Mar 10, 2010 05:13AM

AAD: HIFU Shows Promise for Body Sculpting (CME/CE)

MIAMI BEACH (MedPage Today) -- High-intensity focused ultrasound (HIFU) showed potential as a noninvasive way to remove excess subcutaneous fat, according to results of a small, preliminary clinical study. (Source: MedPage Today Dermatology)

Mar 10, 2010 12:00AM

Graceway Announces Journal Of The American Academy Of Dermatology Publishes Articles On New Short-Course Imiquimod Formulation In Actinic Keratosis

The Journal of the American Academy of Dermatology (JAAD) has published Phase III data evaluating the safety and efficacy of imiquimod cream at two doses - 2.5% and 3.75% - administered daily on either 2-week or 3-week treatment cycles. While all study arms met the primary endpoint of complete clearance versus placebo, data suggest that, of the regimens studied, imiquimod 3... (Source: Dermatology News From Medical News Today)

Mar 09, 2010 04:00PM

Successful treatment of ulcerated haemangioma with propranolol

Conclusions Propranolol may be the first-choice therapy for ulcerated haemangioma. (Source: Journal of the European Academy of Dermatology and Venereology)

Mar 09, 2010 04:00PM

Therapeutic and experimental therapeutic studies on acupuncture and itch: review of the literature

This article summarizes the rational for the use of acupuncture in treatment of itch and reviews therapeutic and experimental therapeutic studies on acupuncture and itch. (Source: Journal of the European Academy of Dermatology and Venereology)

Mar 09, 2010 04:00PM

The epidemiology of adolescent acne in North East China

Conclusion Adolescent acne includes a familial genetic predisposition. Additional environmental factors of psychological stress, skin oiliness and high caloric diets may also contribute to the onset of acne in Chinese adolescents. (Source: Journal of the European Academy of Dermatology and Venereology)

Mar 09, 2010 04:00PM

Complications of ambulatory major dermatological surgery in patients older than 85 years

Conclusions No intra or post-surgical mortality or life-threatening local complications were detected. Most post-surgical local complications appeared after wide excisions and complex reconstruction techniques that prolonged the length of the surgery. (Source: Journal of the European Academy of Dermatology and Venereology)

Mar 09, 2010 12:44PM

ACS Stats Find Gains in War on Cancer

Cancer is not quite the killer it was 20 years ago. The American Cancer Society found that "age-standardized" cancer deaths among men declined by 21% from 1990, while the rate among women declined by 12% from 1991 to 2006. (Source: MedPage Today Dermatology)

Mar 09, 2010 10:34AM

High SPF Essential at High Altitudes to Protect Against Sun Damage

Golfers playing in Vail, Colorado, at 2500 meters (roughly 8200 feet) above sea level, got significantly more burn protection from sunscreen with a sun protection factor (SPF) of 70+ compared to one with an SPF of 15. Reuters Health Information (Source: Medscape Dermatology Headlines)

Mar 09, 2010 06:55AM

AAD: When First Anti-TNF Fails Try a Second One (CME/CE)

MIAMI BEACH (MedPage Today) -- Half of patients with psoriasis unresponsive to high-dose etanercept (Enbrel) achieved significant improvement with ustekinumab (Stelara), investigators in a randomized clinical trial reported here. (Source: MedPage Today Dermatology)

Mar 09, 2010 06:10AM

Reverse-namaskar: A new sign in

We report another new clinical sign called 'Reverse-Namaskar' sign as an important clinical finding in EDS, based on the family pedigree study of the proband. (Source: Indian Journal of Dermatology)

Mar 09, 2010 06:10AM

Atypical cutaneous lesions of

We report a case with verrucous lesions over nose and face due to Penicillium marneffei infection after HAART treatment. A 28-year-old man presented, after two weeks of HAART treatment, with multiple erythematous, scaly, papules and nodules with central necrosis predominantly in face and both extremities and scrotum. Microbiological investigations confirmed the diagnosis of Penicillium marneffei infection. This is perhaps the first case report with such manifestation due to Penicillium marneffei infection. (Source: Indian Journal of Dermatology, Venereology and Leprology)

Mar 09, 2010 06:00AM

AAD: Sequenced TNF Blockers Control Psoriasis (CME/CE, with video)

MIAMI BEACH (MedPage Today) -- Two-thirds of psoriasis patients who had inadequate responses to etanercept (Enbrel) achieved total clearance or minimal disease activity with infliximab (Remicade), according to data reported here. (Source: MedPage Today Dermatology)

Mar 09, 2010 04:43AM

AAD: Psoriasis Comorbidity Increases over Time (CME/CE)

MIAMI BEACH (MedPage Today) -- Patients with psoriasis have multiple comorbid conditions that tend to worsen over time, data from a review of medical records showed. (Source: MedPage Today Dermatology)

Mar 08, 2010 11:00PM

Treating Psoriasis If Enbrel Fails

Title: Treating Psoriasis If Enbrel FailsCategory: Health NewsCreated: 3/9/2010 10:10:00 AMLast Editorial Review: 3/9/2010 10:10:12 AM (Source: MedicineNet Skin General)

Mar 08, 2010 11:00PM

New Drug Relieves Hand Eczema

Title: New Drug Relieves Hand EczemaCategory: Health NewsCreated: 3/9/2010 10:23:00 AMLast Editorial Review: 3/9/2010 10:23:33 AM (Source: MedicineNet Skin General)

