Dr. William Ting, Board-Certified Dermatologist
at California Dermatology Care

2262 Camino Ramon, San Ramon, CA 94583
Tel: 925-328-0255
Email: staff@CalDermCare.com


Advanced Care with a Personal Touch

   

 

 

Medical Dermatology    Evidence-based medicine   Customized solution   Personal care

Latest Dermatology Headlines

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* Patient Biopsy Results via LabCalls


MEDICAL DERMATOLOGY

Acne and Acne Scar

Excimer Laser for Psoriasis & Vitiligo

Keloid & Hypertrophic Scar Laser Therapy

Mohs Surgery for Skin Cancers

Nail Fungus GenesisPlus Laser Therapy

Photodynamic Therapy

Psoriasis & NBUVB Phototherapy

RadioTherapy Nonsurgical SRT-100 for Skin Cancer and Keloid 

Skin Allergy Patch Test

Sweating Disorder MiraDry for Hyperhidrosis

Wart Laser Therapy


COSMETIC DERMATOLOGY

Aesthetician Services
Microdermabrasion
 

Botox, Dysport & Xeomin

Cellulaze Cellulite Therapy

new! CoolSculpting

Facial Redness/Vein Laser Therapy

Fillers injection for Wrinkles

Fractional CO2 laser

new! Hair Transplant with Neograft

Laser Surgery Services
Acne/Pore reducing Laser
Collagen Stimulating Laser
Excimer Laser
Facial Veins laser
Hair Laser Removal
IPL Fotofacial
Melasma Laser
Nail Fungus Laser
Resurfacing Laser
Scar revision Laser
Tattoo Removal Lasers
VBeam Pulse Dye Laser
Wart Laser


Latisse

Leg Vein Laser Therapy & Asclera Sclerotherapy

Liposonix + Vaser Shape Nonsurgical Body Sculpting
 

Melasma and Pigmentation newly updated!

Pore Size Reduction and Laser Rejuvenation

Sculptra Liquid Facelift

SideLaze Lift

Ulthera natural lift & skin tightening of face and neck


Related Websites
FaceUpLifting.com
iCellulaze.com
MoreHair4Me.com
SideLazeLift.com
SonixLipo.com


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* Review Dr. Ting's 717+ Q&A on RealSelf

Dr. William Ting has expertise in treating the entire spectrum of medical dermatology, with emphasis in preventive medicine and personalized recommendations. He enjoys taking care of patients with acne, eczema, hair and nail disorders, rashes, psoriasis and skin cancers.

He is at the forefront of medical dermatology and dermatologic research. He continues to publish articles in peer-reviewed dermatology journals. He is an early pioneer of photodynamic therapy (PDT) and one of the most experienced practitioners of PDT in the Bay Area. He is the first dermatologist in the San Francisco Bay Area and Northern California to introduce Lutronic Spectra Laser for melasma, acne, scar revision, pore size reduction as well as the Cutera GenesisPlus laser for advanced nail fungus laser treatment, keloid and hypertrophic scar, warts and scar revision.

Dr. Ting is a fellow of the American Academy of Dermatology (AAD) and American Society of Dermatologic Surgery (ASDS). He is a member of the National Psoriasis Foundation and International Hyperhidrosis Society.

Innovative Therapeutic Approach to Common Skin Conditions

Acne

Eczema (Atopic Dermatitis)

Hair and Nail disorders

  • Maximize therapeutic synergy and efficacy by utilizing both prescription-strength and over-the counter products when available
  • Comprehensive workup including bloodwork and biopsy if necessary
  • Systemic oral hormonal therapy for women and men when indicated

Psoriasis 

Rosacea

  • Multi-prong approach to minimize redness
  • Low-dose 'non-antibiotic' anti-inflammatory oral medication for long-term remission 
  • Emphasis on prevention
  • Fotofacial/IPL laser utilizing Cynosure XPL/Elite MPX
  • Cutera GenesisPlus Laser with or without combination with IPL 
  • Diode laser for facial veins
  • VBeam Pulse Dye Laser, the new gold standard for rosacea and facial redness

Skin Cancer 

  • Emphasis on prophylactic treatments with topical 5-FU, imiquimod, diclofenac, ingenol mebutate and oral chemopreventive therapy such as Soriatane.
  • Reduce future risks of skin cancer with photodynamic therapy, TCA chemical peels and/or fractional CO2 resurfacing laser  
  • Mohs Surgery to achieve highest cure rate and tissue sparing
  • Close colloboration with plastic surgeon(s) as needed  

Sweating Disorder (Hyperhidrosis) 

Vitiligo

Warts 


ABCD of Mole Check

 

 

Common Medical Dermatology Diagnostics and Therapeutics:

Dermatology Links:

American Academy of Dermatology
American Society of Dermatologic Surgery
American Society of Mohs Surgery
International Hyperhidrosis Society
National Psoriasis Foundation

 Latest Dermatology Headlines:

Latest Dermatology Headlines
Mon, 26 Jan 2015 15:30:52 +0100

http://www.medworm.com/rss/index.php/Dermatology/12/

Jan 26, 2015 07:28AM

Rosai?Dorfman disease presenting as panniculitis?like

(Source: Journal of the European Academy of Dermatology and Venereology)

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Jan 26, 2015 07:27AM

Association between Skin and Joint Involvement in Patients with Psoriatic Arthritis Treated with Adalimumab: Analysis of Data from a German Non-Interventional Study

Conclusion: The severity of skin manifestations does not correlate with the severity of joint disease in PsA patients; even patients with mild skin disease may have extensive musculoskeletal involvement.Dermatology (Source: Dermatology)

Jan 25, 2015 04:55PM

Editorial board members and reviewers.

Authors: Foster A PMID: 25611091 [PubMed - in process] (Source: Veterinary Dermatology)

Jan 25, 2015 04:00PM

Whole?exome sequencing solves diagnostic dilemma in a rare case of sporadic acrokeratosis verruciformis

(Source: Journal of the European Academy of Dermatology and Venereology)

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Jan 25, 2015 04:00PM

Cutaneous endometrial cancer arising from heterotopic endometriosis in an abdominal caesarean section scar

(Source: Journal of the European Academy of Dermatology and Venereology)

Jan 25, 2015 04:00PM

Identification of macrolide?resistant Mycoplasma genitalium using real?time PCR

ConclusionOur TaqMan assay detects common genotypes associated with macrolide?resistant M. genitalium, namely, A2058G, A2059G and A2058C. We show association between the presence of resistant M. genitalium and treatment failure, thereby confirming the validity of testing for these mutants to prevent further spread of antimicrobial resistance and to allow informed choice of antibiotics for treatment. (Source: Journal of the European Academy of Dermatology and Venereology)

Jan 25, 2015 04:00PM

Cutaneous Epstein?Barr virus?associated lymphoproliferative polymorphic disease ? AIDS presenting manifestation

(Source: Journal of the European Academy of Dermatology and Venereology)

Jan 25, 2015 04:00PM

Elevated prevalence of Type D (distressed) personality in moderate to severe psoriasis is associated with mood status and quality of life impairment: a comparative pilot study

ConclusionBecause Type D personality could represent a frequent type of personality among individuals with moderate to severe psoriasis, it could serve as a ?marker? of more psychologically vulnerable patients, probably related to dysfunctional coping strategies. The Type D personality could represent a profile more frequently encountered among patients with psoriasis, and might therefore help identify subjects physiologically more vulnerable to disease, most likely due to inadequate adaptation mechanisms. (Source: Journal of the European Academy of Dermatology and Venereology)

Jan 25, 2015 04:00PM

Piano glissando purpura: another cutaneous curiosity in musicians

(Source: Journal of the European Academy of Dermatology and Venereology)

