroxide both alone and together. The researchers monitored the cultures for bacterial growth or killing for 10 days. They found that benzoyl peroxide was able to initially kill the bacteria at all concentration levels, but the effect was short lived and didn?t last beyond the first 24 hours. Resveratrol didn?t have a strong killing capability, but it inhibited bacterial growth for a longer period of time. Surprisingly, the two compounds together proved the most effective in reducing bacteria counts. ...

Sep 30, 2014 05:32AM

Evidence-Based Treatment for Melasma: Expert Opinion and a Review

Conclusion The key therapy recommended is fluorinated steroid containing 2?4% HQ-based triple combination for first line, with additional selective peels if required in second line. Lasers are a last resort. (Source: Dermatology and Therapy)

Sep 30, 2014 05:31AM

Body mass index is negatively associated with acne lesion counts in Taiwanese women with post?adolescent acne

ConclusionInitial findings indicate that BMI is negatively associated with the number of acne lesions in Taiwanese women with moderate to severe post?adolescent acne. (Source: Journal of the European Academy of Dermatology and Venereology)

Sep 30, 2014 05:28AM

In Situ Assessment Of Pi3k And Pten Alterations In Mycosis Fungoides: Correlation With Clinicopathological Features

This article is protected by copyright. All rights reserved. (Source: Experimental Dermatology)

Sep 30, 2014 05:27AM

Melasma treatment using an erbium:YAG laser: a clinical, immunohistochemical, and ultrastructural study

ConclusionsErbium:YAG laser resurfacing effectively improves melasma; however, the almost universal appearance of transient postinflammatory hyperpigmentation necessitates prompt and persistent intervention. (Source: International Journal of Dermatology)

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Sep 30, 2014 04:10AM

Radiotherapy for Dermatofibrosarcoma Protuberans

Conclusions:RT may improve local control and reduce the risk of recurrence postoperatively in patients with DFSP. (Source: American Journal of Clinical Oncology - Current Table Of Contents)

Sep 30, 2014 03:44AM

Common Dermatologic Manifestations of Primary Immune Deficiencies

Abstract The skin is the largest organ of our body; it consists of the epidermis, dermis, hair follicles, sweat glands, blood vessels, and connective tissue matrix. Its main function is to act as a barrier to the outside world and protect us from infections. Any component of the skin is subject to insults from the environment and/or from within the body. Primary immune deficiency patients present with recurrent or prolonged infections not frequently seen in healthy individuals. Oftentimes, these infections involve the skin. Primary immune deficiency may also present with noninfectious cutaneous signs, such as eczema; erythroderma; granulomas; dysplasia of the skin, hair, nails, or teeth; pigmentary changes; angioedema; urticaria; vasculitis; or autoimmune skin disease due to immu...

Sep 29, 2014 04:00PM

Tomotherapy concomitant with cetuximab, followed by cetuximab as single-agent therapy for unresectable squamous cell carcinoma of the skin: a case report

Conclusion: The treatment was effective and feasible. Considering these excellent results, further studies about concomitant tomotherapy with Cetuximab for advanced/inoperable SCC of the skin are needed. (Source: BMC Dermatology)

Sep 29, 2014 04:00PM

Single?nucleotide polymorphisms in pigment genes and nonmelanoma skin cancer predisposition: a systematic review

Summary Nonmelanoma skin cancer (NMSC) is the most common cancer in the U.S.A. The two most common NMSCs are basal cell carcinoma and squamous cell carcinoma. The associations of single?nucleotide polymorphisms (SNPs) in pigmentation pathway genes with NMSC are not well characterized. There is a series of epidemiological studies that have tested these relationships, but there is no recent summary of these findings. To explain overarching trends, we undertook a systematic review of published studies. The summarized data support the concept that specific SNPs in the pigmentation pathway are of importance for the pathogenesis of NMSC. The SNPs with the most promising evidence include MC1R rs1805007(T) (Arg151Cys) and rs1805008(T) (Arg160Trp), and ASIP AH haplotype [rs4911414(T) and rs101536...

Sep 29, 2014 04:00PM

The histamine?synthesizing enzyme histidine decarboxylase is upregulated by keratinocytes in atopic skin

ConclusionsKeratinocytes express abundant HDC protein, and the levels increase in atopic skin. LPS, HDM and cytokines, which are implicated in allergic inflammation, promote the expression of the enzyme and upregulate histamine levels in keratinocytes. Actively produced histamine influences keratinocyte differentiation, suggesting functional relevance of the axis to atopic dermatitis. The findings therefore identify a new point of therapeutic intervention. (Source: British Journal of Dermatology)

Sep 29, 2014 04:00PM

High?frequency ultrasonography but not 930?nm optical coherence tomography reliably evaluates melanoma thickness in vivo: a prospective validation study

ConclusionsHFUS is a reliable and reproducible noninvasive method for assessing melanoma thickness. Routine use of HFUS may allow single?step excision of equivocal melanocytic lesions, with surgical margins determined by in vivo assessment of tumour thickness. (Source: British Journal of Dermatology)

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Sep 29, 2014 04:00PM

Regulated genes in psoriatic skin during treatment with fumaric acid esters

ConclusionsFAE treatment induces glutathione and Nrf2 pathway genes in lesional skin of patients with psoriasis. In responders, FAEs specifically regulate the transcription factors PTTG1, NR3C1, GATA3 and NF?BIZ, which are important in normal cutaneous development, and the T?helper (Th)2 and Th17 pathways, respectively. (Source: British Journal of Dermatology)

Sep 29, 2014 04:00PM

A randomized, double?blind, placebo?controlled clinical trial on the efficacy and safety of 3% Rumex occidentalis cream versus 4% hydroquinone cream in the treatment of melasma among Filipinos

ConclusionsRumex occidentalis 3% cream is a safe and effective skin?lightening agent for melasma and is comparable in efficacy with 4% HQ cream. (Source: International Journal of Dermatology)

Sep 29, 2014 04:00PM

Six years' follow?up of multibacillary leprosy patients treated with uniform multi?drug therapy in China

ConclusionsA 6?month administration of UMDT is effective in MB leprosy patients. The changes in BI values and the frequency of leprosy reactions were similar to those cited in reports in the literature of patients treated with 1? or 2?year regimens of MDT. However, further research should be conducted to confirm the present results. (Source: International Journal of Dermatology)

Sep 29, 2014 04:00PM

First reported case of Aspergillus nidulans eumycetoma in a sporotrichoid distribution

ConclusionsAspergillus spp. have emerged as important opportunistic pathogens, especially in immunosuppressed patients. Aspergillus nidulans occurs frequently in soil, decaying vegetation, and water but has very rarely been described as a cause of mycetoma. The infection responds well to treatment with itraconazole, voriconazole, and amphotericin B. The current patient represents the first demonstration of A. nidulans mycetoma presenting in a sporotrichoid distribution. (Source: International Journal of Dermatology)

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Sep 29, 2014 04:00PM

Downregulation of involucrin in psoriatic lesions following therapy with propylthiouracil, an anti?thyroid thioureylene: immunohistochemistry and gene expression analysis

ConclusionsIn psoriasis, there is increased expression of involucrin, which leads to abnormal keratinocyte differentiation and hence to the formation of psoriatic plaques. The therapeutic effect of PTU in psoriasis may be attributable to the downregulation of involucrin. Larger trials should further elucidate the mechanism and therapeutic potential of PTU in psoriasis. (Source: International Journal of Dermatology)

Sep 29, 2014 04:00PM

Flagellate erythema in parvovirus B19 infection

(Source: International Journal of Dermatology)