Mar 08, 2010 05:13AM

AAD: Low Infection Risk Seen with Methotrexate (CME/CE)

MIAMI BEACH (MedPage Today) -- Methotrexate appears to pose only a small risk of serious infection with long-term use, according to results of a meta-analysis reported here. (Source: MedPage Today Dermatology)

Mar 07, 2010 11:00PM

Chemical in Furniture Linked to Skin Rashes

Title: Chemical in Furniture Linked to Skin RashesCategory: Health NewsCreated: 3/8/2010 11:52:00 AMLast Editorial Review: 3/8/2010 11:52:45 AM (Source: MedicineNet Skin General)

Mar 07, 2010 04:00PM

Evaluating lotion transfer from products to skin using the behind-the-knee test

Adding lotions or emollients to the surface of a variety of paper products confers a number of benefits to the skin of consumers. A modification of the 'behind-the-knee (BTK)' test model was used as a means of measuring the effectiveness of lotion transfer to the skin. Two series of feminine protection pads were prepared: (1) identically constructed pads differing only in the amount of lotion applied to the surface and (2) pads of various compositions to compare the influence of other product characteristics. For the first series, pads were applied for 3 h using the BTK protocol, and lotion transfer was evaluated. For the second series of products, two sample pads were applied consecutively for 3 h each, and lotion transfer was evaluated a both time points (e.g., 3 and 6 h). In addition, a...

Mar 07, 2010 04:43AM

AAD: Topical Agent Clears Actinic Keratoses (CME/CE)

MIAMI BEACH (MedPage Today) -- More than 70% of patients with actinic keratoses had complete or partial clearance of lesions after two applications of a plant-derived topical agent, data from a randomized trial showed. (Source: MedPage Today Dermatology)

Mar 07, 2010 01:00AM

Johnson & Johnson Consumer Companies, Inc., Unveils CYTOMIMIC? Technology At 68th Annual Meeting Of The American Academy Of Dermatology

Building on decades of research into how the body's electrical field affects skin regeneration, scientists at Johnson & Johnson Consumer Companies, Inc., have discovered how to harness the power of bioelectricity to help improve skin rejuvenation... (Source: Dermatology News From Medical News Today)

Mar 06, 2010 06:03AM

Antibodies to adalimumab affect treatment response in psoriasis patients

Some patients who take adalimumab for the treatment of plaque psoriasis develop antibodies to the drug, which could impair their responses to the treatment, researchers report. (Source: MedWire News - Psoriasis)

Mar 06, 2010 06:03AM

Antibodies to adalimumab affect treatment response in psoriasis patients

Some patients who take adalimumab for the treatment of plaque psoriasis develop antibodies to the drug, which could impair their responses to the treatment, researchers report. (Source: MedWire News - Dermatology)

Mar 06, 2010 04:43AM

Severe Acne Responds to Combo Therapy (CME/CE)

Patients with severe acne had significantly greater improvement when topical adapalene/benzoyl peroxide (Epiduo) was added to oral doxycycline, according to results of a randomized clinical trial. (Source: MedPage Today Dermatology)

Mar 06, 2010 01:00AM

Phase III REGION-I Study Shows PEP005 (ingenol Mebutate) Gel 0.05% May Reduce Pre-Cancerous Skin Lesions In Patients With Actinic Keratosis

Discussion: P105)... (Source: Dermatology News From Medical News Today)

Mar 06, 2010 01:00AM

COPPERTONE(R) Solar Research Center Unveils Studies On Efficacy Of Topical Antioxidants In Sunscreens At 2010 Annual Meeting

Schering-Plough HealthCare Products, Inc., the consumer healthcare division of Merck & Co., Inc., the makers of COPPERTONE®, announced at the 2010 Annual Meeting of the American Academy of Dermatology the results of studies demonstrating the efficacy of topical antioxidants in broad spectrum sunscreens... (Source: Dermatology News From Medical News Today)

Mar 05, 2010 04:00PM

Dermatitis from common ivy (Hedera helix L. subsp. helix) in Europe: past, present, and future

The objective of the article is to present the results of aimed patch testing with the main common ivy allergen, falcarinol, during a 16-year period and review the newer literature. Consecutive patients tested with falcarinol 0.03% petrolatum from May 1993 to May 2009 were included. Cases published since 1987 were retrieved from the PubMed database. One hundred and twenty-seven Danish patients were tested with falcarinol and 10 (7.9%) tested positive. Seven were occupationally sensitized. Between 1994 and 2009, 28 new cases of contact dermatitis from ivy were reported, 2 of which were occupational. Only 11 of the 28 patients were tested with pure allergens. Falcarinol is not only widely distributed in the ivy family, but also in the closely related Apiaceae. Sensitization may occur in chil...