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Jan 25, 2015 04:00PM

Dermoscopy of periungual pigmented Bowen's disease: its usefulness in differentiation from malignant melanoma

(Source: Journal of the European Academy of Dermatology and Venereology)

Jan 25, 2015 04:00PM

Early non?ablative fractional laser improves the appearance of punch biopsy scars ? a clinical report

(Source: Journal of the European Academy of Dermatology and Venereology)

Jan 25, 2015 04:00PM

Prevalence of methylchloroisothiazolinone and methylisothiazolinone contact allergy in facial dermatitis: a single centre Irish study

ConclusionsContact allergies to MCI/MI and MI are commoner than what was reported before and is an emerging cause of facial dermatitis. The detection rate of this allergen was increased by 5% in our cohort since the inclusion of MI (0.2%) in the standard series. (Source: Journal of the European Academy of Dermatology and Venereology)

Jan 25, 2015 04:00PM

Resolution of septic shock in a patient with myelomeningocele (spina bifida) complicated with deforming Elephantiasis Nostras Verrucosa

(Source: Journal of the European Academy of Dermatology and Venereology)

Jan 25, 2015 04:00PM

Prognostic and predictive values of oncogenic BRAF, NRAS, c?KIT and MITF in cutaneous and mucous melanoma

ConclusionClinical and pathological characteristics of the primary melanoma differed between wild?type and BRAF? or NRAS?mutated tumours. Patients with BRAF?mutated tumours were younger at diagnosis of primary melanoma. Patients carrying mutations showed better responses better to specific kinase inhibitors and interestingly also to systemic cytotoxic chemotherapy. (Source: Journal of the European Academy of Dermatology and Venereology)

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Jan 25, 2015 03:25AM

Intracellular signaling of the aging suppressor protein klotho.

Authors: Sopjani M, Rinnerthaler M, Kruja J, Dermaku-Sopjani M Abstract The Klotho protein deficiency is known to participate in premature aging. As an aging suppressor, Klotho is an important molecule in aging processes and its overexpression results in longevity. Due to many reasons, the insulin/insulin-like growth factor-1 (IGF-1) has been considered as a key pathway in aging research. The Klotho gene is closely related to this pathway. The Klotho gene encodes a transmembrane protein that after cleavage is also found as a secreted protein. Importantly, its overexpression suppresses insulin/IGF-1 signaling and thus extends the lifespan. In addition, Klotho participates in the regulation of several other intracellular signaling pathways, including regulation of FGF23 signaling, cA...

Jan 24, 2015 04:03PM

Sporotrichosis: an overview and therapeutic options.

Authors: Mahajan VK Abstract Sporotrichosis is a chronic granulomatous mycotic infection caused by Sporothrix schenckii, a common saprophyte of soil, decaying wood, hay, and sphagnum moss, that is endemic in tropical/subtropical areas. The recent phylogenetic studies have delineated the geographic distribution of multiple distinct Sporothrix species causing sporotrichosis. It characteristically involves the skin and subcutaneous tissue following traumatic inoculation of the pathogen. After a variable incubation period, progressively enlarging papulo-nodule at the inoculation site develops that may ulcerate (fixed cutaneous sporotrichosis) or multiple nodules appear proximally along lymphatics (lymphocutaneous sporotrichosis). Osteoarticular sporotrichosis or primary pulmonary sporo...

Jan 24, 2015 04:00PM

Juvenile Dermatomyositis: A 20-year Retrospective Analysis of Treatment and Clinical Outcomes

Conclusion Factors such as male sex and Gowers' sign were unlikely to favor the achievement of complete clinical remission in juvenile dermatomyositis. Certain complications cannot be avoided, and thus more effective treatments and monitoring strategies are needed for better control of juvenile dermatomyositis. (Source: Pediatrics and Neonatology)

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Jan 24, 2015 04:00PM

Dalbergia odorifera Extract Ameliorates UVB?Induced Wrinkle Formation by Modulating Expression of Extracellular Matrix Proteins

This study examined the antiwrinkle effects of ethanol extracts of D. odorifera in UVB?irradiated human skin cells. Ethanol extracts of D. odorifera and thier constituents, dalbergin and sativanone, induced expression of collagen type I and transforming growth factor (TGF)??1 in human dermal fibroblasts. In HR?1 hairless mice exposed to UVB, the ethanol extract reduced wrinkle formation and skin thickness. This inhibitory effect of ethanol extract was associated with the restoration of collagen type I, TGF??1, and elastin to levels approaching those in skin tissues not exposed to UVB, which was accompanied by the reduction of matrix metalloproteinase?2 and upregulation of tissue inhibitors of metalloproteinase (TIMP)?2 and TIMP?3 in skin tissue exposed to UVB. These results...

Jan 24, 2015 04:00PM

Estimated cost efficacy of systemic treatments that are approved by the US Food and Drug Administration for the treatment of moderate to severe psoriasis

Newer psoriasis treatments tout higher efficacy but are generally more expensive. (Source: Journal of the American Academy of Dermatology)

Jan 24, 2015 04:00PM

Rosiglitazone Ameliorates Senescence-like Phenotypes in a Cellular Photoaging Model

(Source: Journal of Dermatological Science)

Jan 24, 2015 12:32PM

Adult acne: how to treat it?

A Mayo Clinic dermatologist gives tips on how adults can prevent and treat acne. Treatment options include over the counter medications as well as prescription medications.Acne has 3 stages that can be remembered by the mnemonic "CIN":Comedonal - black/whitehead, open/closedInflammatory - pimples/zitsNodulocysticUse Topical Treatment such as Differin gel as on CCC-F: Cheek, Chin, Cheek, Forehead Posted at Clinical Cases and Images. Stay updated and subscribe, follow us on Twitter and connect on Facebook. (Source: Clinical Cases and Images)

Jan 24, 2015 12:49AM

Molecular identification and classification of Trichophyton mentagrophytes complex strains isolated from humans and selected animal species

Summary Species differentiation within Trichophyton mentagrophytes complex group currently poses a major diagnostic challenge, with molecular methods increasingly supplementing classical identification based on the morphological and physiological properties of the fungi. Diagnostic and epidemiological research aimed at determining the source and means of transmission of dermatophytoses in both humans and animals requires not only species differentiation of isolates but also differentiation within species. The study was conducted on 24 isolates originating in humans and various animal species with clinical symptoms of dermatophytosis. The analysis included phenotypical identification methods and molecular methods: internal transcribed spacer sequencing and ITS?restriction fragment length ...

Jan 23, 2015 10:50PM

Forefront Dermatology Assists Retiring Green Bay Dermatologist

Green Bay Dermatology Practice Transition to Forefront Offers Patients a Seamless Experience & Continuity of Care(PRWeb January 23, 2015)Read the full story at http://www.prweb.com/releases/2015/01/prweb12465407.htm (Source: PRWeb: Medical Pharmaceuticals)

Jan 23, 2015 09:22PM

Hair Loss in Women

Hair loss is a common cause of morbidity for many women. As a key member of the woman?s health care team, the obstetrician/gynecologist may be the first person to evaluate the complaint of hair loss. Common types of nonscarring hair loss, including female pattern hair loss and telogen effluvium, may be diagnosed and managed by the obstetrician/gynecologist. A systematic approach to diagnosis and management of these common forms of hair loss is presented. (Source: Clinical Obstetrics and Gynecology)

Jan 23, 2015 09:22PM

Cutaneous Malignancies of the Perineum

This review discusses multiple cutaneous malignancies that can present on the perineum. Although all of these neoplasms are uncommon, a focus will be on the more common neoplasms including extramammary Paget disease, basal cell carcinoma, squamous cell carcinoma, and melanoma. Other more rare entities discussed are superficial leiomyosarcoma, giant solitary trichoepithelioma, and cutaneous endometriosis. (Source: Clinical Obstetrics and Gynecology)

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Jan 23, 2015 09:22PM

Sexually Transmitted Diseases

Sexually transmitted diseases (STDs) continue to be a global epidemic with significant risk of morbidity/mortality for the fetus. STDs with prominent cutaneous findings including condylomata acuminata, genital herpes infections, and syphilis are reviewed. Important clinical cutaneous findings help aid early diagnosis and facilitate treatment. Condylomata acuminata have the potential of causing cervical cancer, anogenital cancer, and oropharyngeal cancer. Significant advances have been made in human papilloma virus vaccinations and treatment. Genital herpes infection can produce significant physical and emotional distress to the patient and significant potential harm to the fetus. Early clinical recognition of STDs and their appropriate management is critical. (Source: Clinical Obstetrics a...

