Aug 19, 2008 11:57PM

A study of the mu opioid receptor gene polymorphism a118g in patients with primary biliary cirrhosis with and without pruritus.

A Study of the Mu Opioid Receptor Gene Polymorphism A118G in Patients with Primary Biliary Cirrhosis with and without Pruritus.

Acta Derm Venereol. 2008;88(4):323-6

Authors: Wei LX, Floriani A, Variola A, El Younis C, Bergasa NV

The increase in opioidergic tone by the central administration of morphine, which binds to the mu opioid receptor, is associated with pruritus. Pruritus is a symptom of cholestasis, which appears to result, in part, from increased opioidergic tone; a central mechanism has been proposed. The single nucleotide polymorphism Al18G in exon 1 of the opioid receptor mu 1 (OPRM1) gene, which codes for the mu opioid receptor, has been associated with alterations in functions mediated by the endogenous opioid system. In this study we found A118G in hetero-zygosity in 29% of the DNA samples from patients with primary biliary cirrhosis from the USA and from Italy with and without pruritus. A118G was 1.5 times more frequent in the samples from patients without pruritus from the USA than in the rest of the samples. The possibility of protection from pruritus associated with A118G supports the study of genetic polymorphisms of the OPRM1 gene in patients with cholestasis.

PMID: 18709298 [PubMed - in process]

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Aug 19, 2008 11:57PM

In vitro and in vivo characterization of a novel liposomal butorphanol formulation for treatment of pruritus.

In vitro and In vivo Characterization of a Novel Liposomal Butorphanol Formulation for Treatment of Pruritus.

Acta Derm Venereol. 2008;88(4):327-30

Authors: Lim GJ, Ishiuji Y, Dawn A, Harrison B, Kim do W, Atala A, Yosipovitch G

As yet no transdermal topical formulations have been developed for the treatment of chronic itch. We developed a formulation containing 2 mg butorphanol tartrate in 100 microl purified water encapsulated into multilamellar phospholipid vesicles. Drug permeation experiments were studied with Franz diffusion chambers using human skin in vitro and on rat skin in vivo. Histological analysis of rat skins was performed to evaluate skin irritation of the formulation in vivo. Physical properties showed stable formulation with desirable viscosity. In vitro dermal penetration rate data suggest that there was significant permeation at time-points 2 h and 4 h, and a steady state was achieved afterwards to 24 h. Maximal plasma butorphanol concentration was noted at 2 h and steady state was achieved at 8 h. Visual skin assessment as well as histological analysis of excised rat skin did not demonstrate any evidence of inflammation and irritation. In vitro and in vivo analysis demonstrated release of a consistent amount of butorphanol in a sustained manner for 24 h. This liposomal transdermal delivery formulation could serve as a method to deliver butorphanol for patients with chronic pruritus.

PMID: 18709299 [PubMed - in process]

Aug 19, 2008 11:57PM

Frequency of bacteria, candida and malassezia species in balanoposthitis.

Frequency of bacteria, Candida and malassezia species in balanoposthitis.

Acta Derm Venereol. 2008;88(4):331-6

Authors: Alsterholm M, Flytström I, Leifsdottir R, Faergemann J, Bergbrant IM

Balanoposthitis is an inflammatory disorder of the prepuce and glans penis. Microbes involved in balanopos-thitis have been investigated, but no single study has cove-red the growth of both bacteria, Candida and Malassezia. We report here the prevalence of these microbes in 100 patients with balanoposthitis and in 26 control patients. Among patients with balanoposthitis there was a significantly higher frequency of positive cultures than in the control group (59% and 35%, respectively, p<0.05). In the balanoposthitis group Staphylococcus aureus was found in 19%, group B streptococci in 9%, Candida albicans in 18% and Malassezia in 23% of patients. In the control group S. aureus was not found at all, whereas C. albicans was found in 7.7% and Malassezia in 23% of patients. Different microbes did not correspond with distinct clinical manifestations. In summary, we report increased frequency of microbes, specifically S. aureus, in the area of the prepuce and glans penis in balanoposthitis.