Mar 05, 2010 04:00PM

The Four-color FISH probe in the diagnosis of melanocytic lesions

(Source: Journal of the European Academy of Dermatology and Venereology)

Mar 05, 2010 04:00PM

Ustekinumab induces rapid clearing of erythrodermic psoriasis after failure of antitumour necrosis factor therapies

(Source: British Journal of Dermatology)

Mar 05, 2010 04:00PM

Regional nerve blockade prior to direct injection to achieve anaesthesia of the nasal ala

Conclusions An IOB provides effective alar anaesthesia in the majority of patients. In those where it is ineffective for complete anaesthesia, an ENB is a useful adjunct. We recommend using an IOB (and ENB if required) prior to direct infiltration of local anaesthetic into the nasal ala to reduce patient discomfort. (Source: British Journal of Dermatology)

Mar 05, 2010 04:00PM

Expression of Snail1 in the fibrotic dermis of postmenopausal frontal fibrosing alopecia: possible involvement of an epithelial–mesenchymal transition and a review of the Japanese patients

(Source: British Journal of Dermatology)

Mar 05, 2010 10:05AM

Severe Acne Responds to Combo Therapy (CME/CE, with audio)

Patients with severe acne had significantly greater improvement when topical adapalene/benzoyl peroxide (Epiduo) was added to oral doxycycline, according to results of a randomized clinical trial. (Source: MedPage Today Dermatology)

Mar 05, 2010 06:03AM

Atypical pyoderma gangrenosum following total knee replacement surgery: first report in dermatologic literature

Um pioderma gangrenoso atípico, similar a uma infecção cutânea e subcutânea pós-operatório, está sendo relatado pela primeira vez na literatura mundial, depois de realização de artroplastia do joelho, tendo como foco inicial o local da cirurgia. Cirurgiões ortopédicos e gerais devem estar cientes da existência dessa doença e de sua associação ao trauma cirúrgico.An atypical pyoderma gangrenosum mimicking a post surgical cutaneous and subcutaneous infection is being reported for the first time in international literature after knee replacement surgery with the operation site being the starting point of pyoderma gangrenosum. Orthopedic surgeons and general surgeons should be aware of the existence of this disease and its association with surgical trauma. (Source: Anais Brasi...

Mar 05, 2010 06:02AM

Extensive congenital vulvar lymphangioma mimicking genital warts

Mehta Vandana, Nayak Sudhir, Balachandran C, Monga Puja, Rao RaghavendraIndian Journal of Dermatology 2010 55(1):121-122 (Source: Indian Journal of Dermatology)

Mar 05, 2010 06:02AM

Erythema annulare centrifugum in pregnancy

Senel Engin, Gulec Ayse TulinIndian Journal of Dermatology 2010 55(1):120-121 (Source: Indian Journal of Dermatology)

Mar 05, 2010 06:02AM

Pigmented contact cheilitis to paraphenylenediamine

Mehta Vandana, Nayak Sudhir, Balachandran CIndian Journal of Dermatology 2010 55(1):119-120 (Source: Indian Journal of Dermatology)

Mar 05, 2010 06:02AM

Oral manifestations in human immunodeficiency virus infected patients

Conclusion:</b> HIV disease presents a plethora of oral manifestations, which provide valuable diagnostic and prognostic information. (Source: Indian Journal of Dermatology)

Mar 05, 2010 06:02AM

Pyrazinamide-induced phototoxicity: A case report and review of literature

Katiyar Subodh K, Bihari Shailesh, Prakash ShiveshIndian Journal of Dermatology 2010 55(1):113-115A 40-year-old male presented with a fresh case of pulmonary tuberculosis and itchy oozing rashes distributed characteristically over the sun exposed areas of the skin. These rashes had developed since six days following 10 days of start of antitubercular drugs (streptomycin, isoniazid, rifampicin, pyrazinamide and ethambutol at standard dosages). A possibility of drug-induced reaction was entertained and all the antitubercular drugs were discontinued; subsequently they were reintroduced in a sequential manner starting with small dosages, gradually increasing them to their normal dose. The rashes reappeared after introduction of pyrazinamide. We tried to desensitize this very important antitube...

Mar 05, 2010 06:02AM

Coexistence of papulonecrotic tuberculide with lichen scrofulosorum

We report the case of an adult male without any known internal tubercular focus who showed two types of skin lesions, clinically typical and histopathologically consistent with the diagnoses of papulonecrotic tuberculide and lichen scrofulosorum, occurring simultaneously. Polymerase chain reaction showed the presence of <i>Mycobacterium</i> <i>tuberculosis</i> DNA in papulonecrotic tuberculide type of lesion, and both types of lesions responded promptly to anti-tubercular drugs. (Source: Indian Journal of Dermatology)

Mar 05, 2010 06:02AM

Segmental neurofibromatosis: A report of 3 cases

We describe three cases of segmental neurofibromatosis (SNF). These cases have been classified as segmental NF according to Riccardi's definition of SNF and classification of neurofibromatosis. Segmental form of NF may evolve into a complete form over time. Also, this disorder may be transmitted to the offspring's of these individuals. Hence genetic counseling of these individuals must include these facts. (Source: Indian Journal of Dermatology)

Mar 05, 2010 06:02AM

A family with leukonychia totalis

Balighi Kamran, Moeineddin Fatemeh, Lajevardi Vahideh, Ahmadreza RajaeeIndian Journal of Dermatology 2010 55(1):102-104A family presented to our dermatology clinic with a complaint of white nails. Physical examination revealed clinical feature of leukonychia totalis and the presence of sensorineural hearing loss, palmo plantar keratoderma and knuckle pads (four essential criteria for the diagnosis of Bart Pumphrey syndrome).Three consecutive generations of this family were affected with variable presentations of Bart Pumphrey syndrome in male and female; and autosomal dominant pattern of inheritance. (Source: Indian Journal of Dermatology)

