Dr. William Ting, Board-Certified Dermatologist
at California Dermatology Care

2262 Camino Ramon, San Ramon, CA 94583
Tel: 925-328-0255
Email: staff@CalDermCare.com


Advanced Care with a Personal Touch

   

 

 

Medical Dermatology    Evidence-based medicine   Customized solution   Personal care

Latest Dermatology Headlines

Dr. William Ting has expertise in treating the entire spectrum of medical dermatology, with emphasis in preventive medicine and personalized recommendations. He enjoys taking care of patients with acne, eczema, hair and nail disorders, rashes, psoriasis and skin cancers.

He is at the forefront of medical dermatology and dermatologic research. He continues to publish articles in peer-reviewed dermatology journals. He is an early pioneer of photodynamic therapy (PDT) and one of the most experienced practitioners of PDT in the Bay Area. He is the first dermatologist in the San Francisco Bay Area and Northern California to introduce Lutronic Spectra Laser for melasma, acne, scar revision, pore size reduction as well as the Cutera GenesisPlus laser for advanced nail fungus laser treatment, keloid and hypertrophic scar, warts and scar revision.

Dr. Ting is a fellow of the American Academy of Dermatology (AAD) and American Society of Dermatologic Surgery (ASDS). He is a member of the National Psoriasis Foundation and International Hyperhidrosis Society.

Innovative Therapeutic Approach to Common Skin Conditions

Acne

Eczema (Atopic Dermatitis)

Hair and Nail disorders

  • Maximize therapeutic synergy and efficacy by utilizing both prescription-strength and over-the counter products when available
  • Comprehensive workup including bloodwork and biopsy if necessary
  • Systemic oral hormonal therapy for women and men when indicated

Psoriasis 

Rosacea

  • Multi-prong approach to minimize redness
  • Low-dose 'non-antibiotic' anti-inflammatory oral medication for long-term remission 
  • Emphasis on prevention
  • Fotofacial/IPL laser utilizing Cynosure XPL/Elite MPX
  • Cutera GenesisPlus Laser with or without combination with IPL 
  • Diode laser for facial veins
  • VBeam Pulse Dye Laser, the new gold standard for rosacea and facial redness

Skin Cancer 

  • Emphasis on prophylactic treatments with topical 5-FU, imiquimod, diclofenac, ingenol mebutate and oral chemopreventive therapy such as Soriatane.
  • Reduce future risks of skin cancer with photodynamic therapy, TCA chemical peels and/or fractional CO2 resurfacing laser  
  • Mohs Surgery to achieve highest cure rate and tissue sparing
  • Close colloboration with plastic surgeon(s) as needed  

Sweating Disorder (Hyperhidrosis) 

Vitiligo

Warts 


ABCD of Mole Check

 

 

Common Medical Dermatology Diagnostics and Therapeutics:

Dermatology Links:

American Academy of Dermatology
American Society of Dermatologic Surgery
American Society of Mohs Surgery
International Hyperhidrosis Society
National Psoriasis Foundation

 Latest Dermatology Headlines:

Latest Dermatology Headlines
Sun, 19 Apr 2015 07:37:53 +0100

http://www.medworm.com/rss/index.php/Dermatology/12/

Apr 18, 2015 11:35PM

A 3-month, randomized, double-blind, placebo-controlled study evaluating the ability of an extra-strength marine protein supplement to promote hair growth and decrease shedding in women with self-perceived thinning hair.

Authors: Ablon G Abstract An oral marine protein supplement (MPS) is designed to promote hair growth in women with temporary thinning hair (Viviscal Extra Strength; Lifes2good, Inc., Chicago, IL). This double-blind, placebo-controlled study assessed the ability of MPS to promote terminal hair growth in adult women with self-perceived thinning hair associated with poor diet, stress, hormonal influences, or abnormal menstrual cycles. Adult women with thinning hair were randomized to receive MPS (N = 30) or placebo (N = 30) twice daily for 90 days. Digital images were obtained from a 4?cm(2) area scalp target area. Each subject's hair was washed and shed hairs were collected and counted. After 90 days, these measures were repeated and subjects completed Quality of Life and Self-Asse...

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Apr 18, 2015 07:29AM

Risk factors identified for gestational eczema

HOUSTON? New-onset eczema during pregnancy is a common phenomenon with several newly identified risk factors. This disease entity deserves a proper name: gestational eczema, Dr. Wilfried J.J. Karmaus asserted at the annual meeting of the American Academy of Allergy, Asthma, and Immunology. In... (Source: Skin and Allergy News)

Apr 17, 2015 08:01PM

A Review of the Diagnosis and Management of Erythroderma (Generalized Red Skin)

No abstract available (Source: Advances in Skin and Wound Care)

Apr 17, 2015 08:01PM

Auditing Wound Care Documentation

No abstract available (Source: Advances in Skin and Wound Care)

Apr 17, 2015 08:01PM

The Effect of Salivary Gland Extract of Lucilia sericata Maggots on Human Dermal Fibroblast Proliferation within Collagen/Hyaluronan Membrane In Vitro: Transmission Electron Microscopy Study

CONCLUSION: The authors believe that increased cell metabolism and protein production corresponded with formation of microfibrillar net used for migration of fibroblasts in culture, but mainly for proper production of extracellular matrix. The authors suggest that their results may help explain the effect of SGE on wound healing and support implementation of maggot therapy into human medicine. (Source: Advances in Skin and Wound Care)

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Apr 17, 2015 08:01PM

A Review of the Diagnosis and Management of Erythroderma (Generalized Red Skin)

PURPOSE: To provide information about the diagnosis and management of erythroderma. TARGET AUDIENCE: This continuing education activity is intended for physicians and nurses with an interest in skin and wound care. OBJECTIVES: After participating in this educational activity, the participant should be better able to: 1. Identify erythroderma causes, symptoms, and diagnostic testing. 2. Summarize treatment and management recommendations for erythroderma. ABSTRACT: Erythroderma is a condition caused by several etiologies that result in red inflamed skin on 90% or more of the body surface. To optimize the diagnosis and management of the erythrodermic patient, healthcare professionals should be familiar with the underlying etiologies and treatment modalities. Patients with erythroderma require...