PMID: 18709300 [PubMed - in process]

Aug 19, 2008 11:57PM

Inflammation and hypercoagulable state in adult psoriatic men.

Inflammation and hypercoagulable state in adult psoriatic men.

Acta Derm Venereol. 2008;88(4):337-40

Authors: Karabudak O, Ulusoy RE, Erikci AA, Solmazgul E, Dogan B, Harmanyeri Y

Hyperhomocysteinaemia is a well-known risk factor for cardiovascular disease and plays a role in athero-thrombosis. Psoriasis is a common chronic and recurrent inflammatory skin disease associated with increased thrombosis. The aim of this study was to examine serum homocysteine levels and their relationships with inflammatory and atherothrombotic markers in psoriasis. Twenty patients with mild or moderate psoriasis and 20 age-matched healthy men were included in this study. Patients with acquired hyperhomocysteinaemia were excluded from both groups. The inflammation markers, mean platelet volume, C-reactive protein and ceruloplasmin levels, were significantly increased in the study group compared with the control group. In the study group there was decreased antithrombin III and total homocysteine levels, for haemostatic parameters. Folic acid levels, cardiovascular risk factors, endothelial inflammation markers and blood coagulation factors demonstrated significant correlations. Folic acid levels correlated inversely with homocysteine and positively with fibrinogen levels. In conclusion, increased homocysteine concentration and inflammation markers may play a role in the atherothrombotic state in psoriasis.

PMID: 18709301 [PubMed - in process]

Aug 19, 2008 11:57PM

Measurement of liver iron content by magnetic resonance imaging in 20 patients with overt porphyria cutanea tarda before phlebotomy therapy: a prospective study.

Measurement of Liver Iron Content by Magnetic Resonance Imaging in 20 Patients with Overt Porphyria Cutanea Tarda before Phlebotomy Therapy: A Prospective Study.

Acta Derm Venereol. 2008;88(4):341-5

Authors: Dereure O, Jumez N, Bessis D, Gallix B, Guillot B

Liver iron content was evaluated by a magnetic resonance imaging-based method in 20 consecutive patients with either sporadic or familial porphyria cutanea tarda. Serum ferritin, hepatitis C infection and the presence of the 2 main mutations of the hemochromatosis gene were also investigated. All patients showed good clinical response to phlebotomy. Initial liver iron content was normal (< 40 mumol/g) in 9 cases, slightly increased (40-59 mumol/g) in 3 cases, moderately increased (60-99 mumol/g) in 6 cases or markedly increased (100-199 mumol/g) in 2 cases). The ferritin level was raised (> 400 ng/ml) in 14/20 patients and there was no obvious relationship with liver iron. Increased liver iron content was observed more frequently in patients with hemochromatosis mutation and less frequent in those with hepatitis C infection. Clinical response to phlebotomies was slightly better in patients with increased liver iron content even slightly, but patients with normal liver iron content also responded well, which suggests that iron depletion is an outstanding treatment independent of liver iron content. This study shows that increased liver iron content is not a constant finding in patients with porphyria cutanea tarda, especially in women, and that it is not a prerequisite for the efficiency of phlebotomy.

PMID: 18709302 [PubMed - in process]

Aug 19, 2008 11:57PM

Atrichia with papular lesions: a report of three novel human hairless gene mutations and a revision of diagnostic criteria.

Atrichia with papular lesions: a report of three novel human hairless gene mutations and a revision of diagnostic criteria.

Acta Derm Venereol. 2008;88(4):346-9

Authors: Yip L, Horev L, Sinclair R, Zlotogorski A

Atrichia with papular lesions is a rare autosomal recessive condition characterized by complete irreversible hair loss during the first months of life and papules that appear during early childhood. Atrichia with papular lesions is frequently misdiagnosed as alopecia universalis, despite increasing reports of its prevalence and the presence of well-defined diagnostic criteria. Most cases of atrichia with papular lesions have been reported in consanguineous families residing in small geographical regions, but the increasing number of sporadic cases of unrelated individuals suggests that atrichia with papular lesions is more common than previously thought. Mutations in the human hairless gene on chromosome 8p12 have been implicated in this disease. Here, we report two novel heterozygous mutations in an Australian family and a novel homozygous mutation in 2 Arab siblings. We also revise the diagnostic criteria for atrichia with papular lesions in order to clarify its uniqueness and distinguishing features from alopecia universalis.

