Dr. William Ting, Board-Certified Dermatologist
at California Dermatology Care
2262 Camino Ramon, San Ramon, CA 94583
500 Alfred Nobel Drive, Suite #185, Hercules, CA 94547
Tel: 925-328-0255
Email: staff@CalDermCare.com


Advanced Care with a Personal Touch

   

 

 

Medical Dermatology    Evidence-based medicine   Customized solution   Personal care

Latest Dermatology Headlines

Dr. William Ting has expertise in treating the entire spectrum of medical dermatology, with emphasis in preventive medicine and personalized recommendations. He enjoys taking care of patients with acne, eczema, hair and nail disorders, rashes, psoriasis and skin cancers.

He is at the forefront of medical dermatology and dermatologic research. He continues to publish articles in peer-reviewed dermatology journals. He is an early pioneer of photodynamic therapy (PDT) and one of the most experienced practitioners of PDT in the Bay Area. He is the first dermatologist in the San Francisco Bay Area and Northern California to introduce Lutronic Spectra Laser for melasma, acne, scar revision, pore size reduction as well as the Cutera GenesisPlus laser for advanced nail fungus laser treatment, keloid and hypertrophic scar, warts and scar revision.

Dr. Ting is a fellow of the American Academy of Dermatology (AAD) and American Society of Dermatologic Surgery (ASDS). He is a member of the National Psoriasis Foundation and International Hyperhidrosis Society.

Innovative Therapeutic Approach to Common Skin Conditions

Acne

Eczema (Atopic Dermatitis)

Hair and Nail disorders

  • Maximize therapeutic synergy and efficacy by utilizing both prescription-strength and over-the counter products when available
  • Comprehensive workup including bloodwork and biopsy if necessary
  • Systemic oral hormonal therapy for women and men when indicated

Psoriasis 

Rosacea

  • Multi-prong approach to minimize redness
  • Low-dose 'non-antibiotic' anti-inflammatory oral medication for long-term remission 
  • Emphasis on prevention
  • Fotofacial/IPL laser utilizing Cynosure XPL/Elite MPX
  • Cutera GenesisPlus Laser with or without combination with IPL 
  • Diode laser for facial veins
  • VBeam Pulse Dye Laser, the new gold standard for rosacea and facial redness

Skin Cancer 

  • Emphasis on prophylactic treatments with topical 5-FU, imiquimod, diclofenac, ingenol mebutate and oral chemopreventive therapy such as Soriatane.
  • Reduce future risks of skin cancer with photodynamic therapy, TCA chemical peels and/or fractional CO2 resurfacing laser  
  • Mohs Surgery to achieve highest cure rate and tissue sparing
  • Close colloboration with plastic surgeon(s) as needed  

Sweating Disorder (Hyperhidrosis) 

Vitiligo

Warts 


ABCD of Mole Check

 

 

Common Medical Dermatology Diagnostics and Therapeutics:

Dermatology Links:

American Academy of Dermatology
American Society of Dermatologic Surgery
American Society of Mohs Surgery
International Hyperhidrosis Society
National Psoriasis Foundation

 Latest Dermatology Headlines:

Latest Dermatology Headlines
Fri, 22 May 2015 10:41:23 +0100

http://www.medworm.com/rss/index.php/Dermatology/12/

May 22, 2015 02:31AM

Protomyofibroblast Pathway in Early Thermal Burn Healing

In conclusion, healing of partial thickness thermal burns involves a diversity of cell types including PMF. In the present samples, the PMF density remained low.Skin Pharmacol Physiol 2015;28:250-254 (Source: Skin Pharmacology and Physiology)

MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.

May 22, 2015 02:31AM

Effectiveness of 308-nm Excimer Laser Therapy in Treating Alopecia Areata, Determined by Examining the Treated Sides of Selected Alopecic Patches

Conclusion: The 308-nm excimer laser has a therapeutic effect on AA, which is proven by photograph and phototrichogram analysis by a side-by-side comparison.Dermatology (Source: Dermatology)

May 21, 2015 04:00PM

S1 guideline on occupational skin products: protective creams, skin cleansers, skin care products (ICD 10: L23, L24) ? short version

Summary Job?related hand dermatitis heads up the list of reported occupational diseases. So?called skin products ? understood to mean protective creams, skin cleansers and skin care products ? are used for the primary and secondary prevention of job?related hand dermatitis. In the interests of evidence?based medicine, the only preventive measures and/or occupational skin products that should be used are those whose potential uses and efficacy are underpinned by scientific research. To this end, the Arbeitsgemeinschaft für Berufs? und Umweltdermatologie e.V. (Working Group for Occupational and Environmental Dermatology, ABD) of the DDG (German Dermatological Society) and the Deutsche Gesellschaft für Arbeits? und Umweltmedizin (German Society for Occupational and Environme...

May 21, 2015 04:00PM

Erythematous nodule on the earlobe in a patient from Iraq

(Source: JDDG)

May 21, 2015 04:00PM

Eruptive squamous cell carcinomas with keratoacanthoma?like features in a patient treated with Ruxolitinib

This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)

May 21, 2015 04:00PM

Sentinel lymph node biopsy: in support of equity of access, informed shared decision making and patient choice

This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)

MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.

