Dr. William Ting, Board-Certified Dermatologist
at California Dermatology Care
2262 Camino Ramon, San Ramon, CA 94583
500 Alfred Nobel Drive, Suite #185, Hercules, CA 94547
Tel: 925-328-0255
Email: staff@CalDermCare.com


Advanced Care with a Personal Touch

   

 

 

Medical Dermatology    Evidence-based medicine   Customized solution   Personal care

Latest Dermatology Headlines

Dr. William Ting has expertise in treating the entire spectrum of medical dermatology, with emphasis in preventive medicine and personalized recommendations. He enjoys taking care of patients with acne, eczema, hair and nail disorders, rashes, psoriasis and skin cancers.

He is at the forefront of medical dermatology and dermatologic research. He continues to publish articles in peer-reviewed dermatology journals. He is an early pioneer of photodynamic therapy (PDT) and one of the most experienced practitioners of PDT in the Bay Area. He is the first dermatologist in the San Francisco Bay Area and Northern California to introduce Lutronic Spectra, GenesisPlus, Picosure Lasers for melasma, acne, scar revision, pore size reduction as well as the Cutera GenesisPlus laser for advanced nail fungus laser treatment, keloid and hypertrophic scar, warts and scar revision.

Dr. Ting is a fellow of the American Academy of Dermatology (AAD) and American Society of Dermatologic Surgery (ASDS). He is a member of the National Psoriasis Foundation and International Hyperhidrosis Society.

Innovative Therapeutic Approach to Common Skin Conditions

Acne

Eczema (Atopic Dermatitis)

Hair and Nail disorders

  • Maximize therapeutic synergy and efficacy by utilizing both prescription-strength and over-the counter products when available
  • Comprehensive workup including bloodwork and biopsy if necessary
  • Systemic oral hormonal therapy for women and men when indicated

Psoriasis 

Rosacea

  • Multi-prong approach to minimize redness
  • Low-dose 'non-antibiotic' anti-inflammatory oral medication for long-term remission 
  • Emphasis on prevention
  • Fotofacial/IPL laser utilizing Cynosure XPL/Elite MPX
  • Cutera GenesisPlus Laser with or without combination with IPL 
  • Diode laser for facial veins
  • VBeam Pulse Dye Laser, the new gold standard for rosacea and facial redness

Skin Cancer 

  • Emphasis on prophylactic treatments with topical 5-FU, imiquimod, diclofenac, ingenol mebutate and oral chemopreventive therapy such as Erivedge, and Soriatane.
  • Reduce future risks of skin cancer with photodynamic therapy, TCA chemical peels and/or fractional CO2 resurfacing laser  
  • Superficial Radiotherapy (SRT) may be the new gold standard as a nonsurgical modality to treat non-melanoma skincancer
  • Mohs Surgery to achieve highest cure rate and tissue sparing
  • Close colloboration with plastic surgeon(s) as needed  

Sweating Disorder (Hyperhidrosis) 

Vitiligo

Warts 


ABCD of Mole Check

 

 

Common Medical Dermatology Diagnostics and Therapeutics:

Dermatology Links:

American Academy of Dermatology
American Society of Dermatologic Surgery
American Society of Mohs Surgery
International Hyperhidrosis Society
National Psoriasis Foundation

 Latest Dermatology Headlines:

Latest Dermatology Headlines
Thu, 11 Feb 2016 14:09:58 +0100

http://www.medworm.com/rss/index.php/Dermatology/12/

Feb 11, 2016 06:09AM

Erratum

Skin Appendage Disord 2015;1:168 (Source: Skin Appendage Disorders)

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Feb 11, 2016 06:09AM

Disseminated nodules after vaccines for hyposensitization for mites. Pseudolymphoma or lymphoma?

(Source: Journal of the European Academy of Dermatology and Venereology)

Feb 11, 2016 06:08AM

Facial Scars following Toxic Epidermal Necrolysis: Role of Adnexal Involvement?

