Dr. William Ting, Board-Certified Dermatologist
at California Dermatology Care
2262 Camino Ramon, San Ramon, CA 94583
500 Alfred Nobel Drive, Suite #185, Hercules, CA 94547
Tel: 925-328-0255
Email: staff@CalDermCare.com


Advanced Care with a Personal Touch

   

 

 

Medical Dermatology    Evidence-based medicine   Customized solution   Personal care

Latest Dermatology Headlines

Dr. William Ting has expertise in treating the entire spectrum of medical dermatology, with emphasis in preventive medicine and personalized recommendations. He enjoys taking care of patients with acne, eczema, hair and nail disorders, rashes, psoriasis and skin cancers.

He is at the forefront of medical dermatology and dermatologic research. He continues to publish articles in peer-reviewed dermatology journals. He is an early pioneer of photodynamic therapy (PDT) and one of the most experienced practitioners of PDT in the Bay Area. He is the first dermatologist in the San Francisco Bay Area and Northern California to introduce Lutronic Spectra Laser for melasma, acne, scar revision, pore size reduction as well as the Cutera GenesisPlus laser for advanced nail fungus laser treatment, keloid and hypertrophic scar, warts and scar revision.

Dr. Ting is a fellow of the American Academy of Dermatology (AAD) and American Society of Dermatologic Surgery (ASDS). He is a member of the National Psoriasis Foundation and International Hyperhidrosis Society.

Innovative Therapeutic Approach to Common Skin Conditions

Acne

Eczema (Atopic Dermatitis)

Hair and Nail disorders

  • Maximize therapeutic synergy and efficacy by utilizing both prescription-strength and over-the counter products when available
  • Comprehensive workup including bloodwork and biopsy if necessary
  • Systemic oral hormonal therapy for women and men when indicated

Psoriasis 

Rosacea

  • Multi-prong approach to minimize redness
  • Low-dose 'non-antibiotic' anti-inflammatory oral medication for long-term remission 
  • Emphasis on prevention
  • Fotofacial/IPL laser utilizing Cynosure XPL/Elite MPX
  • Cutera GenesisPlus Laser with or without combination with IPL 
  • Diode laser for facial veins
  • VBeam Pulse Dye Laser, the new gold standard for rosacea and facial redness

Skin Cancer 

  • Emphasis on prophylactic treatments with topical 5-FU, imiquimod, diclofenac, ingenol mebutate and oral chemopreventive therapy such as Soriatane.
  • Reduce future risks of skin cancer with photodynamic therapy, TCA chemical peels and/or fractional CO2 resurfacing laser  
  • Mohs Surgery to achieve highest cure rate and tissue sparing
  • Close colloboration with plastic surgeon(s) as needed  

Sweating Disorder (Hyperhidrosis) 

Vitiligo

Warts 


ABCD of Mole Check

 

 

Common Medical Dermatology Diagnostics and Therapeutics:

Dermatology Links:

American Academy of Dermatology
American Society of Dermatologic Surgery
American Society of Mohs Surgery
International Hyperhidrosis Society
National Psoriasis Foundation

 Latest Dermatology Headlines:

Latest Dermatology Headlines
Wed, 02 Sep 2015 09:33:12 +0100

http://www.medworm.com/rss/index.php/Dermatology/12/

Sep 02, 2015 01:28AM

Ectopic Foot Nails: Clinical and Dermoscopic Features, Treatment and Outcome in 20 Cases

Conclusion: In this article, new aspects on EFN from the clinical-morphological and dermoscopic points of view are reported; these may facilitate the diagnosis of an anomaly even without a histological examination.Dermatology (Source: Dermatology)

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Sep 02, 2015 01:28AM

Report of Three Novel Germline CYLD Mutations in Unrelated Patients with Brooke-Spiegler Syndrome, Including Classic Phenotype, Multiple Familial Trichoepitheliomas and Malignant Transformation

Brooke-Spiegler syndrome is a rare autosomal-dominant genetic disorder characterized by multiple adnexal tumors, including cylindromas, spiradenomas, spiradenocylindromas and trichoepitheliomas. It is caused by germline CYLD mutations commonly leading to a premature stop codon. We here report on 3 novel CYLD mutations in 3 unrelated BSS patients, including the classic phenotype, multiple familial trichoepitheliomas phenotype and malignant transformation. These included c.1821_1826+1delinsCT/L607Ffs*9, c.2666A>T/p.D889V and c.2712delT/p.905Kfs*8. By extending the spectrum of CYLD mutations, better understanding of the molecular mechanisms of BSS can be gained, which might later assist in finding new treatment options.Dermatology (Source: Dermatology)

Sep 01, 2015 04:00PM

Cosmetic Dermatology and the Distortion of Beauty

(Source: Journal of Cosmetic Dermatology)

Sep 01, 2015 04:00PM

Nail-patella syndrome with infertility in a 37 years old Saudi Male : A case report

Publication date: Available online 1 September 2015 Source:Journal of Dermatology & Dermatologic Surgery Author(s): Nada J. Al-ghamdi Nail-patella syndrome (NPS) which also known as hereditary osteo-onychodysplas is a rare autosomal-dominant disorder characterized by a classic clinical tetrad of changes in the nails, knees, elbows and the presence of iliac horns . Occasionally the central nervous system, the eyes and the renal system are affected. NPS reported worldwide, affecting males and females equally. Infertility was not mentioned in this syndrome before. Here we are reporting a case of NPS in a 38 years old Saudi male, in association with infertility, which was exceptional and could represent an additional manifestation to the syndrome. (Source: Journal of Dermatology and...

Sep 01, 2015 04:00PM

Gorlin Syndrome in a type IV-skin person with a novel PTCH1 mutation: Case Report and Literature Review

Publication date: Available online 1 September 2015 Source:Journal of Dermatology & Dermatologic Surgery Author(s): S. AlSalem, Y. Binamer Nevoid basal cell carcinoma syndrome (NBCCS), or Gorlin Syndrome, is an autosomal dominant multisystem disorder, characterized by multiple developmental abnormalities and inactivation germline mutations in the human homolog of the patched (PTCH) gene. We are presenting a case of NBCCS in a skin type 4 Saudi male with a novel PTCH1 gene mutation. To the best of our knowledge, this is the third case reported in Saudi Arabia but the first in adult population. Moreover, our patient harbors a novel heterozygosity mutation in patch1 gene. (Source: Journal of Dermatology and Dermatologic Surgery)

Sep 01, 2015 10:31AM

The efficacy of tacrolimus in patients with refractory dermatomyositis/polymyositis: a systematic review

Abstract The purpose of this study is to examine the efficacy and safety of tacrolimus (FK506) in the management of polymyositis (PM)/dermatomyositis (DM). The Cochrane Central Register of Controlled Trials (CENTRAL), PubMed, Embase, and China National Knowledge Infrastructure (CNKI) were searched to find articles published between May 1980 and April 2015 concerning tacrolimus therapy in PM/DM. The initial search yielded 107 articles. In the end, eight studies met our inclusion criteria and involved a total of 134 patients who received tacrolimus therapy for DM/PM. All studies were non-randomized. Oral tacrolimus of 0.075 mg/kg/day or 1.0?3.5 mg/d was administered twice daily or once daily together with glucocorticoids (GCs). According to comprehensive analysis of the studies,...