May 21, 2015 04:00PM

Recommendations for treatment of Lymphomatoid papulosis with methotrexate: a report from the Dutch Cutaneous Lymphoma Group

This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)

May 21, 2015 04:00PM

Vismodegib induces significant clinical response in locally advanced trichoblastic carcinoma

This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)

May 21, 2015 04:00PM

Autosomal recessive congenital ichthyoses in the Czech Republic

This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)

May 21, 2015 04:00PM

Correlates of Hair Loss in Adult Women of African Descent in London, United Kingdom; Findings of a Cross?Sectional Study

This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)

May 21, 2015 04:00PM

Salicylic acid deposition from wash?off products: comparison of in vivo and porcine deposition models

ConclusionThe methods employed in this work highlight the utility of the use of EEMs, in conjunction with multivariate analysis tools such as parallel factor analysis and multiway partial least?squares calibration, in determining sources of spectral variability in skin and quantification of exogenous species deposited on skin. The human model exhibited the widest range of linearity, but porcine model is still useful up to deposition levels of 25 ?g cm?2 or used with nonlinear calibration models. Résumé ObjectifL'acide salicylique est un actif anti?acné largement utilisé dans les produits de nettoyage du visage. Seulement environ 1?2% de la dose totale est effectivement déposée sur la peau pendant le lavage et les systèmes de dépôt plus efficaces sont recherchés. L'obj...

MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.

May 21, 2015 04:00PM

Vitamin D controls apoptosis and proliferation of cutaneous T?cell lymphoma cells

(Source: Experimental Dermatology)

May 21, 2015 04:00PM

Erratum

(Source: Journal of the European Academy of Dermatology and Venereology)

May 21, 2015 04:00PM

Forthcoming Events

(Source: Journal of the European Academy of Dermatology and Venereology)

MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.

May 21, 2015 04:00PM

Announcement

(Source: Journal of the European Academy of Dermatology and Venereology)

May 21, 2015 01:47PM

Is Your AC Making You Sick? 5 Things You Need to Know

There are times when I am extremely thankful for air conditioning -- usually after I have had a long workout on a hot summer's day and am still sweating after a cold shower. The cold, dry air is invigorating and refreshing. But usually, after about 30 minutes, I find myself shivering and needing to go back outside. Indeed, I have found that the majority of homes I have visited and more so, public offices and stores, the air conditioning temperature is set so low that I find myself feeling sick so that I have to step outside. I also find that I am more tired and my muscles more sore from shivering all day. So I decided to look into why this is and what we should all know about air conditioning. To begin, I do contest to the positive side of air conditioners, as they are beneficial to those...

May 21, 2015 01:16PM

Clinical profile and quality of life of patients with occupational contact dermatitis from New Delhi, India

ConclusionsFarmers were most frequently affected, followed by construction workers and housewives. OACD was found at a higher frequency than OICD. The most frequent allergens were Parthenium hysterophorus in farmers, potassium dichromate in construction workers, and vegetables in housewives. OCD has a significant impact on QOL. Patch testing, in addition to standard treatment, improves the outcome considerably. (Source: Contact Dermatitis)

MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.

May 21, 2015 12:26PM

Successful treatment of subcorneal pustular dermatosis with maxacalcitol

(Source: Clinical And Experimental Dermatology)

May 21, 2015 10:52AM

PAS: Use high-dose acyclovir to treat HSV-infected infants

SAN DIEGO ? Infants given high-dose acyclovir for the treatment of herpes simplex virus (HSV) infections experienced a number of adverse reactions, including seizure, hypotension, and thrombocytopenia, according to the results of a new study, but it is unclear if the root cause of these events is... (Source: Skin and Allergy News)

May 21, 2015 08:07AM

Amelanotic Vulvar Melanoma: A Case Report

Abstract: A 14-year-old girl stated that she has vulvar pruritus, pain, and bleeding and underwent a complete gynecological evaluation during which a suspicious 2-cm achromic lesion on her vulva was observed. Initially, it was suspected to be a pyogenic granuloma, in relation to the patient's age. A biopsy was taken, and a histopathological diagnosis of amelanotic mucosal melanoma was made. Pyogenic granuloma is a reactive hyperproliferation vascular response to trauma or other stimuli. It predominantly occurs in the second decade of life in young females, in relation to the vascular effects of female hormones. Primary mucosal melanoma is a rare and aggressive neoplasm, characterized by a higher aggressiveness and a worse prognosis than her cutaneous counterpart. The female genital tract i...

May 21, 2015 08:07AM

Delayed Onset of the Jarisch?Herxheimer Reaction in Doxycycline-Treated Disease: A Case Report and Review of its Histopathology and Implications for Pathogenesis

Abstract: The Jarisch?Herxheimer reaction (JHR) is a transient inflammatory syndrome triggered hours after the start of antibiotic treatment of spirochete infections, namely syphilis. Clinically, JHR manifests as an abrupt onset of constitutional symptoms and exacerbation of cutaneous lesions that resolve without intervention. JHR's pathogenesis is unclear and it is histopathologically rarely reported. Herein, the authors report a 47-year-old woman, with solitary erythema migrans and positive Lyme disease serology, who presented for medical care 14 days after commencement of doxycycline therapy. She complained of malaise, facial flushing, gingival erythema, and acquisition of additional plaques characterized by swelling, increased erythema, pruritus, and exfoliative scale. Punch biopsies...

May 21, 2015 08:07AM

Amelanotic Melanoma Mimicking an Atypical Fibrohistiocytic Lesion

No abstract available (Source: The American Journal of Dermatopathology)

May 21, 2015 08:07AM

Primary Cutaneous Spindle Cell B-Cell Lymphoma of Follicle Origin Mimicking Acne Rosacea

We report a case of a 35-year-old woman who presented with a well-defined erythematous plaque with 2 nodular, nontender nonscaling nonulcerated lesions on her right cheek mimicking acne rosacea. Microscopic examination revealed a tumor mainly centered in the reticular dermis and mostly composed of spindle-shaped large B lymphocytes exhibiting bizarre shapes with ?boomerang-like? or ?spermatozoa-like? appearance. The immunohistochemical staining demonstrated neoplastic lymphocytes positive for CD20, CD79?, and BCL-6, and negative for CD3, CD43, CD10, BCL-2, and MUM-1. These results supported the diagnosis of a follicle center B-cell lymphoma with spindle cells. Although this rare variant of primary cutaneous B-cell lymphoma is not included in the recent WHO?EORTC classification, ...

