Dr. William Ting, Board-Certified Dermatologist
at California Dermatology Care
2262 Camino Ramon, San Ramon, CA 94583
500 Alfred Nobel Drive, Suite #185, Hercules, CA 94547
Tel: 925-328-0255
Email: staff@CalDermCare.com


Advanced Care with a Personal Touch

   

 

 

Medical Dermatology    Evidence-based medicine   Customized solution   Personal care

Latest Dermatology Headlines

Dr. William Ting has expertise in treating the entire spectrum of medical dermatology, with emphasis in preventive medicine and personalized recommendations. He enjoys taking care of patients with acne, eczema, hair and nail disorders, rashes, psoriasis and skin cancers.

He is at the forefront of medical dermatology and dermatologic research. He continues to publish articles in peer-reviewed dermatology journals. He is an early pioneer of photodynamic therapy (PDT) and one of the most experienced practitioners of PDT in the Bay Area. He is the first dermatologist in the San Francisco Bay Area and Northern California to introduce Lutronic Spectra Laser for melasma, acne, scar revision, pore size reduction as well as the Cutera GenesisPlus laser for advanced nail fungus laser treatment, keloid and hypertrophic scar, warts and scar revision.

Dr. Ting is a fellow of the American Academy of Dermatology (AAD) and American Society of Dermatologic Surgery (ASDS). He is a member of the National Psoriasis Foundation and International Hyperhidrosis Society.

Innovative Therapeutic Approach to Common Skin Conditions

Acne

Eczema (Atopic Dermatitis)

Hair and Nail disorders

  • Maximize therapeutic synergy and efficacy by utilizing both prescription-strength and over-the counter products when available
  • Comprehensive workup including bloodwork and biopsy if necessary
  • Systemic oral hormonal therapy for women and men when indicated

Psoriasis 

Rosacea

  • Multi-prong approach to minimize redness
  • Low-dose 'non-antibiotic' anti-inflammatory oral medication for long-term remission 
  • Emphasis on prevention
  • Fotofacial/IPL laser utilizing Cynosure XPL/Elite MPX
  • Cutera GenesisPlus Laser with or without combination with IPL 
  • Diode laser for facial veins
  • VBeam Pulse Dye Laser, the new gold standard for rosacea and facial redness

Skin Cancer 

  • Emphasis on prophylactic treatments with topical 5-FU, imiquimod, diclofenac, ingenol mebutate and oral chemopreventive therapy such as Soriatane.
  • Reduce future risks of skin cancer with photodynamic therapy, TCA chemical peels and/or fractional CO2 resurfacing laser  
  • Mohs Surgery to achieve highest cure rate and tissue sparing
  • Close colloboration with plastic surgeon(s) as needed  

Sweating Disorder (Hyperhidrosis) 

Vitiligo

Warts 


ABCD of Mole Check

 

 

Common Medical Dermatology Diagnostics and Therapeutics:

Dermatology Links:

American Academy of Dermatology
American Society of Dermatologic Surgery
American Society of Mohs Surgery
International Hyperhidrosis Society
National Psoriasis Foundation

 Latest Dermatology Headlines:

Latest Dermatology Headlines
Thu, 02 Jul 2015 03:05:19 +0100

http://www.medworm.com/rss/index.php/Dermatology/12/

Jul 01, 2015 07:02PM

Clinical, Histological and Trichoscopic Correlations in Scalp Disorders

Trichoscopy is the term coined for the dermoscopic imaging of scalp and hair. This diagnostic technique, simple and noninvasive, can be used as a handy bedside tool for the diagnosis and follow-up of hair and scalp disorders. It allows the recognition of morphologic structures not visible by the naked eye and provides the clinician with a range of dermoscopic findings necessary for differential diagnosis. Trichoscopy observation can be broadly grouped as interfollicular patterns and follicular patterns. Recently, a third mixed class, called the follicular plus interfollicular pattern, has been introduced. Some of these features are specific to a certain scalp disease, while others can be found in many hair disorders. Although studies suggest that the use of trichoscopy can improve clinical...

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Jul 01, 2015 04:00PM

Programmed death-ligand 1, 2 expressions are decreased in the psoriatic epidermis

In conclusion, we demonstrated that PD-L1, 2 are decreased in psoriatic epidermis in mRNA and protein levels. In addition, we showed that their expression was significantly lower than other inflammatory skin diseases. We suggest that decreased expression of PD-L1, 2 on psoriatic epidermis can contribute to its chronic unregulated inflammatory characteristics. (Source: Archives of Dermatological Research)

Jul 01, 2015 01:00PM

Afamelanotide improves erythropoietic protoporphyria

Afamelanotide dramatically reduces the number and severity of phototoxic reactions, shortens recovery time, and markedly improves disease-related quality of life in adults who have erythropoietic protoporphyria, according to a report published online July 2 in the New England Journal of Medicine.... (Source: Skin and Allergy News)

Jul 01, 2015 08:26AM

'Why Do People Go Bald' Video Tackles Hair Loss Head On

Damn you, genetic variant on chromosome 20! A new SciShow video that explains why people go bald says the genetic variant makes men seven times more likely to lose their hair, but doesn't appear to affect women. Abnormalities in chromosome 20 have been linked to serious diseases, such as blood cancers. But in 2008, researchers found that regions on the chromosome appear to be associated with baldness. The video offers other fun tidbits about failing follicles, but may still leave sufferers at a loss. That's because science has yet to cure baldness, which narrator Hank Green calls "the holy grail of beauty." Statistics tell us that, at some point, we'll all have to deal with thinning or disappearing locks. Two-thirds of American men have "some degree of appreciable hair loss" by age 35, a...

