Dr. William Ting, Board-Certified Dermatologist
at California Dermatology Care

2262 Camino Ramon, San Ramon, CA 94583
Tel: 925-328-0255
Email: staff@CalDermCare.com


Advanced Care with a Personal Touch

   

 

 

Medical Dermatology    Evidence-based medicine   Customized solution   Personal care

Latest Dermatology Headlines

Dr. William Ting has expertise in treating the entire spectrum of medical dermatology, with emphasis in preventive medicine and personalized recommendations. He enjoys taking care of patients with acne, eczema, hair and nail disorders, rashes, psoriasis and skin cancers.

He is at the forefront of medical dermatology and dermatologic research. He continues to publish articles in peer-reviewed dermatology journals. He is an early pioneer of photodynamic therapy (PDT) and one of the most experienced practitioners of PDT in the Bay Area. He is the first dermatologist in the San Francisco Bay Area and Northern California to introduce Lutronic Spectra Laser for melasma, acne, scar revision, pore size reduction as well as the Cutera GenesisPlus laser for advanced nail fungus laser treatment, keloid and hypertrophic scar, warts and scar revision.

Dr. Ting is a fellow of the American Academy of Dermatology (AAD) and American Society of Dermatologic Surgery (ASDS). He is a member of the National Psoriasis Foundation and International Hyperhidrosis Society.

Innovative Therapeutic Approach to Common Skin Conditions

Acne

Eczema (Atopic Dermatitis)

Hair and Nail disorders

  • Maximize therapeutic synergy and efficacy by utilizing both prescription-strength and over-the counter products when available
  • Comprehensive workup including bloodwork and biopsy if necessary
  • Systemic oral hormonal therapy for women and men when indicated

Psoriasis 

Rosacea

  • Multi-prong approach to minimize redness
  • Low-dose 'non-antibiotic' anti-inflammatory oral medication for long-term remission 
  • Emphasis on prevention
  • Fotofacial/IPL laser utilizing Cynosure XPL/Elite MPX
  • Cutera GenesisPlus Laser with or without combination with IPL 
  • Diode laser for facial veins
  • VBeam Pulse Dye Laser, the new gold standard for rosacea and facial redness

Skin Cancer 

  • Emphasis on prophylactic treatments with topical 5-FU, imiquimod, diclofenac, ingenol mebutate and oral chemopreventive therapy such as Soriatane.
  • Reduce future risks of skin cancer with photodynamic therapy, TCA chemical peels and/or fractional CO2 resurfacing laser  
  • Mohs Surgery to achieve highest cure rate and tissue sparing
  • Close colloboration with plastic surgeon(s) as needed  

Sweating Disorder (Hyperhidrosis) 

Vitiligo

Warts 


ABCD of Mole Check

 

 

Common Medical Dermatology Diagnostics and Therapeutics:

Dermatology Links:

American Academy of Dermatology
American Society of Dermatologic Surgery
American Society of Mohs Surgery
International Hyperhidrosis Society
National Psoriasis Foundation

 Latest Dermatology Headlines:

Latest Dermatology Headlines
Fri, 06 Mar 2015 12:24:39 +0100

http://www.medworm.com/rss/index.php/Dermatology/12/

Mar 06, 2015 04:20AM

A study of the human skin-whitening effects of resveratryl triacetate

Abstract Resveratrol has a variety of bioactivities that include its anti-melanogenic effects, but its use in cosmetics has been challenging partly because of its chemical instability. Resveratryl triacetate (RTA) is a prodrug that can enhance stability. The purpose of this study was to examine the skin safety and whitening effects of RTA in human subjects. The primary skin irritation potentials of RTA and resveratrol were tested at 0.1 and 0.5 % on human subjects. Resveratrol at a concentration of 0.5 % induced weak skin irritation, whereas RTA did not induce any skin responses. The skin-whitening efficacy of a cosmetic formulation containing 0.4 % RTA was evaluated in two different test models. In the artificial tanning model, the test product and the control product were app...

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Mar 05, 2015 04:00PM

Occupational exposure to polycyclic aromatic hydrocarbons: relations between atmospheric mixtures, urinary metabolites and sampling times

Conclusions Lack of correlation between metabolites concentrations emphasizes the non-relevance of 1-OHP, from a non-carcinogenic gaseous and particulate compound, and the great interest of 3-OHBaP, from carcinogenic BaP. Its slower urinary elimination prevents the risk of exposure underestimation, and urinary analysis should be performed at the beginning of shift the end of working week, especially in case of high exposure variability. (Source: International Archives of Occupational and Environmental Health)

Mar 05, 2015 04:00PM

Squamoid eccrine ductal carcinoma of the scalp

Abstract An 85?year?old man presented with an ulcerated pruritic nodule on the scalp. Histology of a deep curette specimen showed the typical features of a squamoid eccrine ductal carcinoma: superficial squamous differentiation and deep ductal structures. (Source: Australasian Journal of Dermatology)

Mar 05, 2015 04:00PM

The rising trend in allergic contact dermatitis to acrylic nail products

We describe four cases of allergic contact dermatitis (ACD) to acrylates found in Shellac nail products, involving three beauticians and one consumer who purchased the product over the internet. Increasing use of these new acrylic nail products means that dermatologists need to be aware of the possibility of ACD occurring. Testing with hydroxyethyl methacrylate alone, which is included in the Australian Baseline Series, is adequate for screening for acrylate allergy. (Source: Australasian Journal of Dermatology)

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Mar 05, 2015 04:00PM

Perianal lichen dermatoses: A review of 60 cases

ConclusionsWe encountered a spectrum of perianal lichen dermatoses, with LS, LP and LSC all represented. LS biopsied at the perianus is often lichenified. Hypertrophic LP is a common form of LP at the perianus. (Source: Australasian Journal of Dermatology)

Mar 05, 2015 04:00PM

Cutaneous manifestations of peripheral T?cell lymphoma, not otherwise specified: A case series highlighting the diagnostic challenges for this heterogeneous group

We present a case series from a large tertiary institution of seven cases of PTCL, NOS with skin involvement, highlighting the variable presentations and diagnostic challenges for this heterogeneous group. (Source: Australasian Journal of Dermatology)

Mar 05, 2015 04:00PM

Analysis of gene expression dynamics revealed delayed and abnormal epidermal repair process in aged compared to young skin

Abstract With aging, epidermal homeostasis and barrier function are disrupted. In a previous study, we analyzed the transcriptomic response of young skin epidermis after stratum corneum removal, and obtained a global kinetic view of the molecular processes involved in barrier function recovery. In the present study, the same analysis was performed in aged skin in order to better understand the defects which occur with aging. Thirty healthy male volunteers (67 ± 4 years old) were involved. Tape-strippings were carried out on the inner face of one forearm, the other unstripped forearm serving as control. At 2, 6, 18, 30 and 72 h after stripping, TEWL measurements were taken, and epidermis samples were collected. Total RNA was extracted and analyzed using DermArray® cDNA microa...

Mar 05, 2015 05:59AM

Intraoperative Localized Urticarial Reaction During Q-switched Nd:YAG Laser Tattoo Removal.