Jan 23, 2015 09:22PM

Allergic Contact Dermatitis of the Vagina and Perineum: Causes, Incidence of, and Differentiating Factors

Review of allergic contact dermatitis of the vagina and perineum, including causes, incidence of, and differentiating factors. The causes include common allergens found in everyday products. The true incidence of contact dermatitis of the vagina and perineum is unknown, however, it is a common problem facing clinicians. The differentiating factors include itching, erythema, and persistence. (Source: Clinical Obstetrics and Gynecology)

Jan 23, 2015 09:22PM

Lichen Sclerosus and Lichen Planus in Women and Girls

Lichen planus and lichen sclerosus are common, chronic inflammatory vulvar dermatoses with significant morbidity. The course may wax and wane but disease often persists for decades. These autoimmune diseases have varied clinical presentations that extend beyond the genitalia. Management is best undertaken using a multidisciplinary approach and active patient involvement. The first-line treatment of both conditions is superpotent topical corticosteroids. Supportive measures and adjunct therapies can optimize patient outcomes. Patients who fail to improve despite correct medication use should be re-evaluated, and clinicians should be vigilant in detecting concomitant contact dermatitis, secondary infection, and malignancy. (Source: Clinical Obstetrics and Gynecology)

Jan 23, 2015 09:22PM

Vulvodynia

is a genital pain syndrome occurring in 7% to 8% of women. Although common, most practitioners are uncomfortable with the diagnosis and management of these women?s pain, and many believe this is psychologically based. Multifactorial in origin, ubiquitous factors include pelvic floor muscle abnormalities, neuropathic pain, anxiety, and primary or secondary sexual dysfunction. Although there are many published studies on vulvodynia, quality trials that evaluate therapy are lacking. However, experience suggests that most patients are significantly improved with pelvic floor physical therapy, medication for neuropathic pain, psychological support, and attention to sexual function. (Source: Clinical Obstetrics and Gynecology)

Jan 23, 2015 09:22PM

Dermatoses of Pregnancy

The dermatoses of pregnancy represent a distinct heterogenous group of cutaneous disorders that can impact the health of the pregnant woman and potentially the fetus. The current classification of pregnancy-specific cutaneous disorders is reviewed, along with important clinical features. Advances in management of these disorders, along with fetal implications, are discussed. The diagnosis of these disorders is challenging, but important clinical features can aid in diagnosis. There have been important advances in the management of these disorders and better understanding of potential fetal risks. Early recognition is critical for appropriate care. (Source: Clinical Obstetrics and Gynecology)

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Jan 23, 2015 09:22PM

Dermatologic Therapy in Pregnancy

Patients present during pregnancy with a variety of dermatologic conditions, most of which can be treated conservatively with topical medication by a primary obstetrician if he or she is familiar with common treatment options. Patients with moderate to severe forms of dermatologic disease or those requiring systemic therapy should be treated in consultation with a dermatologist. Dermatologic surgery can be performed safely in the second trimester using local anesthesia if needed. (Source: Clinical Obstetrics and Gynecology)

Jan 23, 2015 09:22PM

Physiological Skin Changes During Pregnancy

Physicians may often mistake normal physiological skin changes in pregnancy for pathologic changes, so being able to recognize the skin manifestations unique to pregnancy is of the utmost importance to avoid unnecessary testing and stress for the obstetric patient. Most physiological skin changes will resolve postpartum, so reassurance and expectant management is indicated in almost all cases. (Source: Clinical Obstetrics and Gynecology)

Jan 23, 2015 09:22PM

Contributors: Dermatologic Disorders.

No abstract available (Source: Clinical Obstetrics and Gynecology)

Jan 23, 2015 09:22PM

Foreword

No abstract available (Source: Clinical Obstetrics and Gynecology)

Jan 23, 2015 07:21PM

Rickettsial Infection in Animals, Humans and Ticks in Paulicéia, Brazil

Summary A previous study in Paulicéia Municipality, south?eastern Brazil, reported 9.7% of the Amblyomma triste ticks to be infected by Rickettsia parkeri, a bacterial pathogen that causes spotted fever in humans. These A. triste ticks were shown to be associated with marsh areas, where the marsh deer Blastocerus dichotomus is a primary host for this tick species. During 2008?2009, blood serum samples were collected from 140 horses, 41 dogs, 5 opossums (Didelphis albiventris) and 26 humans in farms from Pauliceia Municipality. Ticks were collected from these animals, from vegetation and from additional wildlife in these farms. Overall, 25% (35/140) of the horses, 7.3% (3/41) of the dogs, 3.8% (1/26) of the humans and 100% (5/5) of the opossums were seroreactive (titre ?64) to spott...

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Jan 23, 2015 05:01PM

Demonstration of the biphasic release of 0.1% halcinonide cream.

Authors: Draelos ZD Abstract Halcinonide in Halog Cream is formulated in a unique cream base that allows a biphasic release of this Class II steroid. Halcinonide in this product exists in two phases-a solution phase that is released immediately and a suspension phase that has a delayed release over time. The goal of this study was to evaluate this biphasic release of halcinonide into the skin using a novel noninvasive method.<br /> A dermal tape stripping protocol was used to quantify halcinonide concentration at 6 sequential depths in the skin of 4 sites on the forearms of 5 subjects. D-Squame strips were sequentially applied with consistent pressure and removed at 1, 3, 6, and 9 hours after application of halcinonide. Halcinonide was extracted from the strips and quantified...

Jan 23, 2015 05:01PM

Non-tuberculous mycobacterial infections following cosmetic laser procedures: a case report and review of the literature.

Authors: Berliner JG, Aldabagh B, Mully T, Yu SS, Schwartz BS, Berger TG Abstract Skin infections are not uncommon after cosmetic laser procedures. Infection rates following ablative laser resurfacing procedures are reported to be as high as 7.6%, compared to 1.9% for fractional ablation. <sup>1,2</sup> An infrequent yet important infectious complication of ablative laser treatment is that caused by non-tuberculous mycobacteria (NTM). <br/><br/> <em>J Drugs Dermatol.</em> 2015;14(1):80-83. PMID: 25607912 [PubMed - in process] (Source: Journal of Drugs in Dermatology)

Jan 23, 2015 05:01PM

Effective treatment of acne scars using pneumatic injection of hyaluronic Acid.

This study evaluated the clinical efficacy and safety of pneumatic injections of Hyaluronic Acid in the treatment of acne scars.<BR /> Two patients (Fitzpatrick skin type IV-V) with acne scars received two sessions of pneumatic, needleless injections of crosslinked hyaluronic acid (HA) at 4-week intervals. The treatment response was assessed by comparing pre- and 3-month posttreatment clinical photography.<BR /> The patients' acne scar grade improved from 2 to 1 in the first case, and 3 to 2 in the second case, based on independent physician assessment. Patient degree of satisfaction was similar to the physicians' assessment. No significant adverse events were noted. We conclude that pneumatic injection technology to deliver HA to the tissue is an effective and safe method for ...

