Dr. William Ting, Board-Certified Dermatologist
at California Dermatology Care

2262 Camino Ramon, San Ramon, CA 94583
Tel: 925-328-0255
Email: staff@CalDermCare.com


Advanced Care with a Personal Touch

   

 

 

Medical Dermatology    Evidence-based medicine   Customized solution   Personal care

Latest Dermatology Headlines

Dr. William Ting has expertise in treating the entire spectrum of medical dermatology, with emphasis in preventive medicine and personalized recommendations. He enjoys taking care of patients with acne, eczema, hair and nail disorders, rashes, psoriasis and skin cancers.

He is at the forefront of medical dermatology and dermatologic research. He continues to publish articles in peer-reviewed dermatology journals. He is an early pioneer of photodynamic therapy (PDT) and one of the most experienced practitioners of PDT in the Bay Area. He is the first dermatologist in the San Francisco Bay Area and Northern California to introduce Lutronic Spectra Laser for melasma, acne, scar revision, pore size reduction as well as the Cutera GenesisPlus laser for advanced nail fungus laser treatment, keloid and hypertrophic scar, warts and scar revision.

Dr. Ting is a fellow of the American Academy of Dermatology (AAD) and American Society of Dermatologic Surgery (ASDS). He is a member of the National Psoriasis Foundation and International Hyperhidrosis Society.

Innovative Therapeutic Approach to Common Skin Conditions

Acne

Eczema (Atopic Dermatitis)

Hair and Nail disorders

  • Maximize therapeutic synergy and efficacy by utilizing both prescription-strength and over-the counter products when available
  • Comprehensive workup including bloodwork and biopsy if necessary
  • Systemic oral hormonal therapy for women and men when indicated

Psoriasis 

Rosacea

  • Multi-prong approach to minimize redness
  • Low-dose 'non-antibiotic' anti-inflammatory oral medication for long-term remission 
  • Emphasis on prevention
  • Fotofacial/IPL laser utilizing Cynosure XPL/Elite MPX
  • Cutera GenesisPlus Laser with or without combination with IPL 
  • Diode laser for facial veins
  • VBeam Pulse Dye Laser, the new gold standard for rosacea and facial redness

Skin Cancer 

  • Emphasis on prophylactic treatments with topical 5-FU, imiquimod, diclofenac, ingenol mebutate and oral chemopreventive therapy such as Soriatane.
  • Reduce future risks of skin cancer with photodynamic therapy, TCA chemical peels and/or fractional CO2 resurfacing laser  
  • Mohs Surgery to achieve highest cure rate and tissue sparing
  • Close colloboration with plastic surgeon(s) as needed  

Sweating Disorder (Hyperhidrosis) 

Vitiligo

Warts 


ABCD of Mole Check

 

 

Common Medical Dermatology Diagnostics and Therapeutics:

Dermatology Links:

American Academy of Dermatology
American Society of Dermatologic Surgery
American Society of Mohs Surgery
International Hyperhidrosis Society
National Psoriasis Foundation

 Latest Dermatology Headlines:

Latest Dermatology Headlines
Mon, 02 Mar 2015 02:34:31 +0100

http://www.medworm.com/rss/index.php/Dermatology/12/

Feb 28, 2015 04:00PM

Ipilimumab and immune-mediated adverse events: a case report of anti-CTLA4 induced ileitis

Conclusions: The aim of this article is to support further investigations concerning epigenetic and genetic analysis in order to personalize biological therapy and to reduce immune related adverse events observed after ipilimumab administration. (Source: BMC Cancer)

MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.

Feb 28, 2015 10:44AM

Current landscape for treatment of advanced basal cell carcinoma.

Authors: Foley P Abstract Basal cell carcinomas (BCCs) account for around 80% of non-melanoma skin cancer. Australia has the highest incidence of BCC globally and the rates continue to increase in both Australia and New Zealand. BCC causes significant morbidity, placing an enormous burden on the healthcare system. Treatment of patients with advanced BCC can be particularly challenging. A panel of UK experts recently defined advanced disease as BCC that in which current treatment modalities are considered potentially contraindicated by clinical or patient-driven factors. Research has found that mutations in the hedgehog signalling pathway underpin the pathogenesis of the vast majority of sporadic BCC, as well as Gorlin syndrome. The first-in-class oral small molecule hedgehog pathwa...

Feb 28, 2015 10:01AM

Pediatric Scalp Burns: Hair Today, Gone Tomorrow?

Scalp burns in the pediatric population appear relatively uncommon, with most reported cases occurring in adults secondary to electrical burns. We reviewed our experience with the management of these injuries in children. A retrospective review was conducted at our institution from March 2004 to July 2011. Scalp burns were defined as any burn crossing over the hairline into the scalp region. During the 7-year 4-month study, there were 107 scalp burns, representing 1.8% of the 6074 burns treated at our institution during that time. The cause was scald in 97, contact in 4, flame in 3, friction in 2, and chemical in 1. The majority (n = 93, 87%) appeared superficial to mid-dermal, with an average time to complete healing of 10.3 days. The remaining 14 cases (13%) were mid-dermal to full thick...

MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.

Feb 28, 2015 01:59AM

Evaluation of the tolerability and safety of a 0.015% ingenol mebutate gel compared to 5% 5?fluorouracil cream for the treatment of facial actinic keratosis: a prospective randomized trial

ConclusionFor treating AKs, the local skin reactions in the IMB group were more short?lived compared with those of 5?FU, but both treatments seemed to be safe and tolerable. (Source: Journal of the European Academy of Dermatology and Venereology)

Feb 28, 2015 01:51AM

Cosmetic procedures and the distortion of beauty

(Source: Journal of Cosmetic Dermatology)

Feb 28, 2015 01:22AM

Prospective Randomized Comparison of Scar Appearances between Cograft of Acellular Dermal Matrix with Autologous Split-Thickness Skin and Autologous Split-Thickness Skin Graft Alone for Full-Thickness Skin Defects of the Extremities

Conclusions: For cases with traumatic full-thickness skin defects on the extremities, a statistically significant better result was achieved with cograft of acellular dermal matrix with autologous split-thickness skin graft than with autologous split-thickness skin graft alone in terms of Vancouver Scar Scale score. CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, II. (Source: Plastic and Reconstructive Surgery)

MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.