May 21, 2015 08:07AM

Pruritic Red Papules of the Right Flank

No abstract available (Source: The American Journal of Dermatopathology)

MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.

May 21, 2015 08:07AM

Specific Skin Infiltration as First Sign of Localized Stage Hodgkin's Lymphoma Involving an Epitrochlear Node

We present a 44-year-old man with erythematous indurate papules and plaques in the right forearm and arm where skin biopsy showed an HL. He also has an enlarged epitrochlear node, and later histopathologic study confirmed the diagnosis of HL subtype?mixed cellularity. Immunohistochemical stains in both biopsies showed that the atypical cells were positive for CD30 and CD15, and negative for CD20 and CD3. PAX5 stained the nuclei of the atypical large lymphoid cells weakly and Oct-2 staining was negative in the atypical cells. EBER and LMP1 protein were negative in both biopsies. Epitrochlear involvement in HL, like in our case, is a rare event ( (Source: The American Journal of Dermatopathology)

May 21, 2015 08:07AM

Squamous Cell Carcinoma With Perineural and Intraneural Invasion Associated With Hyalinized Tumor Nodules: A Diagnostic Pitfall and Review of the Literature

We report a case of a common tumor with an uncommon finding. A 57-year-old white man presented with paresthesias and a new lesion at the site of a previously resected squamous cell carcinoma. At the time of case review, present deep in the dermis, were large hyalinized tumor nodules. These nodules could have easily have been dismissed as sclerotic tumor nodules or fibrotic in-transit metastases. With the clinical history in mind, these nodules were further investigated by immunohistochemistry and reviewed in conjunction with the Mohs frozen section slides. These nodules were subsequently diagnosed as significant peri- and intraneural invasion. This extremely unusual presentation of PNI is a potential diagnostic pitfall that is potentially under-recognized by dermatopathologists but crucial...

May 21, 2015 08:07AM

Metastatic Melanoma in Association With a Giant Congenital Melanocytic Nevus in an Adult: Controversial CGH Findings

We report the case of a 22-year-old woman with a nodule arising in a GCMN and with an axillary mass suggesting a nodal metastasis of melanoma, and discuss the unusual clinical, histopathologic, and molecular findings that make this case particularly interesting. (Source: The American Journal of Dermatopathology)

May 21, 2015 08:07AM

Pruritic Red Papules on the Right Flank: Challenge

No abstract available (Source: The American Journal of Dermatopathology)

May 21, 2015 08:07AM

Pediatric Aleukemic Leukemia Cutis: Report of 3 Cases and Review of the Literature

We present 3 cases of ALC in pediatric patients. (Source: The American Journal of Dermatopathology)

MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.

May 21, 2015 08:07AM

Myxoid Onychomatricoma: An Unusual Variant of a Rare Nail Unit Tumor

Abstract: A 57-year-old woman presented with a 3-year history of a thickened, yellowed, over-curved nail plate of the left second toe. The proximal nail fold had an associated nodule. When observed head-on, the distal nail plate demonstrated multiple circular perforations. Avulsion of the nail plate revealed a 0.7 cm pale white mass within the proximal nail matrix, which was excised. Histologic sections of the nail plate showed longitudinal cystic spaces associated with papillary projections of nail matrix epithelium. The parenchyma of the lesion demonstrated bland-appearing spindled cells in a prominent myxoid stroma with abundant mast cells. The spindled cells were focally positive for CD34 and factor XIIIa and negative for S100, pan-cytokeratin, desmin, smooth muscle actin, epithelial m...

May 21, 2015 08:07AM

Scar and Induction of Follicles: An Association Worthy of Greater Awareness

Abstract: Alterations in the dermal connective tissue can sometimes induce epidermal changes with adnexal differentiation. Typically associated with dermatofibromas, such changes can also be seen in a wide range of reactive and neoplastic conditions. Scar is sometimes listed as an underlying cause of follicular induction, but this association seems to be poorly recognized and not widely discussed in the literature. In this article, the authors illustrate the spectrum of follicular induction, which may be associated with a dermal scar emphasizing on patterns, which can be mistaken for a basal cell carcinoma. (Source: The American Journal of Dermatopathology)

May 21, 2015 08:07AM

Seborrheic Keratosis With Bowenoid Transformation: The Immunohistochemical Features and Its Association With Human Papillomavirus Infection

In conclusion, a portion of the cases of SK with bowenoid transformation were associated with HPV infection. Selective immunohistochemical stains were helpful in the diagnosis of malignant change in these cases. (Source: The American Journal of Dermatopathology)

May 21, 2015 08:07AM

Metastatic Atypical Fibroxanthoma: A Series of 11 Cases Including With Minimal and No Subcutaneous Involvement

Abstract: Atypical fibroxanthoma (AFX) is a dermal mesenchymal neoplasm arising in sun-damaged skin, primarily of the head and neck region of older men. Conservative excision cures most. However, varying degrees of subcutaneous involvement can lead to a more aggressive course and rare metastases. Thus, AFX involving the subcutis are termed pleomorphic dermal sarcomas or other monikers by some to recognize the more threatening natural history. We reviewed cases of ?metastatic AFX? from our institution and from the files of a consultative dermatopathology practice. Nine of 152 patients with AFX were identified at a single institution (2000?2011). Two additional patients were identified from the files of a consultative practice. Clinical, radiological, and pathological features were rev...