Authors: Wilken R, Ho D, Petukhova T, Jagdeo J Abstract Q-switched lasers, such as the neodymium:yttrium-aluminum-garnet (Nd:YAG) laser, are the gold standard for tattoo removal. Allergy to tattoo pigment is well-documented, but adverse allergic reactions during or shortly after laser tattoo removal are rare with few reports in the medical literature. Here we describe an intraoperative, localized urticarial reaction that developed during treatment of a tattoo using a 1064-nm Nd:YAG laser. As laser tattoo removal becomes increasingly popular amongst our patients, it is important for dermatologists to be aware of urticarial allergic reactions as well as their management. We outline our recommendations for medical management of this condition and hope that these guidelines will facili...

Mar 05, 2015 05:59AM

DNA Repair Enzymes: An Important Role in Skin Cancer Prevention and Reversal of Photodamage? A Review of the Literature.

Authors: Kabir Y, Seidel R, McKnight B, Moy R Abstract The incidence of skin cancer continues to increase annually despite preventative measures. Non-melanoma skin cancer affects more than 1,000,000 people in the United States every year.<sup>1</sup> The current preventative measures, such as sunscreens and topical antioxidants, have not shown to be effective in blocking the effects of UV radiation based on these statistics. The level of antioxidants contained in the majority of skin creams is not sufficient to majorly impact free radical damage. Sunscreens absorb only a portion of UV radiation and often are not photostable. In this review article, we present the novel use of exogenous DNA repair enzymes and describe their role in combating photocarcinogenesis and photo...

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Mar 05, 2015 05:59AM

12-month Effects of Stabilized Hyaluronic Acid Gel Compared With Saline for Rejuvenation of Aging Hands.

Authors: Gubanova EI, Starovatova PA, Rodina MY Abstract In this evaluator-blind, placebo-controlled study, microinjections of stabilized hyaluronic acid (HA) gel for rejuvenation of aging hands were evaluated. Patients received three injections of 1.0 ml HA gel (20 mg/ml HA) in the dorsum of one hand and 1.0 ml saline in the other, over 3 months (M). Treatments were compared up to M03; comparisons with Day 1 (D01) were made up to M05 and M12 (extension study). Efficacy was evaluated by patients and investigators using the Global Aesthetic Improvement Scale (GAIS). Self-assessment questionnaires, biomechanical measurements, and adverse events (AEs) were analyzed.<BR /> Thirty women (mean age: 53 years) provided data up to M05. At M03, HA gel treatment improved hand skin condi...

Mar 05, 2015 05:59AM

A Phase I Safety and Pharmacokinetic Study of ATX-101: Injectable, Synthetic Deoxycholic Acid for Submental Contouring.

Authors: Walker P, Fellmann J, Lizzul PF Abstract ATX-101 (deoxycholic acid [DCA] injection) is a proprietary formulation of pure synthetic DCA. When injected into subcutaneous fat, ATX-101 results in focal adipocytolysis, the targeted destruction of fat cells. ATX-101 is undergoing investigation as an injectable drug for contouring the submental area by reducing submental fat (SMF). The purpose of this study was to evaluate the safety and pharmacokinetics (PK) of the maximal therapeutic dose of ATX-101 (100 mg total dose). Following PK evaluation of endogenous DCA, subjects (N = 24) received subcutaneous injections of ATX-101 (2 mg/cm<sup>2</sup>, with or without 0.9% benzyl alcohol) into SMF; PK evaluation was repeated periodically over 24 hours. Endogenous DCA plasma...

Mar 05, 2015 05:59AM

One-year Topical Stabilized Retinol Treatment Improves Photodamaged Skin in a Double-blind, Vehicle-controlled Trial.

CONCLUSION: This study confirms that a stabilized retinol (0.1%) formulation can significantly improve the signs of photoaging, and improvements in photodamage continue with prolonged use.<BR /><BR /> <em>J Drugs Dermatol</em>. 2015;14(3):271-276. PMID: 25738849 [PubMed - as supplied by publisher] (Source: Journal of Drugs in Dermatology)

Mar 05, 2015 05:59AM

Evolving Perspectives on the Etiology and Pathogenesis of Acne Vulgaris.

Authors: Eichenfield LF, Del Rosso JQ, Mancini AJ, Cook-Bolden F, Stein Gold L, Desai S, Weiss J, Pariser D, Zeichner J, Bhatia N, Kircik L Abstract As the pathophysiology of acne is complex and multifactorial, the continued influx of new basic science and clinical information requires careful analysis before drawing conclusions about what truly contributes to the development and progression of this chronic disease. Our objective is to review the latest evidence and highlight a number of important perspectives on the pathophysiology of acne. An improved understanding of acne pathogenesis should lead to more rational therapy and a better understanding of the role of P acnes opens new perspectives for the development of new treatments and management. Further research may be directed ...

Mar 05, 2015 05:59AM

Polypodium Leucotomos Extract: A Status Report on Clinical Efficacy and Safety.

Authors: Winkelmann RR, Del Rosso J, Rigel DS Abstract Various extracts of polypodium leucotomos (PLE) applied topically or taken orally have been shown to have several beneficial antioxidant, photoprotectant, antimutagenic, and immunoregulatory effects. Modern studies have evaluated the efficacy of PLE orally as a photoprotective agent and for use in several photo-aggravated dermatologic disorders such as polymorphous light eruption, other photodermatoses, and melasma. No articles have been published evaluating the safety of PLE. We performed a PUBMED search for any randomized clinical trials related to PLE, or anapsos, a synonym. The primary safety endpoint of the review was any mention of an adverse event, side effect, or toxicity. Overall, 19 human and 6 basic science studies w...

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Mar 05, 2015 05:59AM

Next-generation Biologics in the Management of Plaque Psoriasis: A Literature Review of IL-17 Inhibition.

Authors: Yamauchi PS, Bagel J Abstract Advances in the understanding of the pathogenesis of psoriasis have led to the development of biologic agents that target T cells and cytokines that play a specific role in the underlying inflammation associated with psoriasis (eg, tumor necrosis factor-α inhibitors, interleukin [IL]-12/23 inhibitors). In this review, evidence for the central role of IL-17 in the pathophysiology of psoriasis is presented, along with available clinical trial data on the selective IL-17 inhibitors in development. Three biologic agents that target IL-17 are currently in clinical development: secukinumab, ixekizumab, and brodalumab. Clinical studies to date suggest a favorable safety profile and the potential for better efficacy over the previous generat...

Mar 05, 2015 05:59AM

The Use of a Reliable, Ubiquitous, Inexpensive, and User-Friendly Tablet-Based System to Track Target Lesion Improvements in Subjects With Plaque Psoriasis Treated With Clobetasol Propionate 0.05% Spray.