PMID: 18709303 [PubMed - in process]

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Aug 19, 2008 11:57PM

Febrile ulceronecrotic mucha-habermann disease: a case report and review of the literature.

Febrile ulceronecrotic mucha-habermann disease: a case report and review of the literature.

Acta Derm Venereol. 2008;88(4):350-5

Authors: Sotiriou E, Patsatsi A, Tsorova C, Lazaridou E, Sotiriadis D

Febrile ulceronecrotic Mucha-Habermann disease is a severe variant of pityriasis lichenoides et varioliformis acuta characterized by the sudden onset of ulceronecrotic skin lesions and associated with high fever and systemic symptoms. We report here a case of a 20-year-old woman in whom the disease started as pityriasis lichenoides et varioliformis acuta and evolved to febrile ulceronecrotic Mucha-Habermann disease. Almost 90% of the body surface was involved, together with high fever and malaise. Steroids alone proved to be an insufficient therapeutic procedure. The remission achieved was attributed to the use of methotrexate. To our knowledge, only 39 cases of febrile ulceronecrotic Mucha-Habermann disease have been reported in the literature to date.

PMID: 18709304 [PubMed - in process]

Aug 19, 2008 11:57PM

Patient's estimation of efficacy of various hyperhidrosis treatments in a dermatological clinic.

Patient's Estimation of Efficacy of Various Hyperhidrosis Treatments in a Dermatological Clinic.

Acta Derm Venereol. 2008;88(4):356-62

Authors: Amini M, Harmsze AM, Tupker RA

Hyperhidrosis is a common ailment, which is accompanied by a low quality of life. There are many current treatment options. The aims of this study were to investigate: (i) the characteristics of sweating in patients referred for hyperhidrosis; (ii) their quality of life, using the Dermatology Life Quality Index and the Hyperhidrosis Disease Severity Scale; and (iii) their estimation of efficacy of the treatments given, using a patient's global assessment score and the quality of life scores. In 47 of 94 patients (50%) responding to the questionnaires, hyperhidrosis was confined exclusively to the axillae. In 21 (22%) of the patients, sweating in the axillae was combined with sweating of the hands and/or feet, face or other, more widespread, regions. Fifteen patients (16%) had generalized hyperhidrosis. In half of all cases, sweating occurred in attacks. Attacks were mostly triggered by warmth, exercise, emotions, or had no apparent cause. Quality of life was low in all cases. All treatments improved quality of life.

PMID: 18709305 [PubMed - in process]

Aug 19, 2008 11:57PM

Clinical manifestations and characteristics of patients with acute generalized exanthematous pustulosis in asia.

Clinical manifestations and characteristics of patients with acute generalized exanthematous pustulosis in Asia.

Acta Derm Venereol. 2008;88(4):363-5

Authors: Chang SL, Huang YH, Yang CH, Hu S, Hong HS

Acute generalized exanthematous pustulosis is a rare, sterile inflammation of the skin (and mucous membranes) characterized by acute onset of generalized pustule formation, fever and leukocytosis, and a rapid resolution. A computer-based search of the literature revealed only a limited series of reports, none of them based on Asian patients. We identified and retrospectively analysed 16 biopsy-proven and criteria-matched patients over a 15-year period in a single medical centre. The study showed a female predominance (11 of 16 patients), a relatively low association with systemic drugs (62.5% vs. 87% in a previous report) and normal renal function (in contrast to a previous report where 32% of patients had renal failure). The study also revealed high levels of C-reactive protein (76.0 mg/l) and normal absolute eosinophil count (176.2/mul) in most patients. Furthermore, there was no difference between different treatment regimens regard-ing the course and duration of the disease or the length of fever (p>0.05). In addition, if the patients were subdivided by aetiology into those strongly associated with or not strongly associated with systemic drugs, a significant difference was found in age of onset between the 2 groups (p<0.01).