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Sep 01, 2015 07:09AM

Valeant And AstraZeneca To Partner On Brodalumab

US and EU regulatory submission planned in moderate-to-severe psoriasis in Q4 2015 LAVAL, Quebec, Sept. 1, 2015 -- (Healthcare Sales & Marketing Network) -- Valeant Pharmaceuticals International, Inc. (NYSE: VRX and TSX: VRX) today announced that its a... Biopharmaceuticals, Dermatology, Licensing, DistributionValeant Pharmaceuticals, AstraZeneca, Brodalumab, psoriasis (Source: HSMN NewsFeed)

Sep 01, 2015 02:20AM

Dermal and Ophthalmic Findings in Pseudohypoaldosteronism.

Authors: Korkut S, Gökalp E, Özdemir A, Kurto?lu S, Demirta? ?, Gül Ü, Ba?tu? O Abstract Pseudohypoaldosteronism (PHA) is defined as a state of resistance to aldosterone, a hormone crucial for electrolyte equilibrium. The genetically transmitted type of PHA is primary hypoaldosteronism. Secondary hypoaldosteronism develops as a result of hydronephrosis or hydroureter. PHA patients suffer from severe hyponatremia and a severe clinical condition due to severe loss of salt can be encountered in the neonatal period. Dermal findings in the form of miliaria rubra can also develop in these patients. With the loss of salt, abnormal accumulation of sebum in the eye due to a defect in the sodium channels can also occur. In this paper, a case of PHA in a newborn showing typical derma...

Sep 01, 2015 01:26AM

Flame Hair

Conclusion: The flame hair is a type of broken hair which can be seen in various hair loss disorders. It results from traumatic pulling of anagen hairs or from anagen arrest due to inflammation or drugs.Skin Appendage Disord 2015;1:105-109 (Source: Skin Appendage Disorders)

Sep 01, 2015 12:22AM

Ustekinumab Found to Be Effective in Adolescents With PsoriasisUstekinumab Found to Be Effective in Adolescents With Psoriasis

Adolescents with moderate to severe psoriasis may respond to the human monoclonal antibody ustekinumab as well as adults, with no unexpected side effects, a new study found. Reuters Health Information (Source: Medscape Dermatology Headlines)

Aug 31, 2015 11:00PM

Health Tip: Coping With Mosquito Bites

Title: Health Tip: Coping With Mosquito BitesCategory: Health NewsCreated: 9/1/2015 12:00:00 AMLast Editorial Review: 9/1/2015 12:00:00 AM (Source: MedicineNet Skin General)

Aug 31, 2015 09:00PM

Restoration of Trigeminal Cutaneous Sensation with Cross-Face Sural Nerve Grafts: A Novel Approach to Facial Sensory Rehabilitation

Summary: Although treating facial palsy is considered debilitating for patients, trigeminal nerve palsy and sensory deficits of the face are overlooked components of disability. Complete anesthesia leaves patients susceptible to occult injury, and facial sensation is an important component of interaction and activities of daily living. Sensory reconstruction is well established in the restoration of hand sensation; however, only one previous report proposed a surgical strategy for sensory nerve reconstruction of the face with use of nerve transfers. Nerve transfers, when used alone, have limited application because of their restricted arc of rotation in the face; extending their arc by adding nerve grafts greatly expands their utility. The following cases demonstrate the early results afte...

Aug 31, 2015 06:35PM

Make the Diagnosis: Lesions, Fistulas and Shock

(MedPage Today) -- Case Findings: A 45 year-old male patient presented in septic shock. Multiple well-established ulcers and fistulas were present on his buttocks, thighs, and perineum. Immediate resuscitation and antibiotics were provided, as well as imaging of the lesions. What is your diagnosis? (Source: MedPage Today Dermatology)

Aug 31, 2015 04:00PM

Five?year risk of incident disease following a diagnosis of chronic rhinosinusitis

ConclusionThe risk of other diseases associated with CRS adds to the burden of an already highly burdensome condition, and suggests either that CRS promotes onset of other diseases or is an indicator of systemic disease processes. Different patterns of association with diseases by CRS phenotype may be due to CRSwNP sample size imitations or reflect a different pattern of disease onset by phenotype. These findings have implications for screening guidelines and care of CRS patients.This article is protected by copyright. All rights reserved. (Source: Allergy)

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Aug 31, 2015 04:00PM

Diminution of Langerhans cells in keratitis, ichthyosis and deafness (KID) syndrome patient with recalcitrant cutaneous candidiasis

(Source: Journal of the European Academy of Dermatology and Venereology)

Aug 31, 2015 04:00PM

A Qualitative Comparison of Symptoms and Impact of Varying Stages of Basal Cell Carcinoma

Conclusions Patients with non-advanced or locally advanced and metastatic BCC experience disease-related symptoms that affect their HRQL, activities of daily living, emotional well-being, and social and/or leisure activities. Qualitative descriptions of patient experiences can help healthcare providers and caregivers better understand the impact of BCC from the patient perspective. Funding Eli Lilly and Company. (Source: Dermatology and Therapy)

Aug 31, 2015 04:00PM

Allergic contact dermatitis and nail damage mimicking psoriasis caused by nail hardeners

(Source: Contact Dermatitis)

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Aug 31, 2015 04:00PM

A Spanish Mohs surgery registry (REGEMOHS). The first step in an ambitious project.

Authors: Nagore E PMID: 26319098 [PubMed - as supplied by publisher] (Source: Actas Dermo-Sifiliograficas)

Aug 31, 2015 04:00PM

Translating Atopic Dermatitis Management Guidelines Into Practice for Primary Care Providers

This article evaluates these recent treatment guidelines in terms of evaluation criteria, treatment recommendations, usability, accessibility, and applicability to nonspecialists and integrates them with clinical evidence to present a streamlined severity-based treatment model for the management of a majority of atopic dermatitis cases. Because each patient’s situation is unique, individualization of treatment plans is critical as is efficient communication and implementation of the plan with patients and caregivers. Specifically, practical suggestions for individualizing, optimizing, implementing, and communicating treatment plans such as choosing a moisturizer formulation, avoiding common triggers, educating patients/caregivers, providing written treatment plans, and scheduling phy...