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Jan 23, 2015 05:01PM

Successful Botulinum Toxin (OnabotulinumtoxinA) Treatment of Hailey-Hailey Disease.

Authors: Ho D, Jagdeo J Abstract Hailey-Hailey disease is a genetic disorder that affects flexural skin with scale, blisters, and maceration. Botulinum toxins have been previously used to treat Hailey-Hailey disease. Here, we present a patient who underwent one treatment of onabotulinumtoxinA and achieved excellent improvement that was sustained for three months post initial treatment.<BR /><BR /> <EM>J Drugs Dermatol.</EM> 2015;14(1):68-70. PMID: 25607910 [PubMed - in process] (Source: Journal of Drugs in Dermatology)

Jan 23, 2015 05:01PM

Efinaconazole topical solution, 10%: the benefits of treating onychomycosis early.

CONCLUSIONS: Treatment of onychomycosis early to avoid disease progression to other toenails is important. Once daily efinaconazole topical solution, 10% is particularly effective in these patients.<BR /><BR /> <EM>J Drugs Dermatol.</EM> 2015;14(1):58-62. PMID: 25607909 [PubMed - in process] (Source: Journal of Drugs in Dermatology)

Jan 23, 2015 05:01PM

Biological properties of a new volumizing hyaluronic Acid filler: a systematic review.

CONCLUSION: This 20 mg/ml HA dermal filler demonstrated volumizing ability, and maintaining viscosity and free-flowing characteristics for easy injection, tissue lifting, and molding. We hope future research incorporates biological properties analysis of this HA dermal filler in clinical trials.<BR /><BR /> <EM>J Drugs Dermatol.</EM> 2015;14(1):50-54. PMID: 25607908 [PubMed - in process] (Source: Journal of Drugs in Dermatology)

Jan 23, 2015 05:01PM

Anti-Inflammatory Activities of Colloidal Oatmeal (Avena sativa) Contribute to the Effectiveness of Oats in Treatment of Itch Associated With Dry, Irritated Skin.

CONCLUSIONS: These results demonstrate that colloidal oat extracts exhibit direct anti-oxidant and anti-inflammatory activities, which may provide the mechanisms for observed dermatological benefits while using the colloidal oatmeal skin protectant lotion.<BR /><BR /> <EM>J Drugs Dermatol.</EM> 2015;14(1):43-48. PMID: 25607907 [PubMed - in process] (Source: Journal of Drugs in Dermatology)

Jan 23, 2015 05:01PM

Optimizing the use of topical brimonidine in rosacea management: panel recommendations.

Authors: Tanghetti EA, Jackson JM, Belasco KT, Friedrichs A, Hougier F, Johnson SM, Kerdel FA, Palceski D, Hong HC, Hinek A, Cadena MJ Abstract Rosacea is a chronic inflammatory disease with a complex pathophysiology that manifests with central facial redness with or without papulopustular lesions. Often, patients with rosacea present with a constellation of signs and symptoms; for best results, the treatment plan should take into account all symptoms manifesting in the individual patient. The first available pharmacologic treatment to address the redness associated with rosacea is topical brimonidine. In the United States, brimonidine topical gel 0.33% is indicated for persistent facial erythema of rosacea; approval was based on clinically significant efficacy and good safety data...

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Jan 23, 2015 05:01PM

A Randomized, Double-blind, Split-face Study Comparing the Efficacy and Tolerability of Three Retinol-based Products vs. Three Tretinoin-based Products in Subjects With Moderate to Severe Facial Photodamage.

Authors: Babcock M, Mehta RC, Makino ET Abstract Retinol, has been shown to improve the appearance of photodamaged skin when applied topically, and is generally considered to be approximately ten times less potent than tretinoin. To assess this theory, three cosmetic formulations containing 0.25%, 0.5%, and 1.0% retinol were developed to correspond to the three commonly prescribed concentrations of tretinoin (0.025%, 0.05%, and 0.1%). A randomized, double-blind, split-face comparison study was conducted to compare the three concentrations retinol (Ret) including 0.25%, 0.5%, and 1.0%, against the respective three strengths of tretinoin (Tret) 0.025%, 0.05%, and 0.1% in subjects with moderate to severe facial photodamage. Subjects were randomized into three groups: Group 1 (Ret 0.25...

Jan 23, 2015 05:01PM

Clinical evaluation of a cross-linked hyaluronic Acid dermal filler applied for facial augmentation.

CONCLUSION: Good - excellent volume enhancement was noted almost immediately after the HA injections, improving patient reported quality of life aspects. HA treatment was shown to be safe.<BR /><BR /> <EM>J Drugs Dermatol.</EM> 2015;14(1):19-23. PMID: 25607904 [PubMed - in process] (Source: Journal of Drugs in Dermatology)

Jan 23, 2015 05:01PM

Single Blind, Randomized, Controlled Trial of a Lightening Product With and Without Iontophoresis versus Tretinoin and Vehicle for Hyperpigmentation.

CONCLUSION: The investigational product was effective and may be better tolerated than tretinoin cream.<BR /><BR /> <EM>J Drugs Dermatol.</EM> 2015;14(1):13-18. PMID: 25607903 [PubMed - in process] (Source: Journal of Drugs in Dermatology)

Jan 23, 2015 05:01PM

Therapeutic Update on the Treatment of Striae Distensae.

Authors: Sarnoff DS Abstract . PMID: 25607902 [PubMed - as supplied by publisher] (Source: Journal of Drugs in Dermatology)

Jan 23, 2015 05:01PM

Message from the Editors.

Authors: Robins P, Sarnoff DS Abstract . PMID: 25607901 [PubMed - as supplied by publisher] (Source: Journal of Drugs in Dermatology)

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Jan 23, 2015 05:01PM

Update on the management of rosacea: a status report on the current role and new horizons with topical azelaic Acid.

Authors: Del Rosso JQ, Kircik LH Abstract Azelaic acid (AzA) 15% gel has been available in the United States for slightly over a decade, approved for treatment of the inflammatory lesions (papules and pustules) of rosacea. Efficacy and safety have been established in multiple studies both as monotherapy and in combination with oral doxycycline. Azelaic acid 15% gel has been shown not to induce epidermal permeability barrier impairment, and proper skin care reduces the likelihood of neurosensory adverse effects of stinging and burning that can affect a subset of patients with rosacea. Azelaic acid 15% gel appears to produce a quicker onset of clinical effect than metronidazole in some patients when either agent is used in combination with subantimicrobial dose doxycycline; however, ...

Jan 23, 2015 05:01PM

Challenges and Advances in Rosacea Management.

Authors: Kircik LH Abstract . PMID: 25607797 [PubMed - as supplied by publisher] (Source: Journal of Drugs in Dermatology)

Jan 23, 2015 05:01PM

Cutaneous non-tuberculous mycobacterial infections in the outpatient setting: presentation of a case, review of the literature, and therapeutic considerations.

Authors: Spicer T, Beer K Abstract Mycobacterial infections are not common issues for many dermatologists. Recognition and treatment of these infections are frequently delayed by incorrect diagnoses. Frequently, the diagnosis of a mycobacterial infection is hampered by coinfection with bacteria including Staphylococcus. In some instances, patients will have infections with both mycobacteria and Staphylococcus. For some patients, as was the case with the patient reported herein, a biopsy is required to establish an accurate diagnosis. Physicians need to keep an open mind when presented with cutaneous infections and consider mycobacterial infections for patients that do not improve with standard antibacterial medications.<br /><br /> <em>J Drugs Dermatol</em>....