Apr 17, 2015 08:01PM

Case Studies Evaluating Transdermal Continuous Oxygen for the Treatment of Chronic Sickle Cell Ulcers

CONCLUSION: The authors conclude that TCOT may be a novel, effective, and inexpensive modality in treating patients with sickle cell disease ulcers. Improvement was typically noticeable within 2 weeks. Further clinical trials may be considered to evaluate the efficacy of TCOT in sickle cell ulcers. (Source: Advances in Skin and Wound Care)

Apr 17, 2015 08:01PM

Pulsed Electromagnetic Field Therapy Promotes Healing and Microcirculation of Chronic Diabetic Foot Ulcers: A Pilot Study

CONCLUSION: In this study, PEMF therapy seemed to accelerate wound healing and improve microcirculation. (Source: Advances in Skin and Wound Care)

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Apr 17, 2015 08:01PM

From the editor?s desk

No abstract available (Source: Advances in Skin and Wound Care)

Apr 17, 2015 08:01PM

Industry news

No abstract available (Source: Advances in Skin and Wound Care)

Apr 17, 2015 08:01PM

CAUTION: All ?Wound Care Clinics? Do Not Qualify for the Same Medicare Payment

No abstract available (Source: Advances in Skin and Wound Care)

Apr 17, 2015 08:01PM

Platelet-Rich Plasma and Myofibroblasts: Is the Composition the Key to Success?

No abstract available (Source: Advances in Skin and Wound Care)

Apr 17, 2015 08:01PM

The War on Amputations: 2 Fronts

No abstract available (Source: Advances in Skin and Wound Care)

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Apr 17, 2015 07:18PM

Safety and efficacy of cetirizine versus cetirizine plus ranitidine in chronic urticaria: Double-blind randomized placebo-controlled study

Journal of Dermatological Treatment, Ahead of Print. (Source: Journal of Dermatological Treatment)

Apr 17, 2015 06:19PM

FDA Warns of Counterfeit Botox in the United StatesFDA Warns of Counterfeit Botox in the United States

The FDA says the counterfeit drug may have reached physicians' offices and medical clinics nationwide. Learn how to spot the fakes. News Alerts (Source: Medscape Dermatology Headlines)

Apr 17, 2015 04:00PM

Identifying the need for a multidisciplinary approach for early recognition of mucopolysaccharidosis VI (MPS VI)

Publication date: Available online 26 March 2015 Source:Molecular Genetics and Metabolism Author(s): Yew Sing Choy , Kaustuv Bhattacharya , Shanti Balasubramaniam , Michael Fietz , Antony Fu , Anita Inwood , Dong-Kyu Jin , Ok-Hwa Kim , Motomichi Kosuga , Young Hee Kwun , Hsiang-Yu Lin , Shuan-Pei Lin , Nancy J. Mendelsohn , Torayuki Okuyama , Hasri Samion , Adeline Tan , Akemi Tanaka , Verasak Thamkunanon , Meow-Keong Thong , Teck-Hock Toh , Albert D. Yang , Jim McGill Mucopolysaccharidosis VI (MPS VI, Maroteaux?Lamy syndrome) is caused by deficient activity of the enzyme, N-acetylgalactosamine-4-sulfatase, resulting in impaired degradation of the glycosaminoglycan dermatan sulfate. Patients experience a range of manifestations including joint contractures, short stature, dysostosis mu...

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Apr 17, 2015 04:00PM

Molecular examinations of Babesia microti in rodents and rodent-attached ticks from urban and sylvatic habitats in Germany

Publication date: Available online 16 April 2015 Source:Ticks and Tick-borne Diseases Author(s): Anna Obiegala , Martin Pfeffer , Kurt Pfister , Carolin Karnath , Cornelia Silaghi Small mammals serve as reservoir hosts for tick-borne pathogens, especially for those which are not transmitted transovarially in ticks - such as Babesia microti. Molecular investigations on the prevalence of B. microti in wild small mammals and on attached ticks from differently structured areas may provide information on the circulation of B. microti in different ecological niches. In 2012 and 2013, 622 rodents (396 Myodes glareolus, 178 Apodemus flavicollis, 36 Apodemus sylvaticus, 4 Apodemus agrarius, 7 Microtus arvalis, 1 Microtus agrestis) were captured from three differently structured habitats (urban, s...

Apr 17, 2015 04:00PM

Omalizumab in patients with chronic spontaneous urticaria: a systematic review and GRADE assessment

This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)

Apr 17, 2015 04:00PM

Living with vitiligo: results from a national survey indicate differences between skin phototypes

This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)

Apr 17, 2015 04:00PM

Coexistence of autoimmune bullous diseases (AIBDs) and psoriasis: A series of 145 cases

Many case reports have described the coexistence of autoimmune bullous diseases (AIBDs) and psoriasis. Among them, anti-laminin ?1 (p200) pemphigoid is the best known. (Source: Journal of the American Academy of Dermatology)

Apr 17, 2015 04:00PM

Serum prolactin levels in dermatological diseases: A case control study

Conclusions Prolactin may play a role in the pathogenesis of alopecia areata, psoriasis, and vitiligo; and may serve as a biological marker of disease activity in patients with psoriasis and alopecia areata. (Source: Journal of Dermatology and Dermatologic Surgery)