Aug 31, 2015 04:00PM

Belt Buckles--Increasing Awareness of Nickel Exposure in Children: A Case Report

We describe allergic contact dermatitis in 12 children with peri-umbilical nickel dermatitis (with and without generalized involvement) caused by dimethylglyoxime-positive belt buckles. The patients’ symptoms resolved with avoidance of the nickel-containing products. (Source: PEDIATRICS)

Aug 31, 2015 04:00PM

Folliculotropic Mycosis Fungoides as a Posttransplant Lymphoproliferative Disorder

Posttransplant lymphoproliferative disorder (PTLD) is a known complication of solid organ transplantation. The majority are B cell in origin and related to Epstein-Barr virus infection. T-cell PTLD is much less common; most are Epstein-Barr virus negative and have a worse prognosis. Primary cutaneous T-cell lymphoma (CTCL) as a presentation of PTLD is rare. CTCL has a less favorable prognosis in transplant patients compared with that in immune-competent patients. Herein, we report a case of a 13-year-old boy who developed folliculotropic mycosis fungoides, a rare subtype of CTCL, subsequent to renal transplantation. To our knowledge, this is the first report of this type of PTLD in a pediatric patient. (Source: PEDIATRICS)

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Aug 31, 2015 04:00PM

Inhibition of Angiofibromas in a Tuberous Sclerosis Patient Using Topical Timolol 0.5% Gel

Angiofibromas are the most recognized cutaneous manifestations of tuberous sclerosis complex. Angiofibromas can be associated with disfigurement, bleeding, pruritus, and erythema and may lead to significant psychosocial consequences for affected patients. Histopathologically, angiofibromas consist of a mixture of vascular and interstitial cells. Traditional treatment options include cryotherapy, electrocoagulation, radiofrequency ablation, dermabrasion, laser treatment, and topical agents such as podophyllotoxin. However, complications such as pain, postinflammatory hyperpigmentation, scarring, and the frequent recurrence rate reduce the utility of these treatment options. The introduction of topical rapamycin marked a turning point for treatment of facial angiofibromas; however, the lack ...

Aug 31, 2015 04:00PM

[In Process Citation].

CONCLUSIONS: Antibodies seem to be useful markers for distinct clinical subsets, for predicting the prognosis of myositis and the effectiveness of the therapy. Orv. Hetil., 2015, 156(36), 1451-1459. PMID: 26320599 [PubMed - in process] (Source: Orvosi Hetilap)

Aug 31, 2015 04:00PM

Angiopoietin-4 increases permeability of blood vessels and promotes lymphatic dilation [Research Communication]

The angiopoietin (Ang) ligands are potential therapeutic targets for lymphatic related diseases, which include lymphedema and cancer. Ang-1 and Ang-2 functions are established, but those of Ang-4 are poorly understood. We used intravital fluorescence microscopy to characterize Ang-4 actions on T241 murine fibrosarcoma-associated vessels in mice. The diameters of lymphatic vessels draining Ang-4- or VEGF-C (positive control)-expressing tumors increased to 123 and 135 μm, respectively, and parental, mock-transduced (negative controls) and tumors expressing Ang-1 or Ang-2 remained at baseline (~60 μm). Ang-4 decreased human dermal lymphatic endothelial cell (LEC) monolayer permeability by 27% while increasing human dermal blood endothelial cell (BEC) monolayer permeability by 200%. In v...

Aug 31, 2015 04:00PM

Pigment epithelium-derived factor as a multifunctional regulator of wound healing

During dermal wound repair, hypoxia-driven proliferation results in dense but highly permeable, disorganized microvascular networks, similar to those in solid tumors. Concurrently, activated dermal fibroblasts generate an angiopermissive, provisional extracellular matrix (ECM). Unlike cancers, wounds naturally resolve via blood vessel regression and ECM maturation, which are essential for reestablishing tissue homeostasis. Mechanisms guiding wound resolution are poorly understood; one candidate regulator is pigment epithelium-derived factor (PEDF), a secreted glycoprotein. PEDF is a potent antiangiogenic in models of pathological angiogenesis and a promising cancer and cardiovascular disease therapeutic, but little is known about its physiological function. To examine the roles of PEDF in ...

Aug 31, 2015 04:00PM

Psoriasis?like lesions in a patient with familial Mediterranean fever

We report a case of FMF with annular erythema and psoriasis?like lesions, the latter of which demonstrated parakeratosis with neutrophil microabscesses and mild inflammatory mononuclear cell infiltration in the upper dermis. Immunofluorescence staining showed IL?17?positive T?cells. Skin eruption with neutrophil migration in the epidermis may be provoked by T?helper 17 cell activation through the abnormal IL?1? cascade in FMF. (Source: The Journal of Dermatology)

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Aug 31, 2015 04:00PM

Revisiting Buruli ulcer

This article will revisit BU, reviewing clinical features as well as the most recent epidemiological and scientific findings of the disease, to raise awareness of BU among dermatologists worldwide. (Source: The Journal of Dermatology)

Aug 31, 2015 04:00PM

Eccrine porocarcinoma shares dermoscopic characteristics with eccrine poroma: A report of three cases and review of the published work

Abstract Eccrine porocarcinoma (EPC) is a rare malignant skin tumor presumably arising from the intraepidermal ductal portion of the sweat gland. EPC occasionally mimics eccrine poroma (EP), seborrhea keratosis (SK), basal cell carcinoma (BCC), pyogenic granuloma (PG) and amelanotic melanoma with its clinical appearance as a pink nodule. Dermoscopy is an invaluable technique in diagnosing skin tumors. However, few cases of EPC have been reported using dermoscopic images, and their details were not well examined. Here, we present three histopathologically proven cases of EPC and summarize their dermoscopic findings together with five previously reported cases. None of the eight cases showed dermoscopic evidence indicative of SK (comedo?like openings, milia?like cysts, fissures and ridge...

Aug 31, 2015 04:00PM

Yearly reduction of glucocorticoid dose by 50% as tapering schedule achieves complete remission for 124 pemphigus vulgaris patients

Abstract Glucocorticoids are the first?line treatment for pemphigus vulgaris. Among 140 patients receiving systemic glucocorticoids, 124 patients achieved complete remission off or on a prednisone dose of ?10 mg/day or less for 6 months or more. The mean average steroid controlling doses were 0.65, 0.62, 0.80, 1.08 and 1.38 mg/kg per day for the mucosal?dominant patients and the mild, moderate, severe and extensive cutaneous?involved patients, respectively (P < 0.001). The mean durations of the initial tapering after controlling doses started were 77.98, 48.78, 31.74 and 28.83 days when the disease was controlled with doses of 40 mg/day or less, 45?60 mg/day, 65?80 mg/day and more than 80 mg/day for the cutaneous?involved types, respectively (P < 0.005). Of ...

