Dr. William Ting, Board-Certified Dermatologist
at California Dermatology Care
2262 Camino Ramon, San Ramon, CA 94583
500 Alfred Nobel Drive, Suite #185, Hercules, CA 94547
Tel: 925-328-0255
Email: staff@CalDermCare.com
Prescription concerns: rx@CalDermCare.com




Advanced Care with a Personal Touch

   

 

 

Medical Dermatology    Evidence-based medicine   Customized solution   Personal care

Latest Dermatology Headlines

Dr. William Ting has expertise in treating the entire spectrum of medical dermatology, with emphasis in preventive medicine and personalized recommendations. He enjoys taking care of patients with acne, eczema, hair and nail disorders, rashes, psoriasis and skin cancers.

He is at the forefront of medical dermatology and dermatologic research. He continues to publish articles in peer-reviewed dermatology journals. He is an early pioneer of photodynamic therapy (PDT) and one of the most experienced practitioners of PDT in the Bay Area. He is the first dermatologist in the San Francisco Bay Area and Northern California to introduce Lutronic Spectra, GenesisPlus, Picosure Lasers for melasma, acne, scar revision, pore size reduction as well as the Cutera GenesisPlus laser for advanced nail fungus laser treatment, keloid and hypertrophic scar, warts and scar revision.

Dr. Ting is a fellow of the American Academy of Dermatology (AAD) and American Society of Dermatologic Surgery (ASDS). He is a member of the National Psoriasis Foundation and International Hyperhidrosis Society.

Innovative Therapeutic Approach to Common Skin Conditions

Acne

Eczema (Atopic Dermatitis)

Hair and Nail disorders

  • Maximize therapeutic synergy and efficacy by utilizing both prescription-strength and over-the counter products when available
  • Comprehensive workup including bloodwork and biopsy if necessary
  • Systemic oral hormonal therapy for women and men when indicated

Psoriasis 

Rosacea

  • Multi-prong approach to minimize redness
  • Low-dose 'non-antibiotic' anti-inflammatory oral medication for long-term remission 
  • Emphasis on prevention
  • Fotofacial/IPL laser utilizing Cynosure XPL/Elite MPX
  • Cutera GenesisPlus Laser with or without combination with IPL 
  • Diode laser for facial veins
  • VBeam Pulse Dye Laser, the new gold standard for rosacea and facial redness

Skin Cancer 

  • Emphasis on prophylactic treatments with topical 5-FU, imiquimod, diclofenac, ingenol mebutate and oral chemopreventive therapy such as Erivedge, and Soriatane.
  • Reduce future risks of skin cancer with photodynamic therapy, TCA chemical peels and/or fractional CO2 resurfacing laser  
  • Superficial Radiotherapy (SRT) may be the new gold standard as a nonsurgical modality to treat non-melanoma skincancer
  • Mohs Surgery to achieve highest cure rate and tissue sparing
  • Close colloboration with plastic surgeon(s) as needed  

Sweating Disorder (Hyperhidrosis) 

Vitiligo

Warts 


ABCD of Mole Check

 

 

Common Medical Dermatology Diagnostics and Therapeutics:

Dermatology Links:

American Academy of Dermatology
American Society of Dermatologic Surgery
American Society of Mohs Surgery
International Hyperhidrosis Society
National Psoriasis Foundation

 Latest Dermatology Headlines:

Latest Dermatology Headlines
Mon, 28 Mar 2016 15:26:33 +0100

http://medworm.com/rss/index.php/Dermatology/12/

Mar 27, 2016 07:04AM

Occupational asthma in a fruit and vegetables vendor.

CONCLUSIONS: The clinical history and the results of the allergologic investigations, plus an on-the-spot inspection, permitted us to ascertain that this subject had developed occupational asthma due to Pleurotus ostreatus spores. We advised her to stop handling and selling mushrooms, and she has no longer suffered asthmatic symptoms, over seven years of follow-up, and regularly continued to work without needing to take anti-asthma drugs. PMID: 27015024 [PubMed - as supplied by publisher] (Source: Medicina del Lavoro)

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Mar 27, 2016 04:33AM

Lipoid proteinosis.

Authors: Kartal D, Ē?nar SL, Kartal L, Saka Ö?, Borlu M Abstract Lipoid proteinosis (LP) is an uncommon, autosomal, recessively inherited disorder. It is typically characterized by hoarseness from early infancy, together with various cutaneous manifestations such as waxy papules, acneiform scarring, and eyelid beading. A 42-year-old woman was admitted to our dermatology outpatient clinic complaining of rigidity of the oral mucosa and limitation in tongue movement. She also had a burning sensation and decreased taste perception in the mouth while eating, as well as hoarseness of voice. She was diagnosed with lipoid proteinosis. The typical cutaneous manifestations of LP include waxy yellow papules with generalized skin thickening on the face, extremities, and trunk. Here we repo...

Mar 27, 2016 04:33AM

Late onset pityriasis rubra pilaris type IV treated with low-dose acitretin.

We report a 19-year-old male patient with a 2-week history of pruritic, scaling dermatosis of the hands, feet, elbows, and knees. He had no family history of skin disease. On physical examination, we observed circumscribed, reddish-orange, scaling plaques affecting the elbows and knees and a waxy palmoplantar keratoderma. The skin biopsy showed acanthosis, alternating orthokeratosis, parakeratosis, and follicular plugging suggestive of pityriasis rubra pilaris. The patient started treatment with oral acitretin, 25 mg every other day. The treatment was tolerated well, and after 6 months the lesions had resolved completely. Pityriasis rubra pilaris is a chronic papulosquamous disorder of unknown pathogenesis, characterized by reddish-orange scaly plaques, palmoplantar keratoderma, and kerato...

Mar 27, 2016 04:33AM

Lifelong widespread warts associated with human papillomavirus type 70/85: a new diagnostic entity?

We present a patient with HPV 70/85-positive widespread cutaneous warts characterized by clinical and histological features atypical for classic generalized verrucosis or epidermodysplasia verruciformis. The cutaneous HPV infection is characterized by verrucous papules or plaques variable in size, number, and distribution depending on the genotype of HPV involved and the immune status of the patient. Human papillomaviruses comprise ?ve genera (alpha, beta, gamma, mu, and nu papillomavirus) with different life-cycle characteristics, epithelial tropisms, and disease associations. Epidermodysplasia verruciformis (EV) is a rare, lifelong, autosomal recessive skin disease characterized by persistent cutaneous human papillomavirus infection not necessarily associated with immune system defects...

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Mar 27, 2016 04:33AM

Immunohistochemical analysis of melanocyte content in different zones of vitiligo lesions using the Melan-A marker.