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Apr 17, 2015 10:34AM

FDA moves to alert physicians, public to counterfeit Botox

Counterfeit Botox has been found in the United States and could be in offices and clinics across the country, the Food and Drug Administration announced on April 17.... (Source: Skin and Allergy News)

Apr 17, 2015 10:00AM

New psoriatic arthritis screening tool passes initial validation

The second version of the Toronto Psoriatic Arthritis screen performed well at identifying psoriatic arthritis in 336 psoriasis patients, 131 psoriatic arthritis patients, and 89 individuals in the general population, according to Dr. Brian Tom and his associates. The sensitivities of the capped... (Source: Skin and Allergy News)

Apr 17, 2015 09:00AM

Psoriatic arthritis associated with heavy drinking

Heavy alcohol consumption was associated with incident psoriatic arthritis in women, Shaowei Wu, Ph.D., and his associates reported in a study of 116,430 female registered nurses in the Nurses? Health Study II. The investigators found 141 incident cases of psoriatic arthritis (PsA) during... (Source: Skin and Allergy News)

Apr 17, 2015 05:01AM

Use of off-label doses is frequent in biologic therapy for moderate to severe psoriasis: A cross-sectional study in clinical practice

Journal of Dermatological Treatment, Ahead of Print. (Source: Journal of Dermatological Treatment)

Apr 17, 2015 05:01AM

Clinical symptoms and self-reported disease severity among patients with psoriasis ? Implications for psoriasis management

Journal of Dermatological Treatment, Ahead of Print. (Source: Journal of Dermatological Treatment)

Apr 17, 2015 05:01AM

Efficacy and safety of 1064-nm Nd:YAG laser in treatment of onychomycosis

Journal of Dermatological Treatment, Ahead of Print. (Source: Journal of Dermatological Treatment)

Apr 17, 2015 05:01AM

Cryotherapy versus imiquimod 5% cream combined with a keratolytic lotion in cutaneous warts in children: A randomized study

Journal of Dermatological Treatment, Ahead of Print. (Source: Journal of Dermatological Treatment)

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Apr 17, 2015 05:01AM

Excision versus incision biopsy in the management of malignant melanoma

Journal of Dermatological Treatment, Ahead of Print. (Source: Journal of Dermatological Treatment)

Apr 17, 2015 05:01AM

How often do pharmacology textbooks address medication adherence?

Journal of Dermatological Treatment, Ahead of Print. (Source: Journal of Dermatological Treatment)

Apr 17, 2015 05:01AM

Evidence-based adverse effects of biologic agents in the treatment of moderate-to-severe psoriasis: Providing clarity to an opaque topic

Journal of Dermatological Treatment, Ahead of Print. (Source: Journal of Dermatological Treatment)

Apr 17, 2015 05:01AM

Safety of alitretinoin for severe refractory chronic hand eczema: Clinical studies and postmarketing surveillance

Journal of Dermatological Treatment, Ahead of Print. (Source: Journal of Dermatological Treatment)

Apr 17, 2015 12:22AM

Unusual Case of Papillary Thyroid Carcinoma with Choroidal Metastasis.

CONCLUSION: We report a rare and unique case of choroidal metastasis from PTC that presented with concurrent new dermal metastasis in addition to lung and mediastinal lymph node progression. Furthermore, our patient developed choroid and dermal lesions while on a tyrosine kinase inhibitor and remained stable without recurrence in these regions after switching to an alternate multikinase inhibitor. PMID: 25872533 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)

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Apr 17, 2015 12:03AM

Blood Money: The Cyril Karabus Story

It would be a fantastic fiction novel, if indeed it were not all true. The story begins a decade ago, in October 2002. The plot includes false accusations and missing documents, an intricate web of international politics, and extraordinary actions by ordinary individuals. The story is set in a nation?the United Arab Emirates?that does not conform to the principles of jurisprudence of most modern countries. A trial against a physician after the unfortunate death of a child from leukemia has concluded, and a guilty verdict has been declared that resulted in an order to pay ?blood money? to the child?s family. (Source: Clinics in Dermatology)

Apr 17, 2015 12:03AM

Daisy Maude Orleman Robinson: The first American woman dermatologist

Born in 1868 and the first American woman to become a dermatologist, Daisy Maude Orleman (later Robinson) graduated from the National Medical College of Columbian University, now George Washington University, in 1890. After training in dermatology in Paris and Zurich and after marriage to Andrew Rose Robinson in 1904, she joined the faculty of the New York Polyclinic Medical School and the Northwestern Dispensary in New York, where she was an attending dermatologist starting in 1905. Her achievements included being the first woman dermatologist to present a case at a dermatologic meeting, to publish a scholarly paper in dermatology, to present a case at an international dermatology meeting, and to have a documented clinical practice in dermatology in the United States. (Source: Clinics in ...

Apr 17, 2015 12:03AM

Treatment of alopecia areata with squaric acid dibutylester

Squaric acid dibutylester is a topical sensitizing agent utilized for the treatment of alopecia areata. The mechanism of action is not fully understood, but is believed to redirect the inflammatory response by invoking allergic contact dermatitis. Several studies have compared the efficacy of squaric acid dibutylester to other treatments vs placebo with favorable results. This contribution reviews the history of the topical sensitizing agent squaric acid dibutylester and discusses the mechanism of action, the use in alopecia areata, and the efficacy and safety of this therapeutic agent. (Source: Clinics in Dermatology)

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Apr 17, 2015 12:03AM

Newborn infant skin: Physiology, development, and care

Infant skin is critical to the newborn child?s transition from the womb environment to the journey to self-sufficiency. This review provides an integrative perspective on the skin development in full term and premature infants. There is a particular focus on the role of vernix caseosa and on the implications of skin development for epidermal penetration of exogenous compounds. Healthy full-term newborn skin is well-developed and functional at birth, with a thick epidermis and well-formed stratum corneum (SC) layers. (Source: Clinics in Dermatology)