May 21, 2015 08:07AM

Melanomas Arising on Skin With Chronic Sun-Induced Damage Exhibit Low Degree of Angiogenesis and Lymphangiogenesis

Abstract: Differences in gene expression between melanomas arising on skin intermittently and chronically sun-exposed areas were described. Additionally, several studies have shown differences in clinical characteristics and prognosis, suggesting distinct biological pathways in the development of these tumors. We performed a retrospective investigation aimed on evaluation of the differences in angiogenesis and lymphangiogenesis between melanomas arising on skin with and without signs of chronic sun-induced damage. For that purpose, we evaluated relative blood and lymphatic vessel areas, blood and lymphatic endothelial cell proliferation fractions, separately for peritumoral and intratumoral areas. We have shown that melanomas arising on sun-exposed skin exhibit lower angiogenic and lymphan...

MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.

May 21, 2015 08:07AM

Primary Cutaneous Small/Medium CD4+ T-Cell Lymphoma Occurring During Treatment With Vemurafenib for Advanced Melanoma

We report for the first time a patient with metastatic melanoma harboring BRAF V600E mutation that develops a primary, cutaneous small/medium CD4+ T-cell lymphoma secondarily to the treatment with vemurafenib. A 54-year-old man with a history of metastatic melanoma treated with the oral BRAF inhibitor vemurafenib presents, 4 months after the initiation of the treatment, with multiple, nodular firm nonulcerated lesions on his back. Two skin biopsies from the lesions revealed a primary, cutaneous small/medium CD4+ T-cell lymphoma. The extensive use of recently approved mutation-specific RAF inhibitors seems to be speeding up the emergence of unknown nonpreventable toxicities of these agents. Our patient developed a primary, cutaneous small/medium CD4+ T-cell lymphoma, which presented 4 month...

May 21, 2015 08:07AM

Clinicopathologic Spectrum of Cutaneous Tuberculosis: A Retrospective Analysis of 165 Indians

Conclusions: CTB has a varied clinical and morphological spectrum. Cytology and histopathology play a key role in its diagnosis. An additional adjunct is the clinical response to antituberculosis treatment. (Source: The American Journal of Dermatopathology)

May 21, 2015 08:07AM

Microscopic Nail Clipping Findings in Patients With Psoriasis

Conclusions: Nail clippings from patients with psoriasis present abnormally thickened subungual region with prominent hypercorneocytosis, serous lakes, bacteria, neutrophils, and blood collections. If fungi are present, usually there are spores. Clinically, normal-looking nails in patients with psoriasis can present microscopic abnormalities. (Source: The American Journal of Dermatopathology)

May 21, 2015 07:50AM

Role of endothelin-1 in the skin fibrosis of systemic sclerosis.

In conclusion, our results demonstrated that ET-1 may induce fibrosis in dermal fibroblasts through Akt signals. PMID: 25990837 [PubMed - as supplied by publisher] (Source: European Cytokine Network)

May 21, 2015 04:00AM

Up the anesthesia when treating axillary hyperhidrosis

KISSIMMEE, FLA. ? Patients who received more local anesthesia before undergoing microwave-based treatment for axillary hyperhidrosis were happier with results and achieved the same objective improvements as patients who received less anesthesia, a follow-up study found. ?Patient satisfaction with... (Source: Skin and Allergy News)

MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.

May 20, 2015 07:05PM

Clinical Order Sets for Arterial Ulcers

No abstract available (Source: Advances in Skin and Wound Care)

May 20, 2015 07:05PM

A Research Design for the Quantification of the Neuropeptides Substance P and Calcitonin Gene-Related Peptide in Rat Skin Using Western Blot Analysis

CONCLUSION: This study described a research design that uses WB analysis as a reproducible, technically accessible, and cost-effective method for the quantification of SP and CGRP in rat skin that overcomes technical biases. (Source: Advances in Skin and Wound Care)

May 20, 2015 07:05PM

Dressings for Preventing Pressure Ulcers: A Meta-analysis

ABSTRACT: The purpose of this analysis is to determine the effectiveness of dressing material in the prevention of pressure ulcers. Results showed that hydrocolloid, foam, and film were more effective than a standard care protocol in patients at risk for pressure ulcers. (Source: Advances in Skin and Wound Care)

May 20, 2015 07:05PM

Practice Implications for Peristomal Skin Assessment and Care from the 2014 World Council of Enterostomal Therapists International Ostomy Guideline

PURPOSE: To provide an overview of the 2014 World Council of Enterostomal Therapists International Ostomy Guideline recommendations. TARGET AUDIENCE: This continuing education activity is intended for physicians and nurses with an interest in skin and wound care. OBJECTIVES: After participating in this educational activity, the participant should be better able to: 1. Describe the anatomy and physiology of ostomies and their complications. 2. Identify evidence-based best practice interventions to prevent and manage ostomy complications. ABSTRACT: All persons with an ostomy are at risk for development of peristomal skin problems. This is true regardless of the person?s nation of residence, type of stoma, or supplies available for stoma care. There are measures that can be taken to lessen ...

May 20, 2015 07:05PM

Wound Centers: Is It Time for Organizational Accreditation

No abstract available (Source: Advances in Skin and Wound Care)

May 20, 2015 07:05PM

Medicare Changes That You May Not Know

No abstract available (Source: Advances in Skin and Wound Care)

May 20, 2015 07:05PM

A Study of the Utility and Equivalency of 2 Methods of Wound Measurement: Digitized Tracing Versus Digital Photography

CONCLUSIONS: The 2 methods are in agreement on the important parameter of healing rate. Both methods are feasible in clinical settings. Wound photography may be more useful than digitized tracings because it simultaneously captures wound appearance. (Source: Advances in Skin and Wound Care)

May 20, 2015 06:35PM

Smoking Worsens Life With IBD (CME/CE)

(MedPage Today) -- More joint problems seen in Crohn's, ulcerative colitis patients who smoke. (Source: MedPage Today Dermatology)

May 20, 2015 06:30PM

New Technique of Immediate Nipple Reconstruction During Immediate Autologous DIEP or MS-TRAM Breast Reconstruction