CONCLUSION: In some vitiligo patients the residual melanocytes are preserved in depigmented skin. Melan-A marker is useful for identi cation of melanocytes in vitiligo patients' skin. PMID: 27014772 [PubMed - in process] (Source: Acta Dermatovenerologica Alpina, Panonica, et Adriatica)

Mar 27, 2016 04:33AM

Angiotensin-converting enzyme inhibitors as a cause of isolated angioedema in a Slovenian population.

CONCLUSION: ACEI was shown to be the most frequent removable cause of isolated AE. About two-thirds of AE cases taking ACEI were resolved after removal of the drug. PMID: 27014771 [PubMed - in process] (Source: Acta Dermatovenerologica Alpina, Panonica, et Adriatica)

Mar 27, 2016 01:51AM

Filaggrin Polymorphism Pro478Ser Is Associated With the Severity of Atopic Dermatitis and Colonization by Staphylococcal aureus.

Authors: Lopes C, Rocha L, Sokhatska O, Soares J, Tavaria F, Correia O, Pintado M, Fernandes S, Delgado L, Moreira A PMID: 27012026 [PubMed - in process] (Source: Journal of Investigational Allergology and Clinical Immunology)

Mar 26, 2016 03:00PM

Continuous usage of a hair dye product containing 2?methoxymethyl?para?phenylenediamine by hair?dye?allergic individuals

ConclusionsHair dye products with the less sensitizing ME?PPD were tolerated by 29 of 43 (67%) PPD/PTD?allergic individuals throughout continued hair dyeing with an average of nine treatments per year. Five individuals reacted upon pretesting, while only mild?to?moderate/marked skin reactions occurred upon hair dyeing in nine individuals who were not identified by the pretest. To our knowledge this is the first study among PPD/PTD?allergic individuals indicating that a negative 45?min pretest with a hair dye product helps to avoid severe allergic reactions. (Source: British Journal of Dermatology)

Mar 26, 2016 03:00PM

High prevalence of psychiatric disorders in patients with skin?restricted lupus: a case?control study

ConclusionsThis study demonstrates a high prevalence of several psychiatric disorders (anxiety, depression, suicide risk, alcohol dependence) in patients with SRL. (Source: British Journal of Dermatology)

Mar 26, 2016 03:00PM

Early management in children with burns: Cooling, wound care and pain management

Conclusion Referring physicians of children with burns were overall well informed: they cool the wound after burns and cover it before transport to prevent hypothermia and reduce the pain. Additional studies should be conducted to clarify the duration and temperature for cooling to be effective. Furthermore, there is room and a need for improvement regarding early pain management. (Source: Burns)

Mar 26, 2016 03:00PM

Incidence of ventilator associated pneumonia in burn patients with inhalation injury treated with high frequency percussive ventilation versus volume control ventilation: A systematic review

Conclusion Evidence about decreased incidence of VAP in burn patients with inhalation injuries who are on HFPV compared to those on VCV is inconclusive. Although enhanced airway clearance by HFPV was thought to play a role in decreasing VAP in this population, high tidal volume in the VCV arms could be a confounding factor that should be eliminated in future studies before a firm conclusion can be reached. More RCTs comparing HFPV to low tidal volume VCV are needed. (Source: Burns)

Mar 26, 2016 10:31AM

Vitamin D in Atopic Dermatitis, Chronic Urticaria and Allergic Contact Dermatitis.

Authors: Quirk SK, Rainwater E, Shure AK, Agrawal DK Abstract Vitamin D influences allergen-induced pathways in the innate and adaptive immune system, and its potential immunomodulatory role in allergic skin disorders has been explored. This comprehensive review article provides an overview of the role of vitamin D in three common dermatologic conditions: atopic dermatitis (AD), chronic urticaria, and allergic contact dermatitis (ACD). Whereas the literature regarding vitamin D and AD has resulted in mixed findings, several studies have described an inverse relationship between vitamin D levels and AD severity, and improvement in AD with vitamin D supplementation. Similarly, several studies report an inverse relationship between vitamin D levels and severity of chronic urticaria. A...

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Mar 26, 2016 09:02AM

Soothing and anti-itch effect of quercetin phytosome in human subjects: a single-blind study.

CONCLUSION: Quercetin has a skin protective effect against damage caused by a variety of insults, including UV radiation, histamine, or contact with toxic chemical compounds. Indeed, quercetin is able to reduce redness, itching, and inflammation of damaged skin; it may also help restore skin barrier function, increasing hydration, and reducing water loss. PMID: 27013898 [PubMed] (Source: Clinical, Cosmetic and Investigational Dermatology)

Mar 26, 2016 02:49AM

Psoriatic arthritis prevalence in the clinical practice of dermatologists in north-west tuscany centres of excellence for psoriasis: a screening experience.

CONCLUSIONS: The results were consistent with the scientific literature in the field. The experience seems to confirm the opportunity of screening programs on arthropathy in cutaneous psoriasis patients. About a quarter of psoriasis patients had relevant arthropathic features, and more than half of these required challenging therapies like biologics. PMID: 27013149 [PubMed - as supplied by publisher] (Source: Giornale Italiano di Dermatologia e Venereologia)

Mar 26, 2016 02:49AM

Azeloglycine and nicotinamide down-regulate pro-inflammatory mediators in vitro.

Authors: Lembo S, DI Caprio R, Balato A, Bigioni AR, Caiazzo G, Schiattarella M, Monfrecola G PMID: 27013148 [PubMed - as supplied by publisher] (Source: Giornale Italiano di Dermatologia e Venereologia)

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Mar 26, 2016 02:49AM

Cutaneous melanoma in octogenarians: a single-institution review.

CONCLUSIONS: In our octogenarians, death for CM was not related to the old age but to the delayed diagnosis of cancer. Our results suggest that continuing educational programs for early diagnosis of CM should specifically include this segment of population. PMID: 27013147 [PubMed - as supplied by publisher] (Source: Giornale Italiano di Dermatologia e Venereologia)

Mar 25, 2016 03:00PM

Childhood atopic dermatitis and risk of attention deficit/hyperactivity disorder: A cohort study

Atopic dermatitis (AD) is a chronic, or chronically relapsing, inflammatory skin disease and it is the most common chronic disease of childhood.1 Inflammatory processes are known to play an important role in the development of psychiatric diseases.2 Attention deficit/hyperactivity disorder (ADHD) is one of the most common childhood psychiatric disorders.3 However, only 1 questionnaire-based follow-up study exists on the association between AD and ADHD and it does not report results related to sex. (Source: Journal of Allergy and Clinical Immunology)

Mar 25, 2016 03:00PM

The aldo-keto reductase AKR1B10 is upregulated in keloid epidermis, implicating retinoic acid pathway dysregulation in the pathogenesis of keloid disease