Authors: Wiser TH, Meckfessel MH, Winkelman W Abstract Ubiquitous electronic devices, such as smartphones and tablets, have the potential to enable a fundamental shift in the paradigm of healthcare as these devices may allow patients and health care providers (HCPs) to rapidly and remotely communicate with each other. Once fully realized, these devices may facilitate interactions between patients and HCPs. While these devices hold much promise, much work remains in assessing their viability in various diseases. A pilot study was conducted to investigate the use of a tablet-based numeric rating scale to assess improvements in a plaque psoriasis target lesion treated with clobetasol propionate 0.05% spray (CPS). Twenty-eight subjects with plaque psoriasis enrolled and were treated wi...

Mar 05, 2015 05:59AM

Leflunomide: An Immune Modulating Drug That May Have a Role in Controlling Secondary Infections With Review of Its Mechanisms of Action.

CONCLUSIONS: LEF has previously been reported to be a useful immune modulator for the treatment of severe atopic dermatitis. The spectrum of anti-viral effects previously seen with leflunomide did appear beneficial in these patients in clearing verrucae and MC, which had been resistant to conventional therapies while the patients were on azathioprine.<BR /><BR /> <em>J Drugs Dermatol</em>. 2015;14(3):230-234. PMID: 25738844 [PubMed - as supplied by publisher] (Source: Journal of Drugs in Dermatology)

Mar 05, 2015 05:59AM

Onychomycosis: Epidemiology, Diagnosis, and Treatment in a Changing Landscape.

This article reviews the state of knowledge and describes, briefly, these new treatment options.<BR /><BR /> <em>J Drugs Dermatol</em>. 2015;14(3):223-228. PMID: 25738843 [PubMed - as supplied by publisher] (Source: Journal of Drugs in Dermatology)

Mar 05, 2015 05:59AM

Vismodegib as a Neoadjuvant Treatment to Mohs Surgery for Aggressive Basal Cell Carcinoma.

CONCLUSIONS: Neoadjuvant therapy with vismodegib for 6 months prior to Mohs surgery was effective in reducing the size of primary and recurrent aggressive basal cell carcinoma. However, residual tumor nests were found during surgery. Further larger studies are needed to evaluate the efficacy of Vismodegib as a neoadjuvant treatment prior to Mohs surgery.<BR /><BR /> <EM>J Drugs Dermatol</EM>. 2015;14(3):219-221. PMID: 25738842 [PubMed - as supplied by publisher] (Source: Journal of Drugs in Dermatology)

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Mar 05, 2015 05:59AM

Tinea Pedis Presenting as Asymmetric Purpuric Papules on the Sole of the Foot: A Case Report

In this report we describe a unique case of tinea pedis. A 29-year-old man presented with a 3-day history of asymptomatic purpuric papules predominantly on his left foot. Potassium hydroxide preparation demonstrated fungal hyphae and culture yielded Trichophyton mentagrophytes. This patient presented unusually with purpuric papules, unlike the three commonly described types of tinea pedis. Given the morphology, positive potassium hydroxide slide preparation, T. mentagrophytes on fungal culture and clinical response to ketoconazole cream, we conclude that this represents a unique variant of tinea pedis. We recognize that even common dermatological diagnoses can have unique presentations, and it is important for clinicians to maintain a broad differential for new dermatologic cases.Case Rep ...

Mar 05, 2015 05:57AM

In vitro Dermal Absorption: Sample Application and Seal Quality in a Franz Diffusion Cell System

One of the known drawbacks of in vitro dermal absorption methods is their high interlaboratory variation. Although often attributed to biological skin differences, it has been shown that validation of other parameters such as temperature and stirring speed can reduce the high variability observed. The Organisation for Economic Co-operation and Development (OECD) and, at the EU level, the Scientific Committee on Consumer Safety (SCCS) have published guidance documents of how to perform these in vitro tests. For the parameter ?sample application' and ?adequate seal', it is indicated to apply the sample homogeneously and provide an adequate seal between the donor chamber and the membrane on which the sample is applied. Here, a simple and visual densitometer-based method is provided, which...

Mar 05, 2015 05:26AM

In vitro evaluation of allergen potencies of commercial house dust mite sublingual immunotherapy reagents.

CONCLUSIONS: The allergen potencies of commercially available HDM SLIT reagents are markedly different. Consensus regarding the optimal allergen concentration for SLIT reagents used to treat HDM respiratory allergies is needed. PMID: 25729619 [PubMed] (Source: Allergy, Asthma and Immunology Research)

Mar 05, 2015 05:26AM

Three-Year Follow-up Results of Sublingual Immunotherapy in Patients With Allergic Rhinitis Sensitized to House Dust Mites.

CONCLUSIONS: Allergic symptoms significantly decreased after 1 year of SLIT treatment, and this effect was sustained after 2 or 3 years of treatment. By increasing compliance through patient education, the 3-year use of SLIT for house dust mite allergies may be effective in the management of allergic rhinitis. PMID: 25729618 [PubMed] (Source: Allergy, Asthma and Immunology Research)

Mar 05, 2015 05:26AM

Natural history and risk factors of atopic dermatitis in children.

Authors: Pyun BY Abstract Atopic dermatitis (AD) is one of the most common inflammatory allergic diseases with pruritic skin lesions particularly in infancy. It is considered to be the first step of atopic march and has variable disease courses. Many children with AD may resolve their AD symptoms with increasing age and may develop respiratory allergies such as asthma and rhinoconjunctivitis at certain ages. Natural course of AD has been supported by many cross-sectional and longitudinal studies in many countries. In general, atopic dermatitis tends to be more severe and persistent in young children, particularly if they have some risk factors including genetic factors. It appears that approximately 40%-70% of childhood AD will get resolved when they reach the age of 6-7 years. How...

Mar 05, 2015 05:18AM

Twin Infants With Rashes: Same Diagnosis?Twin Infants With Rashes: Same Diagnosis?

Do these fraternal twins have the same skin condition? Medscape Pediatrics (Source: Medscape Dermatology Headlines)

Mar 04, 2015 11:00PM

Medical Bills Another Burden for Eczema Patients: Study

Title: Medical Bills Another Burden for Eczema Patients: StudyCategory: Health NewsCreated: 3/4/2015 12:00:00 AMLast Editorial Review: 3/5/2015 12:00:00 AM (Source: MedicineNet Skin General)

Mar 04, 2015 11:00PM

Health Tip: Easing the Pain of Shingles

Title: Health Tip: Easing the Pain of ShinglesCategory: Health NewsCreated: 3/5/2015 12:00:00 AMLast Editorial Review: 3/5/2015 12:00:00 AM (Source: MedicineNet Skin General)

Mar 04, 2015 04:00PM

Topical Timolol Solution Versus Laser in Treatment of Infantile Hemangioma: A Comparative Study

The objective of this study was to compare the effectiveness of topical timolol 5 mg/mL solution with that of combined sequential dual?wavelength laser in the treatment of IHs. Sixty children with IHs were divided randomly into two equal groups. Group 1 was treated with applications of timolol drops (5 mg/mL) twice daily. Group 2 was treated with sequential pulsed dye and Nd:Yag laser. Treatments were performed every month for a maximum of six sessions. Efficacy was evaluated clinically and by measuring the average hemoglobin level. A significant decrease in the average hemoglobin level was determined in both groups and a dramatic response was observed in superficial hemangiomas in the timolol group. The timolol group received treatment for an average of 4.0 ± 1.1 months and the la...