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Jul 01, 2015 07:00AM

Indoor tanning declines, says CDC

People are using indoor tanning less, according to new statistics released by the Centers for Disease Control and Prevention. ?We observed significant reductions in indoor tanning from 2010 to 2013: from 5.5% to 4.2% (P < .001) among all adults, from 8.6% to 6.5% (P < .001)...googletag.display('div-gpt-ad-cta'); (Source: Skin and Allergy News)

Jul 01, 2015 06:06AM

Silver nanoparticles with antimicrobial activities against Streptococcus mutans and their cytotoxic effect.

Authors: Pérez-Díaz MA, Boegli L, James G, Velasquillo C, Sánchez-Sánchez R, Martínez-Martínez RE, Martínez-Castañón GA, Martinez-Gutierrez F Abstract Microbial resistance represents a challenge for the scientific community to develop new bioactive compounds. The goal of this research was to evaluate the antimicrobial activity of silver nanoparticles (AgNPs) against a clinical isolate of Streptococcus mutans, antibiofilm activity against mature S. mutans biofilms and the compatibility with human fibroblasts. The antimicrobial activity of AgNPs against the planktonic clinical isolate was size and concentration dependent, with smaller AgNPs having a lower minimum inhibitory concentration. A reduction of 2.3 log in the number of colony-forming units of S. mutans was observed ...

Jun 30, 2015 07:56PM

The Phytotherapeutic Fenugreek as Trigger of Toxic Epidermal Necrolysis

We describe the case of a 32-year-old woman who presented to the hospital with generalized painful exanthema, blisters and erosions 1 month after giving birth to a healthy girl. The patient's medical history was inconspicuous for comorbidities; however, it included the incidental intake of pain killers and a herbal preparation (fenugreek), which she took regularly over the last 4 weeks to improve lactation. Based on the clinical characteristics, we suspected toxic epidermal necrolysis (TEN), a severe cutaneous adverse drug reaction, which was confirmed by skin biopsy. The patient was treated with high-dose intravenous human immunoglobulins and was discharged 2 weeks after hospital admission in good condition. The allergological workup identified fenugreek as the most likely causative agent...

Jun 30, 2015 07:56PM

Coagulation Status in Hidradenitis Suppurativa: A Danish Population- and Hospital-Based Cross-Sectional Study

Conclusion: We did not find an association between HS and prothrombotic/hypercoagulable status. Thus, thrombocytes may not be activated in HS. Furthermore, INR may not be affected in HS, suggesting that intrinsic and vitamin K-dependent coagulation factors appear unaffected.Dermatology (Source: Dermatology)

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Jun 30, 2015 04:00PM

The Role of Textiles in Dermatitis: An Update

Abstract Dermatitis has important implications for individuals who are affected. It can significantly impair function and quality of life. Dermatitis is multi-factorial and often includes elements of atopic dermatitis, allergic contact dermatitis, and irritant contact dermatitis in a co-existent manner. Textiles are in contact with the human skin for extended periods of time and as a result, they are an important part of the cutaneous environment. Thus, it is not surprising that textiles play a major role in both the etiology and the treatment of various types of dermatitis. This review discusses the role of textiles in dermatitis with an emphasis on interesting and recent advances, trends, perspectives, gaps, and conflicts in the field. In addition, we mention other disease proc...

Jun 30, 2015 04:00PM

Soluble mediators produced by the crosstalk between microvascular endothelial cells and dengue-infected primary dermal fibroblasts inhibit dengue virus replication and increase leukocyte transmigration

Abstract When dengue virus (DENV)-infected mosquitoes use their proboscis to probe into human skin during blood feeding, both saliva and virus are released. During this process, cells from the epidermis and dermis layers of the skin, along with small blood vessels, may get exposed to or infected with DENV. In these microenvironments of the skin, the presence of DENV initiates a complex interplay among the DENV-infected and non-infected neighboring cells at the initial bite site. Previous studies suggested that DENV-infected human dermal fibroblasts (HDFs) participate in the immune response against DENV by secreting soluble mediators of innate immunity. In the present study, we investigated whether DENV-infected HDFs activate human dermal microvascular endothelial cells (HDMECs...

Jun 30, 2015 04:00PM

Genetic variations of the EVER genes, cutaneous human papillomavirus (HPV) infection, and squamous cell carcinoma of the skin

This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)

Jun 30, 2015 04:00PM

Current and Emerging Therapeutic Strategies for the Treatment of Meibomian Gland Dysfunction (MGD)

Abstract Meibomian gland (MG) dysfunction (MGD) is a multifactorial, chronic condition of the eyelids, leading to eye irritation, inflammation and ocular surface disease. Initial conservative therapy often includes a combination of warm compresses in addition to baby shampoo or eyelid wipes. The practice of lid hygiene dates back to the 1950s, when selenium sulfide-based shampoo was first used to treat seborrhoeic dermatitis of the eyelids. Today, tear-free baby shampoo has replaced dandruff shampoo for MGD treatment and offers symptom relief in selected patients. However, many will not achieve significant improvement on this therapy alone; some may even develop an allergy to the added dyes and fragrances in these products. Other manual and mechanical techniques to treat MGD inclu...

Jun 30, 2015 04:00PM

Vascular Anomalies Classification: Recommendations From the International Society for the Study of Vascular Anomalies

Vascular anomalies represent a spectrum of disorders from a simple "birthmark" to life- threatening entities. Incorrect nomenclature and misdiagnoses are commonly experienced by patients with these anomalies. Accurate diagnosis is crucial for appropriate evaluation and management, often requiring multidisciplinary specialists. Classification schemes provide a consistent terminology and serve as a guide for pathologists, clinicians, and researchers. One of the goals of the International Society for the Study of Vascular Anomalies (ISSVA) is to achieve a uniform classification. The last classification (1997) stratified vascular lesions into vascular malformations and proliferative vascular lesions (tumors). However, additional disease entities have since been identified that are complex and ...