Apr 17, 2015 12:03AM

Pediatric dermatology, part II: More hot topics in pediatric dermatology

The development of the field of pediatric dermatology has created an expansion in publications and understanding of dermatologic diseases in childhood. Pediatric dermatology is a small but vibrant subspecialty in the United States, with the first pediatric dermatology board having been offered to eligible dermatologists with pediatrics/pediatric dermatology training since 2004, with 232 individuals nationwide (as of September 8, 2014) having become board certified by the American Board of Dermatology since that time With the 10-year span since the first board examination, initially board certified pediatric dermatologists are now completing the 10-year cycle of the Maintenance of Certification program. (Source: Clinics in Dermatology)

Apr 17, 2015 12:03AM

Epidemiology of childhood atopic dermatitis

Atopic dermatitis (AD) or eczema is a chronic inflammatory skin disorder with significant morbidity and quality of life impairment. Elucidating the epidemiology of AD is important for understanding disease risk factors and facilitates development of interventions for disease prevention. This contribution aims to summarize recent developments in the epidemiology of AD, including the US prevalence, regional differences, and secular trends of disease prevalence, genetic and environmental determinants, distribution, and determinants of disease severity and health care use for AD. (Source: Clinics in Dermatology)

Apr 17, 2015 12:03AM

Obesity and the metabolic syndrome in pediatric psoriasis

Psoriasis is a common, chronic inflammatory dermatosis that often has its onset during childhood. There is increasing evidence that psoriasis in adults is associated with obesity, the metabolic syndrome, and associated comorbidities, including insulin resistance/type 2 diabetes, dyslipidemia, hypertension, and cardiovascular disease. This association is postulated to arise, at least in part, as a result of a systemic proinflammatory state that is mediated by adipose tissue. Several recent observational studies suggest that children and adolescents with psoriasis may be at increased risk of being overweight and obese as well as having an increased risk for features of the metabolic syndrome. (Source: Clinics in Dermatology)

Apr 17, 2015 12:03AM

Systemic therapy of childhood atopic dermatitis

Atopic dermatitis (AD) is a common childhood inflammatory disease that, in a small percentage of cases, can become severe enough to require potent systemic treatment. Many trials have been conducted with systemic agents for the treatment of severe pediatric AD; we review the evidence here. Although corticosteroids are widely used in practice, they are not generally recommended as a systemic treatment option for AD in children. Most patients experience a relatively rapid and robust response to cyclosporine. (Source: Clinics in Dermatology)

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Apr 17, 2015 12:03AM

Antifungal therapy for onychomycosis in children

Onychomycosis is a chronic infection of the nail unit, and its prevalence increases with age. Treatment options for children are similar to those for adults and include both oral and topical therapies. Oral agents, such as terbinafine, itraconazole, and fluconazole have been reported to have good efficacy and a low rate of side effects in children. Topical therapies, such as amorolfine and ciclopirox, can also be used as monotherapy or combined with oral agents to treat onychomycosis. Due to their thinner, faster-growing nails, children are more likely to respond to topical monotherapy than adults. (Source: Clinics in Dermatology)

Apr 17, 2015 12:03AM

Cutaneous reactions to vaccinations

Vaccinations are important for infectious disease prevention; however, there are adverse effects of vaccines, many of which are cutaneous. Some of these reactions are due to nonspecific inflammation and irritation at the injection site, whereas other reactions are directly related to the live attenuated virus. Rarely, vaccinations have been associated with generalized hypersensitivity reactions, such as erythema multiforme, Stevens-Johnson syndrome, urticaria, acute generalized exanthematous pustulosis, and drug hypersensitivity syndrome. (Source: Clinics in Dermatology)

Apr 17, 2015 12:03AM

Nickel contact dermatitis in children

Nickel is the most commonly detected cutaneous allergen on patch testing in the United States for children. The ubiquitous nature of nickel as a hardening agent in metal products makes avoidance difficult. Allergy in childhood can be hard to recognize, especially when a strong idiopathic response is noted. Although the standard belt buckle and jewelry trigger still occur, newer sources include technology equipment, such as cases for mobile phones, computers, and tablet devices This contribution reviews the various clinical appearances of nickel contact allergy in childhood, as well as strategies for treatment and avoidance. (Source: Clinics in Dermatology)

Apr 17, 2015 12:03AM

Hidradenitis suppurativa in prepubescent and pubescent children

Hidradenitis Suppurativa (HS) is an uncommon disease, which is particularly rare in young and prepubescent children. HS pathology centers on the follicular unit and involves aberrant cutaneous cellular immunity. HS tends to first manifest in puberty, but a handful of prepubescent cases of HS have been reported and are linked to hormonal disorders, in particular elevated testosterone. The most common manifestations of HS are abscesses, scarring, acne inversa, and keloids, especially in the intertriginous areas of the groin and the axilla. (Source: Clinics in Dermatology)

Apr 17, 2015 12:03AM

Infantile seborrheic dermatitis: A pediatric Siddha medicine treatise

Siddha medicine is one of the oldest (5000 years old) well-documented Indian traditional medicines, compared with Ayurveda, Unani, and traditional Chinese medicine, by way of keen observation and experimentation. It mentions 108 diseases that occur in childhood, which are further classified and described into various subtypes based on the clinical features and different stages of a particular disease. The authors translate the elegant and detailed description of one neonatal disorder, infantile seborrheic dermatitis (cradle cap), called kabaala kuttam (KK), described in 17 stanzas of four lines for each stanza from Tamil language script into English. (Source: Clinics in Dermatology)