Conclusions: One-stage nipple reconstruction with immediate breast reconstruction using our technique of 3 local flaps on skin envelope flap is possible. This simple, reliable, and rapid technique gives stable aesthetic results over time. Reconstruction may be completed sooner and with fewer procedures. Nipple reconstruction should no longer be considered as a secondary complement to immediate breast reconstruction using deep inferior epigastric perforator or muscle-sparing transverse rectus abdominis myocutaneous flap. Our technique is suitable for patients with ptotic or hypertrophic breasts. (Source: Annals of Plastic Surgery)

May 20, 2015 06:30PM

Nipple-Sparing Mastectomy via an Inframammary Fold Incision for Patients With Scarring From Prior Lumpectomy

Conclusions: Patients with scarring from prior lumpectomy do not have a higher rate of NAC ischemia and may be considered for NSM via an IMF incision. (Source: Annals of Plastic Surgery)

May 20, 2015 04:00PM

Vulvar dermatoses: a histopathologic review and classification of 183 cases

ConclusionsOur study has determined the relative frequencies of a wide variety of vulvar dermatoses, and identified new diagnostic clues for early LS, LSC, and Zoon vulvitis. (Source: Journal of Cutaneous Pathology)

May 20, 2015 04:00PM

Brooke?Spiegler syndrome presenting multiple concurrent cutaneous and parotid gland neoplasms: Cytologic findings on fine?needle sample and description of a novel mutation of the CYLD gene

Multiple dermal cylindromas and membranous basal cell adenoma of parotid gland in a 67?year?old woman with Brooke?Spiegler syndrome (BSS) were examined by fine?needle cytology. Histology, immunochemistry, and CYLD germline mutation testing were also performed. Cytomorphology and immunochemistry of the two lesions showed basaloid neoplasms, remarkably similar, composed by proliferating epithelial cells of basal type accompanied by a smaller proportion of myoepithelial cells. CYLD gene showed a novel germline splice acceptor site mutation (c.2042?1G>C) with skipping of the entire exon 15. The occurrence of analogous tumors, dermal cylindromas, and membranous basal cell adenoma of the parotid gland, in the same patient may result from the action of a single gene on ontogeneticall...

May 20, 2015 04:00PM

Rescue of the Mucocutaneous Manifestations by Human Cord Blood Derived Nonhematopoietic Stem Cells in a Mouse Model of Recessive Dystrophic Epidermolysis Bullosa

This study has warranted future clinical investigation of USSCs as a novel and universal allogeneic stem cell donor source in selected patients with RDEB. Stem Cells 2015;33:1807?1817 (Source: Stem Cells)

MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.

May 20, 2015 04:00PM

Serum vitamin D levels in a cohort of adult and pediatric patients with eosinophilic esophagitis

Vitamin D deficiency has been associated with increased risk for severe asthma, challenge-proven food allergy, and severe atopic dermatitis. Vitamin D levels have not been reported in patients with eosinophilic esophagitis (EoE). (Source: Annals of Allergy, Asthma and Immunology)

May 20, 2015 04:00PM

One stage mastopexy augmentation in the ptotic patient. The superiorly based dermal flap for autologous reinforcement of the inferior pole

The use of one stage mastopexy augmentation in the ptotic patient remains controversial. Expansion of breast volume and reduction of the skin envelope contradict each other and increase the risks of potential complications. By carefully selecting and consenting patients appropriately I describe the use of the superiorly based dermal flap for autologous reinforcement of the inferior pole to increase safety and reliability in one stage mastopexy augmentation. (Source: Journal of Plastic, Reconstructive and Aesthetic Surgery)

May 20, 2015 04:00PM

Effect of etanercept therapy on psoriasis symptoms in patients from Latin America, Central Europe, and Asia: a subset analysis of the PRISTINE trial

Background: Psoriasis prevalence and characteristics in Asia, Central Europe, and Latin America have not been thoroughly investigated and there are no large trials for biologic treatments for patients from these regions. The goal of this analysis was to report clinical response to anti-tumor necrosis factor-alpha treatment in these patients. Methods: Patients from Argentina, Czech Republic, Hungary, Mexico, Taiwan, and Thailand (N?=?171) were included in this subset analysis of the PRISTINE trial. Patients with stable moderate-to-severe plaque psoriasis were blinded and randomized to receive etanercept 50 mg once weekly (QW) or biweekly (BIW) for 12 weeks, followed by 12 weeks of open-label QW treatment with etanercept 50 mg through week 24 (QW/QW vs. BIW/QW). Concomitant methotrex...

May 20, 2015 04:00PM

Case of bilateral acroangiodermatitis due to symmetrical arteriovenous fistulas of the soles

Abstract A 58?year?old woman presented painful chronic inflammation of the outside skin of the bilateral soles. A skin biopsy revealed chronic inflammation of the dermis and subcutaneous tissue, as well as the marked dilatation and proliferation of capillaries and veins, and the thick deposition of elastic fibers around the thick?walled veins. 3?D contrasted computed tomography of the lower extremities demonstrated early bilateral imaging of the veins, and fistulas of the peroneal as well as posterior tibial artery and vein of the bilateral soles. On the basis of a diagnosis of bilateral acroangiodermatitis due to symmetrical arteriovenous fistulas, the patient underwent compression therapy using elastic bandages, and the symptoms reduced in several days. (Source: The Journal of De...

MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.

May 20, 2015 04:00PM

Malignant melanoma on female clitoris with bidirectional upper and lower lymphatic flow

(Source: The Journal of Dermatology)

May 20, 2015 04:00PM

Validation of the Cutaneous Dermatomyositis Disease Area and Severity Index (CDASI): characterizing disease severity and assessing responsiveness to clinical change

ConclusionsThe CDASI is a valid and responsive measure that can be used to characterize cutaneous dermatomyositis severity and detect improvement in disease activity. Variations in cutoffs may be due to differences in disease severity between the two populations or inter?rater variations in use of the external gold measures.This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)

May 20, 2015 04:00PM

Mycosis fungoides associated with splenic infarction and muscle involvement

This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)

May 20, 2015 04:00PM

Prioritization of therapy uncertainties in congenital ichthyosis results from a priority setting partnership

This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)

MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.