Jun 30, 2015 04:00PM

Making Sense of "Red Birth Marks"

(Source: PEDIATRICS)

Jun 30, 2015 04:00PM

Women?s Faces Are Redder During Ovulation, Study Says

But these subtle changes aren't detectable to the human eye (Source: Fertility News - Doctors Lounge)

Jun 30, 2015 04:00PM

Postoperative Expansion is not a Primary Cause of Infection in Immediate Breast Reconstruction with Tissue Expanders

Abstract Perioperative infection is the most common and dreaded complication associated with tissue expander (TE) breast reconstruction. Historically, the expansion period was thought to be the time of greatest hazard to the implant. However, recent institutional observations suggest infectious complications occur prior to expansion. This investigation, therefore, was conducted to determine the timing of infectious complications associated with two?stage TE breast reconstructions. Following IRB approval, a retrospective review of all consecutive two?stage immediate TE breast reconstructions at a single institution from November 2007 to November 2011 was conducted. Reconstructions were then divided into two cohorts: those suffering infectious complications and those that did not. Infect...

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Jun 30, 2015 04:00PM

Case of concurrence of anti?laminin gamma?1 pemphigoid and scabies

(Source: The Journal of Dermatology)

Jun 30, 2015 04:00PM

External ear canal lesions of crusted scabies: A pitfall of recurrence?

(Source: The Journal of Dermatology)

Jun 30, 2015 04:00PM

Case of nevoid basal cell carcinoma syndrome with multiple cutaneous keratocysts

(Source: The Journal of Dermatology)

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Jun 30, 2015 04:00PM

Clinical evaluation of 30 patients with localized nasal rosacea

This study was designed to analyze the subtypes and severity of localized nasal rosacea. Our present study included 30 patients with localized nasal rosacea. The erythematotelangiectatic subtype (13/30, 43.3%) was the most common type, followed by the phymatous subtype (9/30, 30%). The duration of rosacea was shorter and the severity of localized nasal rosacea was lower in the erythematotelangiectatic subtype cases compared with the patients with mixed or phymatous subtypes. Almost all of the papulopustular eruptions or phymatous lesions were associated with erythematotelangiectatic lesions. These findings suggest that the erythematotelangiectatic subtype may be considered the initial phase of localized nasal rosacea. (Source: The Journal of Dermatology)

Jun 30, 2015 04:00PM

Immediate allergy due to raw garlic (Allium sativum L.)

(Source: The Journal of Dermatology)

Jun 30, 2015 04:00PM

Improvement in early diagnosis of Japanese spotted fever by using a novel Rick PCR system

Abstract Rickettsia diseases, including Japanese spotted fever (JSF), are serious infections. Delayed diagnosis occasionally results in life?threatening liver disorders and disseminated intravascular coagulation (DIC). Because of the shortness of the latent period, serological diagnosis is not preferable for early diagnosis of JSF. Until now, a polymerase chain reaction (PCR)?based diagnosis method has been used for early diagnosis, and the sensitivity reaches as high as 90% using skin biopsy samples as we previously reported. On the other hand, the sensitivity of the same PCR method using blood samples is limited at less than 50%. In the present study, using peripheral blood samples, we developed a novel diagnostic method for JSF using a Rick PCR system with original PCR primers, show...

Jun 30, 2015 04:00PM

CARD14 Glu138 mutation in familial pityriasis rubra pilaris does not warrant differentiation from familial psoriasis

Abstract Some familial cases of pityriasis rubra pilaris (PRP) have the CARD14 gene mutations that are also detected in familial psoriasis vulgaris. However, genotype?phenotype correlation in these two entities is poorly understood. Here, we report a case of PRP with a new mutation in CARD14. Genomic analysis of a 40?year?old female patient with sporadic PRP type V identified a heterozygous dominant c.412G>A mutation (p.Glu138Lys) in CARD14. Two types of CARD14 mutations causing Glu138 substitutions have been reported in cases of familial PRP and pustular psoriasis. All three types, including the present case, are predicted to cause similar loss of the negative charges at this site. This suggests that the difference in molecular charge and the resulting change in molecular interac...

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Jun 30, 2015 04:00PM

Correlation between vascular endothelial growth factor and subclinical atherosclerosis in patients with psoriasis

ConclusionThis study supported the possible role of VEGF in the pathogenesis of subclinical atherosclerosis in psoriatic patients. (Source: International Journal of Dermatology)

Jun 30, 2015 04:00PM

Mercury(II) determination in commercial cosmetics and local Thai traditional medicines by flow injection spectrophotometry

ConclusionEnhancement in sensitivity and rapidity for Hg(II) assay by FIA could be achieved by adding SDS in ascorbic acid. The method would be useful for routine analysis of Hg(II) in real samples.This article is protected by copyright. All rights reserved. (Source: International Journal of Cosmetic Science)

Jun 30, 2015 04:00PM

Dermatologic Features of ADA2 Deficiency

This case report suggests that ADA2 deficiency be considered in patients with cutaneous polyarteritis nodosa. (Source: JAMA Dermatology)

Jun 30, 2015 04:00PM

Frequency of Indoor Tanning Among US Adults

This analysis of data from the National Health Interview Survey reports significant reductions in indoor tanning among US adults from 2010 to 2013. (Source: JAMA Dermatology)

Jun 30, 2015 04:00PM

Acantholytic Dyskeratotic Epidermal Nevus

This case report describes a possible solution to the challenge of clinically distinguishing acantholytic dyskeratotic epidermal nevus, often a congenital condition, from Darier disease, which is acquired. (Source: JAMA Dermatology)

Jun 30, 2015 01:30PM

Faster ipilimumab infusion for solid cancers proves safe

Thirty-minute infusions of ipilimumab appear to be as safe as standard 90-minute infusions for patients with metastatic melanoma and other solid tumors, with ?an acceptably low incidence of infusion-related reactions,? investigators reported online in the Journal of Clinical Oncology. The...googletag.display('div-gpt-ad-cta'); (Source: Skin and Allergy News)