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Apr 17, 2015 12:03AM

Lice update: New solutions to an old problem

An estimated 6 to 12 million children are affected by lice annually in the United States.1 Knowledge of the various treatment options for this diagnosis is essential. This paper aims to provide an overview of the myriad therapeutic options available for lice infestations in children. U.S. Food and Drug Administration?approved drugs, off-label drug therapies, over-the counter-products, and herbal remedies are all discussed in detail. Clinicians may use this information to teach patients and families about the latest available care for the eradication of head lice in pediatric patients. (Source: Clinics in Dermatology)

Apr 17, 2015 12:03AM

Update on hand-foot-and-mouth disease

Hand-foot-and-mouth disease is a viral exanthem caused, primarily by Coxsackie A16 and enterovirus 71 with typical clinical features of fever, painful papules and blisters over the extremities and genitalia and an enanthem involving ulceration of the mouth, palate, and pharynx. Other enteroviruses have recently been noted to cause severe neurologic illness and paralysis (enterovirus 68) with variable cutaneous features. A recent outbreak of Coxsackie A6 infection has been seen worldwide with cases reported in the United States, Japan, Southeast Asia, and Europe. (Source: Clinics in Dermatology)

Apr 17, 2015 12:03AM

Update on melanocytic nevi in children

A new or changing melanocytic nevus in a child or adolescent often leads to concern in parents and physicians. To avoid undue alarm and unnecessary procedures, dermatologists should be aware of the natural history and clinical spectrum of nevi in pediatric patients, as well as findings that are potentially worrisome in this age group. This review provides an update on melanocytic nevi in children, focusing on their dynamic evolution over time, molecular insights into nevogenesis, and phenotypic markers for increased risk of melanoma in adolescence and adulthood. (Source: Clinics in Dermatology)

Apr 17, 2015 12:03AM

Systemic conditions in children associated with pigmentary changes

Systemic conditions may have pigmentary associations. Prompt recognition of these associations allows the practitioner to initiate the appropriate workup and therapy when indicated. This contribution highlights some of the clinical features of neurofibromatosis 1, LEOPARD syndrome, acanthosis nigricans, hypomelanosis of Ito, incontinentia pigmenti, CHILD syndrome, and piebaldism to assist the dermatologist in making the proper diagnosis. (Source: Clinics in Dermatology)

Apr 17, 2015 12:03AM

Table of Contents

(Source: Clinics in Dermatology)

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Apr 17, 2015 12:03AM

Editorial Board

(Source: Clinics in Dermatology)

Apr 17, 2015 12:03AM

Update on indoor tanning legislation in the United States

The incidence of melanoma has been increasing over the past several decades, with notable increases in the pediatric and adolescent population. Indoor tanning has been proven carcinogenic and is associated with an increased risk of melanoma, especially when used at a young age. The incidence and frequency of usage of indoor tanning in the United States is high, particularly among adolescents, with roughly 20% reporting using a tanning bed at least once. The Food and Drug Administration recently made changes to its regulation of indoor tanning devices, reclassifying them as class II devices necessitating stricter premarket review, and strengthened its warnings for these devices; however, federal regulation of indoor tanning is still limited and most regulation of indoor tanning in minors is...

Apr 17, 2015 12:01AM

Human skin penetration of hyaluronic acid of different molecular weights as probed by Raman spectroscopy

ConclusionRaman spectroscopy represents an analytical, non?destructive, and dynamic method to evaluate the permeation of actives in the skin layers. (Source: Skin Research and Technology)

Apr 17, 2015 12:00AM

Acute generalised exanthematous pustulosis and other severe drug eruptions from over the counter medications: A case report and review of the literature

We present a case of acute generalised exanthematous pustulosis in an 11?year?old girl who used Duro?Tuss, an over?the?counter cough mixture containing pholcodine, and present a comprehensive review of the literature on severe drug reactions resulting from using non?prescription medications. This case reinforces the importance of taking a complete medication history. (Source: Australasian Journal of Dermatology)

Apr 16, 2015 11:00PM

Health Tip: Applying Artificial Nails

Title: Health Tip: Applying Artificial NailsCategory: Health NewsCreated: 4/17/2015 12:00:00 AMLast Editorial Review: 4/17/2015 12:00:00 AM (Source: MedicineNet Skin General)

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Apr 16, 2015 04:00PM

??The Dermal Internal Brassiere Flap,?? A New Modification of Inferior Pedicle Breast Reduction Technic

In this study, we achieved an internal fascial reconstruction using a pair of triangular and quadrangular dermal flaps suspended to the rib periosteum. We believe that our modifications will contribute to decreasing the disadvantages of the inferior pedicle breast reduction technique. Level of Evidence V This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266. (Source: Aesthetic Plastic Surgery)

Apr 16, 2015 04:00PM

Does Acellular Dermal Matrix Really Improve Aesthetic Outcome in Tissue Expander/Implant-Based Breast Reconstruction?

Conclusions Mean aesthetic scores were higher in the ADM-assisted breast reconstruction cohort including the total aesthetic score which was statistically significant. Aesthetic outcome alone may justify the added expense of incorporating biologic mesh. Moreover, ADM has other benefits which may render it cost-effective. Larger prospective studies are needed to provide plastic surgeons with more definitive guidelines for ADM use. Level of Evidence IV This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266. (Source: Aesthetic Plastic Surgery)

Apr 16, 2015 04:00PM

Topical Retinoids and Cosmeceuticals: Where Is the Scientific Evidence to Recommend Products to Patients?