Feb 28, 2015 01:21AM

Secondary Upper Lid Blepharoplasty: A Clinical Series Using the Tarsal Fixation Technique

Conclusions: The postblepharoplasty look of patients undergoing secondary upper lid blepharoplasty differs from the lid appearance of patients presenting for primary blepharoplasty. Tarsal fixation and lipoinfiltration are major advances in secondary upper lid blepharoplasty. (Source: Plastic and Reconstructive Surgery)

Feb 28, 2015 01:15AM

New Drug on the Block: Apremilast for Plaque PsoriasisNew Drug on the Block: Apremilast for Plaque Psoriasis

Will this new oral agent for plaque psoriasis provide the relief your patients need? Medscape Pharmacists (Source: Medscape Dermatology Headlines)

Feb 27, 2015 04:00PM

Human pulmonary artery endothelial cells in the model of mucopolysaccharidosis VI present a prohypertensive phenotype

Conclusion Our data suggest that MPS VI endothelium presents a prohypertensive phenotype due to the reduction of endothelium's proliferation ability and expression of vasorelaxing factors. (Source: Molecular Genetics and Metabolism Reports)

Feb 27, 2015 04:00PM

Wound measurement techniques: Comparing the use of ruler method, 2D imaging and 3D scanner

The statistics on the growing number of non healing wounds is alarming. In the United States, chronic wounds affect 6.5 million patients. An estimated US $25 billion is spent annually on treatment of chronic wounds and the burden is rapidly growing due to increasing health care costs, an aging population and a sharp rise in the incidence of diabetes and obesity worldwide(1). Accurate wound measurement techniques will help health care personnel to monitor the wounds which will indirectly help improving care (7,9). (Source: Journal of the American College of Certified Wound Specialists)

MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.

Feb 27, 2015 03:43PM

Two Sunscreen Ingredients Not Safe or Effective, FDA SaysTwo Sunscreen Ingredients Not Safe or Effective, FDA Says

The agency told manufacturers it needs more data before it can make a final decision. Medscape Medical News (Source: Medscape Medical News Headlines)

Feb 27, 2015 01:53PM

Synthesis, X-ray characterization and biological evaluation of some new 2-(4-methy-2-oxo-2 H -chromen-7yloxy) acetamide derivatives

Abstract Newly designed coumarinyloxy acetamide derivatives (7a?7n) were synthesized in good yields and characterised by advanced spectroscopic studies and the XRD studies indicated that no polymorphism is observed in the molecules. Synthesized coumarinyloxy acetamides showed potent antimicrobial activity on human pathogens. Some of the analogues were found to have comparable or even more potency than the standard drugs (Ciprofloxacin for bacteria and Griseofulvin for dermatophytic fungi). Aromatic coumarinyloxy amides possess good antimicrobial activity followed by alicyclic compounds but aliphatic straight chain coumarinyloxy amides showed poor antimicrobial activity. In vitro results were correlated with docking studies. (Source: Medicinal Chemistry Research)

Feb 27, 2015 01:53PM

Molecular modeling and correlation of PFI1625c-peptide models of bioactive peptides with antimalarial properties

Abstract Bioactive peptides are active against the malaria parasite growth through targeting various stages of life cycle, but their mechanism of action is not fully understood. PFI1625c, a metalloprotease present in Plasmodium falciparum, is a potential drug target, and it shows best binding to peptide P550 (LVIVAKRA). Out of 20 selected antimalarial peptides, 4 peptides namely Dermaseptin S3, Cyclosporin A, Angiotensin II, and PcFK2 show high affinity with PFI1625c. Dermaseptin S3 is making polar contacts and hydrophobic interactions with the residues present within the catalytic site of PFI1625c. The affinity of bioactive peptides toward PFI1625c and anti-malarial activity of peptide shows a strong correlation (R = 0.921), indicating PFI1625c as a potential target behind...

Feb 27, 2015 01:36PM

Combination Therapy Helpful in Refractory AlopeciaCombination Therapy Helpful in Refractory Alopecia

Combination therapy with diphenylcyclopropenone (DPCP) and anthralin is more effective than DPCP alone in patients with chronic extensive alopecia areata (AA), according to Turkish researchers. Reuters Health Information (Source: Medscape Dermatology Headlines)

Feb 27, 2015 12:23PM

Chromosome 1p36.22p36.21 duplications/triplication causes Setleis syndrome (focal facial dermal dysplasia type III)

Focal facial dermal dysplasias (FFDD) are characterized by congenital bitemporal or preauricular atrophic skin lesions, and either autosomal dominant or autosomal recessive inheritance. Setleis syndrome (SS), FFDD type III, is a severe form of FFDD with the ectodermal lesions plus other striking facial features. Autosomal recessive nonsense and frameshift mutations in TWIST2 have been found to cause SS in some but not all individuals. Here, we report on four unrelated individuals, one with an unclassified FFDD and the other three with classic SS. Chromosomal microarray analyses revealed unique copy number variants of 1p36 in two individuals with duplications at 1p36.22p36.21 and one with a triplication at 1p36.22p36.21. The fourth patient had normal chromosomes by microarray analysis. All ...

Feb 27, 2015 07:35AM

Fine?needle aspiration of superficial myxoid neurofibroma in the region of the breast

We present an unusual case of superficial myxoid neurofibroma in the region of the breast that underwent pre?operative fine?needle aspiration (FNA). The differential diagnosis for a myxoid subcutaneous lesion should include myxoid neurofibroma when myxoid material is encountered in an otherwise hypocellular FNA. Diagn. Cytopathol. 2015. © 2015 Wiley Periodicals, Inc. (Source: Diagnostic Cytopathology)

Feb 27, 2015 07:05AM

Surgical Management of Vaginal Agglutination due to Lichen Planus

Lichen planus is a rare dermatological disorder, which is often associated with painful and disfiguring vulvovaginal effects. At our vulvar specialty center we see many women with vulvovaginal lichen planus each year, frequently with marked scarring and vulvovaginal agglutination which precludes vaginal intercourse. Through our experience we developed a protocol for operative management and post-operative care for severe vulvovaginal agglutination. Our objective is to share this protocol with a wider audience so that women at other centers with these devastating effects of lichen planus can benefit from our experience. (Source: The Journal of Minimally Invasive Gynecology)

Feb 27, 2015 02:21AM

Skin Tumour Surgery in Primary Care: Do General Practitioners Need to Improve Their Surgical Skills?

Conclusion: This study underlines the difficulties in skin tumour management in primary care. To stimulate adequate resource use, the number of excisions of benign lesions could be lowered, and pretreatment biopsy in non-melanoma skin cancer management should be encouraged. GPs should be aware of their limitations and consider referral of high-risk malignancies.Dermatology (Source: Dermatology)

Feb 26, 2015 11:26PM

Early treatment in preschool children: an evidence-based approach

Purpose of review: Wheezing is a common symptom in early childhood but only some of these children will experience continued wheezing symptoms in later childhood making the diagnosis and treatment of these children challenging. This review covers recent findings regarding the epidemiology, diagnosis, evaluation, and treatment of preschool-aged children with asthma. Recent findings: Key characteristics that distinguish the childhood asthma-predictive phenotype include male sex, history of wheezing with lower respiratory tract infections, history of parental asthma, history of atopic dermatitis, eosinophilia, early sensitization to food or aeroallergens, or lower lung function in early life. The preschool-aged asthma population tends to be characterized as exacerbation prone with relatively ...