PMID: 18709306 [PubMed - in process]

Aug 19, 2008 11:57PM

Cooling by frozen gel pack as pain relief during treatment of axillary hyperhidrosis with botulinum toxin a injections.

Cooling by frozen gel pack as pain relief during treatment of axillary hyperhidrosis with botulinum toxin a injections.

Acta Derm Venereol. 2008;88(4):366-9

Authors: Skiveren J, Kjaerby E, Nordahl Larsen H

Botulinum toxin A injection is a well-described efficacious treatment for axillary hyperhidrosis. Although considered a safe treatment, many patients experience pain during injections. The purpose of the present study was to examine whether cooling by frozen gel packs applied in the axilla for 5 min before treatment could reduce pain. Thirty-six patients with axillary hyperhidrosis were included in this randomized, open-label prospective study, in which patients were their own controls. Pain was assessed before, during (four times), and immediately after treatment, using a numeric rating scale. The patients experienced statistically significant pain reduction, of 14-19%, in areas cooled by frozen gel pack (p<0.01). However, the clinical relevance of this relatively small pain reduction is questionable.

PMID: 18709307 [PubMed - in process]

Aug 19, 2008 11:57PM

Clinical follow-up of 102 anti-ro/ssa-positive patients with dermatological manifestations.

Clinical Follow-up of 102 Anti-Ro/SSA-positive Patients with Dermatological Manifestations.

Acta Derm Venereol. 2008;88(4):370-5

Authors: Popovic K, Wahren-Herlenius M, Nyberg F

Patients with Ro/SSA autoantibodies can develop cutaneous lupus erythematosus and photosensitivity. The aim of this study was to evaluate disease progression and clinical outcome in Ro/SSA-positive patients after 2 years in a prospectively followed cohort. A total of 102 previously clinically and serologically characterized Ro/SSA-positive patients received a questionnaire 2 years after the baseline investigation. Evaluation of 98 questionnaire responses was performed and clinical exami-nation was offered to patients with cutaneous lupus erythematosus established at baseline, or skin symptoms developed over the 2 year period since baseline. Skin symptoms (42%) and arthralgia (31%) were common self-reported health-related answers. Twenty of the 98 patients (20%) showed disease progression with development of new diagnoses such as drug-induced subacute cutaneous lupus erythematosus. This prospective study reveals that new autoimmune diseases and skin disease progress are common in Ro/SSA-positive patients also in the short-term perspective, and stresses the importance of regular follow-up of these patients.

PMID: 18709308 [PubMed - in process]

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Aug 19, 2008 11:57PM

Targeted broadband ultraviolet b phototherapy produces similar responses to targeted narrowband ultraviolet b phototherapy for vitiligo: a randomized, double-blind study.

Targeted Broadband Ultraviolet B Phototherapy Produces Similar Responses to Targeted Narrowband Ultraviolet B Phototherapy for Vitiligo: A Randomized, Double-blind Study.

Acta Derm Venereol. 2008;88(4):376-81

Authors: Asawanonda P, Kijluakiat J, Korkij W, Sindhupak W

Narrowband ultraviolet B (NB-UVB) phototherapy, with a 308-nm xenon chloride excimer laser, and targeted UVB phototherapy have produced encouraging therapeutic results for vitiligo. However, very few studies employing broadband UVB exist. Moreover, there has been no direct comparison study between broadband UVB and NB-UVB for the treatment of vitiligo. The aims of this study were to compare the repigmenting efficacy of targeted broadband UVB phototherapy with that of NB-UVB in an equi-erythemogenic manner. Twenty identical vitiliginous lesions from 10 patients were randomly allocated to receive either targeted broadband UVB or targeted NB-UVB phototherapy. UV fluences were started at 50% of the minimal erythema dose detected within the vitiliginous patches, then increased gradually, in the same manner, to ensure equi-erythemogenic comparison. Treatments were carried out twice weekly for 12 weeks. The results show that grade 1, i.e. 1-25% repigmentation, to grade 2, 26-50% repigmentation, occurred in 6 of 10 subjects. Responses in terms of repigmentation, de--pigmentation, or lack thereof, were similar between lesions receiving broadband and NB-UVB phototherapy. Onset of repigmentation occurred as early as 4 weeks of treatment in most subjects. Treatments were well tolerated, with only minimal erythema and hyperpigmentation. Limitations: the study was carried out in a small number of patients with skin types III, IV and V. The irradiation device was a targeted UVB device and thus the results may not be applicable to other light sources, such as the excimer laser or total-body irradiation cabinets. In conclusion, targeted broadband UVB produces similar clinical responses to targeted NB-UVB in the treatment of the non-segmental type of vitiligo.