May 20, 2015 04:00PM

Making a diagnosis of psoriasis requires knowledge, experience and expertise

This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)

May 20, 2015 04:00PM

?What is it about your skin cancer that bothers you the most??: 700 patients respond

(Source: British Journal of Dermatology)

May 20, 2015 04:00PM

Effects of pharmacological interventions on muscle protein synthesis and breakdown in recovery from burns

Conclusion Data support the efficacy of testosterone, oxandrolone, human recombinant growth hormone, insulin, metformin, and propranolol in improving skeletal muscle protein net balance in patients with severe burns. The mechanisms underlying the improvement of protein net balance differ between types and dosages of drugs, but their main effect is on protein synthesis. Finally, the majority of studies have been conducted during the acute hypermetabolic phase of the injury. Except for oxandrolone, the effects of drugs on muscle protein kinetics following discharge from the hospital are largely unknown. (Source: Burns)

May 20, 2015 04:00PM

Clinical and forensic signs related to chemical burns: A mechanistic approach

Publication date: June 2015 Source:Burns, Volume 41, Issue 4 Author(s): Ricardo Jorge Dinis-Oliveira , Félix Carvalho , Roxana Moreira , Jorge Brandão Proença , Agostinho Santos , José Alberto Duarte , Maria de Lourdes Bastos , Teresa Magalhães This manuscript highlights and critically analyses clinical and forensic signs related to chemical burns. Signs that may lead to suspicion of a particular chemical are thoroughly discussed regarding its underlying mechanisms. Burns due to sulfuric, hydrofluoric, nitric, hydrochloric (muriatic) and acetic (including derivatives) acids, hydrogen sulphide, sodium (caustic soda) and calcium (cement) hydroxides, paraquat, burns after inflation and rupture of airbags, povidone?iodine, chlorhexidine/alcohol (in preterm infants), laxatives, and ves...

May 20, 2015 04:00PM

Human acellular dermal matrix allograft: A randomized, controlled human trial for the long-term evaluation of patients with extensive burns

This study was designed to retrospectively evaluate the long-term outcomes of the cograft acellular dermal matrix with autologous thin split-thickness skin for the coverage of wounds in extensively burned patients. Thirty burn patients treated with a composite graft of ADM with autologous split-thickness skin from January 2007 to December 2009 were enrolled in this study. Another group of thirty patients who received only an autogenous split-thickness skin implant served as the control. Our study revealed that the collagen in the dermis treated with ADM were ordered, and the proportion of collagen III/I was much higher in the control group than in the ADM group. The basement membrane was prominent and continuous. Meanwhile, the VBSS (Vancouver Burn Skin Score) was used to evaluate skin qua...

MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.

May 20, 2015 04:00PM

Paediatric burns patients: Reasons for admission at a tertiary centre

Conclusion The findings of this study demonstrate that it is not just children with severe burns who are admitted. One third of children are admitted because of the impact of the burn injury on the family, not because of a need for immediate management of the burns injury itself. The full impact of paediatric burns on our healthcare system is not solely determined by the physical characteristics of the burn itself. (Source: Burns)

May 20, 2015 04:00PM

The past 25 years of pediatric burn treatment in Graz and important lessons been learned. An overview

Conclusion The study provides a good opportunity to review changes in burn care over a long time period, at a single center, including children and adolescents, with stable surgical and rehabilitation staff. The data is also important for the design of prevention programs and establishment of burn care capacities, since the analysis showed no change in the incidence of burn related admissions over the time period studied. (Source: Burns)

May 20, 2015 04:00PM

Comparison of long-term quality of life of pediatric burn survivors with and without inhalation injury

Conclusions Overall the groups were comparable in their reports of disability and quality of life. Inhalation injury did not affect long-term quality of life. (Source: Burns)

May 20, 2015 04:00PM

Transfer time to a specialist burn service and influence on burn mortality in Australia and New Zealand: A multi-centre, hospital based retrospective cohort study

Conclusion In ANZ, pre-hospital transport systems and peripheral hospital stabilisation were not associated with an increased risk of death due to burn except when inhalation injury was present. The results of this study indicate that burn patients with inhalation injury should be stabilised and transferred to a burn service within 16h of burn. (Source: Burns)

MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.

May 20, 2015 04:00PM

Health-related quality of life 6 months after burns among hospitalized patients: Predictive importance of mental disorders and burn severity

Conclusion Self-perceived HRQoL among acute burn patients at 6 months after injury seems to be mostly as good as in general population studies in Finland. The high standard of acute treatment and the inclusion of small burns (%TBSA<5) in the cohort may partly explain the weak effect of burn itself on HRQoL. Mental disorders strongly predicted HRQoL at 6 months. (Source: Burns)

May 20, 2015 04:00PM

A comparison of Biobrane? and cadaveric allograft for temporizing the acute burn wound: Cost and procedural time

Conclusion Biobrane? is superior to cadaveric allograft as a temporizing skin substitute in the acute burn wound, both in terms of procedure time and associated cost. We believe that this is largely due to the relative ease of application of Biobrane?. Furthermore, given its unique characteristics, Biobrane? may serve as a triage and transport option for severe burns in the military and mass casualty settings. (Source: Burns)

May 20, 2015 04:00PM

Chemical burns in children: Aetiology and prevention

Conclusion Chemical burns remain infrequent but potentially preventable. These burns mainly occur in the domestic setting due to non-intentional exposure of household chemicals in children <10, and due to deliberate self-harm in children ?10. The use of child-resistant packaging, similar to that used for medications, and improved parental practices could help decrease the incidence of burns in children <10. (Source: Burns)