Abstract Vitamin A and its derivatives have long been purported to support healthy skin. This has naturally led to their appearance in over-the-counter (OTC) products that fall under the umbrella term ?cosmeceuticals,? a term used to describe OTC cosmetic products with biologically active ingredients. The lure of these products includes their accessibility and the claims made by marketing campaigns that tap into the psyche of the consumer. Compared to prescription retinoids, however, the scientific evidence behind the efficacy of retinol-containing cosmeceuticals is less abundant. Here, we review the relevant scientific data to date regarding the use of retinols and retinoids for photoaging, dyspigmentation, and acne. (Source: Current Dermatology Reports)

Apr 16, 2015 04:00PM

A phase 1 study of ABT-806 in subjects with advanced solid tumors

Conclusions ABT-806 has unique pharmacokinetic and safety profiles. Toxicities were infrequent and typically low grade at the RP2D. Linear ABT-806 pharmacokinetics suggest lack of significant binding to wild-type EGFR in normal tissues. (Source: Investigational New Drugs)

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Apr 16, 2015 04:00PM

Cytosolic 5'?nucleotidase 1A is a common target of circulating autoantibodies in several autoimmune diseases

Conclusion: Anti?NT5C1a is a common target of circulating autoantibodies, especially in IBM, but also in several different autoimmune diseases. In SLE and SS, anti?NT5C1a auto?reactivity is not associated with muscle disease. This article is protected by copyright. All rights reserved. (Source: Arthritis Care and Research)

Apr 16, 2015 04:00PM

Dioxin Disrupts Cranial Cartilage and Dermal Bone Development in Zebrafish Larvae

Publication date: Available online 16 April 2015 Source:Aquatic Toxicology Author(s): Felipe R. Burns , Richard E. Peterson , Warren Heideman (Source: Aquatic Toxicology)

Apr 16, 2015 04:00PM

[Research Article] Identification and isolation of a dermal lineage with intrinsic fibrogenic potential

Dermal fibroblasts represent a heterogeneous population of cells with diverse features that remain largely undefined. We reveal the presence of at least two fibroblast lineages in murine dorsal skin. Lineage tracing and transplantation assays demonstrate that a single fibroblast lineage is responsible for the bulk of connective tissue deposition during embryonic development, cutaneous wound healing, radiation fibrosis, and cancer stroma formation. Lineage-specific cell ablation leads to diminished connective tissue deposition in wounds and reduces melanoma growth. Using flow cytometry, we identify CD26/DPP4 as a surface marker that allows isolation of this lineage. Small molecule?based inhibition of CD26/DPP4 enzymatic activity during wound healing results in diminished cutaneous scarrin...

Apr 16, 2015 04:00PM

Alantolactone from Saussurea lappa Exerts Antiinflammatory Effects by Inhibiting Chemokine Production and STAT1 Phosphorylation in TNF?? and IFN???induced in HaCaT cells

Skin inflammation is the most common condition seen in dermatology practice and can be caused by various allergic reactions and certain toxins or chemicals. In the present study, we investigated the antiinflammatory effects of Saussurea lappa, a medicinal herb, and its marker compounds alantolactone, caryophyllene, costic acid, costunolide, and dehydrocostuslactone in the HaCaT human keratinocyte cell line. HaCaT cells were stimulated with tumor necrosis factor?alpha (TNF??) and interferon?gamma (IFN??), and treated with S.?lappa or each of five marker compounds. Chemokine production and expression were analyzed by enzyme?linked immunosorbent assay and reverse transcription?polymerase chain reaction, respectively. Phosphorylation of signal transducer and activator of transc...

Apr 16, 2015 04:00PM

Late-onset group B streptococcal cellulitis

A 33-week gestational age female infant was delivered by non-elective caesarean section for intrauterine growth restriction (birth weight 1130 g). She received continuous positive airway pressure support for 72 h and empiric penicillin and gentamicin for 48 h. Initial blood culture, full blood count and C reactive protein were normal. The maternal Group B streptococci (GBS) status was unknown. She was fully enterally fed with expressed breast milk on day 6 of life. On day 12, she developed rapidly progressive erythema in the napkin area with a violaceous hue that spread to her lower abdomen and back (figures 1 and 2). Her blood culture grew group B streptococcus (Streptococcus agalactiae). There was no evidence of meningitis. Within 12 h of starting empirical antibiotic...

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Apr 16, 2015 04:00PM

Novel foci of Dermacentor reticulatus ticks infected with Babesia canis and Babesia caballi in the Netherlands and in Belgium

Conclusions: D. reticulatus is continuing its spread into novel areas. The finding that some autochthonous ticks are infected with B. canis and B. caballi poses a threat to the resident dog and horse population and justifies year-round tick control measures. (Source: Parasites and Vectors)

Apr 16, 2015 04:00PM

Ongoing decline in genital warts among young heterosexuals 7 years after the Australian human papillomavirus (HPV) vaccination programme

Conclusions Genital warts have now become rare in young Australian women and heterosexual men 7 years after the launch of the national HPV vaccination programme but in stark contrast, remain common in men who have sex with men. (Source: Sexually Transmitted Infections)

Apr 16, 2015 04:00PM

Biologics for Psoriasis: A Translational Research Success Story

Journal of Investigative Dermatology 135, 1205 (May 2015). doi:10.1038/jid.2014.549 Author: Mark Lebwohl (Source: Journal of Investigative Dermatology)

Apr 16, 2015 04:00PM

Clinical Snippets

Journal of Investigative Dermatology 135, 1208 (May 2015). doi:10.1038/jid.2015.96 (Source: Journal of Investigative Dermatology)

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Apr 16, 2015 04:00PM

BJD Editor's Choice

Journal of Investigative Dermatology 135, 1209 (May 2015). doi:10.1038/jid.2015.97 (Source: Journal of Investigative Dermatology)

Apr 16, 2015 04:00PM

Editors' Picks

Journal of Investigative Dermatology 135, 1210 (May 2015). doi:10.1038/jid.2015.98 (Source: Journal of Investigative Dermatology)