Keloid disease (KD) is a recurrent fibroproliferative, cutaneous tumour of unknown pathogenesis whose clinical management remains unsatisfactory. To obtain new insights into hitherto underappreciated aspects of keloid pathobiology, we took a laser capture microdissection-based whole genome microarray analysis approach to identify distinct KD-associated gene expression patterns within defined keloid regions. Identification of the aldo-keto reductase enzyme AKR1B10 as highly upregulated in keloid epidermis suggested an imbalance of retinoic acid (RA) metabolism is likely associated with KD. (Source: Journal of Investigative Dermatology)

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Mar 25, 2016 03:00PM

Plant?based active photoprotectants for sunscreens

Abstract Excessive exposure to the sun's radiation is the major exogenous mediator of skin damage, which accelerates skin ageing and increases the risk of developing skin cancer. Compounds with photoprotectant activity are extremely useful for decreasing the effect of ultraviolet (UV) radiation on the skin; however, numerous sun filters, especially organic sunscreens, are allergenic. Therefore, the development of formulations containing plant extracts, which may be potentially safer, is extensively being explored. Plant?based cosmetics are commonly used to avoid skin ageing because they contain antioxidant agents that minimize free radical activity, and numerous studies have investigated the skin?protectant effects of related plant species. In addition to their antioxidant properties, ...

Mar 25, 2016 03:00PM

Antimicrobial and antioxidant activity and chemical characterisation of Erythrina stricta Roxb. (Fabaceae)

Conclusions Seven compounds, including a new chromanone, were isolated from the antimicrobial dichloromethane extract of the stem bark of E. stricta. Six of the seven compounds showed antibacterial and/or antioxidant activities. These findings provide support for the customary (traditional and contemporary) use of E. stricta bark for the treatment of skin and wound infections. Graphical abstract (Source: Journal of Ethnopharmacology)

Mar 25, 2016 03:00PM

Thinking Outside the Box

Question: A 69-year-old man presented with a 7-year history of abdominal pain. The pain was intermittent, with month-long asymptomatic periods, usually located in a rather small area, 2 × 3 cm, in the right upper quadrant. The pain usually had no radiation, although in some periods it had radiated to the back (following roughly the D9-10 dermatomes of the right side). The pain worsened with some movements, like getting up from a bed or a chair. Various diagnostic procedures had been previously performed: upper digestive endoscopy presented no alterations and a 5-mm tubular adenoma was found on colonoscopy; blood testing showed no abnormalities. (Source: Gastroenterology)

Mar 25, 2016 03:00PM

Dermatologic Concerns of the Lower Extremity in the Pediatric Patient

This article covers the most common skin conditions seen on the lower extremity in the pediatric population. (Source: Clinics in Podiatric Medicine and Surgery)

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Mar 25, 2016 03:00PM

Bier's anemic spots, cyanosis with urticaria-like eruption (BASCULE) syndrome: a new entity?

This article is protected by copyright. All rights reserved. PMID: 27016170 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)

Mar 25, 2016 03:00PM

Schnitzler Syndrome: A Dramatic Response to Anakinra

We report a 50-year-old woman with Schnitzler syndrome for 10 years, with major impact on her quality of life and refractory to conventional therapies. The patient was started on anakinra, an IL-1 receptor antagonist, with a rapid and sustained remission of the syndrome manifestations. (Source: Dermatology and Therapy)

Mar 25, 2016 02:16PM

This Woman Fit 3 Years Of Her Trash In A Freaking Mason Jar

Sustainability never looked so stylish -- or straightforward. Lauren Singer runs Trash Is for Tossers, a no-waste lifestyle blog that is brimming with smart, simple and sleek-looking tips, tricks and DIY projects for adopting a more sustainable life. "I would like people to take away that we can all, regardless of our background, our beliefs, where we live or our socioeconomic status, take simple steps to reduce our environmental impact. It is simple to say no to a plastic straw or carry a reusable bag," Singer told The Huffington Post. Singer’s environmental epiphany struck her three years ago when she was a senior at NYU, where she was earning a degree in environment studies. “One day after class I went home to make dinner and opened my refrigerator and saw that everything i...

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Mar 25, 2016 10:53AM

Ustekinumab Linked to More Outpatient Visits and Greater Pharmacy Costs Versus Adalimumab in Psoriasis Patients

Psoriasis patients who switched from etanercept (ETA) to ustekinumab (UST) incurred higher health care resource utilization and health care costs over 12 months compared to patients who switched from... (Source: Cutis: Cutaneous Medicine for the Practitioner)

Mar 25, 2016 09:18AM

Men With Psoriasis Could Be More Likely To Have This Sexual Problem

(Reuters Health) - Men with psoriasis may be more prone to erectile dysfunction than their peers without this skin disease, and their odds of sexual difficulties are even higher if they are depressed or have other health problems like diabetes or high blood pressure, a Chinese study suggests.  Researchers studied sexual function in 191 patients with psoriasis and an equal number of healthy men. They found 53 percent of the men with psoriasis reported erectile dysfunction, compared with 40 percent in the healthy control group. Men with psoriasis were significantly more likely to report severe erectile dysfunction, while the men without the condition were much more apt to describe milder difficulties. When men with psoriasis do develop erectile dysfunction, they may be able to improve t...

Mar 25, 2016 04:34AM

Monophasic Hyaluronic Acid Filler for Nasolabial FoldsMonophasic Hyaluronic Acid Filler for Nasolabial Folds

The addition of lidocaine to hyaluronic acid dermal fillers may help alleviate injection pain -- but is it safe? Plastic and Reconstructive Surgery (Source: Medscape Today Headlines)

Mar 25, 2016 04:16AM

Antifungal potential of plant species from brazilian caatinga against dermatophytes.

This study evaluated the in vitro antidermatophytic activity of 23 crude extracts from nine plant species of semiarid vegetation (caatinga) found in Brazil. The extracts were tested at concentrations ranging from 1.95 to 1,000.0 mg/mL by broth microdilution assay against the reference strains T. rubrum ATCC 28189 and T. mentagrophytesATCC 11481, and 33 clinical isolates of dermatophytes. All plants showed a fungicidal effect against both fungal species, with MIC/MFC values of the active extracts ranging from 15.6 to 250.0 µg/mL. Selected extracts of Eugenia uniflora (AcE), Libidibia ferrea (AE), and Persea americana (AcE) also exhibited a fungicidal effect against all clinical isolates of T. rubrum and T. mentagrophytes complex. This is the first report of the antifungal activity of Schin...

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Mar 25, 2016 04:16AM

SIXTEEN YEARS OF DERMATOMYCOSIS CAUSED BY Candida spp. IN THE METROPOLITAN AREA OF PORTO ALEGRE, SOUTHERN BRAZIL.

Authors: Heidrich D, Stopiglia CD, Magagnin CM, Daboit TC, Vettorato G, Amaro TG, Scroferneker ML Abstract The yeasts of the genus Candida infect skin, nails, and mucous membranes of the gastrointestinal and the genitourinary tract. The aim of this study was to determine the prevalence of dermatomycoses caused by Candida spp., and their etiological aspects in the metropolitan area of Porto Alegre, Brazil. A retrospective study with data obtained from tertiary hospital patients, from 1996 to 2011, was performed. The analyzed parameters were date, age, gender, ethnicity, anatomical region of lesions, and the direct examination results. For all the statistical analyses, a = 0.05 was considered. Among positive results in the direct mycological examination, 12.5% of the total of 4,815 c...