May 20, 2015 04:00PM

The expression of miR-125b regulates angiogenesis during the recovery of heat-denatured HUVECs

Conclusions Taken together our results show that the expression of miR-125b is time-dependent and miR-125b plays a regulatory role of angiogenesis during wound healing after burns. (Source: Burns)

May 20, 2015 04:00PM

The analysis of distribution of multidrug resistant Pseudomonas and Bacillus species from burn patients and burn ward environment

Conclusion The major finding of our study is the predominance of B. cereus followed by P. aeruginosa in burn patients of Pt. B.D. Sharma University of Health Sciences, Rohtak, Haryana. While considering the role of hospital environment, no direct role of environmental isolates was observed in transfer of bacterial infection. (Source: Burns)

MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.

May 20, 2015 04:00PM

Increased wound pH as an indicator of local wound infection in second degree burns

In conclusion, consecutive pH measurement of exudates is considered to be a useful indicator in the treatment of second degree burns. (Source: Burns)

May 20, 2015 04:00PM

Effect and possible mechanism of monocyte-derived VEGF on monocyte?endothelial cellular adhesion after electrical burns

Conclusion Our results indicate that VEGF is implicated in the pathogenesis of inflammation after electrical burns. Inhibition of VEGF activity could attenuate monocyte?endothelial cells adhesion by suppressing the state of phosphorylation of AKT, which is downstream of the PI3K signaling pathway. (Source: Burns)

May 20, 2015 04:00PM

Interactive effects of acupuncture on pain and distress in major burns: An experiment with rats

This study sought to investigate the interactive effects of acupuncture on pain and distress and the local progress in the burn wound in an experimental major burn model. Forty-eight male Sprague-Dawley rats were divided into six groups: S group (sham/observation during 7 days after injury); SA group (sham/acupuncture/observation during 7 days after injury); B1 group (burns/observation during 1h after injury); BA1 group (burns/acupuncture/observation during 1h after injury); B7 group (burns/observation during 7 days after injury); and BA7 group (burns/acupuncture/observation during 7 days after injury). Pain and distress scores were evaluated throughout the study. The amounts of neutrophils and mononuclear cells were evaluated semiquantitatively, and the number of microvessels was evaluate...

May 20, 2015 04:00PM

Evaluation of saline, RPMI and DMEM/F12 for storage of split-thickness skin grafts

Publication date: June 2015 Source:Burns, Volume 41, Issue 4 Author(s): B.K.H.L. Boekema , B. Boekestijn , R.S. Breederveld Skin grafting is standard of care for severe burn and trauma patients. Graft sites are often accompanied with more pain than the burn sites. To minimize graft site areas, excess skin remaining after harvesting, is stored in saline at 4°C to be used for transplantation up to 1 week later. However, the optimal storage solution and maximum storage time are not known. We set out to determine the storage time after which stored skin is still viable. In addition, different storage solutions were tested. Split-thickness skin from 15 donors with a thickness of 0.3mm was stored in normal saline, in medium, RPMI or DMEM/F12, allowing pairwise comparison. Biopsies were taken ...

May 20, 2015 04:00PM

Epidemiology of filamentous fungal infections in burned patients: A French retrospective study

Conclusion FFI are essentially cutaneous, infrequent and occur in the most severe burned patients. ASP seems to be more serious than other FFI. (Source: Burns)

MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.

May 20, 2015 04:00PM

Nurses? perceptions and experiences regarding Morphine usage in burn pain management

Conclusion The resultant effect of these perception and experiences imply and confirm the under usage of morphine. It is therefore recommended that nurses within the burn unit be taken through training modules on the suitability of morphine in burn pain management. (Source: Burns)

May 20, 2015 04:00PM

Surgical treatment of severe or moderate axillary burn scar contracture with transverse island scapular flap and expanded transverse island scapular flap in adult and pediatric patients?A clinical experience of 15 cases

Conclusions Considering the flap's negligible level of later contracture and minimal trauma, local TISF based on the transverse branch of the circumflex scapular artery is a good choice for reconstruction of axillary burn scar contractures. If the TISF is not able to meet the demand, the expander implanted in advance can be more beneficial. (Source: Burns)

May 20, 2015 04:00PM

Critical care of burn patients. New approaches to old problems

Publication date: Available online 18 May 2015 Source:Burns Author(s): Lavrentieva Athina Recent publications on treatment options in critically ill patients change beliefs and clinical behaviors. Many dogmas, which the modern management of critical illness relies on, have been questioned. These publications (consensus articles, reviews, meta-analysis and original papers) concern some fundamental issues of critical care: interventions in acute respiratory distress syndrome (ARDS), hemodynamic monitoring, glucose control and nutritional support and revise our views on many key points of critical care of burn patients. (Source: Burns)

May 20, 2015 04:00PM

Burns in sub-Saharan Africa: A review

Conclusions These statistics indicate the need for an urgent review of burn policies and related legislation across the sub-Saharan region to help reduce burns, and provide a safe environment for children. (Source: Burns)

May 20, 2015 04:00PM

Role of angiotensin-converting enzyme (ACE) and ACE2 in a rat model of smoke inhalation induced acute respiratory distress syndrome

This study indicated that inflammation pulmonary edema and histological changes resulted from smoke inhalation induced lung injury were possibly attributed to abnormal expression of ACE and ACE2 related pathway. (Source: Burns)

MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.