Mar 05, 2010 06:02AM

Lupus panniculitis as an initial manifestation of systemic lupus erythematosus

Patel Raksha M, Marfatia Y SIndian Journal of Dermatology 2010 55(1):99-101In May, 2003, a 28-year-old female presented with large non-healing ulcers on face, trunk and limbs covered with black hemorrhagic crust. There were no other systemic manifestations. Diagnosis of lupus panniculitis was considered on clinical and histopathological grounds. The lesions healed completely, with scarring, with systemic corticosteroid, hydroxychloroquine and topical 2% mupirocin. She came again in November, 2005, with malar rash, joint pain, scarring alopecia of the scalp and albuminuria. Her ANA, AntidsDNA came positive and diagnosed as having systemic lupus erythematosus (SLE). She responded well to systemic corticosteroid, antimalarial and topical antibacterial. The evolution of lupus panniculit...

Mar 05, 2010 06:02AM

Granuloma annulare - Remission with puvasol

Lakshmi Chembolli, Srinivas C RIndian Journal of Dermatology 2010 55(1):97-98A 64-year-old man with generalized papular granuloma annulare of four years duration with frequent relapses and remissions presented with persistent lesions while on 15 mg prednisolone and achieved complete remission with PUVASOL therapy using solarium. (Source: Indian Journal of Dermatology)

Mar 05, 2010 06:02AM

Remittent idiopathic necrotizing acrocyanosis - A rare entity

We report the case of a 53-year-old male farmer with remittent necrotizing acrocyanosis. (Source: Indian Journal of Dermatology)

Mar 05, 2010 06:02AM

Riga-Fede-Like disease in a 70 year old woman

We describe here a 70 year-old woman showing a painful tongue ulcer with elevated borders and whitish discoloration for the past four years. Repeated histological investigations revealed a benign leukoplakia without dysplasia. Replacement of an ill-fitting prosthesis led to complete remission within two weeks. RDF-like disease is thus a problem in elderly patients for whom topical treatment is insufficient to induce healing. (Source: Indian Journal of Dermatology)

Mar 05, 2010 06:02AM

Reverse-namaskar: A new sign in <i><i><i>Ehlers-Danlos syndrome</i></i></i>: A family pedigree study of four generations

We report another new clinical sign called 'Reverse-Namaskar' sign as an important clinical finding in EDS, based on the family pedigree study of the proband. (Source: Indian Journal of Dermatology)

Mar 05, 2010 06:02AM

Mucocutaneous manifestations of dengue fever

Thomas Emy Abi, John Mary, Kanish BimalIndian Journal of Dermatology 2010 55(1):79-85Dengue viral infection is a cause of considerable morbidity and mortality and may be associated with a variety of mucocutaneous manifestations that may provide important early clues to the diagnosis of this condition. Cutaneous and mucosal findings like confluent erythema, morbilliform eruptions, and hemorrhagic lesions may figure prominently in the clinical features of dengue. The differential diagnoses include a large number of bacterial and viral exanthems as well as drug rash. (Source: Indian Journal of Dermatology)

Mar 05, 2010 06:02AM

Dengue viral infections

Gurugama Padmalal, Garg Pankaj, Perera Jennifer, Wijewickrama Ananda, Seneviratne Suranjith LIndian Journal of Dermatology 2010 55(1):68-78Dengue viral infections are one of the most important mosquito-borne diseases in the world. Presently dengue is endemic in 112 countries in the world. It has been estimated that almost 100 million cases of dengue fever and half a million cases of dengue hemorrhagic fever (DHF) occur worldwide. An increasing proportion of DHF is in children less than 15 years of age, especially in South East and South Asia. The unique structure of the dengue virus and the pathophysiologic responses of the host, different serotypes, and favorable conditions for vector breeding have led to the virulence and spread of the infections. The manifestations of dengue infections ...

Mar 05, 2010 06:02AM

Mucocutaneous manifestations of Chikungunya fever

Bandyopadhyay Debabrata, Ghosh Sudip KumarIndian Journal of Dermatology 2010 55(1):64-67Chikungunya fever (CF) is an arboviral acute febrile illness transmitted by the bite of infected &lt;i&gt;Aedes&lt;/i&gt; mosquitoes. After a quiescence of more than three decades, CF has recently re-emerged as a major public health problem of global scale. CF is characterized by an acute onset of high fever associated with a severe disabling arthritis often accompanied by prominent mucocutaneous manifestations. The disease is usually self-limiting, but the joint symptoms and some of the cutaneous features may persist after the defervescence. A wide range of mucocutaneous changes has been described to occur in association with CF during the current epidemic. Besides a morbill...

Mar 05, 2010 06:02AM

Epidemiology, clinical manifestations, and diagnosis of chikungunya fever: Lessons learned from the re-emerging epidemic

Mohan Alladi, Kiran D.H.N, Manohar I Chiranjeevi, Kumar D PrabathIndian Journal of Dermatology 2010 55(1):54-63Chikungunya fever, caused by &amp;quot;Chikungunya virus,&amp;quot; is an arbovirus disease transmitted by the bite of infected mosquitoes belonging to the genus &lt;i&gt;Aedes&lt;/i&gt;. Chikungunya fever epidemics have been reported from several countries around the world. The disease that was silent for nearly 32 years re-emerged in the October 2005 outbreak in India that is still ongoing. The incubation period ranges from 3 to 12 days. The onset is usually abrupt and the acute stage is characterized by sudden onset with high-grade fever, severe arthralgias, myalgias, and skin rash. Swollen tender joints and crippling arthritis are usua...