Jun 30, 2015 09:11AM

ACOG adds HPV-9 to vaccination advice

The American College of Obstetricians and Gynecologists continues to urge routine vaccination against human papillomavirus for girls and boys and has now added the recently licensed 9-valent HPV vaccine to its recommendation. The updated policy statement from ACOG?s Committee on Adolescent Health...googletag.display('div-gpt-ad-cta'); (Source: Skin and Allergy News)

Jun 30, 2015 08:42AM

Novel naphthochalcone derivative accelerate dermal wound healing through induction of epithelial-mesenchymal transition of keratinocyte

Conclusion: We propose that a novel naphthochalcone derivative TDPN is capable of promoting keratinocyte migration via the induction of EMT resulting acceleration of wound closure and matrix remodeling. (Source: Epidemiologic Perspectives and Innovations)

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Jun 30, 2015 08:40AM

Secukinumab Beats Ustekinumab in Moderate to Severe PsoriasisSecukinumab Beats Ustekinumab in Moderate to Severe Psoriasis

Psoriasis patients experienced greater efficacy and improvement in health-related quality of life (HRQoL) on secukinumab than they did on ustekinumab in a new trial funded by Novartis. Reuters Health Information (Source: Medscape Dermatology Headlines)

Jun 30, 2015 04:05AM

Efficacy of topical benzoyl peroxide on the reduction of propionibacterium acnes during shoulder surgery

The effect that topical benzoyl peroxide (BPO), with chlorhexidine skin preparation, has on the presence of Propionibacterium acnes cultured at the time of shoulder surgery has been the focus of recent study. The authors hypothesized that adding topical BPO, the active ingredient in Clearasil, to the pre-operative skin preparation would reduce the number of positive P. acnes cultures identified during surgery. P. acnes infection is a significant problem after shoulder surgery. Residual P. acnes is found on the skin up to 29% of the time immediately after surgical skin preparation and in 70% of dermal biopsy specimens. These residual bacteria may be a source for infection. Identifying more ideal skin preparation may help reduce the risk of infection. (Source: ScienceDaily Headlines)

Jun 29, 2015 07:07PM

Hidradenitis Suppurativa/Acne Inversa: Criteria for Diagnosis, Severity Assessment, Classification and Disease Evaluation

Conclusion: The provided criteria can be used as tools for the promotion of uniformity in HS evaluation and facilitation of early and timely identification and referral in the primary care setting and thorough and efficient evaluation in daily clinical practice.Dermatology (Source: Dermatology)

Jun 29, 2015 07:05PM

Epithelial deletion of Podoplanin is dispensable for re?epithelialization of skin wounds

This article is protected by copyright. All rights reserved. (Source: Experimental Dermatology)

Jun 29, 2015 07:04PM

Skin manifestations of chromosome 18q deletion syndrome

(Source: International Journal of Dermatology)

Jun 29, 2015 06:35PM

Grapefruit and Melanoma: What's Happening Here? (CME/CE)

(MedPage Today) -- An association, yes. But is there a real risk? (Source: MedPage Today Dermatology)

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Jun 29, 2015 04:00PM

Can Orange Juice, Grapefruit Raise Your Melanoma Risk?

Study authors think compounds in citrus may sensitize skin to sunlight, but further study needed (Source: The Doctors Lounge - Oncology)

Jun 29, 2015 04:00PM

Differential diagnosis of suspected deep tissue injury

Abstract Deep tissue injury (DTI) can be difficult to diagnose because many other skin and wound problems can appear as purple skin or rapidly appearing eschar. The diagnosis of DTI begins with a thorough history to account for times of exposure to pressure, such as ?time down? at the scene or time during which the patient was flat and could not respond. Patients with light skin tones present with classic skin discolouration of purple or maroon tissue, a defined border around the area of injury, and often surrounding erythema is evident. Persistent erythema and hyperpigmentation, rather than blanching, should be used to determine pressure injury in dark skin tone patients. Differential diagnosis includes stage 2 pressure ulcers, incontinence?associated dermatitis, skin tears, bruisin...

Jun 29, 2015 04:00PM

Experience with botulinum toxin therapy for axillary hyperhidrosis and comparison to modelled data for endoscopic thoracic sympathectomy ? A quality of life and cost effectiveness analysis

Conclusions Treatments reached cost equivalence after 13.3 years. However, given the efficacy of the botulinum toxin therapy and the low risk we propose that botulinum toxin therapy for hyperhidrosis should be considered the gold standard. (Source: The Surgeon)

Jun 29, 2015 04:00PM

A common sugar-nucleotide-mediated mechanism of inhibition of (glycosamino)glycan biosynthesis, as evidenced by 6F-GalNAc (Ac3) [Research Communication]

In this study, we probed 11 sugar analogs for their capacity to interfere with GAG biosynthesis. One analog, with a modification not directly involved in the glycosidic bond formation, 6F-N-acetyl-d-galactosamine (GalNAc) (Ac3), was selected for further study on its metabolic and biologic effect. Treatment of human ovarian carcinoma cells with 50 μM 6F-GalNAc (Ac3) inhibited biosynthesis of GAGs (chondroitin/dermatan sulfate by ~50–60%, heparan sulfate by ~35%), N-acetyl-d-glucosamine (GlcNAc)/GalNAc containing glycans recognized by the lectins Datura stramonium and peanut agglutinin (by ~74 and ~43%, respectively), and O-GlcNAc protein modification. With respect to function, 6F-GalNAc (Ac3) treatment inhibited growth factor signaling and reduced in vivo angiogenesis by ~33%. Alth...