Feb 26, 2015 11:26PM

Occupational diseases in individuals exposed to metal working fluids

Purpose of review: To examine the current occurrence of respiratory and skin disease in workers who do metal machining with metal working fluids (MWFs), a common work process in manufacturing. Recent findings: A summary of the 27 recognized outbreaks of respiratory disease in workers exposed to MWFs was published. New studies have identified irritative symptoms among workers with low-level exposures. There were review articles discussing the content, measurement and control of microbial agents in MWFs. Summary: The occurrence of work-related asthma and hypersensitivity pneumonitis appears to have diminished in the last 10 years. This is presumed to be secondary to lower air levels from the use of newer machining equipment, which are enclosed and have local ventilation as well as better con...

Feb 26, 2015 11:26PM

Immunological mechanisms in allergic contact dermatitis

Purpose of review: Allergic contact dermatitis is a skin disease resulting from an adverse reaction of the immune system to low-molecular-weight organic chemicals or metal ions. This review summarizes recent findings that highlight new details of the complex orchestration of the cellular and molecular immune response to contact allergens. Recent findings: Progress has been made in the characterization of the roles of natural killer T cells, natural killer cells, mast cells and neutrophils, as well as in the elucidation of signaling pathways triggered by contact allergens. Global technologies begin to reveal gene signatures for contact allergen identification and improved diagnostics. Summary: Recent progress in contact allergy research has deepened our understanding of the molecular and ce...

Feb 26, 2015 11:00PM

Rear End Takes a Front Seat in Plastic Surgery Offices

Title: Rear End Takes a Front Seat in Plastic Surgery OfficesCategory: Health NewsCreated: 2/26/2015 12:00:00 AMLast Editorial Review: 2/27/2015 12:00:00 AM (Source: MedicineNet Skin General)

MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.

Feb 26, 2015 04:00PM

Pustular pyoderma gangrenosum: Report of two cases

(Source: The Journal of Dermatology)

Feb 26, 2015 04:00PM

Case of familial Michelin tire baby syndrome

(Source: The Journal of Dermatology)

MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.

Feb 26, 2015 04:00PM

Association of anti?RNA polymerase III antibody and malignancy in Japanese patients with systemic sclerosis

Abstract Patients with systemic sclerosis (SSc) have an increased risk of malignancy compared with the general population. Recently, SSc patients with anti?RNA polymerase III antibody have been reported to have an increased risk of malignancy as compared with those with other disease?specific autoantibodies in US, European and Australian populations. Therefore, we studied the relationship between disease?specific autoantibodies and malignancy in 261 Japanese SSc patients. The prevalence of malignancy was significantly higher in patients with anti?RNA polymerase III antibody (7/22, 31.8%) than in those with anti?topoisomerase I antibody (2/82, 2.4%) and in those with anticentromere antibody (8/137, 5.8%). Importantly, among seven patients with anti?RNA polymerase III antibody an...

Feb 26, 2015 04:00PM

Histogenesis of pure and combined Merkel cell carcinomas: An immunohistochemical study of 14 cases

Abstract The histogenesis of Merkel cell carcinoma (MCC) has remained unresolved. Moreover, one of the questions is whether pure MCC and combined MCC represent the same histogenesis and entity. The existence of combined MCC suggests that MCC likely arise from pluripotent stem cells. Merkel cells (MC) localize within the bulge area, which is populated by hair follicle stem cells. We used hair follicle stem cell markers to investigate whether MCC share certain characteristics of these stem cells. Fourteen MCC specimens were examined histologically and immunohistochemically. There were six pure MCC and eight combined MCC. In six combined MCC, both MCC components and squamous components at least focally shared the expression of one or more of cytokeratin (CK)15, CK19 and CD200, which are hair ...

Feb 26, 2015 04:00PM

Poor adherence to medication as assessed by the Morisky Medication Adherence Scale?8 and low satisfaction with treatment in 237 psoriasis patients

This study was conducted among patients registered in monitoring system and 3096 eligible patients were enrolled. Our web?based questionnaire included the following items such as age, sex, annual income, main health?care institution, experience of effectiveness by oral or topical medication, overall satisfaction with treatment, and MMAS?8 for oral or topical medication. Mean adherence score by MMAS?8 was 5.2 for oral and 4.3 for topical medication. More patients with psoriasis used a university hospital and fewer used a private clinic compared with those with the other skin disease patients. Experience of drug effectiveness by oral medication and overall satisfaction with treatment was lower in psoriasis patients than in other patients. In oral medication, significantly better adhe...

Feb 26, 2015 04:00PM

Alteration in regulatory T cells and programmed cell death 1?expressing regulatory T cells in active generalized vitiligo and their clinical correlation

ConclusionsDeficiency in Treg frequency and decreased expression of Treg?associated parameters (TGFB and CCL21) suggested a possible defect in Tregs that may alter their suppression function and skin homing in aGV. The increased PD1+ Tregs suggests that the PD1/PD ligand pathway may be involved in aGV and may have a role in Treg exhaustion. Further study is required to delineate the effect of PD1 in regulating Treg function in aGV. (Source: British Journal of Dermatology)

MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.

Feb 26, 2015 04:00PM

Human herpesvirus 6 involvement in paediatric drug hypersensitivity syndrome

ConclusionsHuman herpesvirus6 positivity with DHS is associated with a more severe disease course. Treatment with systemic corticosteroids was associated with a trend towards reduced hospital LOS and Tfeb, and a significantly reduced number of days until cessation of progression. (Source: British Journal of Dermatology)

Feb 26, 2015 04:00PM

Novel methods for generating fractional epidermal micrografts

ConclusionsStrategy 2 is the more practical method for fractional epidermal micrografting to treat larger lesions with less donor?site trauma and has recently been commercialized. (Source: British Journal of Dermatology)

Feb 26, 2015 04:00PM

Thymic stromal lymphopoietin induction by skin irritation is independent of tumour necrosis factor??, but supported by interleukin?1

ConclusionsThymic stromal lymphopoietin is a general responder to disrupted skin homeostasis and may have a role in triggering the alarm system of the skin. TSLP induction is rapid, transient and driven by a mechanism that does not involve TNF??, but partially relies on the evolutionarily ancient IL?1 system. The irritated skin secretes TSLP into the circulatory system. TSLP regulation varies between species. (Source: British Journal of Dermatology)

Feb 26, 2015 04:00PM

Occlusive gloves and skin conditions: is there a problem? Results of a cross?sectional study in a semiconductor company

ConclusionsProlonged wearing of occlusive gloves with clean hands and without exposure to additional hazardous substances does not seem to affect the skin negatively. (Source: British Journal of Dermatology)

Feb 26, 2015 04:00PM

Genotype?phenotype correlation of xeroderma pigmentosum in a Chinese Han population

ConclusionsThis study identified 13 novel mutations and extended the mutation spectrum of XP in the Chinese Han population. In this cohort, we found that patients with XP?G have no neurological symptoms, and patients with XP?A and XP?V have a high incidence of malignancy. Furthermore, lack of stringent protection against sunlight, late diagnosis and long duration of disease play an important role. (Source: British Journal of Dermatology)

MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.