Aug 31, 2015 04:00PM

Abstracts

Journal of Investigative Dermatology 135, S1 (October 2015). doi:10.1038/jid.2015.247 (Source: Journal of Investigative Dermatology)

Aug 31, 2015 04:00PM

Atopic and nonatopic eczema in adolescence: is there a difference?

ConclusionsAE is more common than non?AE among teenagers. More than one in four teenagers with eczema has moderate?to?severe disease. Onset in adolescence is common, especially for non?AE. AE in adolescence has an earlier onset and is more chronic and more severe than non?AE. (Source: British Journal of Dermatology)

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Aug 31, 2015 02:01PM

4 DIY Home Manicure Must-Haves

by Holly Dawsey There's nothing quite like a fresh manicure to finish a look. Here, our picks for the top polish, base coat, top coat, and nail treatment. The Experts: Ilana Blitzer, Health beauty director; Paul Cucinello, celebrity hair stylist in Los Angeles and New York City; Francesca Fusco, MD, assistant clinical professor of dermatology at Mount Sinai Hospital in New York City; Suzy Gerstein, New York City celebrity makeup artist; Julie Kandalec, celebrity manicurist and creative director of Paintbox in New York City; Joanna Simkin, New York City celebrity makeup artist; Alexis Wolfer, founder of TheBeautyBean.com; Jessica Wu, MD, assistant clinical professor of dermatology at the University of Souther California School of Medicine in Los Angeles. Nail color Essie Cashmere Mattes (...

Aug 31, 2015 07:34AM

Breast Neoplasms with Dermal Analogue Differentiation (Mammary Cylindroma): Report of 3 Cases and a Proposal for a New Terminology

In this study, we present three cylindromatous breast tumours. These lesions were located within the breast, had ill-defined margins and were composed of nests containing a dual population of cytologically bland cells, surrounded at least partially by basement membrane-like material. The lack of cytological atypia and absence of mitoses led to the diagnosis of benign mammary cylindroma in 1 case. The expression of oestrogen receptor, focal absence of basement membrane material and the focal infiltrative nature together with patchy absence of peripheral basement membrane supported the diagnosis of malignancy in the other 2 cases. We discuss the morphological criteria, immunohistochemical profile and diagnostic pitfalls of these tumours. We also review the literature including previously rep...

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Aug 31, 2015 02:29AM

Diet ISN'T causing your eczema and you CAN shower each day

Cutting out food groups, avoiding exercise and swimming will not cure eczema, according to Dr Adam Friedmann, a dermatologist from the Harley Street Dermatology Clinic. (Source: the Mail online | Health)

Aug 30, 2015 11:51PM

Impact of a Glycolic Acid-Containing pH 4 Water-in-Oil Emulsion on Skin pH

The skin pH is crucial for physiological skin functions. A decline in stratum corneum acidity, as observed in aged or diseased skin, may negatively affect physiological skin functions. Therefore, glycolic acid-containing water-in-oil (W/O) emulsions adjusted to pH 4 were investigated regarding their effect on normal or increased skin pH. A pH 4 W/O emulsion was applied on three areas with pathologically increased skin surface pH in diabetics (n = 10). Further, a 28-day half-side trial (n = 30) was performed to test the long-term efficacy and safety of a pH 4 W/O emulsion (n = 30). In summary, the application of a pH 4 W/O emulsion reduced the skin pH in healthy, elderly and diabetic subjects, which may improve epidermal barrier functions.Skin Pharmacol Physiol 2015;28:290-295 (Source: Skin...

Aug 30, 2015 09:00PM

DERMACHLOR FLUSH PLUS (Lidocaine Hydrochloride, Chlorhexidine) Liquid [Henry Schein Animal Health]

Updated Date: Aug 31, 2015 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Aug 30, 2015 08:01PM

AAP: Give peanut products to high-risk infants to cut allergy risk

Infants at high risk for peanut allergy should start a peanut-based diet by age 4-11 months, experts from the American Academy of Pediatrics and nine other medical groups advised in the September issue of the American Journal of Pediatrics. The consensus communication upends traditional views... (Source: Skin and Allergy News)

Aug 30, 2015 04:00PM

Comparative study of nanosized cross-linked sodium-, linear sodium- and zinc-hyaluronate as potential ocular mucoadhesive drug delivery systems

Publication date: 15 October 2015 Source:International Journal of Pharmaceutics, Volume 494, Issue 1 Author(s): Gabriella Horvát, Mária Budai-Sz?cs, Szilvia Berkó, Piroska Szabó-Révész, Judit Soós, Andrea Facskó, Mónika Maroda, Michela Mori, Giuseppina Sandri, Maria Cristina Bonferoni, Carla Caramella, Erzsébet Csányi Hyaluronic acid (HA) and its derivatives play important roles in many fields of therapy, such as arthritis treatment, plastic surgery, dermatology, otology, ophthalmology, etc. With a view to increase the beneficial properties of HA in ocular drug delivery, many types of chemical structural modifications have been performed. In the course of our research work, we characterized nanosized cross-linked ? (CLNaHA), linear sodium hyaluronate (NaHA) and ...

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Aug 30, 2015 04:00PM

Differential Expression of Specific Dermatan Sulfate Domains in Renal Pathology

by Joost F. M. Lensen, Johan van der Vlag, Elly M. M. Versteeg, Jack F. M. Wetzels, Lambert P. W. J. van den Heuvel, Jo H. M. Berden, Toin H. van Kuppevelt, Angelique L. W. M. M. Rops Dermatan sulfate (DS), also known as chondroitin sulfate (CS)-B, is a member of the linear polysaccharides called glycosaminoglycans (GAGs). The expression of CS/DS and DS proteoglycans is increased in several fibrotic renal diseases, including interstitial fibrosis, diabetic nephropathy, mesangial sclerosis and nephrosclerosis. Little, however, is known about structural alterations in DS in renal diseases. The aim of this study was to evaluate the renal expression of two different DS domains in renal transplant rejection and glomerular pathologies. DS expression was evaluated in normal renal tissue and in k...

Aug 30, 2015 04:00PM

Spectrométrie de masse : comment cette révolution technologique va impacter l?ensemble de la démarche diagnostique en parasitologie et mycologie

Publication date: September 2015 Source:Journal de Mycologie Médicale / Journal of Medical Mycology, Volume 25, Issue 3 Author(s): Renaud Piarroux La spectrométrie de masse matrix-assisted laser desorption and ionization time-of-flight (MALDI-TOF), a maintenant supplanté les méthodes traditionnelles d?identification des bactéries dans les laboratoires de biologie médicale. En mycologie médicale, l?expertise du mycologue à la paillasse semble plus difficile à remettre en cause, en particulier pour les moisissures et les dermatophytes. À Marseille cependant, la spectrométrie de masse MALDI-TOF est maintenant à la base de notre processus d?identification de l?ensemble des colonies fongiques, moisissures, levures et dermatophytes inclus. Un recul de trois années et plus...