Mar 04, 2015 04:00PM

A prospective study on the use of teledermatology in psychiatric patients with chronic skin diseases

ConclusionTeledermatology was as effective as face?to?face consultation and reduced the PTAT by 90%, resulting in increased patient convenience, operational efficiency and reduced manpower need. Our study supports the safe and cost?effective use of teledermatology for the follow?up of chronic skin conditions in psychiatric patients. (Source: Australasian Journal of Dermatology)

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Mar 04, 2015 04:00PM

Inter?observer reliability of the PASI in a clinical setting

ConclusionsOur cross?sectional study suggests that the PASI provides a reproducible method of assessing psoriasis severity among patients seen in a busy dermatology clinic at a large tertiary hospital. (Source: Australasian Journal of Dermatology)

Mar 04, 2015 04:00PM

Fractional carbon dioxide laser in recalcitrant vulval lichen sclerosus

We report a case series of four patients undergoing fractional carbon dioxide laser resurfacing and one with ablative carbon dioxide laser for severe, hyperkeratotic vulval lichen sclerosus not responding to super?potent topical corticosteroids. In these patients, carbon dioxide laser was successful in achieving remission. Their vulval lichen sclerosus was subsequently able to be maintained with topical corticosteroid treatment. (Source: Australasian Journal of Dermatology)

Mar 04, 2015 04:00PM

Merkel cell carcinoma: A case of palliative upper limb amputation in a patient with refractory in?transit metastases

We report an unusual case of Merkel cell carcinoma in a 70?year?old woman with the rapid development of left upper limb in?transit and hepatic metastases. The patient had a preceding history of left?sided breast cancer. Palliative chemotherapy with carboplatin and etoposide produced a minimal response. The in?transit metastases rapidly progressed and were refractory to chemotherapy and a single fraction of palliative radiotherapy, leading to a marked impact on her quality of life, secondary to sepsis and bleeding. After lengthy discussion, she consented to an above?elbow amputation resulting in a marked improvement in her well?being. In this case, we believe that palliative amputation of the involved arm was justified and beneficial to the patient. (Source: Australasian Journ...

Mar 04, 2015 04:00PM

Dermatoscopic features of vulval lesions in 97 women

(Source: Australasian Journal of Dermatology)

Mar 04, 2015 04:00PM

Prophylactic antibiotics in dermatological surgery

Abstract This is a review of the common pathogens of surgical site infections, antibiotic coverage for particular anatomical sites, mechanisms by which surgical site infections occur and the latest data and recommendations for prophylactic antibiotics in the prevention of surgical site infections, infective endocarditis and haematogenous joint infections. Recent evidence?based guidelines on surgical prophylaxis is for restricted indications and a shorter duration of antibiotic prophylaxis in situations where no clinical benefit of prolonged therapy has been proven, in order to minimise the potential adverse ecological and clinical effects associated with antibiotic therapy. This review recommends the cautious use of prophylactic antibiotics in dermatological surgery to help prevent the g...

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Mar 04, 2015 04:00PM

Is seborrhoeic dermatitis associated with a diffuse, low?grade folliculitis and progressive cicatricial alopecia?

This study seeks to demonstrate a unique relationship between a clinically identifiable chronic scalp dermatitis?folliculitis with the characteristic histological features of low?grade inflammatory fibrosing alopecia, resulting in a distinctive progressive cicatricial alopecia which we believe is prevalent and hitherto unrecognised, and befits the description of seborrhoeic folliculitis. The clinical, epidemiological and histopathological features of seborrhoeic folliculitis are demonstrated to establish its unique status among the disorders of adult diffuse cicatricial alopecia. (Source: Australasian Journal of Dermatology)

Mar 04, 2015 04:00PM

Multiple lichen planus?like keratoses: Lichenoid drug eruption simulant and under?recognised cause of pruritic eruptions in the elderly

We present six cases of multiple eruptive lichen planus?like keratoses (LPLK), occurring in older individuals predominately confined to previously solar exposed areas. Diagnosis was often confounded by the frequent histological reporting of ?lichenoid drug reaction? (LDR), despite many of the patients being unmedicated. We review the literature regarding eruptive LPLK and reflect on their etiology, clinical aspects, management and importantly their clinicopathological differentiation from LDR. (Source: Australasian Journal of Dermatology)

Mar 04, 2015 04:00PM

Ocular side?effects of topical corticosteroids: what a dermatologist needs to know

Abstract Topical corticosteroids are used frequently in dermatology and atopic dermatitis without significant adverse effects. Though ocular diseases such as glaucoma and cataracts are known complications of systemic corticosteroids, the role of topical corticosteroids is limited to case reports. This review assesses the literature regarding topical steroids and their role in ocular diseases. There is evidence of harm to vision when potent topical corticosteroids are inappropriately used for prolonged periods to periorbital sites. There is no evidence to date that weak TCS to the face or potent TCS to areas other than the eyes results in ocular complications. Further research trials are required in this area. (Source: Australasian Journal of Dermatology)

Mar 04, 2015 04:00PM

Clonal wound re?epithelialisation after radiotherapy for skin cancer

Abstract Simple clinical observations can give useful insights into biological processes in humans. Here we present a temporal series of pictures addressing the tissue response of a basal cell carcinoma to radiotherapy, where re?epithelialisation (RE) after radiotherapy appeared to occur by clonal regrowth, rather than the usually described sheet?like RE. (Source: Australasian Journal of Dermatology)

Mar 04, 2015 04:00PM

Coloured sweat in two brothers: First report of familial chromhidrosis

We describe the first report of familial chromhidrosis of pseudo?eccrine type (pseudochromhidrosis) occurring in two brothers aged 9 and 12 years. The classification and causality of chromhidrosis is described and approaches to assessment and management are outlined. (Source: Australasian Journal of Dermatology)

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Mar 04, 2015 04:00PM

UVB induces epidermal 11??hydroxysteroid dehydrogenase type 1 activity in vivo

This article is protected by copyright. All rights reserved. (Source: Experimental Dermatology)

Mar 04, 2015 04:00PM

A new live cell biobank workflow efficiently recovers heterogeneous melanoma cells from native biopsies

This article is protected by copyright. All rights reserved. (Source: Experimental Dermatology)

Mar 04, 2015 04:00PM

Characterization of the major bacterial?fungal populations colonizing dandruff scalps in Shanghai, China, shows microbial disequilibrium

This article is protected by copyright. All rights reserved. (Source: Experimental Dermatology)

Mar 04, 2015 04:00PM

Comparative genomics reveals conservation of filaggrin and loss of caspase?14 in dolphins

In conclusion, our results suggest that filaggrin is dispensable for the acquisition of fully aquatic lifestyles of whales whereas it appears to confer an evolutionary advantage to dolphins. The discordant evolution of filaggrin, saspase and caspase?14 in cetaceans indicates that the biological roles of these proteins are not strictly interdependent. This article is protected by copyright. All rights reserved. (Source: Experimental Dermatology)