Feb 26, 2015 04:00PM

The humanistic, economic and societal burden of Herpes Zoster in Europe: a critical review

Conclusions: Available evidence highlights that HZ and PHN result in significant humanistic and economic burden for patients, healthcare systems and wider societies. A tendency to focus upon healthcare resource use and the direct costs of management at the expense of other impacts (e.g. informal caregivers and formal social care) may result in an underestimation of the true burden of HZ and PHN. (Source: BMC Public Health)

Feb 26, 2015 04:00PM

Rear End Takes a Front Seat in Plastic Surgery Offices

Men also drove up overall number of cosmetic procedures, doctors say (Source: Fertility News - Doctors Lounge)

Feb 26, 2015 04:00PM

Macrophage apoAI protects against dyslipidemia-induced dermatitis and atherosclerosis without affecting HDL [Research Articles]

Tissue cholesterol accumulation, macrophage infiltration, and inflammation are features of atherosclerosis and some forms of dermatitis. HDL and its main protein, apoAI, are acceptors of excess cholesterol from macrophages; this process inhibits tissue inflammation. Recent epidemiologic and clinical trial evidence questions the role of HDL and its manipulation in cardiovascular disease. We investigated the effect of ectopic macrophage apoAI expression on atherosclerosis and dermatitis induced by the combination of hypercholesterolemia and absence of HDL in mice. Hematopoietic progenitor cells were transduced to express human apoAI and transplanted into lethally irradiated LDL receptor–/–/apoAI–/– mice, which were then placed on a high-fat diet for 16 weeks. Macropha...

Feb 26, 2015 04:00PM

BMC Dermatology reviewer acknowledgement 2014

Contributing reviewersThe editors of BMC Dermatology would like to thank all our reviewers who have contributed to the journal in Volume 14 (2014). (Source: BMC Dermatology)

MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.

Feb 26, 2015 04:00PM

Cancer Risk in Dermatomyositis: A Meta-Analysis of Cohort Studies

Conclusions Compared with the general population, DM patients are at a significantly increased risk for developing cancer. Understanding the magnitude of this risk is highly relevant toward assisting healthcare providers in clinical decision making, such as screening DM patients for cancer. (Source: American Journal of Clinical Dermatology)

Feb 26, 2015 04:00PM

Eumycetoma and actinomycetoma ? an update on causative agents, epidemiology, pathogenesis, diagnostics and therapy

Abstract Mycetoma is a chronic putrid infection of the cutaneous and subcutaneous tissue concerning predominantly the feet, and more rarely other body parts. Mycetoma can be caused by both fungi (eumycetoma) and bacteria (actinomycetoma). Mode of infection is an inoculation of the causative microorganism via small injuries of the skin. The clinical correlate of both forms of mycetoma is tumescence with abscesses, painless nodules, sinuses and discharge. The latter is commonly serous?purulent and contains grains (filamentous granules) which can be expressed for diagnostic purposes. Distinctive for both eumycetoma and actinomycetoma, are the formation of grains. Grains represent microcolonies of the microorganism in vivo in the vital tissue. The most successful treatment option for eumycet...

Feb 26, 2015 04:00PM

Koebner Phenomenon in a Patient With Lichen Sclerosus Following a Jellyfish Sting: An Exceptional Morphology

Publication date: Available online 26 February 2015 Source:Actas Dermo-Sifiliográficas (English Edition) Author(s): I. Pérez-López , C. Garrido-Colmenero , G. Blasco-Morente , J. Tercedor-Sánchez (Source: Actas Dermo-Sifiliograficas)

Feb 26, 2015 04:00PM

Failure of Non-Cultured Melanocyte-Keratinocyte Transplantation in Periungual Vitiligo: A Case eport

Conclusion Acral vitiligo is one of the difficult-to-treat areas, and further studies needed to explain the variable outcomes of non-cultured melanocyte keratinocyte transplantation treatment of clinically stable acral vitiligo patients. (Source: Journal of Dermatology and Dermatologic Surgery)

Feb 26, 2015 04:00PM

Differential effects of some natural compounds on the transdermal absorption and penetration of caffeine and salicylic acid

Publication date: 15 April 2015 Source:International Journal of Pharmaceutics, Volume 483, Issues 1?2 Author(s): Faqir Muhammad , Jim E. Riviere Many natural products have the potential to modulate the dermal penetration of topically applied drugs and chemicals. We studied the effect of five natural compounds (hydroxycitronellal, limonene 1,2-epoxide, terpinyl acetate, p-coumaric acid, transferrulic acid) and ethanol on the transdermal penetration of two marker drugs (14C-caffeine and 14C-salicylic acid) in a flow through in vitro porcine skin diffusion system. The parameters of flux, permeability, diffusivity, and percent dose absorbed/retained were calculated and compared. The dermal absorption of 14C-caffeine was significantly higher with terpinyl acetate and limonene 1,2-epoxide as...

Feb 26, 2015 04:00PM

Social Anxiety Disorder and Agoraphobia in Dermatology Patients; Two Cases and a Review of the Literature.

Authors: Marshall C, Bewley A Abstract Abstract is missing (Short communication). PMID: 25721467 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)

MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.

Feb 26, 2015 04:00PM

Methotrexate Dosing Regimen for Plaque-type Psoriasis: A Systematic Review of the Use of Test-dose, Start-dose, Dosing Scheme, Dose Adjustments, Maximum Dose and Folic Acid Supplementation.

Authors: Menting SP, Dekker PM, Limpens J, Hooft L, Spuls PI Abstract There is a range of methotrexate dosing regimens for psoriasis. This review summarizes the evidence for test-dose, start-dose, dosing scheme, dose adjustments, maximum dose and use of folic acid. A literature search for randomized controlled trials and guidelines was performed. Twenty-three randomized controlled trials (29 treatment groups) and 10 guidelines were included. Two treatment-groups used a test-dose, 5 guidelines recommend it. The methotrexate start-dose in randomized controlled trials varied from 5 to 25 mg/week, most commonly being either 7.5 mg or 15 mg. Guidelines vary from 5 to 15 mg/week. Methotrexate was administered as a single dose or in a Weinstein schedule in 15 and 11 treatment-groups, resp...

Feb 26, 2015 04:00PM

Interferon-gamma Inhibits Melanogenesis and Induces Apoptosis in Melanocytes: A Pivotal Role of CD8+ Cytotoxic T Lymphocytes in Vitiligo.

In this study, a large number of skin infiltrating IFN-?+ cells and CD8+ T cells were detected in progressive vitiligo. Among the peripheral blood mononuclear cells (PBMCs) of vitiligo patients, CD8+ cytotoxic T lymphocytes (CTLs) that express IFN-? exhibited significant expansion, which suggests that activated CTLs are the main source of increased IFN-? in progressive vitiligo. An in vitro analysis demonstrated that IFN-? inhibits melanogenesis in primary cultured human melanocytes by altering melanogenic enzyme mRNA expression and, more importantly, that IFN-? directly induces melanocyte apoptosis. Our data indicate that vitiligo pathophysiology may be linked to globally activated CD8+ CTL subpopulations, which produce increased IFN-? and induce melanocyte dysfunction and apoptosis...