Jan 23, 2015 05:01PM

A Surprising Case of Mycobacterium Avium Complex Skin Infection in an Immunocompetent Patient.

We report a case of MAC skin infection in an immunocompetent individual. The patient is a 49-year-old male with a history of dyshidrotic eczema presenting with a fluctuant, non-draining nodule on his right forearm for 2 to 3 weeks, identified by tissue DNA probe to be a cutaneous MAC infection without systemic complications, as serologies and chest X-ray were unremarkable. MAC should be included in the broader differential diagnosis of deep fungal vs atypical mycobacterial skin infections. Nucleic acid-based assays are an important tool in making a definitive diagnosis, allowing for utilization of appropriate therapy for the specific etiologic pathogen. Given the patient's preceding diagnosis of eczema, it is possible that the compromised skin barrier and dampened cytotoxic Th1 activity pr...

Jan 23, 2015 05:01PM

Integration of thermal imaging with subsurface radiofrequency thermistor heating for the purpose of skin tightening and contour improvement: a retrospective review of clinical efficacy.

DISCUSSION: These data demonstrate the safety and efficacy of the ThermiTIght procedure for the treatment of skin laxity.<br /><br /> <em>J Drugs Dermatol</em>. 2014;13(12):1485-1489. PMID: 25607794 [PubMed - in process] (Source: Journal of Drugs in Dermatology)

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Jan 23, 2015 05:01PM

Effect of Skin Barrier Emulsion Cream vs a Conventional Moisturizer on Transepidermal Water Loss and Corneometry in Atopic Dermatitis: A Pilot Study.

Authors: Kircik LH Abstract The repair and maintenance of the epidermal barrier is of the utmost importance in the treatment of atopic dermatitis (AD). While barrier creams and emollients are considered to be a foundation of AD therapy, there is little comparative data between various product options. This was a pilot study with a small sample size to investigate the use of skin barrier emulsion cream vs a commonly used moisturizing lotion to improve the epidermal barrier in subjects with atopic dermatitis.<BR /><BR /> <EM>J Drugs Dermatol.</EM> 2014;13(12):1482-1484. PMID: 25607793 [PubMed - in process] (Source: Journal of Drugs in Dermatology)

Jan 23, 2015 05:01PM

Safe and Efficacious Use of a Topical Retinoid Under Occlusion for the Treatment of Mycosis Fungoides.

Authors: Aires D, Shaath T, Fraga G, Rajpara A, Fischer R, Liu D Abstract . PMID: 25607792 [PubMed - as supplied by publisher] (Source: Journal of Drugs in Dermatology)

Jan 23, 2015 05:01PM

Dermatofibrosarcoma protuberans: is mohs surgery truly superior? And the success of tyrosine kinase inhibitors.

Authors: Kallini JR, Khachemoune A Abstract Dermatofibrosarcoma protuberans is a rare, slow growing tumor. This growth occurs most frequently in males from ages 20 to 50. The most common area on which DFSP originates is the trunk. DFSP presents clinically as a pink nodule or as a firm, flesh-colored to brown, indurated and exophytic plaque. Pathology shows atypical spindle cells of fibroblast origin surrounding a core of collagen. The definitive treatment of DFSP is surgical excision. Imatinib is a tyrosine kinase inhibitor that has been approved for use in DFSP refractory to surgery.<br /><br /> <em>J Drugs Dermatol</em>. 2014;13(12):1474-1477. PMID: 25607791 [PubMed - in process] (Source: Journal of Drugs in Dermatology)

Jan 23, 2015 05:01PM

Evaluation of efficacy and tolerance of a nighttime topical antioxidant containing resveratrol, baicalin, and vitamin e for treatment of mild to moderately photodamaged skin.

Authors: Farris P, Yatskayer M, Chen N, Krol Y, Oresajo C Abstract Resveratrol is an effective anti-aging molecule with diverse biologic activity. It functions as a dual antioxidant that can neutralize free radicals and increase intrinsic antioxidant capacity. Additionally resveratrol increases mitochondrial biogenesis and has anti-inflammatory, anti-diabetic, and anti-cancer activity. In this paper we will focus on the use of topically applied resveratrol using a proprietary blend containing 1% resveratrol, 0.5% baicalin, and 1% vitamin E. This stabilized high concentration formulation demonstrates percutaneous absorption and alterations in gene expression such as hemoxygenase-1 (HO-1), vascular endothelial growth factor (VEGFA), and collagen 3 (COL3A1). Clinical assessment showed...

Jan 23, 2015 05:01PM

A comparison of super wide field microscopy systems in mohs surgery.

This article reviews 3 SWF microscopy systems: Leica DM2000 (Leica Microsystems, Wetzlar, Germany), Nikon Eclipse Ni (Nikon Instruments Inc., Melville, NY), and Olympus BX43 (Olympus, Center Valley, PA). The Leica DM2000's 1.25x objective results in a VA of 314.16 mm<sup>2</sup>. The Nikon Eclipse Ni's 1x objective results in a VA of 490.87 mm<sup>2</sup>. The Olympus BX43's 1.25x objective results in a VA of 352.99 mm<sup>2</sup>. The maximum VA at the lowest objective for Nikon is nearly 40% greater than for the Olympus and over 50% greater than for the Leica. The Nikon Eclipse Ni has a significantly higher maximum VA than the other 2 systems. <br /><br /> <em>J Drugs Dermatol</em>. 2014;13(12):1463-1465. PMID: 25607789 [Pu...

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Jan 23, 2015 05:01PM

Enhancing transungual delivery and spreading of efinaconazole under the nail plate through a unique formulation approach.

Authors: Kircik LH Abstract Onychomycosis is a very common nail disorder seen in dermatological practice. It is difficult to treat successfully for a multitude of reasons, and although topical antifungal therapy might be considered ideal for mild to moderate onychomycosis, efficacy has been limited by poor nail penetration of active ingredient through the nail plate into the nail bed and nail matrix to the site of infection. The intrinsic properties of an antifungal and its vehicle formulation are both considered important contributors to effective treatment. Here we review the formulation approach to efinaconazole topical solution, 10% an effective and well-tolerated treatment for onychomycosis. We demonstrate that the low surface tension formulation affords better penetration of ...

Jan 23, 2015 05:01PM

Evaluation of a new adipocytolytic solution: adverse effects and their relationship with the number of vials injected.

Authors: Pinto H, Hernandez C, Turra C, Manzano M, Salvador L, Tejero P Abstract Adipocytolytic therapies have always raised the interest of aesthetic medicine physicians, mainly because of the great potential to achieve spectacular results in localized adiposities reduction. In the last few decades, these results have been severely compromised due to the improper or reckless injection of these products, to the extent of some of them being banned in many countries. Today, there is a new adipocytolytic solution that has been approved, is effective, and has theoretic and empiric consensus regarding its safety. The aim of this study for which 331 therapeutic sessions were retrospectively analyzed is to provide evidence of its safety and efficacy. <br /> <br /> <em>J ...

Jan 23, 2015 05:01PM

Safety Observations in 12095 Patients With Psoriasis Enrolled in an International Registry (PSOLAR): Experience With Infliximab and Other Systemic and Biologic Therapies.