Mar 04, 2015 04:00PM

Hypoxia?Inducible Factor?1? and CD271 inversely correlate with melanoma invasiveness

This article is protected by copyright. All rights reserved. (Source: Experimental Dermatology)

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Mar 04, 2015 04:00PM

Heat shock protein 90 is required for ex vivo neutrophil?driven autoantibody?induced tissue damage in experimental epidermolysis bullosa acquisita

This article is protected by copyright. All rights reserved. (Source: Experimental Dermatology)

Mar 04, 2015 04:00PM

Supraspinal actions of N/OFQ, morphine and substance P in regulating pain and itch in nonhuman primates

Conclusions and ImplicationsCollectively, these results demonstrate differential actions of ligands in the primate supraspinal region in regulating pain and itch. This study not only improves scientific understanding of the N/OFQ?NOP receptor system in pain processing, but also supports the therapeutic potential of NOP?related ligands as analgesics. (Source: British Journal of Pharmacology)

Mar 04, 2015 04:00PM

Plants with topical uses in the Ripollès district (Pyrenees, Catalonia, Iberian Peninsula): Ethnobotanical survey and pharmacological validation in the literature

Conclusions Data indicate a high degree of plant knowledge in the studied region regarding dermal conditions, cosmetics and additional affections (such as snake bite). The present study constitutes a good basis for further phytochemical and pharmacological research, which could be of interest in the design of new drugs. Furthermore, the evidence of these folk uses could be the key information in simplified procedures established by the European Union for the registration of herbal medicinal products based on traditionally used plants, reinforcing the already recognized role of ethnobotany in the mentioned applied research and development field. Graphical abstract (Source: Journal of Ethnopharmacology)

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Mar 04, 2015 04:00PM

Marketing Communication of SMEs Specialized in Cosmetic Industry in Magazines for Women

This study is methodologically based on a quantitative and qualitative content analysis of the selected media performed in SPSS which provides us with sufficient depth of research data showing interesting information about SMEs communication. (Source: Procedia Social and Behavioral Sciences)

Mar 04, 2015 04:00PM

Barriers and facilitators in the implementation of recommendations for hand eczema prevention among healthcare workers

ConclusionsTo enhance the implementation of recommendations for the prevention of hand eczema in a healthcare setting, having knowledge about these recommendations seems to be an important first step. In addition, maintaining the attention of the subject, testing the products beforehand and close collaboration with the infection control department might enhance implementation. Furthermore, it is important that the recommendations fit in with the work of the healthcare workers. When the implementation of the recommendations is prepared, these points should be taken into account. (Source: Contact Dermatitis)

Mar 04, 2015 04:00PM

Multidisciplinary approach for evaluation of neurocutaneous disorders in children in Sohag University Hospital, Upper Egypt

Conclusion Neurocutaneous disorders had multiple clinical presentations and required a team work approach including various specialties in their evaluation and management. (Source: Egyptian Journal of Medical Human Genetics)

Mar 04, 2015 04:00PM

Haemanthus coccineus extract and its main bioactive component narciclasine display profound anti?inflammatory activities in vitro and in vivo

Abstract Haemanthus coccineus extracts (HCE) have traditionally been used to treat a variety of diseases, like febrile colds or asthma. Since new therapeutic options against inflammatory processes are still urgently needed, we aimed to pharmacologically characterise the anti?inflammatory potential of HCEin vitro and in vivo and to identify the underlying bioactive component(s). The action of HCE on oedema formation and leucocyte infiltration were analysed in two murine models of inflammation (dermal oedema induced by arachidonic acid and croton oil; kidney injury caused by unilateral ureteral obstruction). The interaction of leucocytes with endothelial cells (ECs) as well as the activation parameters of these two cell types were analysed. Moreover, the nuclear factor ?B (NF?B) pathway ...

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Mar 04, 2015 04:00PM

Influence of altitude on tick-borne encephalitis infection risk in the natural foci of the Altai Republic, Southern Siberia

Publication date: Available online 3 March 2015 Source:Ticks and Tick-borne Diseases Author(s): L.D. Shchuchinova , I.V. Kozlova , V.I. Zlobin The Altai Republic is a highly endemic area as far as tick-borne encephalitis (TBE) is concerned. The aim of the research was to study the effect of altitude on the risk of tick-borne encephalitis infection in the Altai Republic. The paper analyzes the following data: the study of ixodid ticks collected from the vegetation in 116 sites at the 200?2383m elevation above sea level in 2012?2014, TBE virus prevalence of these vectors, tick-bite incidence rate, and TBE incidence rate of the population. Species identification of 4503 specimens has shown that the most common species are Dermacentor nuttalli (45.3%), Ixodes persulcatus (33.1%), Dermace...

Mar 04, 2015 04:00PM

Hepatozoon and Theileria species detected in ticks collected from mammals and snakes in Thailand

We report the detection of Hepatozoon and Theileria in 103 ticks from mammals and snakes in Thailand. By using a genus-specific 18S rRNA PCR, Hepatozoon and Theileria spp. were detected in 8% and 18%, respectively, of ticks (n =79) removed from mammals. Of the ticks removed from snakes (n =24), 96% were infected with Hepatozoon spp., but none were infected with Theileria. Phylogenetic analysis revealed that Hepatozoon spp. detected from Dermacentor astrosignatus and Dermacentor auratus ticks from Wild boar (Sus scrofa) formed a phylogenetic group with many isolates of Hepatozoon felis that were distantly related to a species group containing Hepatozoon canis and Hepatozoon americanum. In contrast, a phylogenetic analysis of the Hepatozoon sequences of snake ticks revealed that Hepatozoon s...

Mar 04, 2015 04:00PM

Ticks on dogs and cats: A pet owner-based survey in a rural town in northeastern Switzerland

Publication date: Available online 13 February 2015 Source:Ticks and Tick-borne Diseases Author(s): Ramon Marc Eichenberger , Peter Deplazes , Alexander Mathis Changes in the endemic foci of tick populations and invasions of tick species to new areas have become evident in Europe, leading to changes in the epidemiology of tick-transmitted diseases. However, data about tick infestations of pet animals are limited. Following the recent identification of a new focus of canine babesiosis in northeastern Switzerland, we investigated the occurrence of tick vectors in this region by using a pet owner-based sampling strategy. All dog owners in a rural town were sent postal requests to send ticks from their dogs and cats over two consecutive years, beginning in April 2012. In total 3003 ticks wer...