Feb 26, 2015 04:00PM

Subungual Angiokeratoma Presenting as a Longitudinal Pigmented Band in the Nail.

Authors: Hasegawa M, Tamura A Abstract Abstract is missing (Short communication). PMID: 25721145 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)

Feb 26, 2015 04:00PM

Congenital and Disseminated Pyogenic Granuloma-like Vascular Lesions.

Authors: Mallet S, Rebelle C, Ligi I, Scavarda D, Bouvier C, Petit P, Fraitag S, Wassef M, Gaudy-Marqueste C, Hesse S, Richard MA, Grob JJ, André N Abstract Abstract is missing (Short communication). PMID: 25720992 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)

Feb 26, 2015 04:00PM

Treponema pallidum Haemagglutination Assay Serum Titres as a Predictor of Cerebrospinal Fluid Abnormalities in Patients with Syphilis.

Authors: Levchik N, Ponomareva M, Surganova V, Zilberberg N Abstract Abstract is missing (Short communication). PMID: 25720837 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)

MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.

Feb 26, 2015 02:00PM

5 New Ways to Treat New and Old Acne Scars

Millions of people suffer from acne. It can start as a young teen or as an adult. Whether your breakouts respond to home treatments or you see a dermatologist regularly one of the most feared complications is acne scarring. This can range from one "pock mark" to an entire face. The strange thing is that no one can predict who will develop a scar and who will clear with no lasting skin damage. Sometimes patients with only a few acne break outs with scar with each one, and some people can have extensive acne and heal without a problem. In recent years the options for treating acne scars have expanded with new and exciting technology that can treat even old scars with minimal downtime. While there are many different type of acne scars, all of the treatments seek to normalize that collagen de...

Feb 26, 2015 12:47PM

Pimecrolimus for Eczema May Have No Added Cancer Risk After AllPimecrolimus for Eczema May Have No Added Cancer Risk After All

Topical pimecrolimus as a treatment for eczema may have no significant cancer risk, contrary to a U.S Food and Drug Administration warning, according to new research published online February 18 in JAMA Dermatology. Reuters Health Information (Source: Medscape Dermatology Headlines)

Feb 26, 2015 12:35PM

Characteristic Dysphagia as a Manifestation of Dermatomyositis on Oropharyngeal Muscle Imaging

No abstract available (Source: JCR: Journal of Clinical Rheumatology)

MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.

Feb 26, 2015 12:35PM

Chronic Graft-Versus-Host Disease Presenting as Eosinophilic Fasciitis: Therapeutic Challenges and an Additional Case

We report a comprehensive review of literature on all reported cases of CGVHD presenting as EF. We also describe an additional interesting case of cGVHD presenting as EF that was resistant to traditional therapy of high-dose glucocorticoids and cyclosporin A, but showed complete resolution of skin manifestations after addition of imatinib. Chronic GVHD presenting as EF is a rare variant of sclerodermatous cGVHD. Diagnosis is difficult, and treatment of cGVHD mimicking EF remains a therapeutic challenge because of obscure pathogenesis and poor response to traditional immunosuppressive medications. Emerging insights into the pathogenesis of cGVHD have resulted in the development of novel targeted therapies, which may improve outcomes and should be attempted in this subset of the disease. Lar...

Feb 26, 2015 11:18AM

The relationship between herpes zoster and stroke.

Authors: Nagel MA, Gilden D Abstract Varicella zoster virus (VZV) infects >95 % of the world population. Typically, varicella (chickenpox) results from primary infection. The virus then becomes latent in ganglionic neurons along the entire neuraxis. In immunocompromised individuals, VZV reactivates and causes herpes zoster (shingles), pain, and rash in 1-2 dermatomes. Multiple case reports showed a link between stroke and zoster, and recent studies have emerged which reveal that VZV infection of the cerebral arteries directly causes pathological vascular remodeling and stroke (VZV vasculopathy). In the past few years, several large epidemiological studies in Taiwan, Denmark, and the U.K. demonstrated that zoster is a risk factor for stroke and that antiviral therapy may reduce ...

Feb 26, 2015 10:05AM

Healthpointe Unveils New Dermatology Site

SkinDoctor.care is set to become Healthpointe?s dermatology oriented project(PRWeb February 26, 2015)Read the full story at http://www.prweb.com/releases/2015/02/prweb12545407.htm (Source: PRWeb: Medical Pharmaceuticals)

Feb 26, 2015 10:05AM

Dermatology Devices Market Was Valued at $6,578.23 Million in 2014 -...

Geographic analysis reveals that North America accounted for the largest share of the global dermatology devices market in 2014....(PRWeb February 25, 2015)Read the full story at http://www.prweb.com/releases/skin-treatment-devices/market/prweb12476937.htm (Source: PRWeb: Medical Pharmaceuticals)

Feb 26, 2015 08:10AM

5% Minoxidil: Treatment for Female Pattern Hair Loss5% Minoxidil: Treatment for Female Pattern Hair Loss

Until recently, the only FDA-approved medication for female pattern alopecia was 2% minoxidil solution, but in 2014 a 5% minoxidil foam became an option. What do you need to know? Skin Therapy Letter (Source: Medscape Today Headlines)

MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.

Feb 26, 2015 05:42AM

Prevalence of foot eczema and associated occupational and non?occupational factors in patients with hand eczema

ConclusionsFoot eczema is common in patients with hand eczema, and is related to both occupational and non?occupational factors. (Source: Contact Dermatitis)

Feb 26, 2015 04:48AM

Antifungal activity and mechanism of action of monoterpenes against dermatophytes and yeasts

Dermatomycosis causes highly frequent dermal lesions, and volatile oils have been proven to be promising as antifungal agents. The antifungal activity of geraniol, nerol, citral, neral and geranial (monoterpenes), and terbinafine and anidulafungin (control drugs) against seven opportunistic pathogenic yeasts and four dermatophyte species was evaluated by the Clinical and Laboratory Standards Institute microdilution tests. Monoterpenes were more active against dermatophytes than yeasts (geometric mean of minimal inhibitory concentration (GMIC) of 34.5 and 100.4 µg.ml-1, respectively). Trichophyton rubrum was the fungal species most sensitive to monoterpenes (GMIC of 22.9 µg.ml-1). The trans isomers showed higher antifungal activity than the cis. The mechanism of action was investigated ev...