Mar 25, 2016 03:05AM

Function of Membrane-Associated Proteoglycans in the Regulation of Satellite Cell Growth.

Authors: Song Y Abstract Muscle growth can be divided into embryonic and postnatal periods. During the embryonic period, mesenchymal stem cells proliferate and differentiate to form muscle fibers. Postnatal muscle growth (hypertrophy) is characterized by the enlargement of existing muscle fiber size. Satellite cells (also known as adult myoblasts) are responsible for hypertrophy. The activity of satellite cells can be regulated by their extracellular matrix (ECM). The ECM is composed of collagens, proteoglycans, non-collagenous glycoproteins, cytokines and growth factors. Proteoglycans contain a central core protein with covalently attached glycosaminoglycans (GAGs: chondroitin sulfate, keratan sulfate, dermatan sulfate, and heparan sulfate) and N- or O-linked glycosylation chains....

Mar 25, 2016 02:22AM

SPF and UVA?PF sunscreen evaluation: are there good correlations among results obtained in vivo, in vitro and in a theoretical Sunscreen Simulator? A real life exercise

ConclusionIn the present study, the use of BASF Sunscreen Simulator and in vitro UVA tests showed good correlations with in vivo results and could be considered as valuable resources in the development of sunscreens.This article is protected by copyright. All rights reserved. (Source: International Journal of Cosmetic Science)

Mar 24, 2016 10:52PM

Isoniazid toxicity and TB development during biological therapy of patients with psoriasis in Colombia.

Conclusions Chemoprophylaxis with INH seems to be effective and safe for the prevention of most TB reactivations in individuals with LTBI receiving biological therapy, but toxicity must be monitored during follow-up. PMID: 27003177 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)

Mar 24, 2016 04:00PM

Transvaginal rectocele repair with human dermal allograft interposition and bilateral sacrospinous fixation with a minimum eight-year follow-up

Human dermal allografts have been used for over a decade for interpositional repair of rectoceles. How do dermal allografts perform with regards to success rate and complications with 8 years? minimum follow-up? (Source: BMC Urology)

Mar 24, 2016 03:00PM

The role of PSMB9 upregulated by interferon signature in the pathophysiology of cutaneous lesions of dermatomyositis and systemic lupus erythematosus

ConclusionsThe interferon signature in DM and SLE skin reduces collagen in dermal fibroblasts, whereas overexpression of PSMB9 induced by interferon stimulates versican inducers in epidermal keratinocytes. In addition, the TGF??2??DiHS?diS1 pathway may be responsible for the specific molecular change in DM skin. (Source: British Journal of Dermatology)

Mar 24, 2016 03:00PM

RAGE and TGF-?1 Cross-Talk Regulate Extracellular Matrix Turnover and Cytokine Synthesis in AGEs Exposed Fibroblast Cells

This study contributes to the understanding of impaired wound healing associated with diabetes complications. (Source: PLoS One)

Mar 24, 2016 03:00PM

Development and Validation of an Improved PCR Method Using the 23S-5S Intergenic Spacer for Detection of Rickettsiae in Dermacentor variabilis Ticks and Tissue Samples from Humans and Laboratory Animals [Clinical Veterinary Microbiology]

A novel nested PCR assay was developed to detect Rickettsia spp. in ticks and tissue samples from humans and laboratory animals. Primers were designed for the nested run to amplify a variable region of the 23S-5S intergenic spacer (IGS) of Rickettsia spp. The newly designed primers were evaluated using genomic DNA from 11 Rickettsia species belonging to the spotted fever, typhus, and ancestral groups and, in parallel, compared to other Rickettsia-specific PCR targets (ompA, gltA, and the 17-kDa protein gene). The new 23S-5S IGS nested PCR assay amplified all 11 Rickettsia spp., but the assays employing other PCR targets did not. The novel nested assay was sensitive enough to detect one copy of a cloned 23S-5S IGS fragment from "Candidatus Rickettsia amblyommii." Subsequently, the detection...

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Mar 24, 2016 03:00PM

IL-36? is involved in psoriasis and allergic contact dermatitis

(Source: Journal of Investigative Dermatology)

Mar 24, 2016 03:00PM

Mast Cells Regulate Epidermal Barrier Function and the Development of Allergic Skin Inflammation

Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by infiltration of eosinophils, T helper cells and mast cells. The role of mast cells in AD is not completely understood. To define the effects of mast cells on skin biology, we observed that mast cells regulate the homeostatic expression of Epidermal Differentiation Complex (EDC) and other skin genes. Decreased EDC gene expression in mice that genetically lack mast cells (KitW-sh/W-sh mice) is associated with increased uptake of protein antigens painted on the skin by dendritic cells, compared to similarly treated wild-type mice, suggesting a protective role for mast cells in exposure to nominal environmental allergens. (Source: Journal of Investigative Dermatology)

Mar 24, 2016 03:00PM

Epithelium-derived Wnt ligands are essential for maintenance of underlying digit bone

Clinically, many nail disorders accompany bone deformities, but whether the two defects are causally related is under debate. To investigate the potential interactions between the two tissue types, we analyzed epithelial-specific ?-catenin deficient mice, in which nail differentiation is abrogated. These mice showed regression of not only the nail plate but also of the underlying digit bone. Characterization of these bone defects revealed active bone resorption, which is suppressed by Wnt activation in osteoblast and osteoclast precursors. (Source: Journal of Investigative Dermatology)

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Mar 24, 2016 03:00PM

Constitutive autophagy and nucleophagy during epidermal differentiation

Epidermal keratinocytes migrate through the epidermis up to the granular layer where, upon terminal differentiation they progressively loose organelles and convert into anucleate cells or corneocytes. Our report explores the role of autophagy in ensuring epidermal function providing the first comprehensive profile of autophagy marker expression in developing epidermis. We show that autophagy is constitutively active in epidermal granular layer where by electron microscopy we identified double membrane-autophagosomes. (Source: Journal of Investigative Dermatology)

Mar 24, 2016 03:00PM

Correlation between the severity of cetuximab-induced skin rash and clinical outcome for head and neck cancer patients: The XXXX experience

Present study evaluated the severity of cetuximab-induced skin rash and its correlation with clinical outcome and late skin toxicity in patients HNSCC treated with chemoradiotherapy and cetuximab in two prospective randomized trials. Grade 2-4 cetuximab rash was associated with better survival possibly due to reduction of distant metastasis. This observation was noted mainly in p16 negative patients. Grade 2-4 acute in-field radiation dermatitis was associated with higher rate of late Grade 2-4 skin fibrosis. (Source: International Journal of Radiation Oncology * Biology * Physics)

Mar 24, 2016 03:00PM

An initial fMRI study on neural correlates of prayer in members of Alcoholics Anonymous.