PMID: 18709309 [PubMed - in process]

Aug 19, 2008 11:57PM

Segmentally arranged basaloid follicular hamartomas with osseous, dental and cerebral anomalies: a distinct syndrome.

Segmentally arranged basaloid follicular hamartomas with osseous, dental and cerebral anomalies: a distinct syndrome.

Acta Derm Venereol. 2008;88(4):382-7

Authors: Happle R, Tinschert S

A 39-year-old man presented with multiple basaloid follicular hamartomas involving the right side of his body in a systematized pattern following Blaschko's lines. His right leg was 22.5 cm shorter than the left, and rudimentary pre-axial polydactyly was noted on the left hand and the right foot. The teeth of the right maxilla were hypoplastic. DNA analysis of blood lymphocytes and fibroblasts from lesional skin did not reveal any mutation in the Patched gene. On account of this case and of 8 similar cases found in th e literature, the spectrum of a distinct syndrome is delineated. Ipsilateral extracutaneous defects include cervical ribs, polydactyly, malformed thumb and disproportionate overgrowth or deficient growth of limb bones; dental anomalies in the form of anodontia, hypodontia or ameloblastoma; and cerebral defects such as mental retardation, unsteady gait, meningioma and optic glioma. The cutaneous lesions of this syndrome should not be called "basal cell naevus" as this will lead to continuing confusion with Gorlin syndrome. The molecular basis of the disorder remains to be elucidated.

PMID: 18709310 [PubMed - in process]

Aug 19, 2008 11:57PM

Punch-grafting to enhance healing and to reduce pain in complicated leg and foot ulcers.

Punch-grafting to Enhance Healing and to Reduce Pain in Complicated Leg and Foot Ulcers.

Acta Derm Venereol. 2008;88(4):389-91

Authors: Nordström A, Hansson C

PMID: 18709311 [PubMed - in process]

Aug 19, 2008 11:57PM

Interaction of human papillomavirus dna with factor xiiia-positive dermal dendrocytes in vulvar lesions.

Interaction of Human Papillomavirus DNA with Factor XIIIa-positive Dermal Dendrocytes in Vulvar Lesions.

Acta Derm Venereol. 2008;88(4):391-3

Authors: Pereira NV, Pagliari C, Fernandes ER, Guedes F, Sotto MN, Duarte MI

PMID: 18709312 [PubMed - in process]

Aug 19, 2008 11:57PM

Bullous dermatomyositis: a marker of poor prognosis and aggressive internal malignancy?

Bullous dermatomyositis: a marker of poor prognosis and aggressive internal malignancy?

Acta Derm Venereol. 2008;88(4):393-4

Authors: Zangrilli A, Papoutsaki M, Bianchi L, Teoli M, Chimenti S

PMID: 18709313 [PubMed - in process]

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Aug 19, 2008 11:57PM

Spontaneous regression of generalized angiolymphoid hyperplasia with eosinophilia in a 2-year-old boy.

Spontaneous Regression of Generalized Angiolymphoid Hyperplasia with Eosinophilia in a 2-year-old Boy.

Acta Derm Venereol. 2008;88(4):395-6

Authors: Koizumi H, Okuyama R, Tagami H, Aiba S

PMID: 18709314 [PubMed - in process]

Aug 19, 2008 11:57PM

Vogt-koyanagi-harada syndrome associated with psoriasis and autoimmune thyroid disease.