Feb 26, 2015 04:23AM

TNF?alpha gene polymorphisms can help to predict response to etanercept in psoriatic patients

ConclusionOur study supports the role of TNF?alpha polymorphisms in predicting the response to anti?TNF?alpha agents. In particular, we found that the presence of ?238G>A and ?308G>A polymorphisms is associated with poor response to a 3?month therapy with etanercept. However, our data have yet to be validated in larger cohorts. (Source: Journal of the European Academy of Dermatology and Venereology)

Feb 26, 2015 04:22AM

FAK and Src expression in premalignant and malignant skin lesions

This article is protected by copyright. All rights reserved. (Source: Experimental Dermatology)

Feb 26, 2015 04:21AM

The skin microbiome: Associations between altered microbial communities and disease

Abstract A single square centimetre of the human skin can contain up to one billion microorganisms. These diverse communities of bacteria, fungi, mites and viruses can provide protection against disease, but can also exacerbate skin lesions, promote disease and delay wound healing. This review addresses the current knowledge surrounding the healthy skin microbiome and examines how different alterations to the skin microbial communities can contribute to disease. Current methodologies are considered, changes in microbial diversity and colonisation by specific microorganisms are discussed in the context of atopic dermatitis, psoriasis, acne vulgaris and chronic wounds. The recent impact of modern Westernised lifestyles on the human skin microbiome is also examined, as well as the potential b...

Feb 26, 2015 02:35AM

Dupilumab Eases Atopic Dermatitis Itch

(MedPage Today) -- Sleep, mood, and quality of life also showed improvement at 16 weeks. (Source: MedPage Today Dermatology)

MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.

Feb 25, 2015 11:12PM

A study investigating the association of dermatological and infusion reactions to infliximab and infliximab trough levels.

CONCLUSION: One-quarter of IBD outpatients receiving stable maintenance infliximab therapy experienced dermatological and infusion reactions. Low ITLs were correlated with infusion reactions, and normal or high ITLs with dermatological events. PMID: 25706572 [PubMed - in process] (Source: Canadian Journal of Gastroenterology)

Feb 25, 2015 09:00PM

BENZEFOAM (Benzoyl Peroxide) Aerosol, Foam [Onset Dermatologics LLC]

Updated Date: Feb 26, 2015 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Feb 25, 2015 04:00PM

Evaluation of patients¿ expectations and benefits in the treatment of allergic rhinitis with a new tool: the patient benefit index ¿ the benefica study

Background: Symptoms of allergic rhinitis (AR) have a detrimental effect on quality of life. The AR-Patient Benefit Index (AR-PBI), a specific self-assessment tool has been developed to assess treatment-related benefit in two separate sections: the Patient Needs Questionnaire (PNQ) which explores the patient?s expectations before treatment and the Patient Benefit Questionnaire (PBQ) which evaluates treatment benefit. For the PNQ, three dimensions summarized patients? expectations: symptoms, social life and emotional state, thus covering a larger field than symptomatic relief. The aim of the study was to validate the French language version of the AR-PBI and to assess the treatment-related expectations and benefits provided in patients with allergic rhinitis treated with H1-antihistamin...

Feb 25, 2015 04:00PM

Biologic Response Modifiers and Pediatric Psoriasis

Abstract The efficacy and safety of biologic response modifiers such as etanercept, adalimumab, infliximab, and ustekinumab have been demonstrated in the treatment of psoriasis in adults, but none are currently approved for the treatment of psoriasis in children in the United States, and only etanercept is approved for the treatment of psoriasis in children in the European Union. Through case reports, case series, and a large clinical trial of the use of etanercept, the literature supports the use of these agents to treat psoriasis in children. Data on the use of the tumor necrosis factor?? antagonists etanercept, adalimumab, and infliximab in the treatment of other inflammatory diseases in children?namely Crohn's disease, juvenile arthritis, and uveitis?support their safety profile...

MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.

Feb 25, 2015 04:00PM

Successful Treatment of Severe Psoriasis in an Adolescent with Ustekinumab

We describe the case of a 12?year?old boy with severe, refractory, chronic plaque psoriasis for 6 years. Various therapeutic regimens including different topical corticosteroids, topical vitamin D analogs, phototherapy, photochemotherapy, systemic therapy with methotrexate, cyclosporin, and combination therapies showed only partial or transient responses with frequent relapses. Because anti?interleukin?12/23 agents have been successfully used in adults with psoriasis, ustekinumab was initiated and our patient showed a rapid, excellent, sustained response. No recurrence or flares have been observed after 33 months of follow?up. This case illustrates that ustekinumab may be an effective and safe therapeutic option in adolescents with psoriasis. (Source: Pediatric Dermatology)

Feb 25, 2015 04:00PM

Lentigines in Resolving Psoriatic Plaques: Rarely Reported Sequelae in Pediatric Cases

We describe three cases of lentigines developing in areas of resolving psoriatic plaques: two in patients treated with etanercept and one before starting etanercept. A possible pathomechanism is proposed. (Source: Pediatric Dermatology)

Feb 25, 2015 04:00PM

Multicentric Reticulohistiocytosis: A Case Report of an Atypical Presentation in a 2?Year?Old

We describe a 2?year?old girl presenting with pink dermal papules on the forehead, thighs, elbows, knees, and palms of the hands. Based on clinical findings and skin biopsy results, she was initially diagnosed with granuloma annulare. At 5 years of age, she developed arthritis, fatigue, and more widespread skin papules leading to the diagnosis of MRH. To our knowledge, this is the youngest individual with MRH yet described. We outline the timeline and unique features of her case and review the literature pertaining to MRH in children. Although rare, MRH can be permanently debilitating, making prompt diagnosis critical. A standardized approach to investigation and management needs to be developed. (Source: Pediatric Dermatology)

Feb 25, 2015 04:00PM

Orange?Brown Chromonychia and Kawasaki Disease: A Possible Novel Association?

Abstract A 4?year?old girl with clinical and laboratory signs of Kawasaki disease (KD) was hospitalized and given intravenous immunoglobulin plus aspirin therapy, with rapid defervescence and clinical improvement, and was discharged 48 hours after admission. At the time of her follow?up echocardiography on day 14, orange?brown pigmentation of the nail beds was noticed and confirmed with dermoscopy. No clear association between KD and orange?brown chromonychia has been demonstrated, although reports and case series suggest a possible link between these two entities. We suggest that this particular finding might be encompassed in late (subacute) changes of extremities as part of KD diagnostic criteria. (Source: Pediatric Dermatology)

Feb 25, 2015 04:00PM

Surgical Site Infection After Skin Excisions in Children: Is Field Sterility Sufficient?

Abstract Skin excisions are common procedures in children. They may be performed in the clinic using field sterility or the operating room with strict sterile technique. We compared the effect of these locations and the use of antibiotics on the incidence of surgical site infection (SSI) after skin excisions. Patients ages 0?18 years presenting to our department for the excision of lesions from 2006 to 2010 with complete medical records were included in our study. Records were reviewed for demographic characteristics, presentation, perioperative conditions, and postoperative SSI and other wound complications. Analyses were performed to estimate the costs associated with sterility technique and perioperative antibiotic use. We identified 700 patients with a mean age of 9.1 years. Of 872 l...

MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.

Feb 25, 2015 04:00PM

Subcutaneous Panniculitis?Like T?Cell Lymphoma in Children: A Review of the Literature

We report a case occurring in a 12?year?old Chinese boy who presented with multiple indolent erythematous subcutaneous nodules on both extremities without systemic symptoms. He had a protracted course of multiple erythematous subcutaneous nodules for 1 year and underwent biopsy of lesional skin for histology and T?cell receptor (TCR) gene analysis. Histopathology showed infiltration of medium to large atypical pleomorphic cells involving the subcutis with characteristic rimming of fat spaces. TCR gene rearrangement shows monoclonal rearrangements of the TCR ? and ? chains. Immunophenotypic studies showed that CD3, CD4, and CD8 were strongly and diffusely positive in lesional cells and that CD56 was focally positive. In contrast, these cells were negative for CD20, CD30, and CD68. ...

Feb 25, 2015 04:00PM

Back to Basics: Steps in Pediatric Dermatologic Diagnosis

(Source: Pediatric Dermatology)

Feb 25, 2015 04:00PM

Cyclosporin Treatment Improves Skin Findings in Omenn Syndrome

Abstract Omenn syndrome is a combined immunodeficiency characterized by a generalized erythematous skin rash, enlarged lymph nodes, hepatosplenomegaly, severe susceptibility to infections, eosinophilia, and hyperimmunoglobulinemia E. A 3?month?old girl was admitted to our hospital with a history of recurrent sepsis. Physical examination revealed severe erythroderma, hepatosplenomegaly, lymphadenopathy, and failure to thrive. Laboratory findings revealed leukocytosis, lymphocytosis with high CD3 T?cells, a high CD4:CD8 ratio, absence of CD19 B?cells, high eosinophil count, and low immunoglobulin levels. A heterozygote RAG1 gene mutation was found. She had itchy, scaling, ichthyosiform erythroderma and protracted diarrhea. Cyclosporin treatment up to 10 mg/kg effectively resolved er...

Feb 25, 2015 04:00PM

Issue Information

(Source: Experimental Dermatology)

MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.

Feb 25, 2015 04:00PM

Evaluation of carotenoids and reactive oxygen species in human skin after UV irradiation: a critical comparison between in vivo and ex vivo investigations

This study provides a critical comparison between in vivo and ex vivo investigations on the ROS formation and carotenoid depletion caused by UV irradiation in human skin. The oxygen content of tissue was also determined. It was shown that the antioxidant status measured in the skin samples in vivo and ex vivo was different. The depletion in the carotenoid concentration in vivo exceeded the value determined ex vivo by a factor of about 1.5, and the radical formation after UV irradiation was significantly greater in vivo by a factor of 3.5 than that measured in excised human skin, which can be explained by the lack of oxygen ex vivo. (Source: Experimental Dermatology)

Feb 25, 2015 04:00PM

A putative antipruritic mechanism of the phosphodiesterase?4 inhibitor E6005 by attenuating capsaicin?induced depolarization of C?fibre nerves

Abstract E6005, a potent, selective phosphodiesterase (PDE) 4 inhibitor, has been developed as a novel topical agent of atopic dermatitis (AD). It has been shown to inhibit itching in patients with AD as well in mouse models. To study the mechanism underlying the anti?pruritic effect of E6005, we examined its effect on the activation of dorsal root ganglion (DRG) neurons associated with the itch sensation. Depolarization of DRG neurons by a transient receptor potential vanilloid 1 (TRPV 1) activator, capsaicin was attenuated by E6005 as well as by a 3?,5??cyclic adenosine monophosphate (cAMP) elevator, forskolin. E6005 elevated intracellular levels of cAMP in DRG cells. Taken together, these results suggest that E6005 suppresses TRPV1?mediated C?fibre depolarization through ele...

Feb 25, 2015 04:00PM

Olopatadine, a non?sedating H1 antihistamine, decreases the nocturnal scratching without affecting sleep quality in atopic dermatitis

Abstract We have demonstrated for the first time that a second?generation antihistamine ameliorates nocturnal scratching behavior in atopic dermatitis patients using a modified wristwatch?type acoustic scratching counting system that we have recently developed. We also analyzed the sleep quality by simultaneous recording of electroencephalogram, and found that sleep quality was unaffected. (Source: Experimental Dermatology)

Feb 25, 2015 04:00PM

Decreased presence of Langerhans cells is a critical determinant for Indian Post kala?azar dermal leishmaniasis

This study delineated the lesional immunopathology in terms of granuloma formation, Langerhans cells, tissue macrophages along with mRNA expression of IL?12p40 and IL?10. Our study in Indian PKDL for the first time identified that the number of CD1a+/CD207+ Langerhans cells are decreased and CD68+ macrophages are increased along with the absence of an epitheloid granuloma. Importantly, this decrease in Langerhans cells was associated with decreased mRNA expression of IL?12p40 and increased IL?10. This was reverted with treatment allowing for elimination of parasites and disease resolution along with an increase in Langerhans cells and decrease in macrophages. Thus, in Indian PKDL, absence of a granuloma formation along with a decrease in Langerhans cells collectively caused immune ...

MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.

Feb 25, 2015 04:00PM

Abstract

(Source: Experimental Dermatology)

Feb 25, 2015 04:00PM

Clinical Snippets

(Source: Experimental Dermatology)

Feb 25, 2015 04:00PM

Frey's syndrome and botulinum toxin type A: duration of efficacy and patient satisfaction

(Source: Journal of the European Academy of Dermatology and Venereology)

Feb 25, 2015 04:00PM

CD57 expression in CD8 T cells and development of cutaneous squamous cell carcinoma in renal transplant recipients: a prospective cohort study

Publication date: 26 February 2015 Source:The Lancet, Volume 385, Supplement 1 Author(s): Matthew Bottomley , Paul Harden , Kathryn Wood Background Cutaneous squamous cell carcinoma is the most common malignancy in renal transplant recipients and a major cause of morbidity and mortality. Various measures have been proposed to identify recipients at increased risk of developing this cancer to allow targeted intervention. CD57 expression might represent a marker of T-cell exhaustion; we hypothesised that expression could predict development of squamous cell carcinoma in renal transplant recipients, and undertook a prospective cohort study to assess its predictive value. Methods Renal transplant recipients with and without previous squamous cell carcinoma (matched by race, age, sex, and im...

Feb 25, 2015 04:00PM

Skin cancer screening in the medically underserved population: A unique opportunity for APNs to make a difference

ConclusionsThe participation rate of 65% supported the feasibility of the skin screening program in a free clinic. The skin screening program allowed for detection of 17 worrisome lesions and all of these patients were referred to either the small procedure clinic, general surgeon, or dermatologist for definitive treatment. Implications for practiceThe project affirmed that clients in this setting are interested in total body skin exams and will participate in the screening program. Furthermore, there were a significant number of worrisome lesions discovered, which underscores the importance of this screening exam and the need for healthcare providers to either perform or refer patients for skin cancer screening on a regular basis. This area of screening is a unique opportunity for advance...