In this report, we present particular facial cutaneous sequelae with histological analysis after TEN. Two young patients who had survived TEN presented permanent multiple hypopigmented papules on the face affecting their quality of life. Histological analysis revealed areas of scarring, dystrophic microcalcifications and sebaceous hyperplasia. Late cutaneous sequelae are well documented; however, the physiopathological mechanisms leading to different clinical presentations remain unknown. We suggest that the destruction of the hair follicle by necrolysis leads to secondary dermal microcalcifications, scarring and sebaceous hyperplasia. Further studies are needed for a better understanding of these findings.Dermatology (Source: Dermatology)

Feb 11, 2016 06:08AM

False-Negative Cases on Confocal Microscopy Examination: A Retrospective Evaluation and Critical Reappraisal

Conclusion: Confocal and dermoscopic examination, along with patient-related information and clinical history, can lead to an optimal patient management.Dermatology (Source: Dermatology)

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Feb 10, 2016 04:00PM

Infantile Hemangiomas in Twins: A Prospective Cohort Study

ConclusionsThese findings suggest that the origin of IHs is multifactorial and that predisposing factors such as birthweight, sex, and GA may interact with one another such that a threshold is reached for clinical expression. (Source: Pediatric Dermatology)

Feb 10, 2016 04:00PM

Unique coexistence of cold and solar urticaria and its efficient treatment

(Source: British Journal of Dermatology)

Feb 10, 2016 04:00PM

Kaposi sarcoma secondary to endogenous adrenocorticotropic hormone?dependent Cushing syndrome

We report a case of KS secondary to endogenous Cushing syndrome (ECS) due to a pituitary adenoma, an association that has been reported only once. We also conducted a search through the Medline and PubMed databases for cases involving KS and ECS, finding only three additional cases that shared common clinical and prognostic features with ours. ECS might favour the development of KS due to immunosuppression. Dermatologists and other clinicians should be aware of this association, as it might be an underdiagnosed condition. It also has an important impact on the management of KS, and based on this review it relies on a good prognosis when ECS is well controlled. (Source: British Journal of Dermatology)

Feb 10, 2016 04:00PM

Immunobullous disease and ulcerative colitis ? the need of an accurate diagnosis

(Source: British Journal of Dermatology)

Feb 10, 2016 04:00PM

Topical diphencyprone for the treatment of locoregional intralymphatic melanoma metastases of the skin; the 5?year Norwich experience

(Source: British Journal of Dermatology)

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Feb 10, 2016 04:00PM

A patient with acantholytic pustular purpuric eruption due to gefitinib successfully treated with systemic antibiotics

Publication date: Available online 9 February 2016 Source:Dermatologica Sinica Author(s): Kai-Lung Chen, Yung-Tsu Cho, Che-Wen Yang, Yi-Shuan Sheen, Jau-Yu Liau, Chia-Yu Chu (Source: Dermatologica Sinica)

Feb 10, 2016 02:04PM

[Isolated epidermal cysts of the vulva].

Authors: Kalampalikis A, Scheungraber C, Goetze S, Schliemann S, Elsner P Abstract Vulvar cysts are rare und benign entities. They are epidermoid cysts which may develop following trauma or surgery. They can also spontaneously develop. They vary in number and size. They grow slowly and tend to show calcification. The treatment consists of surgical removal. Other methods are pinch-punch excision, heat application, and incision. PMID: 26857133 [PubMed - as supplied by publisher] (Source: Der Hautarzt: Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete)

Feb 10, 2016 02:04PM

[Eczematous disorders in adolescents].

Authors: Fölster-Holst R Abstract Eczematous disorders in adolescence (definition WHO: the period between 10 and 20 years) are common and include mainly atopic dermatitis, contact eczema, and seborrheic dermatitis. They all share the similarity of inflammatory reactions which mainly affect the epidermis and can take a chronic course, depending on the underlying dermatosis. In the following article, the particularities of eczematous diseases in adolescents are discussed. PMID: 26857132 [PubMed - as supplied by publisher] (Source: Der Hautarzt: Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete)

Feb 10, 2016 02:04PM

[Overview of dermatological registries in Germany].

Authors: Nast A PMID: 26857131 [PubMed - as supplied by publisher] (Source: Der Hautarzt: Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete)

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Feb 10, 2016 12:40PM

The response of tenocytes to commercial scaffolds used for rotator cuff repair.