Aug 30, 2015 04:00PM

Caractérisation microbiologique de 3193 logements français des enfants de la cohorte ELFE

Conclusion Les cohortes de naissance sont essentielles pour comprendre l?apparition des maladies respiratoires au cours de la vie. Certains enfants de la cohorte ELFE développeront inévitablement de l?asthme entre 4?7ans. Nous pourrons alors comparer la survenue de l?asthme aux types de profils microbiens des logements qu?ils occupaient à la naissance. (Source: Journal of Medical Mycology)

Aug 30, 2015 04:00PM

Épidémiologie des dermatophyties zoophiles sur une période de 5ans à l?hôpital militaire de Rabat

Conclusion Les dermatophyties sont des mycoses superficielles fréquentes de la peau et des phanères, causées par des champignons microscopiques filamenteux. Les dermatophytes zoophiles sont pourvoyeuses de teignes du cuir chevelu et de la barbe, des folliculites et des épidermophyties de la peau glabre ; l?enfant et le jeune adolescent sont les plus touchés. Dans ce sens, le laboratoire de mycologie joue un rôle primordial dans la prise en charge de ces patients. (Source: Journal of Medical Mycology)

Aug 30, 2015 04:00PM

Hidradenitis suppurativa?acne inversa: a relevant dermatosis in paediatric patients

(Source: British Journal of Dermatology)

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Aug 30, 2015 04:00PM

Eccrine poroma: the great dermoscopic imitator

(Source: Journal of the European Academy of Dermatology and Venereology)

Aug 30, 2015 04:00PM

Papillary intralymphatic angioendothelioma (PILA), also referred to as Dabska tumour, in an 83?year?old woman

(Source: Journal of the European Academy of Dermatology and Venereology)

Aug 30, 2015 04:00PM

Fully regressive lesions: how dermoscopy can help us?

(Source: Journal of the European Academy of Dermatology and Venereology)

Aug 30, 2015 04:00PM

Pneumocephalus as a fatal complication of scalp angiosarcoma

(Source: Journal of the European Academy of Dermatology and Venereology)

Aug 30, 2015 04:00PM

Magnet hanging on the skin ? An easy method to detect occult metallic cutaneous foreign body

(Source: Journal of the European Academy of Dermatology and Venereology)

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Aug 30, 2015 04:00PM

Pictorial representation of illness and self measure (PRISM): an effective tool to assess the burden of psoriasis

ConclusionPRISM is a highly reliable tool and new approach to assess perceived burden of patients with psoriasis. It is easy to use and we recommend the application as an additional outcome measure in clinical trial settings. (Source: Journal of the European Academy of Dermatology and Venereology)

Aug 30, 2015 04:00PM

Cutaneous and breast Langerhans cell sarcoma

(Source: Journal of the European Academy of Dermatology and Venereology)

Aug 30, 2015 04:00PM

Clinical Reasoning: A 27-year-old man with rapidly progressive coma

A 27-year-old man was brought to the emergency department by paramedics after being found wandering the street not communicative and with unsteady gait. At the scene, he was noted to have full body tremulousness, which improved after receiving midazolam. He was urgently transported to an emergency department and subsequently developed nausea, vomiting, and progressive deterioration of his mental status. On physical examination, he had tachycardia without fever, and was hemodynamically stable with normal oxygen saturation. He was stuporous; however, all brainstem reflexes were preserved with symmetrically reactive pupils of normal shape and size. He demonstrated spontaneous symmetrical limb movement as well as purposeful withdrawal. He had anicteric sclera, and his dermatologic evaluation s...

Aug 29, 2015 10:12PM

High frequency of contact allergy to implant and bone cement components, in particular gentamicin, in cemented arthroplasty with complications: usefulness of late patch test reading

ConclusionLate reading is useful for patch tests with metals and bone cement components. With only D2/D3 readings, 32 reactions to nickel, cobalt, chromium and bone cement components would have been missed. This underlines the utility of late reading in general and in complicated cemented arthroplasty patients, given the unexpectedly high number of gentamicin reactions. (Source: Contact Dermatitis)

Aug 29, 2015 07:56PM

Clinical Management and Use of Health Care Resources in the Treatment of Nasal Polyposis in Spanish Allergy Centers: The POLAR Study.

CONCLUSIONS: NP is a chronic inflammatory disease that generates considerable use of health care resources. The close association with atopy, asthma, and NSAID hypersensitivity highlights the usefulness of an allergy workup in all patients with NP. Analysis of the clinical management of NP by allergists in Spain revealed a high degree of compliance with EPOS diagnostic and therapeutic recommendations. PMID: 26310042 [PubMed - in process] (Source: Journal of Investigational Allergology and Clinical Immunology)

Aug 29, 2015 04:00PM

Biological therapy induces expression changes in Notch pathway in psoriasis

This study aimed to determine mRNA expression levels by real-time RT-PCR, and protein expression levels, analysed by Western blot and immunohistochemistry, of some components of the Notch pathway, such as NOTCH1, NOTCH2, JAGGED1, and HES1 after biological treatments in psoriatic patients. mRNA and protein levels of NOTCH1, NOTCH2, JAGGED1 and HES1 were upregulated in skin samples from untreated psoriatic patients compared with normal controls. Biological therapy showed to downregulate differently the protein expression levels of the molecules under study. Our study suggests that Notch pathway components might be a potential therapeutic target against psoriasis. (Source: Archives of Dermatological Research)

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Aug 29, 2015 04:00PM

Antiviral activity of some plant oils against herpes simplex virus type 1 in Vero cell culture

Conclusion It can be concluded that the oils studied in this research have significant inhibitory effect on HSV-1 and thus they could be used as an anti-HSV-1 agent in the context of herbal mouth wash. (Source: Journal of Acute Medicine)

Aug 29, 2015 04:00PM

Real-time PCR: A rapid and sensitive method for diagnosis of dermatophyte induced onychomycosis, a comparative study

Conclusion: Real-time PCR followed by melting-point analysis, gives a diagnostic tool that has a higher sensitivity (93.3%) and is faster than nested PCR (73.3%) and other conventional methods. (Source: Alexandria Journal of Medicine)

Aug 29, 2015 04:00PM

Merkel cell carcinoma in Scotland 2000?10

(Source: British Journal of Dermatology)

Aug 29, 2015 04:00PM

Evaluation of anti?acne properties of phloretin in vitro and in vivo

ConclusionsThis study revealed that phloretin inhibits the growth of P. acnes, P. granulosum, and S. epidermidis. In addition, we demonstrated that phloretin attenuates COX?2 and PGE2 expression during the P. acnes?induced upregulation of inflammatory signalling. Clinical studies further suggested that treatment with formulations containing phloretin confers anti?acne benefits. Based on these results, we suggest that phloretin may be introduced as a possible acne?mitigating agent. Résumé ObjectifLa présente étude visait à étudier les propriétés anti?acné de phlorétine in vitro et in vivo. MéthodesL'activité anti?microbienne contre Propionibacterium acnes (P. acnes), Propionibacterium granulosum (P. granulosum), Staphylococcus epidermidis (S. epidermidis) a...