Feb 25, 2015 04:00PM

A Somatic Mutation Is Associated with Verrucous Venous Malformation

Verrucous venous malformation (VVM), also called ?verrucous hemangioma,? is a non-hereditary, congenital, vascular anomaly comprised of aberrant clusters of malformed dermal venule-like channels underlying hyperkeratotic skin. We tested the hypothesis that VVM lesions arise as a consequence of a somatic mutation. We performed whole-exome sequencing (WES) on VVM tissue from six unrelated individuals and looked for somatic mutations affecting the same gene in specimens from multiple persons. We observed mosaicism for a missense mutation (NM_002401.3, c.1323C>G; NP_002392, p.Iso441Met) in mitogen-activated protein kinase kinase kinase 3 (MAP3K3) in three of six individuals. (Source: The American Journal of Human Genetics)

MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.

Feb 25, 2015 04:00PM

Leishmaniasis

Summary Infections with Leishmania spp. rank among the top three most common travel?associated dermatoses. Depending on the country where the infection was acquired and the patient's immune status, different disease manifestations may be observed. Ninety percent of cases present as cutaneous leishmaniasis, but the infection may also affect internal organs (visceral leishmaniasis). Without treatment, the latter is often fatal. Intermediate types include recurrent, diffuse, or mucocutaneous forms. Nodular lesions on exposed skin with a tendency to ulcerate over time in combination with a travel history should therefore prompt workup for leishmaniasis. The diagnosis is made through histology, parasite culture, and PCR using biopsy material. Therapeutic options range from local therapies in ...

Feb 25, 2015 04:00PM

Indications and practical implementation of microbiologic diagnostics in patients with chronic wounds

Summary Microbiology diagnostics are frequently performed in patients with chronic wounds. However, there is currently a lack of uniformity with respect to indications as well as the practical implementation of such workup. The fact that diagnostic results may be significantly affected by the sampling technique used as well as the preceding (wound) preparation underscores the need for uniform standards, which have been missing so far. In Germany, bacteriologic wound swabs are routinely performed, particularly with the intent to screen for multiresistant pathogens. For this indication, prior wound cleansing should be avoided, and sampling using the Essen Rotary technique provides a quick and easy?to?use option. If there is clinical suspicion of an infection, wound cleansing with sterile...

Feb 25, 2015 04:00PM

Indikation und praktische Durchführung mikrobiologischer Diagnostik bei Patienten mit chronischen Wunden

Zusammenfassung Eine bakteriologische Diagnostik wird häufig bei Patienten mit chronischen Wunden durchgeführt. Sowohl die Indikationen als auch die praktische Durchführung dieser bakteriologischen Diagnostik sind jedoch zurzeit nicht einheitlich. Da bekannt ist, dass die Resultate durch die Entnahmetechniken und die jeweilige Vorbereitung wesentlich beeinflusst werden können, zeigt sich die Notwendigkeit für einen einheitlichen Standard, der bislang fehlt. Oberflächlich entnommene bakteriologische Abstriche für Screening?Untersuchungen bei Patienten mit chronischen Wunden werden in Deutschland oft in der täglichen Routine insbesondere für den Nachweis von multiresistenten Erregern entnommen. Bei diesen Abstrichen sollte zuvor keine Wundsäuberung durchgeführt werden. Die Durch...

MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.

Feb 25, 2015 04:00PM

Histologic features of granulomatous skin diseases. Part 1: Non?infectious granulomatous disorders

Summary Granulomatous disorders affecting the skin belong to a heterogeneous group of diseases. With the exception of granulomas induced by infectious agents or foreign bodies, the etiopathogenesis of granulomatous disorders is still poorly understood. The knowledge of histopathologic changes is of great importance for understanding clinical presentation and disease course. (Source: JDDG)

Feb 25, 2015 04:00PM

Histologische Merkmale granulomatöser Hauterkrankungen: Teil 1: nichtinfektiöse granulomatöse Erkrankungen

Zusammenfassung Granulomatöse Hauterkrankungen gehören zu einer heterogenen Gruppe, bei denen mit Ausnahme der infektiös induzierten Granulome und der Fremdkörpergranulome über die Ätiopathogenese wenig bekannt ist. Die Kenntnis der histomorphologischen Veränderungen ist für das Verständnis des klinischen Bildes und des Krankheitsverlaufes von grofler Bedeutung. (Source: JDDG)

Feb 25, 2015 04:00PM

Risikofaktoren für ein vermindertes Ansprechen in der Behandlung des Erysipels

Zusammenfassung HintergrundDas Erysipel kann in den meisten Fällen mittels der initialen antibiotischen Therapie adäquat behandelt werden. Allerdings wird der Kliniker immer wieder mit komplizierten Verläufen dieser Erkrankung, in denen die Patienten nicht auf die initiale Antibiose ansprechen, konfrontiert. Ziel dieser Arbeit war es, Risikofaktoren zu detektieren, die mit einem verminderten Ansprechen der Therapie und damit mit einem komplizierteren Behandlungsverlauf assoziiert sind. Patienten und MethodikEs erfolgte eine retrospektive Auswertung von 98 Patienten mit einem Erysipel, die mit einer Standardtherapie stationär behandelt wurden. Wir führten einen Vergleich der Patientengruppen mit einem unterschiedlichen Ansprechen des Erysipels bezüglich deren klinischer Gesichtspunkte...

Feb 25, 2015 04:00PM

Beliefs, perceptions and psychosocial impact of acne amongst Singaporean students in tertiary institutions

ConclusionsAcne vulgaris causes a considerable amount of psychosocial stress. There are unfounded beliefs surrounding acne and unawareness of treatment options available. (Source: JDDG)

Feb 25, 2015 04:00PM

Vorstellungen, Wahrnehmung und psychosoziale Auswirkungen von Akne bei singapurischen Hochschulstudenten

Zusammenfassung HintergrundAcne vulgaris ist eine häufige Hauterkrankung, die negative Auswirkungen auf die Lebensqualität des Patienten haben kann. Patienten und MethodikUnter Hochschulstudenten wurde eine Umfrage durchgeführt. Die Daten wurden mittels Selbsteinschätzung der Patienten in Bezug auf den Schweregrad ihrer Akne wie auch auf die möglichen Auswirkungen ihrer Akne auf ihr gesellschaftliches Leben erhoben. Ein Klinikarzt vor Ort stufte den Schweregrad der Akne ein. Ergebnisse59,8 % der insgesamt 429 an der Umfrage teilnehmenden Studenten schämten sich aufgrund ihrer Akne oder fühlten sich ihretwegen gehemmt. Zwischen der Einstufung des Aknegrades durch die Teilnehmer selbst und der der Klinikärzte konnte eine niedrige, aber statistisch relevante Korrelation (Spearman?s ...

MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.