CONCLUSIONS: Based on PSOLAR data through 2013, no new safety concerns were observed with infliximab for all-cause mortality, MACE, or malignancy; the data suggest that infliximab was associated with serious infections.<BR /><BR /> <EM>J Drugs Dermatol.</EM> 2014;13(12):1441-1448. PMID: 25607786 [PubMed - in process] (Source: Journal of Drugs in Dermatology)

Jan 23, 2015 05:01PM

Metastatic Hepatocellular Carcinoma With Paraneoplastic Itch: Effective Treatment With Naltrexone.

Authors: Chia BK, Tey HL Abstract . PMID: 25607785 [PubMed - as supplied by publisher] (Source: Journal of Drugs in Dermatology)

Jan 23, 2015 05:01PM

Should Hyaluronic Acid Fillers Be Diluted?

Authors: Smith KJ Abstract . PMID: 25607784 [PubMed - as supplied by publisher] (Source: Journal of Drugs in Dermatology)

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Jan 23, 2015 05:01PM

Principles and Approaches for Optimizing Therapy With Unique Topical Vehicles.

Authors: Rosen J, Landriscina A, Friedman AJ Abstract . PMID: 25607783 [PubMed - as supplied by publisher] (Source: Journal of Drugs in Dermatology)

Jan 23, 2015 05:01PM

News, Views & Reviews. Repurposing of Drugs for Dermatologic Applications: Five Key Medications.

Authors: Adler BL, Friedman AJ Abstract . PMID: 25607712 [PubMed - as supplied by publisher] (Source: Journal of Drugs in Dermatology)

Jan 23, 2015 05:01PM

A case of new onset keratosis pilaris after discontinuation of erlotinib.

CONCLUSIONS AND RELEVANCE: This serves as the first documented case of new onset keratosis pilaris in a patient after discontinuation of erlotinib. We report the present case to show the possible association of keratosis pilaris with not only RAF inhibitors, but also the EGFR inhibitor erlotinib. Further investigation will determine whether this is a class effect with other systemic EGFR inhibitors.<br /><br /> <em>J Drugs Dermatol.</em> 2014;13(11):1410-1411. PMID: 25607711 [PubMed - in process] (Source: Journal of Drugs in Dermatology)

Jan 23, 2015 05:01PM

Efficacy of botulinum neurotoxin type a for treating recalcitrant plaque psoriasis.

We describe sustained local clearance of a psoriasis plaque in a patient following a single off-label injection of intradermal abobotulinumtoxinA. BoNTA may offer a novel therapeutic approach for treating recalcitrant plaque psoriasis.<br /> Case reports and anecdotal evidence suggests that onabotulinumtoxinA may be useful for treating inverse psoriasis.1,2 We previously reported an improvement in skin phenotype in a preclinical mouse model following a single intradermal injection of abobotulinumtoxinA.3 Here we present a patient case report demonstrating efficacy of abobotulinumtoxinA in reversing plaque psoriasis.<BR /><BR /> <EM>J Drugs Dermatol.</EM> 2014;13(11):1407-1408. PMID: 25607710 [PubMed - in process] (Source: Journal of Drugs in Dermatology)

Jan 23, 2015 05:01PM

A single-blinded randomized controlled study to assess the efficacy of twice daily application of sinecatechins 15% ointment when used sequentially with cryotherapy in the treatment of external genital warts.

CONCLUSION: Cryotherapy plus sinecatechins 15% ointment BID resulted in a significant improvement in the reduction of EGW compared to cryotherapy alone. Clinicaltrials.gov registration identifier: NCT02147353<BR /><BR /> <em>J Drugs Dermatol.</em> 2014;13(11):1400-1405. PMID: 25607709 [PubMed - in process] (Source: Journal of Drugs in Dermatology)

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Jan 23, 2015 05:01PM

Access of efinaconazole topical solution, 10%, to the infection site by spreading through the subungual space.

CONCLUSIONS: This study suggests that the vehicle developed for efinaconazole topical solution, 10%, when applied at the hyponychium, spreads into the subungual space between the nail plate and nail bed, reaching the site of infection.<BR /><BR /> <EM>J Drugs Dermatol.</EM> 2014;13(11):1394-1398. PMID: 25607708 [PubMed - in process] (Source: Journal of Drugs in Dermatology)

Jan 23, 2015 05:01PM

Transungual delivery of efinaconazole: its deposition in the nail of onychomycosis patients and in vitro fungicidal activity in human nails.

CONCLUSIONS: Effective transungual delivery of efinaconazole was demonstrated. The high efinaconazole concentrations in patient toenails and fungicidal activity in vitro potentially contribute to the clinical efficacy reported in phase 3 studies.<BR /><BR /> <EM>J Drugs Dermatol.</EM> 2014;13(11)1388-1392. PMID: 25607707 [PubMed - in process] (Source: Journal of Drugs in Dermatology)

Jan 23, 2015 05:01PM

Long-Term Safety of Ivermectin 1% Cream vs Azelaic Acid 15% Gel in Treating Inflammatory Lesions of Rosacea: Results of Two 40-Week Controlled, Investigator-Blinded Trials.

Authors: Stein Gold L, Kircik L, Fowler J, Jackson JM, Tan J, Draelos Z, Fleischer A, Appell M, Steinhoff M, Lynde C, Sugarman J, Liu H, Jacovella J Abstract Papulopustular rosacea (PPR) is characterized by facial erythema and inflammatory lesions believed to be primarily caused by dysregulation of the innate immune system. More recent evidence also suggests that <EM>Demodex folliculorum</EM> mites may contribute to the etiology of PPR. Ivermectin (IVM) 1% cream is a novel topical treatment developed to treat PPR. Two phase 3 trials have demonstrated that IVM 1% cream was significantly better than vehicle at investigator global assessment (IGA) success rate and lesion reductions and that it was safe and well tolerated. Two 40-week extension studies of those trials were ...

Jan 23, 2015 05:01PM

Real-life treatment profile of calcipotriene and betamethasone dipropionate topical suspension in patients with psoriasis vulgaris.

CONCLUSION: The results of this noninterventional study are consistent with previously reported data from interventional trials and suggest that treatment with CBD topical suspension is efficacious and well tolerated and improves quality of life in patients with psoriasis vulgaris.<BR /><BR /> <EM>J Drugs Dermatol.</EM> 2014;13(11):1374-1379. PMID: 25607705 [PubMed - in process] (Source: Journal of Drugs in Dermatology)

Jan 23, 2015 05:01PM

Microbiome of affected and unaffected skin of patients with atopic dermatitis before and after emollient treatment.

Authors: Seite S, Flores GE, Henley JB, Martin R, Zelenkova H, Aguilar L, Fierer N Abstract Atopic dermatitis (AD) is a chronic inflammatory skin disorder that results in areas of dry, itchy skin. Several cultivation-dependent and -independent studies have identified changes in the composition of microbial communities in these affected areas over time and when compared to healthy control individuals. However, how these communities vary on affected and unaffected skin of the same individual, and how these communities respond to emollient treatment, remains poorly understood. Here we characterized the microbial communities associated with affected and unaffected skin of 49 patients with AD before and after emollient treatment using high-throughput sequencing of the 16S rRNA gene. We ...

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Jan 23, 2015 05:01PM

Antibiotic resistance: shifting the paradigm in topical acne treatment.

CONCLUSION: For mild to moderate acne treatment, topical antibiotics in monotherapy are not to be used but may be combined with a retinoid or BPO to safely achieve more successful outcomes.<BR /><BR /> <EM>J Drugs Dermatol.</EM> 2014;13(11):1358-1364. PMID: 25607703 [PubMed - in process] (Source: Journal of Drugs in Dermatology)

Jan 23, 2015 05:01PM

Treatment of Facial Actinic Keratoses With Aminolevulinic Acid Photodynamic Therapy (ALA-PDT) or Ingenol Mebutate 0.015% Gel With and Without Prior Treatment With ALA-PDT.