Mar 05, 2010 06:02AM

Dengue and chikungunya fever: Resurgent viral infections with prominent mucocutaneous features

Bandyopadhyay DebabrataIndian Journal of Dermatology 2010 55(1):53-53 (Source: Indian Journal of Dermatology)

Mar 05, 2010 06:02AM

The preshaving protocol in body hair-to-scalp transplant to identify hair in anagen phase

Conclusion:&lt;/b&gt; Preshaving the body donor areas is a simple non invasive method of isolating the hair in anagen phase. (Source: Indian Journal of Dermatology)

Mar 05, 2010 06:02AM

Topical 0.03% atropine vs. 15% aluminum chloride in treating multiple eccrine hidrocystomas: A randomized single blind controlled study

Conclusion:&lt;/b&gt; It seems that both Atropine and AlCl&lt;sub&gt; 3&lt;/sub&gt; are useful therapies in eccrine hidrocytomas but the former might be more effective. We think that other randomized clinical trials with larger sample sizes are needed. (Source: Indian Journal of Dermatology)

Mar 05, 2010 06:02AM

Seasonal variation in pediatric dermatoses

Conclusion:&lt;/b&gt; Distribution of lesions of common dermatoses will help diagnose difficult cases and extensive evaluation of the body parts which, by virtue of being commonly affected, are must-examine sites in under-five children. (Source: Indian Journal of Dermatology)

Mar 05, 2010 06:02AM

Bacteriological study of aerobic isolates from plantar ulcers of paucibacillary leprosy patients

Conclusion:&lt;/b&gt; Bacteriological study of plantar ulcers of leprosy patients has revealed &lt;i&gt;Staphylococcus&lt;/i&gt; &lt;i&gt;aureus&lt;/i&gt; as the main pathogen. Treatment with chloramphenicol and gentamycin holds good prospect as per our study. (Source: Indian Journal of Dermatology)

Mar 05, 2010 06:02AM

Pattern of cutaneous manifestations in diabetes mellitus

Conclusion:&lt;/b&gt; Skin is involved in diabetes quite often and the manifestations are numerous. High prevalence of xerosis in our diabetic population is perhaps due to cold and dry climatic conditions in the region for most of the time in the year. (Source: Indian Journal of Dermatology)

Mar 05, 2010 06:02AM

Etiological approach to chronic urticaria

Conclusion:&lt;/b&gt; Nearly half of the patients had chronic autoimmune urticaria on the basis of ASST. A significant number of them had serological makers of autoimmune activity. ASST provides an easy, inexpensive investigation in CU and helps direct attention to underlying systemic auto immune diseases. The presence of these auto antibodies was significantly associated with more frequent and longer lasting urticarial attacks. Exhaustive work ups with extensive laboratory diagnostics, challenge tests, and prick testing should be reserved for individual cases following detailed history. (Source: Indian Journal of Dermatology)

Mar 05, 2010 06:02AM

CTLA-4 A49G gene polymorphism is not associated with vitiligo in South Indian population

Conclusion:&lt;/b&gt; Our results indicate that there is no association between &lt;i&gt; CTLA&lt;/i&gt;-4&lt;/i&gt; A49G&lt;/i&gt; gene polymorphism and vitiligo in southern Indian population. (Source: Indian Journal of Dermatology)

Mar 05, 2010 06:02AM

Impact of HLA-G in the outcome of vitiligo in Tunisian patients

Conclusion:&lt;/b&gt; There is significant negative correlation between HLA-G expression and vitiligo. In our mind, upregulation of HLA-G expression in lesional skin could be local (superficial expression) or systemic (soluble HLA-G isoforms) compensation to restore normal pigmentation in lesions. (Source: Indian Journal of Dermatology)

Mar 05, 2010 06:02AM

A study of androgen and estrogen receptors α, β in skin tags

Conclusion: &lt;/b&gt; These results suggest the possible role of androgen and estrogen receptors in etiogenesis of skin tags, and propose that the neck is an androgen dependent area just similar to the axillae and the groins, though hairless. (Source: Indian Journal of Dermatology)

Mar 05, 2010 06:02AM

Oxidative stress level and tyrosinase activity in vitiligo patients

Conclusion: &lt;/b&gt; Our finding suggests that increased levels of oxidative stress might impact tyrosinase activity and eumelanin synthesis via anabolism pathway of melanin synthesis. In sum, we observed a negative correlation between levels of systemic oxidative stress and of tyrosinase activity. (Source: Indian Journal of Dermatology)

Mar 05, 2010 06:02AM

Botulinum toxin

Nigam P K, Nigam AnjanaIndian Journal of Dermatology 2010 55(1):8-14Botulinum toxin, one of the most poisonous biological substances known, is a neurotoxin produced by the bacterium &lt;i&gt;Clostridium&lt;/i&gt; &lt;i&gt;botulinum&lt;/i&gt;. &lt;i&gt;C&lt;/i&gt;. &lt;i&gt;botulinum&lt;/i&gt; elaborates eight antigenically distinguishable exotoxins (A, B, C&lt;sub&gt; 1&lt;/sub&gt; , C&lt;sub&gt; 2&lt;/sub&gt; , D, E, F and G). All serotypes interfere with neural transmission by blocking the release of acetylcholine, the principal neurotransmitter at the neuromuscular junction, causing muscle paralysis. The weakness induced ...