May 20, 2015 04:00PM

Rigorous, robust and systematic: Qualitative research and its contribution to burn care. An integrative review

Publication date: Available online 13 May 2015 Source:Burns Author(s): Rachel Anne Kornhaber , A.E.E. de Jong , L. McLean Qualitative methods are progressively being implemented by researchers for exploration within healthcare. However, there has been a longstanding and wide-ranging debate concerning the relative merits of qualitative research within the health care literature. This integrative review aimed to exam the contribution of qualitative research in burns care and subsequent rehabilitation. Studies were identified using an electronic search strategy using the databases PubMed, Cumulative Index of Nursing and Allied Health Literature (CINAHL), Excerpta Medica database (EMBASE) and Scopus of peer reviewed primary research in English between 2009 to April 2014 using Whittemore and ...

May 20, 2015 04:00PM

Outcomes of burns in the elderly: Revised estimates from the Birmingham Burn Centre

Publication date: Available online 13 May 2015 Source:Burns Author(s): Christopher Wearn , Joseph Hardwicke , Andreas Kitsios , Victoria Siddons , Peter Nightingale , Naiem Moiemen Outcomes after burn have continued to improve over the last 70 years in all age groups including the elderly. However, concerns have been raised that survival gains have not been to the same magnitude in elderly patients compared to younger age groups. The aims of this study were to analyze the recent outcomes of elderly burn injured patients admitted to the Birmingham Burn Centre, compare data with a historical cohort and published data from other burn centres worldwide. A retrospective review was conducted of all patients ?65 years of age, admitted to our centre with cutaneous burns, between 2004 and 2012....

May 20, 2015 04:00PM

Full thickness facial burns: Outcomes following orofacial rehabilitation

Conclusion This study demonstrates that although positive gains can be achieved through non-surgical exercise after full thickness burn, the duration of rehabilitation is considerable and some degree of long term loss in functional mouth opening remains. (Source: Burns)

May 20, 2015 04:00PM

A model to explain suicide by self-immolation among Iranian women: A grounded theory study

Conclusion The conceptual model, derived through grounded theory study, can guide design of prevention programs. The pivotal role of family conflicts should be emphasized in mental health interventions. The impact of adverse consequences of self-immolation on further suicidal processes necessitates post-suicide prevention programs. Further research to design specific interventions is recommended. (Source: Burns)

May 20, 2015 12:52PM

Eight states enact telemedicine law, commission to be created

Minnesota and Alabama have joined six other states in enacting a law that aims to expand the practice of telemedicine by streamlining physician licensure. Alabama Gov. Robert Bentley (R) and Minnesota Gov. Mark Dayton (D) on May 19 each signed into law the Interstate Medical Licensure Compact, <a... (Source: Skin and Allergy News)

MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.

May 20, 2015 10:29AM

Extreme Beauty Disasters woman's bad reaction to fillers on 60th birthday

Serena, now 62, from London, treated herself to permanent dermal fillers on her 60th birthday to give her appearance and confidence a boost. (Source: the Mail online | Health)

May 20, 2015 05:00AM

Rate ratio of comorbidity high in SLE patients under 40

MANCHESTER, U.K. ? When systemic lupus erythematosus (SLE) occurs before age 40, patients run a high relative risk of end-stage renal disease, data from a retrospective U.K.-based cohort study have shown. While the risk for cardiovascular disease and stroke has been reported previously,... (Source: Skin and Allergy News)

May 19, 2015 07:20PM

Recurrent Facial Erythema with Cytotoxic T Cell Infiltration as a Possible Reactive Eruption in a Human T-Cell Lymphotropic Virus Type 1 Carrier

Human T-cell lymphotropic virus type 1 (HTLV-1) induces adult T cell leukemia/lymphoma (ATLL), HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) and carrier. Approximately half of ATLL patients have direct skin involvement of neoplastic cells. However, there exist HTLV-1-associated reactive eruptions with a predominant infiltrate of non-neoplastic CD8+ T cells in ATLL, HAM/TSP and carrier. A 50-year-old Japanese female HTLV-1 carrier had several episodes of itchy, indurated erythema that occurred diffusely on the face and neck, lasted for 2 weeks and spontaneously subsided without sequelae. Histopathologically, CD3+ T cells infiltrated the upper dermis, and part of the infiltrating cells were CD4+CD25+, sharing the phenotype with ATLL neoplastic cells. An aggregate of CD8...

May 19, 2015 06:20PM

US Sunscreen Use Abysmally Low, Especially Among MenUS Sunscreen Use Abysmally Low, Especially Among Men

Less than 15% of men and 30% of women use sunscreen as recommended, a new CDC analysis showed. Medscape Medical News (Source: Medscape Dermatology Headlines)

MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.

May 19, 2015 04:00PM

Experimental estimation of migration and transfer of organic substances from consumer articles to cotton wipes: Evaluation of underlying mechanisms

Authors: Per Axel Clausen, Suzanne Spaan, Derk H Brouwer, Hans Marquart, Maaike le Feber, Roel Engel, Lieve Geerts, Keld Alstrup Jensen, Vivi Kofoed-Sørensen, Brian Hansen & Katleen De Brouwere (Source: Journal of Exposure Science and Environmental Epidemiology)

May 19, 2015 04:00PM

Chloroquine analogues in drug discovery: new directions of uses, mechanisms of actions and toxic manifestations from malaria to multifarious diseases

Antimalarial drugs (e.g. chloroquine and its close structural analogues) were developed primarily to treat malaria; however, they are beneficial for many dermatological, immunological, rheumatological and severe infectious diseases, for which they are used mostly today. Chloroquine and hydroxychloroquine, two of the most fascinating drugs developed in the last 50 years, are increasingly recognized for their effectiveness in myriad non-malarial diseases. In advanced research, chloroquine and hydroxychloroquine have been shown to have various immunomodulatory and immunosuppressive effects, and currently have established roles in the management of rheumatic diseases, lupus erythematosus (different forms) and skin diseases, and in the treatment of different forms of cancer. Recently, chloroqui...