Vogt-koyanagi-harada syndrome associated with psoriasis and autoimmune thyroid disease.

Acta Derm Venereol. 2008;88(4):397-8

Authors: Kluger N, Mura F, Guillot B, Bessis D

PMID: 18709315 [PubMed - in process]

Aug 19, 2008 11:57PM

Diagnosis of hailey-hailey disease facilitated by dna testing: a novel mutation in atp2c1.

Diagnosis of Hailey-Hailey Disease Facilitated by DNA Testing: A Novel Mutation in ATP2C1.

Acta Derm Venereol. 2008;88(4):399-400

Authors: Nemoto-Hasebe I, Akiyama M, Osawa R, Nakamura H, Shimizu H

PMID: 18709316 [PubMed - in process]

Aug 19, 2008 11:57PM

Bullous pemphigoid of the perineum and perianal area: a rare localized form in adults.

Bullous pemphigoid of the perineum and perianal area: a rare localized form in adults.

Acta Derm Venereol. 2008;88(4):401

Authors: Patsatsi A, Lazaridou E, Papagaryfallou I, Sotiriadis D

PMID: 18709317 [PubMed - in process]

Aug 19, 2008 11:57PM

Coexistence of diffuse reactive angioendotheliomatosis and neutrophilic dermatosis heralding primary antiphospholipid syndrome.

Coexistence of diffuse reactive angioendotheliomatosis and neutrophilic dermatosis heralding primary antiphospholipid syndrome.

Acta Derm Venereol. 2008;88(4):402-3

Authors: Kawaoka J, McBean J, Li H, Mihm MC, Kroumpouzos G

PMID: 18709318 [PubMed - in process]

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Aug 19, 2008 11:57PM

Successful treatment of an elderly patient with refractory ultraviolet-a-sensitive atopic eczema with mycophenolic acid.

Successful Treatment of an Elderly Patient with Refractory Ultraviolet-A-sensitive Atopic Eczema with Mycophenolic Acid.

Acta Derm Venereol. 2008;88(4):404-5

Authors: Bär M, Schmitt J, Bauer A, Wozel G, Meurer M

PMID: 18709319 [PubMed - in process]

Aug 19, 2008 11:57PM

Keratitis-ichthyosis-deafness syndrome lacking subjective hearing impairment.

Keratitis-ichthyosis-deafness syndrome lacking subjective hearing impairment.

Acta Derm Venereol. 2008;88(4):406-8

Authors: Nemoto-Hasebe I, Akiyama M, Yamada N, Inoue Y, Touge C, Shimizu H

PMID: 18709320 [PubMed - in process]

Aug 19, 2008 11:57PM

Traumatized recurrent melanocytic naevus with typical starburst pattern on dermoscopy.

Traumatized recurrent melanocytic naevus with typical starburst pattern on dermoscopy.

Acta Derm Venereol. 2008;88(4):408-9

Authors: Yoshida Y, Yamada N, Adachi K, Tanaka M, Yamamoto O

PMID: 18709321 [PubMed - in process]

Aug 19, 2008 11:57PM

Paraneoplastic pemphigus developed shortly after resection of follicular dendritic cell sarcoma.

Paraneoplastic pemphigus developed shortly after resection of follicular dendritic cell sarcoma.

Acta Derm Venereol. 2008;88(4):410-2

Authors: Lee SE, Kim HR, Hashimoto T, Kim SC

PMID: 18709322 [PubMed - in process]

Aug 19, 2008 11:57PM

Blue naevus with pigment network-like structure on dermoscopy.

Blue Naevus with Pigment Network-like Structure on Dermoscopy.

Acta Derm Venereol. 2008;88(4):412-3

Authors: Tsunemi Y, Saeki H, Tamaki K

PMID: 18709323 [PubMed - in process]

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Aug 19, 2008 11:57PM

Photosensitive psoriasis vulgaris inducible by a single suberythematous dose of ultraviolet b irradiation.

Photosensitive psoriasis vulgaris inducible by a single suberythematous dose of ultraviolet B irradiation.