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Jun 29, 2015 04:00PM

Topical application of Acheflan on rat skin injury accelerates wound healing: a histopathological, immunohistochemical and biochemical study

Background: Dermal wound healing involves a cascade of complex events including angiogenesis and extracellular matrix remodeling. Several groups have focused in the study of the skin wound healing activity of natural products. The phytomedicine Acheflan®, and its main active constituent is the oil from Cordia verbenacea which has known anti-inflammatory, analgesic and antimicrobial activities. To our knowledge, no investigation has evaluated the effect of Acheflan® in an experimental model of skin wound healing.The present study has explored the wound healing property of Acheflan® and has compared it with topical effectiveness of collagenase and fibrinolysin by using Wistar rat cutaneous excision wound model. Methods: Animals were divided into four groups: untreated animals are negative...

Jun 29, 2015 04:00PM

Narrow?band ultraviolet b phototherapy in psoriasis reduces pro?inflammatory cytokine levels and improves vitiligo and neutrophilic asthma

This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)

Jun 29, 2015 04:00PM

Frequency and characteristics of circulating CD4+CD28null T cells in patients with psoriasis

ConclusionsThese data suggest that cytotoxic cells, such as CD4+CD28null lymphocytes, within an inflammatory environment may play a role in the pathogenesis of psoriasis.This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)

Jun 29, 2015 04:00PM

Downmodulation of key inflammatory cell markers with topical JAK1/JAK2 inhibitor

ConclusionsTopical INCB018424 dosed for 28 days QD or BID is pharmacologically active in patients with active psoriasis and modulates pro?inflammatory cytokines in the pathogenesis of psoriatic lesions.This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)

Jun 29, 2015 04:00PM

Photoaggravated contact dermatitis to Kathon CG (methylchloroisothiazolinone/methylisothiazolinone): a novel pattern of involvement in a growing epidemic?

This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)

Jun 29, 2015 04:00PM

Complete remission after rituximab therapy in an HIV positive patient with pemphigus vulgaris

This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)

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Jun 29, 2015 04:00PM

Transient memory impairment and transient global amnesia induced by photodynamic therapy

This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)

Jun 29, 2015 04:00PM

Eosinophilia associated with disease exacerbations in a patient with pyostomatitis vegetans

This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)

Jun 29, 2015 04:00PM

Generalized pruritus in primary sclerosing cholangitis ? implications of histamine release by lysophosphatidic acid

This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)

Jun 29, 2015 04:00PM

Utility of spatial frequency domain imaging (SFDI) and laser speckle imaging (LSI) to non-invasively diagnose burn depth in a porcine model

Publication date: Available online 30 June 2015 Source:Burns Author(s): David M. Burmeister , Adrien Ponticorvo , Bruce Yang , Sandra C. Becerra , Bernard Choi , Anthony J. Durkin , Robert J. Christy Surgical intervention of second degree burns is often delayed because of the difficulty in visual diagnosis, which increases the risk of scarring and infection. Non-invasive metrics have shown promise in accurately assessing burn depth. Here, we examine the use of spatial frequency domain imaging (SFDI) and laser speckle imaging (LSI) for predicting burn depth. Contact burn wounds of increasing severity were created on the dorsum of a Yorkshire pig, and wounds were imaged with SFDI/LSI starting immediately after-burn and then daily for the next 4 days. In addition, on each day the burn wound...

Jun 29, 2015 04:00PM

Alopecia areata universalis in a dog.

CONCLUSIONS AND CLINICAL IMPORTANCE: To the best of the author's knowledge this is the first documented case of canine AAU. The clinical and histopathological features were consistent with a diagnosis of AAU as defined in humans. Treatment with oral ciclosporin resulted in near complete resolution of the alopecia, but after 5 months without treatment the alopecia did not relapse and spontaneous resolution cannot be ruled out. PMID: 26123679 [PubMed - as supplied by publisher] (Source: Veterinary Dermatology)

Jun 29, 2015 04:00PM

Sweat osmolarity shows intra-animal regional variation in the horse.

CONCLUSIONS AND CLINICAL IMPORTANCE: Previous studies have used osmolarity values based on the sweat collected from the horse's back. The current work demonstrates that these values are probably an underestimation of electrolyte loss, which may have implications for the composition and administration of rehydration compounds. PMID: 26123607 [PubMed - as supplied by publisher] (Source: Veterinary Dermatology)

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Jun 29, 2015 04:00PM

Complementary effect of oral administration of Lactobacillus paracasei K71 on canine atopic dermatitis.

CONCLUSIONS AND CLINICAL IMPORTANCE: Oral administration of K71 can be useful in dogs with cAD as a complementary therapy, by providing a steroid-sparing effect. PMID: 26123498 [PubMed - as supplied by publisher] (Source: Veterinary Dermatology)

Jun 29, 2015 04:00PM

Human T?lymphotropic virus type I proviral loads in patients with adult T?cell leukemia?lymphoma: Comparison between cutaneous type and other subtypes

Abstract Adult T?cell leukemia?lymphoma (ATL), characterized by various clinicopathological features, is divided into four clinical subtypes, namely, acute, lymphoma, chronic and smoldering types, and the treatment strategy differs according to the clinical subtype. The designation cutaneous type ATL has been proposed to describe a peculiar subgroup of smoldering type ATL in which the skin is predominantly affected. However, diagnostic criteria and prognostic factors for cutaneous type ATL remain to be determined. Therefore, we performed a retrospective study to obtain a precise method for subtype classification and to clearly define cutaneous type ATL. A total of 87 ATL patients (acute, n = 31; lymphoma, n = 6; chronic, n = 24; smoldering, n = 26) were enrolled. The human T?...