CONCLUSION: AA members' prayer was associated with a relative reduction in self-reported craving and with concomitant engagement of neural mechanisms that reflect control of attention and emotion. These findings suggest neural processes underlying the apparent effectiveness of AA prayer. PMID: 27015258 [PubMed - as supplied by publisher] (Source: The American Journal of Drug and Alcohol Abuse)

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Mar 24, 2016 03:00PM

Reporting of symptoms in randomised controlled trials of atopic eczema treatments: a systematic review.

This article is protected by copyright. All rights reserved. PMID: 27012805 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)

Mar 24, 2016 02:54PM

Ataxia telangiectasia, menkes kinky hair disease, neurocutaneous melanosis: a review of these neurocutaneous syndromes and indications for clinical practice.

This article examines three neurocutaneous syndromes (NCSs), genetic disorders that produce developmental abnormalities of the skin and an increased risk of neurological complications. In this review we examine different aspects of these diseases (Ataxia telangiectasia, Menkes kinky hair disease, Neurocutaneous melanosis): the clinical features, the genetic defect, the mutation spectrum, the pathogenesis, and the neurobiological basis; indications for clinical practice are provided to the reader. The goal of this review is to suggest the importance of cooperation among dermatologist, neurologist and psychiatrist, in order to provide patients suffering from these diseases with timely diagnosis and targeted treatments. PMID: 27002302 [PubMed - as supplied by publisher] (Source: Giornale ...

Mar 24, 2016 02:54PM

Polycystic ovary syndrome and vitiligo: simple association or tight connection?

Authors: Conti R, Manni C, Colucci R, Dragoni F, Moretti S PMID: 27002301 [PubMed - as supplied by publisher] (Source: Giornale Italiano di Dermatologia e Venereologia)

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Mar 24, 2016 11:34AM

The Use of Minipigs for Preclinical Safety Assessment by the Pharmaceutical Industry: Results of an IQ DruSafe Minipig Survey.

Conclusions of this survey indicate that minipig is an acceptable nonrodent species largely limited to studies using small molecules, primarily dermal products, and results are comparable to those reported 5 years ago. PMID: 27006130 [PubMed - in process] (Source: Toxicologic Pathology)

Mar 24, 2016 08:25AM

Sanuwave trial misses efficacy endpoint but shows superiority at 24 weeks

Sanuwave Health (OTC:SNWV) today released 24-week data from the pivotal trial of its dermaPace, saying it missed its 12-week primary efficacy endpoint but returned a greater reduction in wound size and lowered amounts of subjects with increased wound size compared to the control treatment at 24 weeks. Data came from 2 24-week studies at 39 centers across the U.S., studying a total of 336 subjects treated with either the dermaPace and conventional therapy or sham dermaPace and conventional therapy, Alpharetta, Ga.-based Sanuwave said. The primary efficacy endpoint for the studies were the incidence of complete wound closure at 12 weeks post-initial treatment with dermaPace or the sham dermaPace. The primary safety endpoint of the trial was the overall rate of adverse events throughout 24...

Mar 24, 2016 07:22AM

Prevalence of Skin and Skin-Related Diseases in the Rochester Epidemiology Project and a Comparison with Other Published Prevalence Studies

In Olmsted County, Minn., USA, reliable, population-based epidemiologic research studies can be performed because of a unique medical records linkage system, the Rochester Epidemiology Project (REP). Our objective was to summarize the epidemiologic data describing the prevalence of skin and skin-related diseases derived from the REP and to compare the findings with those from other studies worldwide. Retrospectively, we reviewed the results of population-based REP studies reporting the prevalence of skin and skin-related diseases over more than 4 decades and compared them to other published prevalences globally. Prevalences from the REP reported per 100,000 persons were as follows: hidradenitis suppurativa, 130.0; psoriasis, 700.0; psoriatic arthritis in 1992, 100.0, and in 2000, 160.0; Be...

Mar 24, 2016 07:22AM

Microneedle?mediated intradermal delivery of epigallocatechin?3?gallate

ConclusionAddition of glutathione in EGCG formulations significantly reduces its photodegradation. Skin microporation with maltose microneedles facilitates penetration of EGCG across the stratum corneum into the deeper skin layers ? viable epidermis and dermis.This article is protected by copyright. All rights reserved. (Source: International Journal of Cosmetic Science)

Mar 24, 2016 07:22AM

Sex differences in the incidence of skin and skin?related diseases in Olmsted County, Minnesota, United States, and a comparison with other rates published worldwide

Abstract Many skin and skin?related diseases affect the sexes unequally, with attendant implications for public health and resource allocation. To evaluate better the incidence of skin and skin?related diseases affecting males vs. females, we reviewed published population?based epidemiology studies of skin disorders performed utilizing Rochester Epidemiology Project data. Females had a higher incidence of the following diseases: connective tissue diseases (scleroderma, morphea, dermatomyositis, primary Sjögren syndrome, systemic lupus erythematosus [not in all studies]), pityriasis rosea, herpes progenitalis, condyloma acuminatum, hidradenitis suppurativa, herpes zoster (except in children), erythromelalgia, venous stasis syndrome, and venous ulcers. Males had a higher incidence of ...

Mar 24, 2016 03:39AM

The Effect of Food Avoidance in Adult Patients with Chronic Idiopathic Urticaria.

CONCLUSION: Although SPT still yielded a low sensitivity for the diagnosis of FIU, the present study showed a very good response by food avoidance in patients who were SPT positive. PMID: 27004300 [PubMed - in process] (Source: Journal of the Medical Association of Thailand = Chotmaihet thangphaet)

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Mar 24, 2016 02:02AM

[Connective tissue diseases in adolescents].

Authors: Peitz J, Tantcheva-Poór I Abstract In this article we provide a brief review of systemic lupus erythematosus, juvenile dermatomyositis, systemic scleroderma, and mixed connective tissue disease in adolescents. As skin manifestations often belong to the presenting symptoms and may have a significant impact on the quality of life, dermatologists play an important role in the management of patients with connective tissue diseases. Early diagnosis and therapy onset are crucial for the patients' long-term outcome. PMID: 27000182 [PubMed - as supplied by publisher] (Source: Der Hautarzt: Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete)

Mar 24, 2016 02:02AM

Panorama Dermatologische Praxis.