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Aug 29, 2015 12:38PM

Predictors of smoking reduction outcomes in a sample of 287 patients with schizophrenia spectrum disorders.

Authors: Wu BJ, Lan TH Abstract Many studies have investigated whether a type of antipsychotics or type of adjuvant is associated with smoking reduction in patients with schizophrenia. However, there has been no study exploring a comprehensive range of factors related to smoking reduction in schizophrenia patients. We analyzed a dataset of 287 smoking patients with schizophrenia who participated in an 8-week open-label study with high- (n = 90) or low-dose nicotine dermal patches (n = 132) or bupropion (n = 65). A logistic regression model and a linear mixed model were used to explore factors associated with the outcomes of smoking cessation and reduction, i.e., the number of cigarettes smoked and the level of nicotine dependence. The total cessation rate was 6.3 % (18/287)....

Aug 29, 2015 03:46AM

Preserved cutaneous silent period in cervical root avulsion.

Conclusion In brachial plexopathy even with plurisegmental root avulsion, the cutaneous SP was mostly preserved. This method cannot be recommended as a reliable test for diagnosis of single root avulsion; however, it can provide a quick physiological confirmation of functional afferent A-delta fibers through damaged roots and/or trunks. The clinicians may add this test to the diagnosis of spinal cord dysfunction. PMID: 26312387 [PubMed - as supplied by publisher] (Source: Journal of Spinal Cord Medicine)

Aug 28, 2015 11:00PM

Dermatophytosis: a 16-year retrospective study in a metropolitan area in southern Brazil

Conclusion: Monitoring of the evolution of dermatophytosis tracks changes in prevalence over the years and may assist practical measures for the public health control of this disease. (Source: The Journal of Infection in Developing Countries)

Aug 28, 2015 07:58PM

Isotretinoin conundrum: a randomized, openlabel, crossover study in Mexico to evaluate the bioavailability and bioequivalence of three pharmaceutical preparations of isotretinoin in healthy participants.

CONCLUSION: Oratane and Australian-sourced Roaccutane could be considered bioequivalent, but neither formulation was found to be bioequivalent to Mexican-sourced Roaccutan. PMID: 26308169 [PubMed - as supplied by publisher] (Source: International Journal of Clinical Pharmacology and Therapeutics)

Aug 28, 2015 07:32PM

Two Cases of Occupational Contact Urticaria Caused by Percutaneous Sensitization to Parvalbumin

Conclusion: The patients' histories and findings indicate the possibility of percutaneous sensitization through occupational exposure to parvalbumin, leading to food allergy.Case Rep Dermatol 2015;7:227-232 (Source: Case Reports in Dermatology)

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Aug 28, 2015 07:28PM

Lichen planus and lichenoid reactions as a systemic disease

Lichen planus (LP) is a chronic disease that involves the skin, scalp, mucous membranes, and nails. The etiology of LP is still unknown; however, some external and internal factors (eg. drugs, stress, hepatitis C virus) have been suggested to trigger the disease. Many studies have investigated an immunologic pathogenesis that is probably related to T-cell autoimmunity with the keratinocyte as the target cell. Altered self-antigens on the surface of basal keratinocytes modified by viruses or by drugs are believed to be the targets of the T-cell response. (Source: Clinics in Dermatology)

Aug 28, 2015 07:28PM

Seronegative reactive spondyloarthritis and the skin

Spondyloarthritidies represent a group of conditions affecting the axial and peripheral muscoloskeletal apparatus and are often associated with psoriasis, infections, and inflammatory bowel diseases. Other diseases included in this category are psoriatic arthritis, ankylosing spondylitis, and enteropathic arthritis. Reactive arthritis is an elusive spondyloarthritis, commonly occurring 1 to 3 weeks after a digestive or a genitourinary tract infection, in which microorganisms do not infect the joint directly. (Source: Clinics in Dermatology)

Aug 28, 2015 07:28PM

Pyoderma gangrenosum?a systemic disease?

Pyoderma gangrenosum (PG) is an orphan disease. It belongs to the group of neutrophilic dermatoses. Four major subtypes and several rare manifestations illustrate the great variety of clinical presentations and clinical course. PG is potentially life threatening and associated with a number of internal diseases including chronic inflammatory bowel disease, hematologic disorders, and malignancies. PG itself shows extracutaneous manifestations. These findings are in favor of PG as a systemic disease. (Source: Clinics in Dermatology)

Aug 28, 2015 07:28PM

Cutaneous manifestations of systemic autoinflammatory disorders

Rare systemic autoinflammatory diseases (sAIDs) are driven by cytokine-mediated uncontrolled inflammation that results from activation of innate immune pathways. sAIDs present with recurrent fever episodes, fatigue, musculoskeletal symptoms, gastrointestinal, neurologic, and skin manifestations. They include hereditary monogenic and acquired multifactorial disorders, show a significant morbidity and usually persist for life. Due to the limited awareness of sAIDs, they are often associated with a considerable delay in diagnosis. (Source: Clinics in Dermatology)

Aug 28, 2015 07:28PM

Lyme disease/borreliosis as a systemic disease

Lyme disease/borreliosis (LD) is a well-known arthropod-transmitted entity in the northern hemisphere. The incidence of LD is reportedly rising throughout the world, although better diagnostic facilities may be contributory. The disease distribution is expanding in Europe, with its presence being now documented at higher altitudes and latitudes. Borrelia burgdorferi sensu lato is the most important genospecies leading to LD, although newer ones continue to be discovered. The variations in clinical spectrum with genospecies involved are an interesting feature. (Source: Clinics in Dermatology)

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Aug 28, 2015 07:28PM

Systemic drug reactions with skin involvement: Stevens-Johnson syndrome, toxic epidermal necrolysis, and DRESS

Skin is often affected in adverse drug reactions. Although the majority of cutaneous adverse drug reactions are benign and self-limiting, Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and drug rash with eosinophilia and systemic symptoms (DRESS), affecting multiple organs and systems, are potentially fatal. Many organs can be affected, including the mucosal membranes, gastrointestinal tract, liver, lungs, kidneys, and eyes. We discuss the causes, pathophysiologic aspects, and main clinical features of SJS, TEN, and DRESS as systemic diseases with skin involvement. (Source: Clinics in Dermatology)

Aug 28, 2015 07:28PM

Is herpes simplex a systemic disease?