Jun 29, 2015 04:00PM

Downregulated expression of LBH mRNA in peripheral blood mononuclear cells from patients with systemic lupus erythematosus

This study suggests that decreased expression of LBH mRNA may be correlated with the pathogenesis of SLE. (Source: The Journal of Dermatology)

Jun 29, 2015 01:43PM

ABA: Engineered skin substitutes trim pediatric burn mortality

CHICAGO ? Autologous engineered skin substitutes (EES) reduce mortality and donor-site harvesting in children with extensive, deep burns, a randomized, paired-site comparison showed. ?Autologous ESS offer an alternative therapy for closure of extensive, excised, full-thickness burns,? Steven...googletag.display('div-gpt-ad-cta'); (Source: Skin and Allergy News)

Jun 29, 2015 12:00PM

MassDevice.com +3 | The top 3 medtech stories for June 29, 2015

Say hello to MassDevice +3, a bite-sized view of the top three medtech stories of the day. This feature of MassDevice.com’s coverage highlights our 3 biggest and most influential stories from the day’s news to make sure you’re up to date on the headlines that continue to shape the medical device industry.   3. Medtronic wins aortic valve patent spat with inventor Medtronic won a patent infringement dispute over its CoreValve aortic valve replacement with inventor Dr. Troy Norred, according to legal filings. The district court case, filed by Norred in 2013, had received stays until an inter partes review could examine the patent case, according to legal filings. The 3 judge panel reviewing the case found 7 of Norred’s claims were unpatentable, upholding Medtron...

Jun 29, 2015 07:21AM

Integra LifeSciences picks up TEI Biosciences, TEI Medical for $312m

Integra LifeSciences (NSDQ:IART) said yesterday that it agreed to acquire TEI Biosciences and sister company TEI Medical for $312 million in cash in a bid to expand its footprint in reconstructive surgery and regenerative wound care. The deal, expected to close during the 3rd quarter, brings TEI’s PriMatrix dermal repair scaffold and a 125-member sales force under the Integra umbrella, that Plainsboro, N.J.-based company said. TEI is based in Waltham, Mass. “This acquisition broadens our presence in regenerative wound care and tissue repair and represents a significant push forward toward our growth objectives for 2015 and beyond. The addition of TEI is an important, strategic next step for both our channel and international expansion priorities. We are enthusiastic about bo...

Jun 29, 2015 01:32AM

Regulating Off-Label Promotion of MedicationsRegulating Off-Label Promotion of Medications

In this review, the authors discuss the risks and benefits of off-label drug use in dermatology, from both a clinical and a legal standpoint. Skin Therapy Letter (Source: Medscape Today Headlines)

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Jun 28, 2015 11:00PM

Health Tip: Sunburn May Cause Permanent Damage

Title: Health Tip: Sunburn May Cause Permanent DamageCategory: Health NewsCreated: 6/29/2015 12:00:00 AMLast Editorial Review: 6/29/2015 12:00:00 AM (Source: MedicineNet Skin General)

Jun 28, 2015 11:00PM

Is Eczema Contagious?

Title: Is Eczema Contagious?Category: Diseases and ConditionsCreated: 6/29/2015 12:00:00 AMLast Editorial Review: 6/29/2015 12:00:00 AM (Source: MedicineNet Skin General)

Jun 28, 2015 08:02PM

The bacteriology of Hidradenitis Suppurativa: A systematic review

This article is protected by copyright. All rights reserved. (Source: Experimental Dermatology)

Jun 28, 2015 04:00PM

AAP asks FDA to include children in evaluation of sunscreen ingredients [FOCUS ON SUBSPECIALTIES]

(Source: AAP News)

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Jun 28, 2015 04:00PM

The Dishevelled-binding protein CXXC5 negatively regulates cutaneous wound healing

Wnt/β-catenin signaling plays important roles in cutaneous wound healing and dermal fibrosis. However, its regulatory mechanism has not been fully elucidated, and a commercially available wound-healing agent targeting this pathway is desirable but currently unavailable. We found that CXXC-type zinc finger protein 5 (CXXC5) serves as a negative feedback regulator of the Wnt/β-catenin pathway by interacting with the Dishevelled (Dvl) protein. In humans, CXXC5 protein levels were reduced in epidermal keratinocytes and dermal fibroblasts of acute wounds. A differential regulation of β-catenin, α-smooth muscle actin (α-SMA), and collagen I by overexpression and silencing of CXXC5 in vitro indicated a critical role for this factor in myofibroblast differentiation and c...

Jun 28, 2015 04:00PM

A novel model approach for esophageal burns in rats: A comparison of three methods

Conclusion: A new burn model can thus, we believe, be created without the involvement of invasive laparoscopic surgery and general anesthesia. The burn in our experiment was formed in both the distal and proximal esophagus, as in other models; it can also be formed optionally in the entire esophagus. (Source: Toxicology and Industrial Health)

Jun 28, 2015 04:00PM

Comparison of toxicity values across zebrafish early life stages and mammalian studies: Implications for chemical testing

We present here a meta-analysis of 600 chemicals tested for toxicity in zebrafish embryos and larvae. Nineteen aggregated and 57 individual toxicity endpoints were recorded from published studies yielding 2695 unique data points. These data points were compared to lethality and reproductive toxicology endpoints analyzed in rodents and rabbits and to exposure values for humans. We show that although many zebrafish endpoints did not correlate to rodent or rabbit acute toxicity data, zebrafish could be used to accurately predict relative acute toxicity through the rat inhalation, rabbit dermal, and rat oral exposure routes. Ranking of the chemicals based on toxicity and teratogenicity in zebrafish, as well as human exposure levels, revealed that 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), ben...