Mar 04, 2015 04:00PM

Occurrence of Francisella spp. in Dermacentor reticulatus and Ixodes ricinus ticks collected in eastern Poland

In conclusion, our results suggest a low contribution of D. reticulatus and I. ricinus ticks to the circulation of F. tularensis in eastern Poland. This finding, however, needs to be confirmed by further studies in other areas. Our study confirmed the common infection of D. reticulatus with Francisella-like endosymbionts (FLEs) of unknown pathogenic potential and revealed, for the first time, a low grade of infection of I. ricinus with FLEs. (Source: Ticks and Tick borne Diseases)

Mar 04, 2015 04:00PM

Occurrence of Ixodiphagus hookeri (Hymenoptera: Encyrtidae) in Ixodes ricinus (Acari: Ixodidae) in Southern Italy

This study shows that I. hookeri infests I. ricinus in southern Italy, with nymphs being the main developmental stage affected by this wasp. (Source: Ticks and Tick borne Diseases)

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Mar 04, 2015 04:00PM

Blaschko line acne on pre?existent hypomelanosis reflecting a mosaic FGFR2 mutation

(Source: British Journal of Dermatology)

Mar 04, 2015 04:00PM

Morphological features of naevoid melanoma: results of a multicentre study of the International Dermoscopy Society

ConclusionsWhile NeMs may be clinically difficult to differentiate from naevi, any papillomatous lesion displaying dermoscopically atypical vessels and/or irregular dots/globules should prompt consideration for the possible diagnosis of NeM. (Source: British Journal of Dermatology)

Mar 04, 2015 04:00PM

The efficacy of minocycline in inflammatory dermatoses: a case of prurigo pigmentosa of prepubescent onset in Western world

This report shows that minocycline is rapidly effective probably through its ability to scavenge reactive oxygen species and to inhibit the chemotaxis and neutrophil function. Other than its ethnic rarity, this case is very interesting because it is the third case of PP in Caucasian patient with prepubescent onset. (Source: Dermatologic Therapy)

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Mar 04, 2015 04:00PM

Multiple facial basal cell carcinomas in xeroderma pigmentosum treated with topical imiquimod 5% cream

We describe a 30?year?old Chinese man with XP who had been previously treated with excision and dermatoplasty. Upon recurrence of multiple superficial, ulcerative, and pigmented lesions, imiquimod 5% cream was recommended for 4 months. His multiple facial lesions demonstrated an excellent response to topical imiquimod 5% cream with minor side effects. This favorable response indicates that topical application of imiquimod 5% cream is an effective means of treating multiple basal cell carcinomas in XP. (Source: Dermatologic Therapy)

Mar 04, 2015 04:00PM

Giant neglected squamous cell carcinoma of the skin

We report the case of a giant metastatic cSCC that had been neglected for more than 20 years. Radiotherapy or surgery were not feasible and polichemotherapy (cisplatin, 5?fluorouracil and paclitaxel) was not effective. Therefore, the patient was treated with palliative electrochemotherapy (ECT) achieving a partial reduction of cutaneous metastasis and pain relief but unfortunately the patient died 3 months after the second ECT treatment. (Source: Dermatologic Therapy)

Mar 04, 2015 04:00PM

A case of multiple eccrine hidrocystoma successfully treated with oral oxybutynin

(Source: Dermatologic Therapy)

Mar 04, 2015 04:00PM

Triple combination treatment with fractional CO2 laser plus topical betamethasone solution and narrowband ultraviolet B for refractory vitiligo: a prospective, randomized half?body, comparative study

Abstract Vitiligo on extremities and/or bony prominences is very resistant to treatment. Twenty?five patients with symmetrical and stable vitiligo on extremities and/or bony prominences were enrolled. The treatment side received fractional carbon dioxide laser followed by topical compound betamethasone solution and narrowband ultraviolet B phototherapy. The control side received laser treatment plus phototherapy. The result of treatment side showed that 44% patients achieved over 50% re?pigmentation and patient satisfaction score was 5.12 ± 3.23, higher than those of control (p < 0.05). Adverse events were slight and tolerable. The triple combination treatment could be used as an alternative modality for refractory vitiligo. (Source: Dermatologic Therapy)

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Mar 04, 2015 04:00PM

Treatment of complex periorbital venolymphatic malformation in a neonate with a combination therapy of sirolimus and prednisolone

Abstract Venolymphatic malformations (VLMs) are vascular anomalies consisting of both veins and lymph vessels. A 2?week?old newborn presented with large VLMs on the left forehead, temple, preauricular area, and orbit. Patient was at imminent risk for permanent vision loss due to a localized mass effect. Surgical excision or debulking was contraindicated due to its complexity and proximity to the left eye, and the patient failed to respond to the sildenafil treatment and sclerotherapy. Patient was subsequently started on oral sirolimus 0.8?mg/m2 twice daily in combination with prednisolone 2?mg/kg daily. The patient had an excellent therapeutic outcome for 7 months with complete preservation of vision before treatment was discontinued. However, 2 months after the medical treatments ...

Mar 04, 2015 04:00PM

Analysis of clinical efficacy, side effects, and laboratory changes among patients with acne vulgaris receiving single versus twice daily dose of oral isotretinoin

Abstract Acne vulgaris is a debilitating disorder and requires proper treatment. This work evaluates the clinical efficacy, side effects, and laboratory changes of serum lipids and liver function during oral isotretinoin therapy for acne vulgaris, comparing single versus twice daily dose. Fifty?eight patients with acne vulgaris were included and randomized into group I (26 patients), who received once daily dose, and group II (32 patients), who received twice daily dose of oral isotretinoin. Global acne scoring system was used to evaluate acne severity and post?treatment improvement. Both regimens resulted in highly significant clinical improvement of acne with no significant difference. However, side effects were significantly more common among patients of group I. Both regimens cause...

Mar 04, 2015 04:00PM

Intravenous zinc therapy for acquired zinc deficiency secondary to gastric bypass surgery: a case report

We report a case of acquired zinc deficiency secondary to gastric bypass surgery that resulted in vulvar cutaneous manifestations of delayed onset, with failure to clear after oral supplementation with zinc. The patient experienced improvement of symptoms only after administration of intravenous zinc supplementation. Upon review of the current literature, it is thought that the patient's original suboptimal response to oral supplementation and improvement after receiving intravenous zinc were related to the intentional surgical alteration and bypass of the absorptive capacity of the duodenum and jejunum. With the current prevalence of obesity and availability of surgical weight loss therapies, it is important to be mindful of the resulting nutritional deficiencies, their clinical manifesta...

Mar 04, 2015 04:00PM

Sarcoidosis: ?thinking out of the box is often a matter of perspective?

(Source: Dermatologic Therapy)

Mar 04, 2015 04:00PM

Fractionated carbon dioxide laser therapy as treatment of mild rhinophyma: report of three cases

We present three patients who were treated by a minimally invasive approach using fractionated carbon dioxide (CO2) laser therapy, showing variable response. We observed that fractionated CO2 laser therapy may improve patient?reported outcome in some patients with mild rhinophyma and is associated with a relatively favorable side effect profile compared with conventional surgical techniques. (Source: Dermatologic Therapy)

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Mar 04, 2015 04:00PM

Neoadjuvants for basal cell carcinoma. When and why?