Orofacial herpes simplex virus infections are usually caused by herpes simplex virus 1 (HSV-1), and HSV-2 infections have been accepted as a sexually transmitted disease. HSV establishes a latent infection in the dorsal root ganglia of the host and remains there for the rest of life. HSV affects mainly skin and genitalia, although in immunocompromised patients it may cause local infection with vast skin involvement, chronic herpetic ulcers, or widespread mucous membrane damage, as well as systemic infections localized in the central and peripheral nervous systems, gastrointestinal tract, and ocular system. (Source: Clinics in Dermatology)

Aug 28, 2015 07:28PM

Systemic involvement in mycosis fungoides

Mycosis fungoides (MF) represents almost 50% of all primary cutaneous lymphomas and more than 70% of cutaneous T-cell lymphomas (CTCL). Arising from preferentially skin-homing lymphocytes with genetic instability, MF evolves through stages (IA-IVB), producing inconspicuous inflammatory features in the beginning and finally resulting in a proliferation of cytomorphologic, phenotypic, and genotypic abnormal tumor cells. Over the past 200 years, there has been much confusion in the classification of lymphomas due to semantic disagreements (MF, CTCL, parapsoriasis, lymphosarcoma, reticulum cell sarcoma, and many other terms), lack of diagnostic standard criteria, and new molecular diagnostic methods. (Source: Clinics in Dermatology)

Aug 28, 2015 07:28PM

Acne - a potential skin marker of internal disease

Polycystic ovary syndrome (PCOS) is the most prevalent endocrine disorder in adult women. Hyperandrogenism is the crux of the pathogenesis of both acne and hirsutism, the most frequent clinical presentations of the syndrome. The chronic anovulation that may occur, often but not always associated with enlarged cystic ovaries, has long been recognized as an important feature of PCOS.In recent years major changes have occurred with regard to PCOS:Although management of the common cutaneous manifestations, mainly acne, hirsutism, alopecia, and acanthosis nigricans, remains strictly within the realm of daily dermatologic practice, the pendulum is shifting toward greater awareness of the longer-term systemic implications of PCOS, with emphasis on the unique opportunity and privileged position of...

Aug 28, 2015 07:28PM

Systemic involvement in localized scleroderma/morphea

Localized scleroderma (LoSc), also known as morphea, is a rare fibrosing disorder of the skin and underlying tissues. Sclerosis is mainly limited to the skin, but subcutaneous tissue, fascia, and underlying muscles and bone may also be involved. In some cases, systemic manifestation with visceral abnormalities may occur. Several publications have focused on significant aspects of LoSc: genetics, immunity, epidemiology, scoring systems, and unification of classifications. Clinical studies featuring large cohorts with the disease published by various international study groups have been of great value in furthering the diagnostic and therapeutic management of LoSc. (Source: Clinics in Dermatology)

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Aug 28, 2015 07:28PM

The skin as a target organ in multisystemic diseases II

Progress in medical science has given a new reading to the claim that the skin could be a mirror of the pathological changes found in the internal organs. The concept that we previously promoted is furthered in this issue; namely that the greatest part of skin diseases are systemic ones.In this issue we focus on another group of diseases with systemic involvement and skin manifestations. We review such inflammatory conditions as lichen planus, autoinflammatory syndromes, and pyoderma gangrenosum focusing on their systemic involvement. (Source: Clinics in Dermatology)

Aug 28, 2015 07:28PM

(History of Mexican Dermatology)

This book is handsome?a foot high with a sober navy blue hard cover featuring a 1905 photograph of Mexico?s General Hospital. The one-volume work is printed on high-quality thick, low-reflectance glossy paper. The print is extremely neat and easy to read. The many pictures (not consecutively numbered) are all in black and white, which to me seems somehow appropriate to a historical treatise. Unfortunately, the thick, heavy pages are not well bound, so they tend to come loose. The 43 co-authors are all leaders in contemporary Mexican dermatology. (Source: Clinics in Dermatology)

Aug 28, 2015 07:28PM

?Work itself is a pleasure.? 200th anniversary of the birth of James Paget (1814-1899)

The year 2014 marked the two hundredth anniversary of the birth of James Paget (1814-1899), one of the most famous of English surgeons. Paget was considered an excellent clinician in his own lifetime and was careful in his scientific observations. Rarely did he ever work fewer than 16 hours a day. Not only did he contribute to the development of surgery, but he also made important dermatologic observations. In addition to describing cases of bone deformations, now called Paget?s disease of the bone, he also described chronic ulceration of the nipple associated with breast cancer, additionally known as Paget?s disease. (Source: Clinics in Dermatology)

Aug 28, 2015 07:28PM

Table of Contents

(Source: Clinics in Dermatology)

Aug 28, 2015 07:28PM

Editorial Board

(Source: Clinics in Dermatology)

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Aug 28, 2015 07:25PM

ST2 receptor invalidation maintains wound inflammation, delays healing and increases fibrosis

This article is protected by copyright. All rights reserved. (Source: Experimental Dermatology)

Aug 28, 2015 06:35PM

Spironolactone: The 'Other' Hormonal Acne Therapy

(MedPage Today) -- Expert: drug is effective and its safety issues can be managed (Source: MedPage Today Dermatology)

Aug 28, 2015 04:09PM

Biomarkers for atopic dermatitis: a systematic review and meta-analysis

Purpose of review: A large number of studies investigating the correlation between severity of atopic dermatitis and various biomarkers have been published over the past decades. The aim of this review was to identify, evaluate and synthesize the evidence examining the correlation of biomarkers with disease severity in atopic dermatitis patients, something that has not been performed previously. Recent findings: Three electronic databases were systematically searched and relevant studies were selected for inclusion. A total of 222 articles, reporting on 115 different biomarkers in 30?063 patients, were critically appraised. Studies were divided into two main groups. The first group consisted of longitudinal randomized controlled trials and cohort studies, which reported measurements at m...

Aug 28, 2015 04:09PM

Current novel approaches in systemic therapy of atopic dermatitis: specific inhibition of cutaneous Th2 polarized inflammation and itch

Purpose of review: This present review gives an overview on different approaches on systemic treatment of atopic dermatitis with a focus on molecules that are presently investigated as defined target structures in clinical studies with patients with atopic dermatitis. Recent findings: Available systemic drugs for the treatment of atopic dermatitis are limited. There is a high need for the development of new treatment regimen. Current studies address novel biologicals or small molecules for the treatment of atopic dermatitis. In particular, interventions in the T-helper 2 cell (Th2) allergic inflammation are promising. Dupilumab, a humanized monoclonal antibody to the interteukin-4R is the first antibody (i.e. ?biological?) with published efficacy shown in controlled prospective studies...