Authors: PMID: 27000181 [PubMed - as supplied by publisher] (Source: Der Hautarzt: Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete)

Mar 24, 2016 02:00AM

Medical News Today: Wound healing could be enhanced with modified maggots

Maggots are already used to help heal stubborn wounds; they remove dead tissue and fight microbes. Now, researchers have modified them to produce growth factors to enhance healing. (Source: Health News from Medical News Today)

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Mar 23, 2016 04:00PM

Differential responsiveness of Holstein and Angus dermal fibroblasts to LPS challenge occurs without major differences in the methylome

We have previously found substantial animal-to-animal and age-dependent variation in the response of Holstein fibroblast cultures challenged with LPS. To expand on this finding, fibroblast cultures were establ... (Source: BMC Genomics)

Mar 23, 2016 03:00PM

Pneumocystis jiroveci pneumonia in patients treated with systemic immunosuppressive agents for dermatologic conditions: a systematic review with recommendations for prophylaxis

This study was conducted to determine when dermatology patients treated with immunosuppressive medications should be offered P. jiroveci pneumonia prophylaxis. We searched the literature from January 1, 1993, to December 31, 2013, using terms relating to P. jiroveci pneumonia and dermatologic diagnoses to analyze the clinical characteristics of previously affected patients. Guidelines for P. jiroveci pneumonia prophylaxis from other medical fields were also analyzed. Of 17 dermatology patients reported to have contracted P. jiroveci pneumonia, eight (47.1%) died of the pneumonia. Risk factors included lack of prophylaxis, systemic corticosteroid therapy, lymphopenia, hypoalbuminemia, low serum CD4 counts, comorbid pulmonary or renal disease, malignancy, and prior organ transplantation. The...

Mar 23, 2016 03:00PM

Ticking the wrong boxes

IT IS interesting to see how news of a disease outbreak develops and spreads. In February, Veterinary Record published a short letter from Clive Swainsbury and colleagues at the Forest Veterinary Centre, drawing attention to an outbreak of babesiosis in dogs in Harlow in Essex. Over the previous three months, the disease had been identified in three dogs from three different households. The dogs had been exercised in a local uncultivated park area, and Dermacentor species ticks had been recovered from two of them. Significantly, none of the dogs had travelled abroad (VR, February 13, 2016, vol 178, p 172). A few weeks later, in a follow-up letter, Mr Swainsbury along with Paul Phipps and others at the APHA and Public Health England confirmed that Babesia had been detected in a Dermacentor ...

Mar 23, 2016 03:00PM

Babesia canis infection in ticks in Essex

TO further investigate four locally acquired cases of canine babesiosis (Fig 1) in Essex (VR, February 13, 2016, vol 178, p 172; March 5, 2016, vol 178, pp 243–244), a tick survey was completed on March 11, 2016, in the area where all four dogs had been regularly exercised. The survey aimed to detect an active population of Dermacentor reticulatus within this area and to determine if questing ticks collected at the site were positive for Babesia canis. Locations along a cycle path in central Harlow were surveyed by dragging cloth over the vegetation to attract questing ticks. Eight female and nine male ticks were collected from one area close to a car park located next to Third Avenue and Abercrombie Way. All ticks were identified morphologically as D reticulatus and confirmed u...

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Mar 23, 2016 03:00PM

Propranolol treatment of infantile hemangioma (IH) is not associated with developmental risk or growth impairment at age 4 years

Long-term adverse effects of propranolol treatment for infantile hemangioma (IH) in young children have been suggested. (Source: Journal of the American Academy of Dermatology)

Mar 23, 2016 03:00PM

Desmosomes and corneodesmosomes are enclosed by tight junctions at the periphery of granular cells and corneocytes, suggesting a role in generation of a peripheral distribution of corneodesmosomes in corneocytes

Human-skin thin sections stained with hematoxilin-eosin reveal that stratum corneum (SC), which consists of layered cornified cells (corneocytes), is divided into two distinct layers; i.e., a thin, eosinophilic compact layer in the lower SC, and a basket-weave pattern layer in the upper SC, although it has been known that the latter pattern is not identified in cryo-fixed epidermis. The corneocytes in both of these layers are bound together with corneodesmosomes, which are derived from desmosomes of living epidermal keratinocytes. (Source: Journal of Dermatological Science)

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Mar 23, 2016 03:00PM

Behavioral Interventions for Preventing Sexually Transmitted Infections and Unintended Pregnancies: An Overview of Systematic Reviews

Conclusions There is no evidence that behavioral interventions modify rates of sexually transmitted infections (including human immunodeficiency virus infections) or unintended pregnancies, particularly when effects are assessed using objective, biological data. Primary prevention strategies for sexually transmitted infections and unintended pregnancies need to be re-evaluated. (Source: Actas Dermo-Sifiliograficas)

Mar 23, 2016 03:00PM

Atopic dermatitis, asthma and allergic rhinitis in general practice and the open population: a systematic review.

CONCLUSION: There are significant differences between the self-reported prevalence of atopic disorders in the open population compared with physician diagnosed prevalence of atopic disorders in general practice. Data obtained in the open population cannot simply be extrapolated to the general practice setting. This should be taken into account when considering a research topic or requirements for policy development. GPs should be aware of the possible misclassification of allergic disorders in their practice. KEY POINTS Epidemiological data on atopic disorders in children can be obtained from various sources, each having its own advantages and limitations. On average, the prevalence of atopic disorders is higher in the open population. GPs should take into account the possible misclassific...

Mar 23, 2016 12:58PM

Voluntary self-disclosure: Pros and cons of using the protocol

AUSTIN, TEX. ? Using the federal government?s voluntary self-disclosure protocol to report potential program violations offers advantages and disadvantages. On one hand, the protocol allows health providers to get in front of possible offenses and retain some control, according to Miami health... (Source: Skin and Allergy News)

Mar 23, 2016 12:22PM

Pirfenidone?induced severe phototoxic reaction in a patient with idiopathic lung fibrosis

ConclusionTo our knowledge, this is the first reported case of a severe phototoxic reaction during treatment with pirfenidone. Our aim by presenting this case is to increase the awareness of clinicians for severe phototoxic effects of oral pirfenidone. (Source: Journal of the European Academy of Dermatology and Venereology)

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Mar 23, 2016 12:22PM

Index

Note: Page numbers of article titles are in boldface type. (Source: Dermatologic Clinics)

Mar 23, 2016 12:22PM

Forthcoming Issues

Practice Gaps in Dermatology (Source: Dermatologic Clinics)

Mar 23, 2016 12:22PM

Contents

James Q. Del Rosso and Joshua A. Zeichner (Source: Dermatologic Clinics)

Mar 23, 2016 12:22PM

Contributors

BRUCE H. THIERS, MD (Source: Dermatologic Clinics)

Mar 23, 2016 12:22PM

Copyright

ELSEVIER (Source: Dermatologic Clinics)

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Mar 23, 2016 12:22PM

Advances in Acne Management

DERMATOLOGIC CLINICS (Source: Dermatologic Clinics)