CONCLUSION: ALA-PDT, ingenol mebutate gel, and a combination of the two treatment modalities are successful topical therapies for the reduction of actinic keratoses on the face. The group of subjects receiving 2 consecutive treatments with ALA-PDT, compared to treatment with ingenol mebutate gel alone or sequentially after one course of ALA-PDT had a significantly lower mean composite LSR score and a non-significant trend for greater efficacy. <BR /><BR /> <EM>J Drugs Dermatol.</EM> 2014;13(11):1353-1356. PMID: 25607702 [PubMed - in process] (Source: Journal of Drugs in Dermatology)

Jan 23, 2015 05:01PM

Pulsed dye laser therapy for molluscum contagiosum: a systematic review.

CONCLUSIONS: PDL offers a novel and effective treatment for MC. However, the articles reviewed herein suggest PDL is a safe, effective, quick and well-tolerated treatment for clearing MC lesions that does not cause scarring or permanent pigment change.<BR /><BR /> <EM>J Drugs Dermatol.</EM> 2014;13(11):1349-1352. PMID: 25607701 [PubMed - in process] (Source: Journal of Drugs in Dermatology)

Jan 23, 2015 05:01PM

Home-based wrinkle reduction using a novel handheld multisource phase-controlled radiofrequency device.

This study was performed in order to evaluate the efficacy and safety of a new handheld device delivering multisource radiofrequency to the skin for wrinkle reduction and skin tightening in the home setting.<BR /> PATIENTS AND METHODS: A total of 69 participants (age 54.3 years ± 8.09; age range 37-72 years) were enrolled in the study after meeting all inclusion/exclusion criteria (100%) and providing informed consent. Participants were provided with the tested device together with a user manual and treatment diary, to perform independent treatments at home for 4 weeks. The tested device, (Newa?, EndyMed Medical, Cesarea, Israel) emits 12 W of 1Mhz, RF energy through six electrodes arranged in a linear fashion. Independent control of RF polarity through each one of the 6 elect...

Jan 23, 2015 05:01PM

A focused monopolar radiofrequency causes apoptosis: a porcine model.

CONCLUSION: The study has shown that use of monopolar, focused radiofrequency can induce substantial apoptotic process in a porcine model. The data suggests that the monopolar, focused radiofrequency device can be used for reduction of fat and body shaping.<BR /><BR /> <EM>J Drugs Dermatol.</EM> 2014;13(11):1336-1340. PMID: 25607699 [PubMed - in process] (Source: Journal of Drugs in Dermatology)

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Jan 23, 2015 05:01PM

Radiofrequency: an update on latest innovations.

Authors: Sadick NS, Malerich SA, Nassar AH, Dorizas AS Abstract As the aging population in our society continues to grow, new technologies and procedures promising a more youthful appearance are continuously sought. The utilization of radiofrequency technology remains a novel method for the treatment of many aesthetic and medical dermatological indications. Innovative applications are constantly identified, expanding treatment options for various patient concerns including aging of the hands, cellulite, non-invasive lipolysis, and postpartum skin laxity. Non-invasive treatments are ideal for busy patients seeking minimal recovery time and so called lunch-time procedures. Furthermore, new developments in treatment devices enhance efficacy while decreasing patient discomfort.<BR /...

Jan 23, 2015 05:01PM

Clinical Evaluation of a Non-Ablative 1940 nm Fractional Laser.

CONCLUSION: The 1940nm thulium laser is safe, well tolerated, and results in reduced downtime compared to traditional resurfacing. The study demonstrated that the 1940 nm thulium laser could achieve injury patterns capable of skin rejuvenation.<BR /><BR /> <EM>J Drugs Dermatol.</EM> 2014;13(11):1324-1329. PMID: 25607697 [PubMed - in process] (Source: Journal of Drugs in Dermatology)

Jan 23, 2015 05:01PM

Nonablative 1927 nm Fractional Resurfacing for the Treatment of Facial Photopigmentation.

CONCLUSIONS: Two treatments with a 1927nm non-ablative fractionated thulium laser produced moderate to marked improvement in overall appearance and pigmentation with high patient satisfaction. The response to treatment was maintained at one and three months follow up.<BR /><BR /> <EM>J Drugs Dermatol.</EM> 2014;13(11):1317-1322. PMID: 25607696 [PubMed - in process] (Source: Journal of Drugs in Dermatology)

Jan 23, 2015 05:01PM

Muscle weakness in treatment of palmar hyperhidrosis with botulinum toxin type a: can it be prevented?

CONCLUSIONS: BTX-A led to the reduction of disease severity while transient side effects were reported. PMID: 25607695 [PubMed - in process] (Source: Journal of Drugs in Dermatology)

Jan 23, 2015 05:01PM

VISIA System: A Possible Tool in the Cosmetic Practice.

CONCLUSION: The VISIA Complexion Analysis System is a beneficial tool for dermatology and aesthetic practices with the potential to aid in patient education. PMID: 25607694 [PubMed - in process] (Source: Journal of Drugs in Dermatology)

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Jan 23, 2015 05:01PM

Update on Male Pattern Hair Loss.

Authors: Santos LD, Shapiro J Abstract . PMID: 25607693 [PubMed - as supplied by publisher] (Source: Journal of Drugs in Dermatology)

Jan 23, 2015 05:01PM

Ultrasound Technologies for Dermatologic Applications.

Authors: Alexiades-Aremenakas M Abstract . PMID: 25607692 [PubMed - as supplied by publisher] (Source: Journal of Drugs in Dermatology)

Jan 23, 2015 05:01PM

A variant of palpable migratory arciform erythema.

We present a case of a variant of PMAE in a 30-year-old healthy man with no history of medication use and erythematous to violaceous annular and arciform plaques on his face, scalp and trunk. This case is of particular significance because gene rearrangement studies and histopathologic findings are concerning for folliculotropic mycosis fungoides while the clinical course does not support this diagnosis. The authors' emphasize that clinical history is imperative for definitive diagnosis of palpable migratory arciform erythema as it can clinically and histopathologically resemble other cutaneous lymphocytic diseases.<br/><br/> <em>J Drugs Dermatol.</em> 2014;13(10):1288-1289. PMID: 25607568 [PubMed - in process] (Source: Journal of Drugs in Dermatology)

Jan 23, 2015 05:01PM

An adipocitolitic aqueous micro-gelatinous solution for buffalo hump deformity reduction.

Authors: Rauso R, Rusciani A, Curinga G Abstract Buffalo hump is a manifestation of HIV related lipodistrophy, it is characterized by an enlargment of dorsocervical fat pad and is distressing for patients. Surgical correction until a few years ago was the only option for treatment, however in last years non surgical corrections was carried out with minimally invasive techniques. Authors report this case that describe a longer follow up of an already published study were this deformity was treated with the injection of an adipocitolitic aqueous micro-gelatinous solution and during all the follow up no relapse was observed.<BR /><BR /> <EM>J Drugs Dermatol</EM>. 2014;13(10):1282-1284. PMID: 25607567 [PubMed - in process] (Source: Journal of Drugs in Derma...

Jan 23, 2015 05:01PM

Metastatic squamous cell carcinoma presenting as an erythematous nodule in a man with lung adenocarcinoma.

We present a case of a 50-year-old man with a history of metastatic lung adenocarcinoma who was referred for evaluation of a nodule overlying his right mandible, which had been progressively enlarging for two weeks. Biopsy demonstrated metastatic squamous cell carcinoma. Subsequent CT-guided biopsy of a left retroperitoneal lymph node was conducted and notable for squamous cell carcinoma. Therefore, this patient's skin lesion was the presenting sign of a second primary visceral tumor, likely originating in the lung. We present this case to raise clinical awareness of the rare phenomenon that cutaneous metastasis may be the first sign of a visceral cancer, even in the setting of a previous distinct primary malignancy.<br/><br/> <em>J Drugs Dermatol.</em> 2014...