Jun 28, 2015 04:00PM

Acceleration of skin regeneration in full?thickness burns by incorporation of bFGF?loaded alginate microspheres into a CMCS?PVA hydrogel

Abstract Two important issues in skin tissue engineering are the vascularization and regeneration of the dermis. Basic fibroblast growth factor (bFGF) is known to promote angiogenesis and accelerate wound healing. Direct delivery of bFGF to the wound area, however, would lead to a loss of bioactivity. To this end, bFGF?loaded alginate microspheres (Ms) were fabricated and incorporated into carboxymethyl chitosan (CMCS)?poly(vinyl alcohol) (PVA) to form a composite hydrogel. Scanning electron microscopy (SEM) results indicated that the incorporation of Ms does not significantly affect the inner structure of CMCS?PVA. In an in vitro study, the release of bFGF from Ms?CMCS?PVA in a sustained manner retained higher bioactivity over a 2?week period. Full?thickness burn wounds were...

Jun 28, 2015 04:00PM

Wnt1a maintains characteristics of dermal papilla cells that induce mouse hair regeneration in a 3D preculture system

Abstract Hair follicle morphogenesis and regeneration depend on intensive but well?orchestrated interactions between epithelial and mesenchymal components. Therefore, an alternative strategy to reproduce the process of epithelial?mesenchymal interaction in vitro could use a 3D system containing appropriate cell populations. The 3D air?liquid culture system for reproducibly generating hair follicles from dissociated epithelial and dermal papilla (DP) cells combined with a collagen?chitosan scaffold is described in this study. Wnt?CM was prepared from the supernatant of Wnt1a?expressing bone marrow mesenchymal stem cells (BM?MSCs) that maintain the hair?inducing gene expression of DP cells. The collagen?chitosan scaffold cells (CCS cells) were constructed using a two?step...

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Jun 28, 2015 04:00PM

Diverse Functional Outcomes of Plasmodium falciparum Ligation of EPCR: Potential Implications for Malarial Pathogenesis

In this study, we examined adhesion of DC8? and DC13?expressing parasite lines to endothelial cells from different microvasculature, and the consequences of EPCR engagement on endothelial cell function. We found that IRBC from IT4var19 (DC8) and IT4var07 (DC13) parasite lines adhered to human brain, lung, and dermal endothelial cells under shear stress. However, the relative contribution of EPCR to parasite cytoadherence on the different types of endothelial cell varied. We also observed divergent functional outcomes for DC8 CIDR?1.1 and DC13 CIDR?1.4 domains. IT4var07 CIDR?1.4 inhibited generation of activated protein C (APC) on lung and dermal endothelial cells and blocked the APC?EPCR binding interaction on brain endothelial cells. IT4var19 CIDR?1.1 inhibited thrombin?induce...

Jun 28, 2015 04:00PM

Low incidence of complications using Polyglactin 910 [Vicryl] mesh in Breast Reconstruction: A Systematic Review

Mastectomy and breast reconstruction are essential parts of the treatment of breast cancer. Acellular dermal matrices (ADM) have been used for the reconstruction of the lower pole due to many advantages; however, its cost is seen as a major drawback in this era of concern for allocation of health care funds. Recently, Polyglactin 910 [Vicryl] mesh has been published as an alternative. We assessed the published literature, in particular looking for studies that compare Vicryl mesh to ADM. (Source: Journal of Plastic, Reconstructive and Aesthetic Surgery)

Jun 28, 2015 04:00PM

Role of Narrowband Ultraviolet B Phototherapy in the Treatment of Childhood Psoriasis in Asian Children

Abstract Narrowband ultraviolet B (NBUVB) phototherapy is a well?established treatment modality for psoriasis. We performed a retrospective analysis of children of East Asian descent with psoriasis treated with NBUVB phototherapy at the National Skin Centre, Singapore, over a 5?year period between 2004 and 2008 and found that NBUVB phototherapy is safe and effective for the treatment of psoriasis in children of East Asian descent. (Source: Pediatric Dermatology)

Jun 28, 2015 04:00PM

Case of generalized eruptive keratoacanthoma with probable Sjögren's syndrome

(Source: The Journal of Dermatology)

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Jun 28, 2015 04:00PM

Frequency of metabolic syndrome in patients with knuckle pads

Abstract Knuckle pads are hyperkeratotic, benign skin lesions that we commonly observe in obese patients. There is no study that investigates the association between metabolic syndrome (MetS) and knuckle pads. We aimed to investigate the frequency of MetS in patients with knuckle pads. Forty?seven patients with knuckle pads and 46 age? and sex?matched controls were enrolled. The presence of MetS was evaluated according to National Cholesterol Education Program?Adult Treatment Panel III criteria. In the patient group, waist circumference (P < 0.01), body mass index (BMI; P < 0.01), and systolic (P < 0.01) and diastolic blood pressure (P < 0.01) were higher than controls, and most of the patients had a history of hypertension (P < 0.01). The presence of MetS ...

Jun 28, 2015 04:00PM

Genomic diagnosis by whole genome sequencing in a Korean family with atypical progeroid syndrome

Abstract Clinical genomic diagnosis is unfamiliar to many dermatologists. Limited knowledge of bioinformatics has limited the use of the next generation sequencing method in dermatological clinics. We evaluated the usefulness of whole genome sequencing as a diagnostic approach to inherited dermatological disease. Here, we present our experience with two female siblings with atypical familial generalized lipodystrophy with diabetes mellitus and dyslipidemia. Whole genome sequencing was performed to diagnose the inherited disease. We compared control genomic databases using the Exome Aggregation Consortium, and filtered false?positive calls with the segmental duplication, non?flagged single nucleotide variants and COSMIC mutation databases, and applied the prediction tools of SIFT and Po...