Aug 28, 2015 04:09PM

From genetics to treatment of eosinophilic esophagitis

Purpose of review: Eosinophilic Esophagitis (EoE) is an emerging chronic atopic disease. Recent advances in understanding its genetic and molecular biology pathogenesis may lead to a better management of the disease Recent findings: EoE is an atopic disease. Most of the patients affected by EoE have other atopic diseases such as allergic rhinitis, asthma, IgE-mediated food allergies and/or atopic dermatitis. The local inflammation is a T helper type 2 (Th2) flogosis, which most likely is driven by a mixed IgE and n-IgE-mediated reaction to food and/or environmental allergens. Epidemiological studies show that EoE is an atopic disease with a strong genetic component. Genetic studies have shown that EoE is associated with single nucleotide polymorphism on genes, which are released by the epi...

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Aug 28, 2015 04:06PM

Evaluation of the Role of IgE Responses to Der p 1 and Der p 2 in Chinese House Dust Mite-Allergic Patients

Conclusions: In China, Der p 1 and Der p 2 are the dominant allergens in patients with HDM allergy. The relative importance of Der p 1 and Der p 2 changes with age, in favor of Der p 2. Overall, sIgE titers were positively associated with the number of organs affected.Int Arch Allergy Immunol 2015;167:203-210 (Source: International Archives of Allergy and Immunology)

Aug 28, 2015 04:00PM

Development of a topical ointment of betamethasone dipropionate loaded nanostructured lipid carrier

Publication date: Available online 28 August 2015 Source:Asian Journal of Pharmaceutical Sciences Author(s): Xin Kong, Yuan Zhao, Peng Quan, Liang Fang The purpose of this study was to design an innovative topical ointment containing betamethasone dipropionate loaded nanostructured lipid carrier (BD-NLC) for the treatment of atopic dermatitis (AD). BD-loaded NLC was produced with precirol ATO 5 and oleic oil (OA) by melt emulsification method. Effects of surfactant concentration, amount of solid lipid and liquid lipid on skin retention and skin penetration were investigated by in vitro percutaneous permeation experiment. The optimized BD-NLC showed a homogeneous particle size of 169.1 nm (with PI=0.195), negatively charged surface (?23.4 mV) and high encapsulation efficiency (85%)....

Aug 28, 2015 04:00PM

Diet-induced hypercholesterolemia imparts structure-function changes to erythrocyte chondroitin sulphate/dermatan sulphate

This study was carried out to determine whether diet-induced hypercholesterolemia had any effect on erythrocyte CS/DS and impacted cytoadherence to ECM components. Unlike in diabetes, diet-induced hypercholesterolemia did not show quantitative changes in erythrocyte CS/DS but showed difference in proportion of un-sulphated and 4-O-sulphated disaccharides. Erythrocytes from hypercholesterolemic rats showed increased adhesion to ECM components which was abrogated to various extents when subjected to chondroitinase ABC digestion. However, isolated CS/DS chains showed a different pattern of binding to ECM components indicating that orientation of CS/DS chains could be playing a role in binding. (Source: Journal of Biochemistry)

Aug 28, 2015 04:00PM

ABCB5 Identifies Immunoregulatory Dermal Cells

Publication date: Available online 28 August 2015 Source:Cell Reports Author(s): Tobias Schatton, Jun Yang, Sonja Kleffel, Mayuko Uehara, Steven R. Barthel, Christoph Schlapbach, Qian Zhan, Stephen Dudeney, Hansgeorg Mueller, Nayoung Lee, Juliane C. de Vries, Barbara Meier, Seppe Vander Beken, Mark A. Kluth, Christoph Ganss, Arlene H. Sharpe, Ana Maria Waaga-Gasser, Mohamed H. Sayegh, Reza Abdi, Karin Scharffetter-Kochanek, George F. Murphy, Thomas S. Kupper, Natasha Y. Frank, Markus H. Frank Cell-based strategies represent a new frontier in the treatment of immune-mediated disorders. However, the paucity of markers for isolation of molecularly defined immunomodulatory cell populations poses a barrier to this field. Here, we show that ATP-binding cass...

Aug 28, 2015 04:00PM

Association between childhood eczema and headaches: An analysis of 19 US population-based studies

Atopic dermatitis (or eczema) is a chronic inflammatory disorder associated with sleep disturbances and quality-of-life impairment. Sleep disturbances have been shown to cause headaches in childhood. However, an association between eczema and headaches is not well established. (Source: Journal of Allergy and Clinical Immunology)

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Aug 28, 2015 04:00PM

Successful treatment of bilateral multiple lymph node metastases in extramammary Paget's disease with surgery and sequential chemotherapy of S?1 and docetaxel

(Source: The Journal of Dermatology)

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Aug 28, 2015 04:00PM

Real-time vascular imaging and photodynamic therapy efficacy with micelle-nanocarrier facilitate the delivery of chlorin e6 to the microenvironment of melanoma

Cancer cells in primary tumors are surrounded by a complex microenvironment comprised of numerous types of cells, including endothelial cells of the blood and lymphatic circulation, stromal fibroblasts and a variety of bone marrow-derived cells such as macrophages and endothelial cell progenitors [1]. Endothelial cells are indispensible for angiogenesis, the process whereby new vasculature develops, which plays a pivotal role in tumor growth, invasion and metastasis [2,3]. Hence the tumor vasculature is an attractive target for cancer therapy. (Source: Journal of Dermatological Science)

Aug 28, 2015 04:00PM

Development of a Patient-Reported Outcome Questionnaire for Use in Adults with Moderate-to-Severe Plaque Psoriasis: the Psoriasis Symptoms and Signs Diary

Conclusion The PSSD, developed according to the Food and Drug Administration (FDA) PRO Guidance, assesses severity of symptoms and signs commonly associated with plaque PsO. Its measurement properties are currently being evaluated. (Source: Journal of Dermatology and Dermatologic Surgery)

Aug 28, 2015 04:00PM

Diffuse intramuscular lipoma responsible of monomelic hypertrophy

Conclusion This case report described an adult female patient with an unusually intramuscular lipoma where magnetic resonance imaging was playing an important role in the diagnostic. Indeed the intramuscular is a benign fatty tumor with characteristic appearance on MRI. Its management should be considered in multidisciplinary collaboration. (Source: Journal of Dermatology and Dermatologic Surgery)

Aug 28, 2015 12:17PM

CMS: We?re ready to accept and process ICD-10 claims

The Centers for Medicare and Medicaid Services says it completed its final Medicare fee-for-service end-to-end testing of ICD-10 with positive results. ?This final end-to-end testing [that occurred July 20-24] demonstrated that CMS systems are ready to accept and process ICD-10 claims,? the... (Source: Skin and Allergy News)