Apr 16, 2015 04:00PM

How MicroRNAs Modify Protein Production

Authors: Jessica L Feig, Keith M Giles, Iman Osman & Andrew G Franks (Source: Journal of Investigative Dermatology)

Apr 16, 2015 04:00PM

JID VisualDx Quiz: May 2015

Authors: Alejandra C Vivas & Robert S Kirsner (Source: Journal of Investigative Dermatology)

Apr 16, 2015 04:00PM

Cells to Surgery Quiz: May 2015

Authors: Fleta N Bray, Mohammed Alsaidan, Leyre Falto-Aizpurua, Brian J Simmons, Mohammad-Ali Yazdani Abyaneh, Robert D Griffith & Keyvan Nouri (Source: Journal of Investigative Dermatology)

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Apr 16, 2015 04:00PM

Association between Betapapillomavirus Seropositivity and Keratinocyte Carcinoma?Prospects for Prophylactic Vaccination?

Association between Betapapillomavirus Seropositivity and Keratinocyte Carcinoma—Prospects for Prophylactic Vaccination? Journal of Investigative Dermatology 135, 1211 (May 2015). doi:10.1038/jid.2014.523 Author: Herbert Pfister (Source: Journal of Investigative Dermatology)

Apr 16, 2015 04:00PM

Itch, Eosinophils, and Autoimmunity: A Novel Murine Model of Bullous Pemphigoid

Journal of Investigative Dermatology 135, 1213 (May 2015). doi:10.1038/jid.2014.537 Author: Kim B Yancey (Source: Journal of Investigative Dermatology)

Apr 16, 2015 04:00PM

Autophagy as a Melanocytic Self-Defense Mechanism

Journal of Investigative Dermatology 135, 1215 (May 2015). doi:10.1038/jid.2015.19 Author: Vijayasaradhi Setaluri (Source: Journal of Investigative Dermatology)

Apr 16, 2015 04:00PM

Multifaceted Contributions of Epidermal Langerhans Cells to Cutaneous Carcinogenesis

Authors: Björn E Clausen & Stephan Grabbe (Source: Journal of Investigative Dermatology)

Apr 16, 2015 04:00PM

How does the Merkel Polyomavirus Lead to a Lethal Cancer? Many Answers, Many Questions, and a New Mouse Model

How does the Merkel Polyomavirus Lead to a Lethal Cancer? Many Answers, Many Questions, and a New Mouse Model Journal of Investigative Dermatology 135, 1221 (May 2015). doi:10.1038/jid.2015.4 Authors: Candice D Church & Paul Nghiem (Source: Journal of Investigative Dermatology)

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Apr 16, 2015 04:00PM

The Role of Human Dendritic Cells in HIV-1 Infection

Authors: Zahra Ahmed, Tatsuyoshi Kawamura, Shinji Shimada & Vincent Piguet (Source: Journal of Investigative Dermatology)

Apr 16, 2015 04:00PM

Placebo Effects on Itch: A Meta-Analysis of Clinical Trials of Patients with Dermatological Conditions

Authors: Antoinette I M van Laarhoven, Ineke M van der Sman-Mauriks, A Rogier T Donders, Mathilde C Pronk, Peter C M van de Kerkhof & Andrea W M Evers (Source: Journal of Investigative Dermatology)

Apr 16, 2015 04:00PM

Oxidative Stress?Associated Senescence in Dermal Papilla Cells of Men with Androgenetic Alopecia

Oxidative Stress–Associated Senescence in Dermal Papilla Cells of Men with Androgenetic Alopecia Journal of Investigative Dermatology 135, 1244 (May 2015). doi:10.1038/jid.2015.28 Authors: James H Upton, Rosalind F Hannen, Adiam W Bahta, Nilofer Farjo, Bessam Farjo & Michael P Philpott (Source: Journal of Investigative Dermatology)

Apr 16, 2015 04:00PM

An Autosomal Recessive Mutation of DSG4 Causes Monilethrix through the ER Stress Response

Authors: Madoka Kato, Akira Shimizu, Yoko Yokoyama, Kyoichi Kaira, Yutaka Shimomura, Akemi Ishida-Yamamoto, Kiyoko Kamei, Fuminori Tokunaga & Osamu Ishikawa (Source: Journal of Investigative Dermatology)

Apr 16, 2015 04:00PM

Monochloroacetic Acid Application Is an Effective Alternative to Cryotherapy for Common and Plantar Warts in Primary Care: A Randomized Controlled Trial

Authors: Sjoerd C Bruggink, Jacobijn Gussekloo, Paulette F Egberts, Jan Nico Bouwes Bavinck, Margot W M de Waal, Willem J J Assendelft & Just A H Eekhof (Source: Journal of Investigative Dermatology)

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Apr 16, 2015 04:00PM

MMP-1 and -3 Promoter Variants Are Indicative of a Common Susceptibility for Skin and Lung Aging: Results from a Cohort of Elderly Women (SALIA)

Authors: Andrea Vierkötter, Tamara Schikowski, Dorothea Sugiri, Mary S Matsui, Ursula Krämer & Jean Krutmann (Source: Journal of Investigative Dermatology)

Apr 16, 2015 04:00PM

The Presence of Betapapillomavirus Antibodies around Transplantation Predicts the Development of Keratinocyte Carcinoma in Organ Transplant Recipients: A Cohort Study

Authors: Roel E Genders, Hadi Mazlom, Angelika Michel, Elsemieke I Plasmeijer, Koen D Quint, Michael Pawlita, Els van der Meijden, Tim Waterboer, Hans de Fijter, Frans H Claas, Ron Wolterbeek, Mariet C W Feltkamp & Jan Nico Bouwes Bavinck (Source: Journal of Investigative Dermatology)