Mar 05, 2010 06:02AM

Hirsutism: Evaluation and treatment

This article reviews the current evaluation guidelines and management of hirsutism. (Source: Indian Journal of Dermatology)

Mar 05, 2010 06:02AM

Indian Journal of Dermatology gets re-indexed with PUBMED

Dhar SandipanIndian Journal of Dermatology 2010 55(1):1-2 (Source: Indian Journal of Dermatology)

Mar 05, 2010 04:00AM

Dermatologists Can Help Women Win The Fight Against Common Forms Of Hair Loss

For many women, unexplained hair loss can take a significant psychological toll on their overall quality of life. From altering their hairstyle to hide a thinning part to scaling back their hair care regimen in an effort to halt further hair loss, women try countless ways to cover up this problem and the results are often lukewarm at best... (Source: Dermatology News From Medical News Today)

Mar 04, 2010 04:00PM

Rising trends in incidence of cutaneous malignant melanoma and their future projections in Catalonia, Spain: increasing impact or future epidemic?

Conclusion Improvements in preventive activities should be implemented to decrease incidence and mortality from this cancer. Monitoring stage-specific trends in CMM incidence can assess the impact of preventive strategies; for this reason more complete information on diagnostic features of CMM patients in the Spanish population-based cancer registries are necessary. (Source: Journal of the European Academy of Dermatology and Venereology)

Mar 04, 2010 04:00PM

Adjuvant triamcinolone acetonide injections in oro-pharyngeal pemphigus vulgaris

Conclusion Perilesional/intralesional triamcinolone acetonide injections seems to represent a helpful clinical tool to successfully join CIST, in terms of shortening the time of complete clinical remission, reducing the total amount of corticosteroids and obtaining an acceptable compliance. (Source: Journal of the European Academy of Dermatology and Venereology)

Mar 04, 2010 04:00PM

Q-switched YAG laser vs. punch biopsy excision for iatrogenic radiation tattoo markers – a randomized controlled trial

Conclusion Q-sw YAG laser and punch biopsy excision are effective to clear iatrogenic radiation tattoo markers, but patients preferred the laser treatment because of less pronounced adverse effects. (Source: Journal of the European Academy of Dermatology and Venereology)

Mar 04, 2010 04:00PM

Quality of life of patients with scabies

Conclusion Scabies moderately affected the QoL of the patients. Sulphur could be considered as an effective treatment for patients with scabies. (Source: Journal of the European Academy of Dermatology and Venereology)

Mar 04, 2010 04:00PM

Onycotrychia?: subungual hair follicle as another cause of longitudinal melanonychia or pigmentation – Hair follicle as cause of melanonychia

(Source: Journal of the European Academy of Dermatology and Venereology)

Mar 04, 2010 04:00PM

Aesthetic effects of topical photodynamic therapy

This article reviews the available literature for photodynamic rejuvenation while discussing cosmetic effects, light sources, adverse effects and the mechanism of action. (Source: Journal of the European Academy of Dermatology and Venereology)

Mar 04, 2010 04:00PM

The use of topical bleaching agents among women: a cross-sectional study of knowledge, attitude and practices

Conclusion A major proportion of our sample respondents have overused and/or misused bleaching agents. This was regardless of age, income, education or marital status. There is a need to educate women about the possible risks. (Source: Journal of the European Academy of Dermatology and Venereology)

Mar 04, 2010 04:00PM

Basal cell carcinoma – Epidemiology from 269 cases

(Source: Journal of the European Academy of Dermatology and Venereology)

Mar 04, 2010 04:00PM

HRH4 variants associated with atopic dermatitis

Risk alleles of three single nucleotide polymorphisms in the human histamine receptor H4 gene are associated with increased risk for atopic dermatitis, report researchers. (Source: MedWire News - Dermatology)

Mar 04, 2010 04:00PM

Botox may help alleviate certain types of migraine pain

Botulinum toxin type A injections of cosmetic doses have the potential to alleviate symptoms of imploding and ocular migraines, report researchers. (Source: MedWire News - Dermatology)

Mar 04, 2010 04:00PM

Nailfold capillary abnormalities are prevalent in sclerodermoid graft-versus-host disease and readily detected with dermatoscopy

Conclusions This study shows the identification of distinct nailfold capillaroscopy patterns in patients with Scl GVHD but it does not confer special risk for any other specific clinical symptoms of the disease. (Source: British Journal of Dermatology)

Mar 04, 2010 04:00PM

Mutations in EDARADD account for a small proportion of hypohidrotic ectodermal dysplasia cases

Conclusions Our study demonstrates that EDARADD mutations are not a frequent cause of HED, while mutations in TRAF6, TAB2 and TAK1 may not be implicated in this disease. (Source: British Journal of Dermatology)