(Source: Dermatologic Therapy)

Mar 03, 2015 04:00PM

Dermatological Manifestations of Infective Endocarditis

(Source: Journal of General Internal Medicine)

Mar 03, 2015 04:00PM

Coinjection with TLR2 Agonist Pam3CSK4 Reduces the Pathology of Leishmanization in Mice

by Lu Huang, Meleana Hinchman, Susana Mendez Cutaneous leishmaniasis caused by Leishmania major is an emergent, uncontrolled public health problem and there is no vaccine. A promising prophylactic approach has been immunotherapy with Toll-like receptor (TLR) agonists to enhance parasite-specific immune responses. We have previously reported that vaccination of C57BL/6 mice with live L. major plus the TLR9 agonist CpG DNA prevents lesion development and confers immunity to reinfection. Our current study aims to investigate whether other TLR agonists can be used in leishmanization without induction of lesion formation. We found that live L. major plus the TLR2 agonist Pam3CSK4 reduced the pathology in both genetically resistant (C57BL/6) and susceptible (BALB/c) mouse strains. The addition ...

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Mar 03, 2015 04:00PM

Enhanced biocompatibility and wound healing properties of biodegradable polymer-modified allyl 2-cyanoacrylate tissue adhesive

Publication date: 1 June 2015 Source:Materials Science and Engineering: C, Volume 51 Author(s): Young Ju Lee , Ho Sung Son , Gyeong Bok Jung , Ji Hye Kim , Samjin Choi , Gi-Ja Lee , Hun-Kuk Park As poly L-lactic acid (PLLA) is a polymer with good biocompatibility and biodegradability, we created a new tissue adhesive (TA), pre-polymerized allyl 2-cyanoacrylate (PACA) mixed with PLLA in an effort to improve biocompatibility and mechanical properties in healing dermal wound tissue. We determined optimal mixing ratios of PACA and PLLA based on their bond strengths and chemical structures analyzed by the thermal gravimetric analysis (TGA) and Fourier transform infrared (FT-IR) spectroscopy. In vitro biocompatibility of the PACA/PLLA was evaluated using direct- and indirect-contact methods ac...

Mar 03, 2015 04:00PM

Severe atopic dermatitis is characterized by selective expansion of circulating T2/T2 and T22/T22, but not T17/T17, cells within the skin-homing T-cell population

Past studies of blood T-cell phenotyping in patients with atopic dermatitis (AD) have provided controversial results and were mostly performed before the identification of TH9, TH17, and TH22 T-cell populations in human subjects. (Source: Journal of Allergy and Clinical Immunology)

Mar 03, 2015 04:00PM

Association of common filaggrin null mutations with atopy but not chronic rhinosinusitis

Mutations in the filaggrin gene (FLG) are strongly associated with atopic dermatitis (AD) and skin barrier dysfunction.1,2FLG has been linked to asthma and asthma severity in individuals with and without atopic dermatitis,1,3?5 and individuals with FLG null mutations are at increased risk of allergic sensitization and allergic rhinitis.5 However, despite evidence indicating a link among FLG, barrier dysfunction, and respiratory diseases,1 the importance of FLG in the pathogenesis of chronic rhinosinusitis (CRS) has never been evaluated. (Source: Annals of Allergy, Asthma and Immunology)

Mar 03, 2015 04:00PM

Sarcoidosis: a Critical Review of History and Milestones

Abstract Sarcoidosis is a chronic systemic disease of unknown origin and uncertain prognosis that most commonly affects young adults, and frequently presents with bilateral hilar lymphadenopathy, pulmonary infiltrates and ocular and skin lesions. The diagnosis is established when characteristic clinical-radiological features are supported by compatible histopathology of epithelioid cell granulomas, following exclusion of known causes of granulomatous inflammation. Indeed, sarcoidosis belongs to a large family of disorders that share granuloma formation as common denominator. Since its first description by Jonathan Hutchinson in 1869, sarcoidosis has generated enormous interest and considerable controversy. In Hutchinson?s day, it was considered a dermatological condition, which ...

Mar 03, 2015 04:00PM

Severe adult atopic dermatitis successfully treated with concurrent Unseiin and standard treatment

ConclusionConcurrent treatment with Unseiin and standard treatment may provide an effective treatment option for patients with atopic dermatitis refractory to standard treatment. (Source: Traditional and Kampo Medicine)

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Mar 03, 2015 04:00PM

Frontline of dermatomycology research is just in front of us!

(Source: The Journal of Dermatology)

Mar 03, 2015 04:00PM

Molecular markers useful for epidemiology of dermatophytoses

Abstract Dermatophytosis is a very common skin disorder and the most prevalent infectious disease treated by dermatologists. Recent developments in molecular techniques have markedly changed methods of identifying dermatophytes, with these methods showing intraspecies polymorphisms in some molecular markers. Intraspecies subtyping and strain differentiation have made possible the tracking of infections, the identification of common sources of infections and recurrence or reinfection after treatment. This review describes methods of intraspecies differentiation using mitochondrial DNA, random amplification of polymorphic DNA, non?transcribed spacer regions of ribosomal RNA genes and microsatellite markers, as well as their usefulness and limitations. (Source: The Journal of Dermatology)

Mar 03, 2015 04:00PM

Immunoresponses in dermatomycoses

Abstract Contact with fungal pathogens initiates a series of host responses beginning with innate immunity, which leads to fungal recognition and microbial killing. The innate immune system also modulates the adaptive immune responses, leading to the establishment of immunological memory and protection against pathogens. In the case of dimorphic fungi such as Candida albicans and Malassezia, the immune system plays an important role in tolerance and resistance when managing the organisms either as commensal microbiota or invading pathogens, and disruption of this balance can result in pathological consequences for the host. In addition, Malassezia and dermatophytes have immunomodulatory capabilities that allow them to adapt to their environments and they may exert different effects in heal...

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Mar 03, 2015 04:00PM

Trichophyton tonsurans infection in Japan: Epidemiology, clinical features, diagnosis and infection control

Abstract In this review, we summarize the status of Trichophyton tonsurans infection in Japan in terms of epidemiology, clinical features, diagnosis and infection control. Since approximately 2000, outbreaks of T. tonsurans infections among combat sports club members have been reported frequently, with the infection then spreading to their friends and family members. The most common clinical features of T. tonsurans infection are tinea corporis, which is difficult to differentiate from eczema, and tinea capitis. Tinea capitis is classified as the seborrheic form, kerion celsi form or ?black dot? form, although 90% or more of patients are asymptomatic carriers. The diagnosis of symptomatic T. tonsurans infection is established by potassium hydroxide examination and fungal culture. Ho...

Mar 03, 2015 04:00PM

Malassezia species and their associated skin diseases

Abstract Malassezia spp. are lipophilic fungi that occur on all skin surfaces of humans and animals as commensal and pathogenic organisms. In the 2000s, several new species were added to the Malassezia genus by Japanese researchers. The genus Malassezia now includes 14 species of basidiomycetous yeast. Culture?independent molecular analysis clearly demonstrated that the DNA of Malassezia spp. was predominantly detected in core body and arm sites, suggesting that they are the dominant fungal flora of the human body. Malassezia spp. have been implicated in skin diseases including pityriasis versicolor (PV), Malassezia folliculitis (MF), seborrheic dermatitis (SD) and atopic dermatitis (AD). While Malassezia spp. are directly responsible for the infectious diseases, PV and MF, they act as a...