Authors: Smith RD, Carr A, Dakin SG, Snelling SJ, Yapp C, Hakimi O Abstract Surgical repairs of rotator cuff tears have high re-tear rates and many scaffolds have been developed to augment the repair. Understanding the interaction between patients' cells and scaffolds is important for improving scaffold performance and tendon healing. In this in vitro study, we investigated the response of patient-derived tenocytes to eight different scaffolds. Tested scaffolds included X-Repair, Poly-Tape, LARS Ligament, BioFiber (synthetic scaffolds), BioFiber-CM (biosynthetic scaffold), GraftJacket, Permacol, and Conexa (biological scaffolds). Cell attachment, proliferation, gene expression, and morphology were assessed. After one day, more cells attached to synthetic scaffolds with dense, fine ...

Feb 10, 2016 11:00AM

Mechanism for dust mite?triggered atopic dermatitis identified

Researchers have identified a possible mechanism by which house dust mites could trigger the development of atopic dermatitis in individuals with a genetic predisposition. The study, published online Feb. 10 in Science Translational Medicine, took skin and blood samples from individuals with... (Source: Skin and Allergy News)

Feb 10, 2016 08:11AM

House panel says Medicare biosimilar payment plan will stifle innovation

Questions linger as to whether federal health care payment policies will encourage ? or stifle ? the entry of more biosimilars into the marketplace. Getting the biosimilar approval process right ?doesn?t matter unless we get the charging/reimbursement process right,? Rep. Joe Barton (R-Tex.),... (Source: Skin and Allergy News)

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Feb 10, 2016 03:16AM

Effects of 6-week Nordic walking training on changes in 25(OH)D blood concentration in women after 55 years of age.

CONCLUSION: A six-week Nordic walking training programme in late autumn contributed to the lowering of 25(OH)D blood concentration in women after 55 years of age. The decreased 25(OH)D concentration may have been a result of reduced dermal biosynthesis of vitamin D or due to vitamin D contribution to muscle metabolism. This is an indication that vitamin D3 supplementation should be recommended in periods of intense physical activity during months with little insolation, especially to overweight postmenopausal women. PMID: 26853237 [PubMed - as supplied by publisher] (Source: Journal of Sports Medicine and Physical Fitness)

Feb 10, 2016 03:00AM

Research Shows Inpatient Dermatology Improves Diagnostic Accuracy and Intervention

NEW YORK (Reuters Health) – Inpatient dermatology consultations for skin disorders are associated with improved diagnostic accuracy and faster intervention, researchers have found. Information about the impact of hospitalist dermatology consultative services is limited, Dr. Daniela Kroshinsky from Massachusetts General Hospital in Boston and colleagues note in JAMA  Dermatology, online January 13. To learn more,... [Read More] (Source: The Hospitalist)

Feb 10, 2016 12:19AM

Advanced Dermatology and Cosmetic Surgery, (ADCS Clinics) Announces...

Advanced Dermatology and Cosmetic Surgery, the nation?s largest dermatology practice, acquires dermatology clinic in Florida.(PRWeb February 09, 2016)Read the full story at http://www.prweb.com/releases/2016/02/prweb13204050.htm (Source: PRWeb: Medical Pharmaceuticals)

Feb 09, 2016 10:19PM

Assessment of efficacy, safety, and tolerability of 4-n-butylresorcinol 0.3% cream: an Indian multicentric study on melasma.

CONCLUSION: Our data suggest that the 4-n-butylresorcinol 0.3% cream is safe, effective, and well tolerated in Indian patients with melasma. PMID: 26855596 [PubMed] (Source: Clinical, Cosmetic and Investigational Dermatology)

Feb 09, 2016 05:09PM

Periostin in the Cancer Stroma of Mycosis Fungoides Palmaris et Plantaris: A Case Report and Immunohistochemical Study

In this report, we describe an 85-year-old Japanese man with MFPP. Immunohistochemical staining revealed the dense deposition of periostin in the cancer stroma, as well as infiltration of CD163+CD206- tumor-associated macrophages (TAMs), which suggested the phenotypes of TAMs were not polarized to the M2 phenotype in the lesional skin of MFPP. Our present case might suggest one of the possible reasons for the good prognosis of MFPP.Case Rep Dermatol 2016;8:31-35 (Source: Case Reports in Dermatology)

Feb 09, 2016 05:09PM

Plexiform Fibrohistiocytic Tumor on the Ear: Case Report and Immunohistochemical Investigation of Stromal Factor