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Jan 23, 2015 05:01PM

Successful medical treatment of a severe reaction to red tattoo pigment.

Authors: Feldstein S, Jagdeo J Abstract Tattoo allergies are often eczematous skin rashes that can be complicated by ulceration and infection. These allergies are difficult to resolve, sometimes requiring surgical or laser intervention, with varying success. Here we present a case of a 29-year-old woman with a serious skin allergic reaction to red tattoo ink that ulcerated and became secondarily infected. The patient expressed a desire to have the tattoo allergic reaction treated while preserving the cosmetic appearance of her tattoo for sentimental reasons. This case is being presented to provide an effective treatment algorithm for managing allergic tattoo reactions with ulceration and co-infection, while preserving the aesthetic integrity of the tattoo.<BR /><BR /> &...

Jan 23, 2015 05:01PM

Use of multispectral digital skin lesion analysis for evaluation of nevi in children.

CONCLUSION AND RELEVANCE: An approach that integrates automated imaging technology like the Multispectral Digital Skin Lesion Analysis device, along with another diagnostic aid, with the end result being cost-effective, easy to use by even non-experts and comforting for the pediatric patient is likely to compete to be the new gold standard in successful early diagnosis and management of melanoma.<br/><br/> <em>J Drugs Dermatol.</em> 2014;13(10):1269-1273. PMID: 25607564 [PubMed - in process] (Source: Journal of Drugs in Dermatology)

Jan 23, 2015 05:01PM

A randomized controlled clinical study to evaluate the effectiveness of an active moisturizing lotion with colloidal oatmeal skin protectant versus its vehicle for the relief of xerosis.

Authors: Kalaaji AN, Wallo W Abstract Xerosis is a common skin condition, occurring most often in the winter and in low relative humidity, which results in loss of moisture, cracking, and desquamation. Many emollient creams and lotions are available for use as preventive moisturizers. However, few controlled experiments have been published comparing the efficacy of active moisturizing products versus the vehicle used to deliver the products to the skin. Therefore, we conducted this randomized, double-blind, controlled clinical study to objectively compare a commercially available moisturizing product against its own vehicle. The active colloidal oatmeal moisturizer used in this study showed significant benefits versus its vehicle control in several dermatological parameters used to...

Jan 23, 2015 05:01PM

Comparison of the Efficacy of Long-Pulsed Nd:YAG Laser Intervention for Treatment of Onychomycosis of Toenails or Fingernails.

CONCLUSIONS: The efficacy of long-pulsed Nd:YAG 1064 nm laser intervention against affected toenails is superior to that against fingernails. It is also effective for treatment of onychomycosis with different severity.<br/><br/> <em>J Drugs Dermatol.</em> 2014;13(10):1258-1263. PMID: 25607562 [PubMed - in process] (Source: Journal of Drugs in Dermatology)

Jan 23, 2015 05:01PM

Hailey-hailey disease and review of management.

CONCLUSIONS: Herein we review the literature to identify successful treatments for Hailey-Hailey disease. We have outlined the treatments with the most evidence. The difficult nature of treating this disease requires that clinicians approach each patient differently. The literature shows that no one regiment works for all patients.<BR /><BR /> <EM>J Drugs Dermatol</EM>. 2014;13(10):1254-1257. PMID: 25607561 [PubMed - in process] (Source: Journal of Drugs in Dermatology)

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Jan 23, 2015 05:01PM

Measuring occipital scalp laxity before donor strip harvesting in hair transplantation.

CONCLUSION: Use of data from a simple, objective method to measure occipital scalp laxity simplified adjustment of strip harvesting, allowed for use of wider strips, and resulted in smaller donor wounds and scars from hair transplantation; however, accuracy in estimating the total number of grafts was reduced.<br/><br/> <em>J Drugs Dermatol.</em> 2014;13(10):1248-1252. PMID: 25607560 [PubMed - in process] (Source: Journal of Drugs in Dermatology)

Jan 23, 2015 05:01PM

Assessment of cardiovascular risk in patients with moderate to severe plaque psoriasis.

CONCLUSIONS: Cardiovascular risk was greater in patients with moderate to severe psoriasis than in patients with other dermatological conditions, suggesting that early detection and tailored management of risk factors is essential to reducing cardiovascular morbidity in these patients.<BR /><BR /> <EM>J Drugs Dermatol</EM>. 2014;13(10):1240-1247. PMID: 25607559 [PubMed - in process] (Source: Journal of Drugs in Dermatology)

Jan 23, 2015 05:01PM

Topical cyclosporine versus emulsion vehicle for the treatment of brittle nails: a randomized controlled pilot study.

CONCLUSIONS: Both CsAE and emulsion vehicle applied topically appeared to improve signs and symptoms of brittle nail syndrome and were well tolerated. These findings warrant corroboration in a larger population and inclusion of comparison with an inactive control and a higher concentration of CsAE, the former which may help in distinguishing the efficacy of vehicle emulsion from CsAE.<br/><br/> <em>J Drugs Dermatol.</em> 2014;13(10):1232-1239. PMID: 25607558 [PubMed - in process] (Source: Journal of Drugs in Dermatology)

Jan 23, 2015 05:01PM

Gender-based variability in disease presentation in pemphigus vulgaris.

Authors: Naseer SY, Gill L, Shah J, Sinha AA Abstract Pemphigus vulgaris is a chronic autoimmune blistering disorder of the skin. As with many autoimmune diseases, a female predominance in pemphigus vulgaris is well established. The genetic and physiological basis for this gender bias is not well understood. Moreover, it is unclear whether the affect of gender extends beyond disease susceptibility to influence disease presentation. To address this issue, we performed a comprehensive analysis of 72 male and 125 female pemphigus vulgaris patients across a set of defined demographic (HLA type, ethnicity) and clinical (age at disease onset, anti-desmoglein antibody levels, site of lesions, and history of autoimmune disease) factors. We find that male patients are more likely to present...

Jan 23, 2015 05:01PM

The Effects of Topical L-Selenomethionine on Protection Against UVB-Induced Skin Cancer When Given Before, During, and After UVB Exposure.

Authors: Burke KE, Zhou X, Wang Y, Commisso J, Keen CL, Nakamura RM, Combs GF, Wei H Abstract Previous studies in mice have shown that topical L-selenomethionine (SeMet) can prevent UVB-induced skin cancer when applied continuously before, during, and after the radiation exposure. With topical application of SeMet, selenium levels were shown to increase in the skin and liver, as well as in tumor tissue. Thus, possibly, the timing of SeMet application could affect the degree of inhibition of UVB-tumorigenesis (or maybe even enhance tumorigenesis at some stage). The goal of this research was to determine whether topical SeMet best inhibits UV-induced skin cancer if (a) begun before and continued during and after UVB exposure, (b) if begun before UVB-exposure and discontinued when tum...

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Jan 23, 2015 05:01PM

Split-face vitamin C consumer preference study.

CONCLUSIONS: Products A exhibited superior anti-aging benefits than Products B. Subjects preferred the smell, feel, and application of Products A and experienced significantly less irritation than Products B. Overall, Products A were preferred over Products B with subjects willing to pay more for Products A over Products B.<BR /><BR /> <EM>J Drugs Dermatol</EM>. 2014;13(10):1208-1213. PMID: 25607555 [PubMed - in process] (Source: Journal of Drugs in Dermatology)