Mar 04, 2010 04:00PM

Successful triage of patients referred to a skin lesion clinic using teledermoscopy (IMAGE IT trial)

Conclusions This use of teledermoscopy as a triage tool offers the potential to shorten waiting lists and thus improve healthcare access and delivery. (Source: British Journal of Dermatology)

Mar 04, 2010 04:00PM

Bacterial colonization of chronic leg ulcers: current results compared with data 5 years ago in a specialized dermatology department

Conclusion The results of our investigation demonstrate the current spectrum of the bacterial colonization in patients with chronic leg ulcers in a university dermatological wound centre in comparison to the last 5 years. In our institution we were able to demonstrate a shift of the detected bacterial species from gram-positive in direction to gram-negative germs. Beside the already known problems with MRSA, in future therapeutic strategies in patients with chronic leg ulcers the increasing amount of gram-negative bacteria and especially of P. aeruginosa should considered. (Source: Journal of the European Academy of Dermatology and Venereology)

Mar 04, 2010 04:00PM

Clearance rates of circulating and tissue-bound autoantibodies to type VII collagen in experimental epidermolysis bullosa acquisita

Conclusions Although still to be confirmed in humans, our findings add to the knowledge on turnover rates of circulating and skin-bound autoantibodies in autoimmune bullous dermatoses, which in turn may facilitate a more specific monitoring of these antibodies during the disease course, reduce the need for repeated skin biopsies, and may also be helpful in guiding treatment decisions. (Source: British Journal of Dermatology)

Mar 04, 2010 04:00PM

Annular Fixed Drug Eruption

We describe a case of FDE presenting with multiple annular erythematous lesions over dorsal aspects of both feet following the administration of phenobarbital. To the best of our knowledge, such an atypical demonstration had never been reported. Fixed drug eruption should be considered in the differential diagnosis of annular lesions. (Source: JDDG)

Mar 04, 2010 03:00PM

Clinical Features and Treatment Outcomes of Vitiligo from the Patients’ Perspective: Results of a National Survey in Germany

Dermatology (DOI:10.1159/000275657) (Source: Dermatology)

Mar 04, 2010 03:00PM

Splice Site Mutations in the P-Cadherin Gene Underlie Hypotrichosis with Juvenile Macular Dystrophy

Dermatology (DOI:10.1159/000275673) (Source: Dermatology)

Mar 03, 2010 04:00PM

Skin disorders in chronic psychiatric illness

Conclusions Many chronic psychiatric patients have skin problems. Clinical examination of the skin is important to discover these problems. Patients with diabetes mellitus are particularly at risk for skin infections. Because of their relationship with overweight and diabetes mellitus, atypical antipsychotics may be partly responsible for these serious complications. Only a few other relationships between psychiatric medication and specific skin problems were found. (Source: Journal of the European Academy of Dermatology and Venereology)

Mar 03, 2010 04:00PM

Efficacy and tolerability of pale sulfonated shale oil cream 4% in the treatment of mild to moderate atopic eczema in children: a multicentre, randomized vehicle-controlled trial

Conclusion Pale sulfonated shale oil cream 4% is capable to treat mild to moderate atopic eczema in children more efficaciously than vehicle and is well tolerated. PSSO thus represents a valuable addition to our therapeutic armamentarium. PSSO should be considered in particular when valid alternatives for topical glucocorticoids are sought for. (Source: Journal of the European Academy of Dermatology and Venereology)

Mar 03, 2010 04:00PM

Patch testing in allergic contact dermatitis: is it useful to perform the cosmetic series in addition to the European standard series?

Conclusion Patch testing with cosmetic series in addition to the European standard series increased the capability to detect the relevant allergen/allergens, particularly in patients with a suspicion of cosmetic allergy. However, it is not practical and cost-effective to test those patients routinely with all 45 allergens in the cosmetic series. As the European baseline series which includes methyldibromo glutaronitrile is now widely used as the guideline minimum set of allergens for routine diagnostic patch test investigations, we additionally recommend Euxyl K400 and isopropyl myristate as the candidates for patch testing. (Source: Journal of the European Academy of Dermatology and Venereology)

Mar 03, 2010 04:00PM

Paederus dermatitis in Egypt: a clinicopathological and ultrastructural study

Conclusions Clinical, histopathological and, for the first time, ultrastructural characteristics of paederus dermatitis are described. The pathological abnormalities of the upper epidermis are caused by the irritant effect of pederin toxin. The presence of apoptosis within the lower epidermis can be related to this toxin, a point that needs further research, hoping for its future implications in the management of hyperproliferative disorders. (Source: Journal of the European Academy of Dermatology and Venereology)

Mar 03, 2010 04:00PM

Different application techniques of pathergy testing among dermatologists

(Source: Journal of the European Academy of Dermatology and Venereology)

Mar 03, 2010 04:00PM

Heterogeneous mutations of the ATP2C1 gene causing Hailey–Hailey disease in Hong Kong Chinese

Conclusion The six novel mutations provide additions to the HHD mutation database. No hot-spot mutation was found and high allelic heterogeneity was demonstrated in the Hong Kong Chinese patients. (Source: Journal of the European Academy of Dermatology and Venereology)

Mar 03, 2010 04:00PM

Cutaneous angiosarcoma: own experience over 13 years. Clinical features, disease course and immunohistochemical profile

Background Cutaneous angiosarcoma (AS) is a rare malignant tumour of endothelial origin with very poor prognosis, frequent recurrences and high metastatic potential. Clinical suspicion is often raised too late, but histological findings and immunohistochemical assays have proved to be very helpful in the diagnostic process.Patients and methods Over the last 13 years, nine patients with AS were found in our archives. Clinical features, evolution, treatment and outcome were analysed and all biopsy specimens were reviewed by a trained dermatopathologist, with subsequent immunohistochemical assessment.Results and conclusions Cutaneous AS was clinically diagnosed in 4 of 9 patients, while systemic lupus erythematosus was the most common misdiagnosis. Radiotherapy was the most prescribed treatme...