Mar 23, 2016 12:22PM

Face to Face with Acne in 2016 and Beyond

What is not new is that acne vulgaris (AV) continues to be the most common skin disease encountered in outpatient dermatology practice in the United States. What is new are some of the modern-day challenges clinicians face in managing their patients with AV. One major current challenge is self-management by patients via information sources and product offerings on the Internet, which frequently lead to delays in seeking appropriate care and poor adherence. This often results in unfortunate sequelae such as facial and truncal scarring and persistent dyspigmentation. (Source: Dermatologic Clinics)

Mar 23, 2016 12:22PM

The Clinical Relevance of Antibiotic Resistance

This article summarizes important principles gleaned from the continued efforts of the Scientific Panel on Antibiotic Use in Dermatology; other groups working diligently in this area, such as the Centers for Disease Control and Prevention and the Canadian Antimicrobial Resistance Alliance; and from the published literature. (Source: Dermatologic Clinics)

Mar 23, 2016 12:22PM

When Acne is Not Acne

We present herein an interesting case that was originally misdiagnosed as AV. (Source: Dermatologic Clinics)

Mar 23, 2016 12:22PM

Acne and the Internet

The Internet provides both education and miseducation for acne patients. Although some sites provide disease background information and objective treatment guidance, support networks, and research findings, others may seem to be objective on the surface, but are in reality run by untrained, self-proclaimed experts or are promotional in nature. Providers must be aware of the potential benefits and pitfalls the Internet provides for those suffering with acne. (Source: Dermatologic Clinics)

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Mar 23, 2016 12:22PM

Evaluation of Acne Scars

The prevalence and emotional impact of acne scarring are underestimated by the medical community. Dermatology providers should be able to evaluate the acne scar patient and discuss treatment options. Important aspects of the patient history include current treatments, prior acne scar procedures, and the patient?s goals for treatment. During the physical examination, the scars are assessed and classified by scar morphology and overall severity of scarring. Finally, a treatment plan is developed in which the most appropriate procedures are matched with the scars that will work the best. Helping the patient understand likely expectations for improvement will increase overall satisfaction. (Source: Dermatologic Clinics)

Mar 23, 2016 12:22PM

Evaluation and Management of Refractory Acne Vulgaris in Adolescent and Adult Men

Acne vulgaris alters the normal skin physiology, impairing stratum corneum and transepidermal water loss. A male?s normal skin physiologic state is different than a female?s and may have implications when choosing treatment when the skin is altered in a disease state. Transepidermal water loss, pH, and sebum production are different between the sexes. Several underlying conditions present in male acne patients at several ages that may require a more in-depth evaluation. As knowledge of the pathogenesis of acne expands, the differences in skin physiology between the sexes may alter the manner in which male patients with acne medications are approached. (Source: Dermatologic Clinics)

Mar 23, 2016 12:22PM

Pediatric Acne

This article presents an overview of the clinical presentations of acne by age and our approach to evaluation and management of this common condition. (Source: Dermatologic Clinics)

Mar 23, 2016 12:22PM

Use of Oral Contraceptives for Management of Acne Vulgaris

Acne vulgaris may be effectively treated with combination oral contraceptive pills (COCs) in women. COCs may be useful in any woman with acne in the absence of known contraindications. When prescribing a COC to a woman who also desires contraception, the risks of the COC are compared with the risks associated with pregnancy. When prescribing a COC to a woman who does not desire contraception, the risks of the COC must be weighed against the risks associated with acne. COCs may take 3 cycles of use to show an effect in acne lesion count reductions. (Source: Dermatologic Clinics)

Mar 23, 2016 12:22PM

Oral Isotretinoin

Oral isotretinoin is unrivalled in efficacy and remission capability for treatment of acne. In addition to appropriate monitoring and continued vigilance for safety concerns, appropriate dosing to mitigate avoidable dose-dependent adverse effects is the responsibility of prescribers. Low-dose regimens are better tolerated and effective in inducing acne clearance. Although much progress has been made since the advent of isotretinoin, there remain many unanswered questions regarding optimization to maximize response while minimizing the potential for avoidable adverse events. The ongoing availability of isotretinoin is imperative to patients with acne, their caregivers, and physicians. (Source: Dermatologic Clinics)

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Mar 23, 2016 11:50AM

Dermoscopy in the era of dermato-oncology: from bed to bench side and retour.

Authors: Woltsche N, Schwab C, Deinlein T, Hofmann-Wellenhof R, Zalaudek I Abstract Today dermoscopy is standard-of-care in the diagnosis and management of patients with benign and malignant skin tumors because it increases the diagnostic accuracy of skin lesions compared to the naked-eye examination up to 25%. Despite its role in the routine dermato-oncology, it increasingly gained interest as a bridge connecting clinical with basic molecular research in dermato-oncology. Here, we correlate dermoscopy patterns of nevi and melanomas with high and low susceptibility genes and somatic mutations, provide an overview on the clinical and dermoscopic patterns of cutaneous melanoma subtypes, and highlight the role of dermoscopy in the diagnosis of skin eruptions during systemic treatments...

Mar 23, 2016 07:11AM

Effect of Polycyclic Aromatic Hydrocarbon Source Materials and Soil Components on Partitioning and Dermal Uptake

Environmental Science & TechnologyDOI: 10.1021/acs.est.5b06164 (Source: Environmental Science and Technology)

Mar 23, 2016 06:45AM

Early application of negative pressure wound therapy to acute wounds contaminated with Staphylococcus aureus: An effective approach to preventing biofilm formation.

Authors: Li T, Zhang L, Han LI, Wang G, Yin P, Li Z, Zhang L, Guo QI, Liu D, Tang P Abstract Negative pressure wound therapy (NPWT) has been demonstrated to be effective at preventing biofilm-associated infections; however, its role in biofilm prevention is unknown. The present study evaluated the effect of NPWT on biofilm prevention when rapidly initiated following wound contamination. Full-thickness dermal wounds (8 mm) were created in rabbit ears and inoculated with green fluorescent protein-labeled Staphylococcus aureus (S. aureus). At 6 h following inoculation, continuous NPWT at -125 mmHg was initiated, with the wounds on the contralateral ear left untreated in order to serve as self-controls. S. aureus rapidly formed mature biofilms in the wound beds post-inoculation, with a...