Jun 28, 2015 04:00PM

Adalimumab treatment optimization for psoriasis: Results of a long?term phase 2/3 Japanese study

Abstract The tumor necrosis factor?? inhibitor, adalimumab, is approved to treat moderate?to?severe plaque psoriasis (40 mg every?other?week or 80 mg every?other?week following inadequate response at 40 mg in Japan). This open?label extension (OLE) trial evaluated the optimal adalimumab dose for long?term efficacy and safety in Japanese patients with moderate?to?severe plaque psoriasis following a prior 24?week, phase 2/3, randomized, double?blind study. Of the 169 patients from the phase 2/3 trial, 147 entered the OLE on 40 mg (n = 89) or 80 mg (n = 58) adalimumab every?other?week. Patients on 40 mg with Psoriasis Area and Severity Index (PASI) of less than 50 could escalate to 80 mg. At week 52 (28 of OLE), patients entering the OLE on 80 mg wer...

Jun 28, 2015 04:00PM

Basal cell carcinoma arising within port?wine stains with no preceding radiotherapy

(Source: The Journal of Dermatology)

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Jun 28, 2015 04:00PM

COX inhibition enhances inflammatory immune cell infiltration in UV?irradiated human skin: implications for the treatment of sunburn

This article is protected by copyright. All rights reserved. (Source: Experimental Dermatology)

Jun 28, 2015 04:00PM

Pericytes in wound healing: Friend or foe?

This article is protected by copyright. All rights reserved. (Source: Experimental Dermatology)

Jun 28, 2015 04:00PM

Autosomal dominant cutis laxa resulting from an intronic mutation in ELN

This article is protected by copyright. All rights reserved. (Source: Experimental Dermatology)

Jun 28, 2015 04:00PM

MicroRNAs (miRNAs) in the control of HF development and cycling: The next frontiers in hair research

This article is protected by copyright. All rights reserved. (Source: Experimental Dermatology)

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Jun 28, 2015 04:00PM

Phenotypic variation in epidermolytic ichthyosis: clinical and functional evaluation of the novel p.(Met339Lys) mutation in the L12 domain of KRT1

This article is protected by copyright. All rights reserved. (Source: Experimental Dermatology)

Jun 28, 2015 04:00PM

Decreased SAPK/JNK signaling affects cytokine release and STAT3 activation in psoriatic fibroblasts

This article is protected by copyright. All rights reserved. (Source: Experimental Dermatology)

Jun 28, 2015 04:00PM

IL?33 induces Egr?1?dependent TSLP expression via the MAPK pathways in human keratinocytes

This article is protected by copyright. All rights reserved. (Source: Experimental Dermatology)

Jun 28, 2015 04:00PM

Deficiency of the PTHrP Nuclear Localization and Carboxyl Terminal Sequences Leads to Pre?mature Skin Aging Partially Mediated by the Upregulation of p27

This article is protected by copyright. All rights reserved. (Source: Experimental Dermatology)

Jun 28, 2015 04:00PM

CD1d knockout mice exhibit aggravated contact hypersensitivity responses due to reduced interleukin?10 production predominantly by regulatory B cells

This article is protected by copyright. All rights reserved. (Source: Experimental Dermatology)

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Jun 28, 2015 04:00PM

Klk8 is required for microabscess formation in a mouse imiquimod model of psoriasis

This article is protected by copyright. All rights reserved. (Source: Experimental Dermatology)

Jun 28, 2015 04:00PM

Does fat get you skinny?

This article is protected by copyright. All rights reserved. (Source: Experimental Dermatology)

Jun 28, 2015 04:00PM

A three?dimensional in vitro culture model of Hailey?Hailey disease

This article is protected by copyright. All rights reserved. (Source: Experimental Dermatology)

Jun 28, 2015 04:00PM

Association of microRNA 146a polymorphism rs2910164 and the risk of melanoma in an Italian population

This article is protected by copyright. All rights reserved. (Source: Experimental Dermatology)

Jun 28, 2015 04:00PM

8?methoxypsoralen plus UVA (PUVA) therapy normalizes signaling of phosphorylated component of mTOR pathway in psoriatic skin of K5.hTGFb1 transgenic mice

This article is protected by copyright. All rights reserved. (Source: Experimental Dermatology)

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Jun 28, 2015 04:00PM

Impact of exogenous stress on TGF? inducible Early Gene 1 in human skin cells

This article is protected by copyright. All rights reserved. (Source: Experimental Dermatology)

Jun 28, 2015 04:00PM

Sirolimus use and risk of cutaneous squamous cell carcinoma (SCC) in solid organ transplant recipients (SOTRs)

Little is known about the use of sirolimus for primary prevention of cutaneous squamous cell carcinoma (SCC) among solid organ transplant recipients (SOTRs). (Source: Journal of the American Academy of Dermatology)

Jun 28, 2015 04:00PM

Evidence-based approach to cutaneous hyperandrogenism in women

Hirsutism, acne, and androgenetic alopecia are classically considered signs of cutaneous hyperandrogenism (CHA). These common skin findings have significant impacts on the quality of patients' lives and pose the diagnostic challenge of excluding underlying disorders. Many with CHA have normal serum androgen levels. Hirsutism is more strongly associated with hyperandrogenism than are acne or androgenetic alopecia. Variable association of CHA with hyperandrogenemia results from the complexity of the underlying pathophysiology, including factors local to the pilosebaceous unit. (Source: Journal of the American Academy of Dermatology)

Jun 28, 2015 04:00PM

(2/,4)-2-(2,4-Dihydroxyphenyl)thiazolidine-4-carboxylic acid prevents UV-induced wrinkle formation through NF-?B-mediated inflammation

Skin plays an essential role as a protective barrier against irradiation of ultraviolet (UV) including UVA and UVB. Both UVA and UVB can cause skin damages and photoaging [1]. Wrinkle formation is a characteristics of photoaging and is closely related to collagen fibrils and gelatin fibers [2]. Wrinkle formation is attributed to reduced skin elasticity and degeneration of the extracellular matrix (ECM) which includes fibrous proteins such as elastic fiber, collagen, and glycosaminoglycans produced by fibroblasts in the dermis [2]. (Source: Journal of Dermatological Science)