Mar 03, 2010 04:00PM

Porphyria cutanea tarda and beta-thalassaemia major: causal or casual?

(Source: Journal of the European Academy of Dermatology and Venereology)

Mar 03, 2010 04:00PM

Binding of pemphigus vulgaris IgG to antigens in desmosome core domains excludes immune complexes rather than directly splitting desmosomes

Conclusions These results suggest that the PV IgG/Dsg3 immune complexes are excluded from the desmosomal core domain rather than directly splitting the desmosome. (Source: British Journal of Dermatology)

Mar 03, 2010 04:00PM

Formaldehyde-releasers: relationship to formaldehyde contact allergy. Part 2. Formaldehyde-releasers in clothes: durable press chemical finishes

This is the second part of a review article on formaldehyde-releasers used as durable press chemical finishes (DPCF) in textiles. The early finishes contained large amounts of free formaldehyde, which led to many cases of allergic contact dermatitis to clothes in the 1950s and 1960s. Currently, most finishes are based on modified dimethylol dihydroxyethyleneurea, which releases less formaldehyde. Nevertheless, recent studies in the United States and Israel have identified patients reacting to DPCF, considered to have allergic contact reactions to clothes, either from formaldehyde released by the DPCF therein or from the DPCF per se (in patients negative to formaldehyde). However, all studies had some weaknesses in design or interpretation and in not a single case has the clinical relevance...

Mar 03, 2010 04:00PM

A novel mutation in the cathepsin C gene in a Pakistani family with Papillon-Lefevre syndrome

Conclusion Our data further expand the spectrum of mutations in the CTSC gene underlying PLS. (Source: Journal of the European Academy of Dermatology and Venereology)

Mar 03, 2010 04:00PM

Pre-operative ultrasound with a 12–15 MHz linear probe reliably differentiates between melanoma thicker and thinner than 1 mm

Conclusion Ultrasound examination with a 12[ndash]15 MHz linear transducer can reliably differentiate primary melanoma > 1 mm from those [le] 1 mm. (Source: Journal of the European Academy of Dermatology and Venereology)

Mar 03, 2010 04:00PM

Association of adult mastocytosis with M541L in the transmembrane domain of KIT

(Source: Journal of the European Academy of Dermatology and Venereology)

Mar 03, 2010 04:00PM

Psoriasis: an epidemiological evaluation of disease burden in 590 patients

In this study, 36.8% of patients with severe psoriasis reported a negative impact on their professional life vs. 19.6% for patients with mild psoriasis (P = 0.002). Time devoted to phototherapy was on average 33 h/year/patient and the application of emollients took 25 h/year/patient; 47.3% of patients had a feeling to clean the house more often, in correlation with the severity of the disease. Mean out-of-pocket expenses for the disease was estimated to be 543[euro]/year/patient. High impact of psoriasis on quality of life (DLQI >10), age (Source: Journal of the European Academy of Dermatology and Venereology)

Mar 03, 2010 04:00PM

Guidelines for the laboratory diagnosis of trichomoniasis in East European countries

The laboratory diagnosis of sexually transmitted infections in many Eastern European countries remains suboptimal. The main objective of the present evidence-based guidelines is to provide comprehensive information regarding the laboratory diagnosis of infections caused by Trichomonas vaginalis in East European countries. In particular, the present guidelines recommend: (i) to encourage examination of the wet mounts of vaginal exudates, instead of stained smears, at all clinical settings; (ii) nucleic acid amplification tests (NAATs) or culture could be employed if no trichomonads are detected on microscopic examination of the wet preparation and there is a strong indication of infection and (iii) the use of NAATs is encouraged in screening, using non-invasive specimens, or high volume tes...

Mar 03, 2010 04:00PM

Differential effects of a tertiary individual prevention programme for patients with occupational skin disease depending on diagnosis

Conclusion Professionals working in the field of OSD should not cease to assist AD patients in achieving optimal skin protection behaviour. Tertiary individual prevention measures may need to pay more attention to the needs of individuals with an occupationally relevant AD. This may contribute to their being able to remain active in the workforce. The alternative would entail regular sick leave, poorer quality of life and economic hardship for the AD patient. (Source: Journal of the European Academy of Dermatology and Venereology)

Mar 03, 2010 04:00PM

Analysis of the STS gene in 40 patients with recessive X-linked ichthyosis: a high frequency of partial deletions in a Spanish population

Conclusions Amplification of exons 1, 5 and 10 is reliable in screening RXLI in the population studied here. No correlation was found between phenotype and the extent of the deletions. (Source: Journal of the European Academy of Dermatology and Venereology)