Mar 23, 2016 03:09AM

Teenager with bizarre skin condition urticaria uses her arm as a notepad

Lucy Pearce, 16, from Sheffield, has dermatographia, where a raised, itchy rash appears on the skin at the slightest pressure. She makes notes on her arm which disappear after 30 minutes (Source: the Mail online | Health)

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Mar 22, 2016 11:00PM

Health Tip: Preparing for a Pedicure

Title: Health Tip: Preparing for a PedicureCategory: Health NewsCreated: 3/23/2016 12:00:00 AMLast Editorial Review: 3/23/2016 12:00:00 AM (Source: MedicineNet Skin General)

Mar 22, 2016 08:43PM

Bilateral Aleukemic Myeloid Sarcoma of the Eyelids With Indolent Course

Abstract: Leukemic infiltrates may be seen in the skin in the absence of detectable bone marrow involvement. Leukemia cutis may exceptionally occupy the eyelids. An unusual case of a 58-year-old man presenting bilateral erythematous eyelid lesions, proven to be aleukemic leukemia cutis, is reported. Biopsy was conducted and hematoxylin/eosin stained sections were histologically evaluated. Immunohistochemistry was also performed. Light microscopy revealed cutaneous infiltration by a neoplastic population consisting of medium-sized cells. These cells infiltrated the overlying epidermis leading to focal microulcerations. The morphological and immunohistochemical characteristics of the neoplastic population were compatible with myeloid leukemia cutis. The bone marrow biopsy was normocellular ...

Mar 22, 2016 08:43PM

Cutaneous Cellular Pseudoglandular Schwannoma: An Unusual Histopathologic Variant

Abstract: Cellular schwannoma and pseudoglandular schwannoma are both previously described rare variants of schwannoma. The authors present an unusual case of a cellular spindle cell neoplasm with prominent gland-like structures, having features of both variants. The nature of this lesion was confirmed by histology and immunohistochemistry, with diffuse and strong S100 and membranous collagen type IV staining. The gland-like structures were lined by S100 + cells and contained proteinaceous, mucicarmine-negative material, supporting a degenerative, not true glandular, phenomenon. This is the first case of a cutaneous schwannoma demonstrating both marked cellularity and pseudoglandular formation, which the authors have designated cutaneous cellular pseudoglandular schwannoma. Recognition of ...

Mar 22, 2016 08:43PM

A 36-Year-Old Man With an Enlarging Nodule on the Buttock

No abstract available (Source: The American Journal of Dermatopathology)

Mar 22, 2016 08:43PM

Rituximab-Induced Serum Sickness?Like Reaction: A Histopathologic Viewpoint

No abstract available (Source: The American Journal of Dermatopathology)

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Mar 22, 2016 08:43PM

Mycobacterium leprae Is Usually Positive to Periodic Acid?Schiff and Grocott Stains

No abstract available (Source: The American Journal of Dermatopathology)

Mar 22, 2016 08:43PM

Dermatofibrosarcoma Protuberans in a Patient With Cowden Syndrome: Revisiting the PTEN and PDGF Pathways

Abstract: PTEN hamartoma tumor syndrome, of which Cowden syndrome (CS) is the most recognized variant, is characterized by multiple benign and malignant tumors of ectodermal, mesodermal, and endodermal origins, secondary to germline mutation in the phosphatase and tensin homolog (PTEN) gene. Dermatofibrosarcoma protuberans (DFSP) is a locally aggressive malignant fibroblastic/myofibroblastic tumor of the skin, characterized by the t(17:22)(q22:q13) translocation resulting in fusion of the COL1A1 and PDGFB genes. An association between CS and DFSP has not been reported in the literature to date. The authors have encountered a male patient with CS and a history of DFSP that developed adjacent to a sclerotic fibroma on the parietal scalp, both excised at age 7. He presented at age 21 with an ...

Mar 22, 2016 08:43PM

A Rare Pediatric Example of Subcutaneous Extraskeletal Osteosarcoma: A Case Report and Review of the Morphologic Differential Diagnosis

Abstract: Primary extraskeletal osteosarcoma is an exceedingly rare malignant neoplasm that accounts for approximately 1% of soft tissue sarcomas and most often occurs in the deep soft tissues of adults. Extraskeletal osteosarcoma is characterized by the production of osteoid, bone, and/or chondroid matrix. The diagnosis of extraskeletal osteosarcoma requires careful radiologic and clinical correlation to ensure that the patient does not have an underlying bone primary. This is a case report of primary subcutaneous extraskeletal osteosarcoma arising in the thigh of a 15-year-old girl with a complex karyotype, and the morphologic differential diagnosis is reviewed. (Source: The American Journal of Dermatopathology)

Mar 22, 2016 08:43PM

Deep Penetrating Fibrous Histiocytoma: A Case Report and Implications for Surgical Management

We describe a case of a 24-year-old man diagnosed with DPFH through histologic examination and immunohistochemistry. The lesion displayed diffuse, strong D2-40 positivity and a minority of cells were highlighted with factor XIIIa. The lesion was negative for CD34. The patient's lesion was incompletely excised and a repeat excision was required. (Source: The American Journal of Dermatopathology)

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Mar 22, 2016 08:43PM

Fluorescence In Situ Hybridization for Melanoma Diagnosis: A Review and a Reappraisal

Abstract: Although conventional histopathological examination is the undisputable mainstay for the diagnosis of melanocytic skin neoplasms, fluorescence in situ hybridization (FISH) has the potential to provide important information to morphologically challenging cases. The standard melanoma FISH test targeting RREB1 (6p25), MYB (6q23), CCND1 (11q13), and centromere 6 is an effective compromise between cost, technical complexity, and sensitivity. The authors use the standard FISH-positivity as a tie-breaker for challenging melanocytic neoplasms mainly in a non-Spitzoid morphologic context because the currently available test leaves several unresolved issues: namely, a relatively low diagnostic accuracy in morphologically ambiguous melanocytic neoplasms; a relatively low sensitivity and spe...

Mar 22, 2016 08:43PM

Study of Epithelial to Mesenchymal Transition in Atypical Fibroxanthoma and Undifferentiated Pleomorphic Sarcoma to Discern an Epithelial Origin

Abstract: Atypical fibroxanthoma (AFX) is considered a fibroblastic or myofibroblastic neoplasm probably corresponding to a superficial variant of undifferentiated pleomorphic sarcoma (UPS). However, an epithelial origin has also been postulated. An immunohistochemical study of the epithelial to mesenchymal transition (EMT) phenomenon was performed in a series of 19 AFX and 4 UPS to discern an epithelial origin. A panel of epithelial (cytokeratins AE1-AE3 panel, podoplanin D2-40, and E-cadherin) and EMT (vimentin, Twist, Zeb1, and Snail1) markers were evaluated in both tumoral cells and the adjacent epidermis. Podoplanin and Snail1 were negative in all the samples. Nuclear E-cadherin, Twist, and Zeb1 were detected in most lesions, as previously reported in other sarcomas. In the epidermis,...

Mar 22, 2016 08:43PM

Incidental Melanocytic Nevi in Hemorrhoidectomy Specimens

Conclusions: Although uncommonly, incidental MN can be observed in hemorrhoidal tissue. They may show features of flexural nevi and pagetoid melanocytes. Routine histopathological study of hemorrhoidectomy specimens would help to detect benign or malignant melanocytic tumors of the anal canal as these neoplasms can be easily missed clinically. Furthermore, this practice would allow early diagnosis of significant associated processes. (Source: The American Journal of Dermatopathology)