Acta Derm Venereol. 2008;88(4):414-6

Authors: Buhl T, Krüger U, Emmert S, Bertsch HP, Mössner R

PMID: 18709324 [PubMed - in process]

Aug 19, 2008 11:57PM

Staphylococcal scalded skin syndrome as a harbinger of late-onset staphylococcal septicaemia in a premature infant of very low birth weight.

Staphylococcal Scalded Skin Syndrome as a Harbinger of Late-onset Staphylococcal Septicaemia in a Premature Infant of Very Low Birth Weight.

Acta Derm Venereol. 2008;88(4):416-7

Authors: Hütten M, Heimann K, Baron JM, Wenzl TG, Merk HF, Ott H

PMID: 18709325 [PubMed - in process]

Aug 19, 2008 11:57PM

Psoriasis vulgaris associated with acne vulgaris: differential effects of biologicals?

Psoriasis vulgaris associated with acne vulgaris: differential effects of biologicals?

Acta Derm Venereol. 2008;88(4):418-9

Authors: Colsman A, Sticherling M

PMID: 18709326 [PubMed - in process]

Aug 19, 2008 11:57PM

Beneficial and rapid effect of infliximab on the course of toxic epidermal necrolysis.

Beneficial and rapid effect of infliximab on the course of toxic epidermal necrolysis.

Acta Derm Venereol. 2008;88(4):420-1

Authors: Wojtkiewicz A, Wysocki M, Fortuna J, Chrupek M, Matczuk M, Koltan A

PMID: 18709327 [PubMed - in process]

Aug 19, 2008 11:57PM

Primary cutaneous epithelioid angiosarcoma.

Primary cutaneous epithelioid angiosarcoma.

Acta Derm Venereol. 2008;88(4):422-3

Authors: Kikuchi A, Satoh T, Yokozeki H

PMID: 18709328 [PubMed - in process]

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Aug 19, 2008 11:57PM

A bhd germline mutation identified in an asian family with birt-hogg-dubé syndrome.

A BHD Germline Mutation Identified in an Asian Family with Birt-Hogg-Dubé Syndrome.

Acta Derm Venereol. 2008;88(4):423-5

Authors: Misago N, Joh K, Yatsuki H, Soejima H, Narisawa Y

PMID: 18709329 [PubMed - in process]

Aug 19, 2008 11:57PM

Pseudoporphyria or porphyria cutanea tarda? diagnostic and treatment difficulties.

Pseudoporphyria or porphyria cutanea tarda? Diagnostic and treatment difficulties.

Acta Derm Venereol. 2008;88(4):426-7

Authors: Fevang SA, Kroon S, Skadberg O

PMID: 18709330 [PubMed - in process]

Aug 19, 2008 11:57PM

Skin nodules in rheumatoid arthritis due to infection with mycobacterium haemophilum.

Skin Nodules in Rheumatoid Arthritis Due to Infection with Mycobacterium haemophilum.

Acta Derm Venereol. 2008;88(4):428-9

Authors: Seitz CS, Trautemann A, Bröcker EB, Abele-Horn M, Goebeler M

PMID: 18709331 [PubMed - in process]

Aug 18, 2008 11:00PM

Study lets teens sound off on acne therapies

Title: Study Lets Teens Sound Off on Acne TherapiesCategory: Health NewsCreated: 8/19/2008 2:00:00 AMLast Editorial Review: 8/19/2008 (Source: MedicineNet Skin General)

Aug 18, 2008 02:13AM

Origin of threshold behaviour in psoriatic skin

Dermatology 2008;217:295-298 (DOI:10.1159/000151354) (Source: Dermatology)

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Aug 18, 2008 02:13AM

Treatment following an evidence-based algorithm versus individualised symptom-oriented treatment for atopic eczema

Dermatology 2008;217:299-308 (DOI:10.1159/000151355) (Source: Dermatology)

Aug 17, 2008 11:00PM

Hurricane preparedness

Title: Hurricane PreparednessCategory: Diseases and ConditionsCreated: 8/16/2004Last Editorial Review: 8/18/2008 (Source: MedicineNet Skin General)