Mar 03, 2015 04:00PM

Primary cutaneous mucormycosis caused by Mucor irregularis in an immunocompetent patient

(Source: The Journal of Dermatology)

Mar 03, 2015 04:00PM

Ponatinib?Induced Pityriasiform, Folliculocentric and Ichthyosiform Cutaneous Toxicities

This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)

Mar 03, 2015 04:00PM

Socioeconomic and lifestyle factors and melanoma: a systematic review

Summary Evidence of social determinants of disease and awareness of the impact of these factors on outcomes continues to increase. Social determinants include both socioeconomic and lifestyle factors. This review examines the interface between socioeconomic status (SES) and lifestyle and their effects on melanoma incidence and mortality. Lifestyle factors including occupation, occupational exposures, body mass index, marital status, smoking, recreational sun exposure and tanning were explored as they have a known relationship with melanoma. A remarkable association of SES with melanoma incidence and prognosis has been acknowledged worldwide. Melanoma incidence is increased in populations of higher SES, especially among the highly educated, while lower SES populations present with later?s...

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Mar 03, 2015 04:00PM

Intraoperative diagnosis of nonpigmented nail tumours with ex vivo fluorescence confocal microscopy: 10 cases

ConclusionsEx vivo FCM could be a useful tool to shorten management of nonpigmented nail tumours: in the case of a malignant tumour, it could indeed lead to performing wide excision during the same surgical procedure and possibly assessing the surgical margins. (Source: British Journal of Dermatology)

Mar 03, 2015 04:00PM

8th Georg Rajka International Symposium on Atopic Dermatitis: meeting report

Summary The 8th Georg Rajka International Symposium on Atopic Dermatitis was held in Nottingham in May 2014. The 3?day meeting featured a number of lectures by experts in the field of atopic dermatitis from around the world, as well as several original research presentations and a question and answer session. This paper aims to summarize the main oral presentations from the meeting, but is not meant to be a substitute for reading the conference proceedings and related references. (Source: British Journal of Dermatology)

Mar 03, 2015 04:00PM

Sentinel lymph node biopsy and risk factors for predicting metastasis in cutaneous squamous cell carcinoma

ConclusionsPatients with risk factors (cSCC with a tumour thickness > 4 mm or recurrent disease) may develop metastases within the first 2 years despite a negative SLNB. Therefore these patients should be closely monitored during the follow?up. Based on our data SLNB does not provide diagnostic value for patients with cSCC. (Source: British Journal of Dermatology)

Mar 03, 2015 04:00PM

Sporadic melanoma in South-Eastern Italy: the impact of melanocortin 1 receptor (MC1R) polymorphism analysis in low-risk people and report of three novel variants

We report an overall frequency of MC1R variants in our population higher than in Northern or Central Italy. The most common polymorphism found was V60L, that has been recently reported to spread among South Mediterranean population. This variant influenced phenotypic characteristics of our population while it did not impinge on melanoma risk. An increased risk of melanoma was associated with two or more MC1R variants, when at least one was RHC, compared to people carrying the MC1R consensus sequence or a single MC1R polymorphism. Interestingly, we observed an increased risk of melanoma in subjects with darker skin and lower nevus count, usually considered at low risk, when carrying MC1R polymorphisms. (Source: Archives of Dermatological Research)

Mar 03, 2015 04:00PM

Single TCR-V?2 evaluation discloses the circulating T cell clone in Sezary syndrome: one family fits all!

In conclusion, the single TCR-V?2 expression check, instead of the entire repertoire assessment, represents an easy and cost-effective method for the recognition of CTCL aggressive leukemic variant. (Source: Archives of Dermatological Research)

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Mar 03, 2015 04:00PM

Association between tumor necrosis factor inhibitor (TNFi) therapy and changes in C-reactive protein (CRP), blood pressure, and alanine aminotransferase (ALT) among patients with psoriasis, psoriatic arthritis, or rheumatoid arthritis

The objective was to assess changes in C-reactive protein (CRP), systolic blood pressure (SBP), diastolic blood pressure (DBP), and alanine aminotransferase (ALT) for patients with psoriasis, psoriatic arthritis, or rheumatoid arthritis exposed to a TNFi with concomitant exposure to methotrexate (MTX) compared with patients exposed to MTX therapy with no TNFi. (Source: Journal of the American Academy of Dermatology)

Mar 03, 2015 04:00PM

Cutaneous manifestations of pediatric granulomatosis with polyangiitis: A clinicopathologic and immunopathologic analysis

Granulomatosis with polyangiitis (GPA) is a rare systemic vasculitis associated with variable cutaneous manifestations and histopathologic findings. It is less frequent in children than adults and is often positive for cytoplasmic antineutrophil cytoplasmic antibody (ANCA) or proteinase 3-ANCA. (Source: Journal of the American Academy of Dermatology)

Mar 03, 2015 04:00PM

Factors influencing the development of cutaneous squamous cell carcinoma in patients on BRAF inhibitor therapy

BRAF inhibitors (BRAFi) cause paradoxical activation of the MAPK pathway in keratinocytes resulting in cutaneous squamous cell carcinoma (cuSCC). (Source: Journal of the American Academy of Dermatology)

Mar 03, 2015 04:00PM

Gene expression profiling for molecular staging of cutaneous melanoma in patients undergoing sentinel lymph node biopsy

A gene expression profile (GEP) test able to accurately identify risk of metastasis for patients with cutaneous melanoma has been clinically validated. (Source: Journal of the American Academy of Dermatology)

Mar 03, 2015 04:00PM

LED 590nm photomodulation reduces UVA-induced metalloproteinase-1 expression via upregulation of antioxidant enzyme catalase

(Source: Journal of Dermatological Science)

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Mar 03, 2015 04:00PM

Circulating IgE anti-BP180 autoantibody and its correlation to clinical and laboratorial aspects in bullous pemphigoid patients

In this study, we detected the levels of IgE anti-BP180 autoantibody in Chinese patients with BP and investigated its possible relationship with clinical aspects and laboratorial parameters of these patients. (Source: Journal of Dermatological Science)

Mar 03, 2015 04:00PM

Possible involvement of CCR4CD8 T cells and elevated serum CCL22 and CCL17 in Patients with Rhododenol-induced Leukoderma

Rhododendrol (4-(4-hydroxyphenyl)-2-butanol), brand name: Rhododenol) is a naturally occurring phenol used in skin-whitening cosmetics and has been reported to cause a hypopigmentary disorder called Rhododenol-induced leukoderma (RIL) which developed in approximately 16,000 (2%) consumers [1]. Recent pathological analyses of RIL have revealed a direct cytotoxic effect of rhododendrol on melanocytes, which may explain the loss of melanocytes in the lesional skin [1]. In addition, we speculated that local infiltration of various immune cells may be involved in the pathophysiology of RIL [2]. (Source: Journal of Dermatological Science)

Mar 03, 2015 04:00PM

A Review of the Use of Tanning Beds as a Dermatological Treatment

Conclusion Unsupervised sun exposure is a standard recommendation for some patients to obtain phototherapy. Selected use of commercial tanning beds in the treatment of dermatologic conditions may be another useful and effective treatment for those patients with an inability to access office-based or home-based phototherapy. (Source: Dermatology and Therapy)