Apr 16, 2015 04:00PM

Psoriasis and Cardiometabolic Traits: Modest Association but Distinct Genetic Architectures

Authors: Manja Koch, Hansjörg Baurecht, Janina S Ried, Elke Rodriguez, Sabrina Schlesinger, Natalie Volks, Christian Gieger, Ina-Maria Rückert, Luise Heinrich, Christina Willenborg, Catherine Smith, Annette Peters, Barbara Thorand, Wolfgang Koenig, Claudia Lamina, Henning Jansen, Florian Kronenberg, Jochen Seissler, Joachim Thiery, Wolfgang Rathmann, Heribert Schunkert, Jeanette Erdmann, Jonathan Barker, Rajan P Nair, Lam C Tsoi, James T Elder, Ulrich Mrowietz, Michael Weichenthal, Sören Mucha, Stefan Schreiber, Andre Franke, Jochen Schmitt, Wolfgang Lieb & Stephan Weidinger (Source: Journal of Investigative Dermatology)

Apr 16, 2015 04:00PM

Genetic Heterogeneity of Pseudoxanthoma Elasticum: The Chinese Signature Profile of ABCC6 and ENPP1 Mutations

Authors: Liang Jin, Qiujie Jiang, Zhengsheng Wu, Changxia Shao, Yong Zhou, Luting Yang, Jouni Uitto & Gang Wang (Source: Journal of Investigative Dermatology)

Apr 16, 2015 04:00PM

Deletion of the Major Bullous Pemphigoid Epitope Region of Collagen XVII Induces Blistering, Autoimmunization, and Itching in Mice

Authors: Tiina Hurskainen, Nina Kokkonen, Raija Sormunen, Joanna Jackow, Stefanie Löffek, Raija Soininen, Claus-Werner Franzke, Leena Bruckner-Tuderman & Kaisa Tasanen (Source: Journal of Investigative Dermatology)

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Apr 16, 2015 04:00PM

NKG2D-Dependent Activation of Dendritic Epidermal T Cells in Contact Hypersensitivity

Authors: Morten M Nielsen, Beatrice Dyring-Andersen, Jonas D Schmidt, Deborah Witherden, Paola Lovato, Anders Woetmann, Niels Ødum, Steen S Poulsen, Wendy L Havran, Carsten Geisler & Charlotte M Bonefeld (Source: Journal of Investigative Dermatology)

Apr 16, 2015 04:00PM

Genetic and Pharmacological Analysis Identifies a Physiological Role for the AHR in Epidermal Differentiation

Authors: Ellen H van den Bogaard, Michael A Podolsky, Jos P Smits, Xiao Cui, Christian John, Krishne Gowda, Dhimant Desai, Shantu G Amin, Joost Schalkwijk, Gary H Perdew & Adam B Glick (Source: Journal of Investigative Dermatology)

Apr 16, 2015 04:00PM

An Alternatively Spliced IL-15 Isoform Modulates Abrasion-Induced Keratinocyte Activation

Authors: Tsung-Lin Lee, Mei-Ling Chang, Yu-Jei Lin, Ming-Hsun Tsai, Yi-Hsuan Chang, Che-Ming Chuang, Yun Chien, Tomasz Sosinowski, Chih-Hsiu Wang, Yi-Yuan Chen, Chien-Kuo Lee, Jau-Shiuh Chen, Li-Fang Wang, John T Kung & Chia-Chi Ku (Source: Journal of Investigative Dermatology)

Apr 16, 2015 04:00PM

Keratitis-Ichthyosis-Deafness Syndrome-Associated Cx26 Mutants Produce Nonfunctional Gap Junctions but Hyperactive Hemichannels When Co-Expressed With Wild Type Cx43

Authors: Isaac E García, Jaime Maripillán, Oscar Jara, Ricardo Ceriani, Angelina Palacios-Muñoz, Jayalakshmi Ramachandran, Pablo Olivero, Tomas Perez-Acle, Carlos González, Juan C Sáez, Jorge E Contreras & Agustín D Martínez (Source: Journal of Investigative Dermatology)

Apr 16, 2015 04:00PM

Suppression of Autophagy Dysregulates the Antioxidant Response and Causes Premature Senescence of Melanocytes

Authors: Cheng-Feng Zhang, Florian Gruber, Chunya Ni, Michael Mildner, Ulrich Koenig, Susanne Karner, Caterina Barresi, Heidemarie Rossiter, Marie-Sophie Narzt, Ionela M Nagelreiter, Lionel Larue, Desmond J Tobin, Leopold Eckhart & Erwin Tschachler (Source: Journal of Investigative Dermatology)

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Apr 16, 2015 04:00PM

eIF4E Is an Adverse Prognostic Marker of Melanoma Patient Survival by Increasing Melanoma Cell Invasion

Authors: Shahram Khosravi, Kevin J Tam, Gholamreza S Ardekani, Magdalena Martinka, Kevin J McElwee & Christopher J Ong (Source: Journal of Investigative Dermatology)

Apr 16, 2015 04:00PM

The Role of eIF4E in Response and Acquired Resistance to Vemurafenib in Melanoma

Authors: Yao Zhan, Michael S Dahabieh, Arjuna Rajakumar, Monica C Dobocan, Marie-Noël M’Boutchou, Christophe Goncalves, Lucy Shiru L., Filippa Pettersson, Ivan Topisirovic, Léon van Kempen, Sonia V del Rincón & Wilson H Miller Jr. (Source: Journal of Investigative Dermatology)

Apr 16, 2015 04:00PM

Independent Validation of Six Melanoma Risk Prediction Models

Authors: Catherine M Olsen, Rachel E Neale, Adèle C Green, Penelope M Webb, the QSkin Study, the Epigene Study & David C Whiteman (Source: Journal of Investigative Dermatology)