Aug 17, 2008 08:00PM

Intracutaneous injection of the macrophage-activating lipopeptide-2 (malp-2) which accelerates wound healing in mice – a phase i trial in 12 patients

Please cite this paper as: Intracutaneous injection of the macrophage-activating lipopeptide-2 (MALP-2) which accelerates wound healing in mice [ndash] a phase I trial in 12 patients. Experimental Dermatology 2008.Abstract: Chronic skin ulcers, such as leg ulcers, pressure sores and diabetic foot ulcers, are a challenge to physicians and medical personnel and a cause of tremendous discomfort and ensuing loss of quality of life to the patients. Wound healing involves production and action of various growth factors. A novel approach, distinct from the application of single growth factors, is the administration of the macrophage stimulator macrophage-activating lipopeptide-2 (MALP-2). The rationale is based on the finding that macrophages are the main source of several growth factors required for wound healing, which are sequentially released during this process. MALP-2 has previously been shown to be effective in an established animal model with diabetic mice. The purpose of the present phase I study was to establish tolerability of MALP-2 when applied into small cutaneous wounds in human beings. Twelve patients (six females and six males; mean age 66.8 years; range 52[ndash]87 years) with different diagnoses were enrolled into the study. An artificial wound was created with a 2-mm diameter skin biopsy punch and a volume of 30 [mu]l MALP-2 (0.125[ndash]1 [mu]g) or vehicle control, respectively, was injected intracutaneously into the wound and closed with a water-resistant transparent adhesive. Photos were taken daily from every patient up to 6 days, and skin biopsies were performed after 1 week from six patients. We could show in the present study for the first time that MALP-2 caused a transient erythema and was tolerated without any systemic side effects up to a dose of 1 [mu]g per wound in human beings. In healthy as well as in diabetic patients, MALP-2 induced local inflammation that faded after 48 h. The effectiveness of MALP-2 in the healing of chronic wounds in humans, e.g. in chronic skin ulcers, such as leg ulcers, pressure sores and diabetic foot ulcers, could now be addressed in further studies. (Source: Experimental Dermatology)

Aug 17, 2008 08:00PM

Skinsight: dermoscopy of trichostasis spinulosa

(Source: Archives of Dermatology)

Aug 17, 2008 08:00PM

Correction: error in "methods" section in: delayed immune-mediated adverse effects of polyalkylimide dermal fillers: clinical findings and long-term follow-up

(Source: Archives of Dermatology)

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Aug 17, 2008 08:00PM

Correspondence: palmar-plantar erythrodysesthesia secondary to sunitinib treatment resulting in necrotic foot syndrome aggravated by background diabetic vascular disease

(Source: Archives of Dermatology)

Aug 17, 2008 08:00PM

Correspondence: palmar-plantar erythrodysesthesia caused by mercaptopurine and mesalamine

(Source: Archives of Dermatology)

Aug 17, 2008 08:00PM

Correspondence: extensive nodular secondary syphilis with prozone phenomenon

(Source: Archives of Dermatology)

Aug 17, 2008 08:00PM

Correspondence: pleomorphic adenoma of the soft palate

(Source: Archives of Dermatology)

Aug 17, 2008 08:00PM

Correspondence: neuroma formation and toe amputation resulting from stonefish envenomation

(Source: Archives of Dermatology)

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Aug 17, 2008 08:00PM

Correspondence: therapeutic effect of argatroban on rheumatoid vasculitis with antiphosphatidylserine-prothrombin complex antibody

(Source: Archives of Dermatology)

Aug 17, 2008 08:00PM

Correspondence: successful treatment of darier disease with the flashlamp-pumped pulsed-dye laser

(Source: Archives of Dermatology)

Aug 17, 2008 08:00PM

Correspondence: a pigmented, hemorrhagic genital wart: clinical, dermoscopic, and histopathologic features

(Source: Archives of Dermatology)

Aug 17, 2008 08:00PM

Correspondence: the use of patch tests in determining hypersensitivity to etanercept and infliximab--reply

(Source: Archives of Dermatology)