In this report, we describe a case of PFT on the ear, which showed a dense deposition of periostin (POSTN) in the stromal areas of the tumor. In addition, dense infiltration of CD163+CD206- tumor-associated macrophages (TAMs) was detected in the same areas as POSTN. Since POSTN was previously reported to possess immunomodulatory effects on TAMs, our present report suggested the significance of the POSTN/TAMs axis in the progression of PFT.Case Rep Dermatol 2016;8:26-30 (Source: Case Reports in Dermatology)

Feb 09, 2016 05:09PM

Nodular Cutaneous Amyloidosis Resembling a Giant Tumor

A 79-year-old man presented with a large tumor on the left side of his head, which had grown over 5 years. Regional lymph nodes were impalpable and computed tomography revealed no signs of bone infiltration. Histology showed that the entire dermis was filled with amorphous eosinophilic material. Immunohistochemistry was negative for cytokeratin, but showed that the dermis and parts of the subcutis were filled with amyloid consisting of immunoglobulin light chains. There were no signs of paraproteinemia or underlying plasmocytoma. In electron microscopy, the typical amyloid fibrils were found. The tumor was completely removed via curettage. At 1-year follow-up, the patient was doing fine with no signs of relapse or systemic disease.Case Rep Dermatol 2016;8:22-25 (Source: Case Reports in Der...

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Feb 09, 2016 05:09PM

Successful Treatment of Paecilomyces lilacinus Onychomycosis with Efinaconazole and Tavaborole

Paecilomyces lilacinus, also known as Purpureocillium lilacinum, is a non-dermatophyte mold found in the soil and used as nematocide for crops. P. lilacinus can cause rare opportunistic infections in humans ranging from endocarditis, keratitis, to onychomycosis with significant resistance to conventional antifungals. There are only two cases of onychomycosis caused by P. lilacinus reported in the literature and none that were successfully treated. Here we present a case of successfully treated onychomycosis caused by P. lilacinus with efinaconazole and tavaborole in a patient who had failed treatment with oral fluconazole, itraconazole, terbinafine, and topical ciclopirox and naftifine.Skin Appendage Disord 2015;1:169-171 (Source: Skin Appendage Disorders)

Feb 09, 2016 05:08PM

Participation and health care provision of statutory skin cancer screening in Germany ? a secondary data analysis

ConclusionParticipation rates and health care providers of skin cancer screening can be calculated from secondary data and contribute to identify group? and region?specific participation patterns in order to improve early detection of skin cancer. (Source: Journal of the European Academy of Dermatology and Venereology)

Feb 09, 2016 05:08PM

Successful Treatment of Segmental Vitiligo in Children with the Combination of 1-mm Minigrafts and Phototherapy

Conclusions: Combined treatment of segmental vitiligo with 1-mm minigrafts and phototherapy can be performed safely and is highly effective in young patients.Dermatology (Source: Dermatology)

Feb 09, 2016 05:08PM

Relationship between Histological and Clinical Course of Psoriasis: A Pilot Investigation by Reflectance Confocal Microscopy during Goeckerman Treatment

In this study, we investigated lesional skin in 11 psoriatic patients during a modified Goeckerman treatment using reflectance confocal microscopy (RCM) to study the relationship between clinical clearance and histological normalization of psoriatic skin and the significance of histological abnormalities on the course of disease. The treatment regimen resulted in a significant reduction of the Psoriasis Area and Severity Index (PASI) as well as capillary and papillary diameters (p < 0.0001). The capillary and papillary diameters were still enlarged when compared to those in normal skin (p < 0.001). Capillary and papillary diameters correlated with each other prior to and after treatment (correlation coefficient = 0.63 and 0.64, p = 0.01 and 0.002, respectively) but not with the PASI. Capil...

Feb 09, 2016 05:08PM

Characteristics and Young's Modulus of Collagen Fibrils from Expanded Skin Using Anisotropic Controlled Rate Self-Inflating Tissue Expander

In conclusion, the anisotropic controlled rate self-inflating tissue expander produced a loosely packed collagen network and the fibrils exhibited similar D-banding characteristics as the control group in a sheep model. However, the fibrils from the expanded skin were significantly narrower. The stiffness of the fibrils from the expanded skin was higher but it was not statistically different.Skin Pharmacol Physiol 2016;29:55-62 (Source: Skin Pharmacology and Physiology)

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Feb 09, 2016 04:02PM

Biosimilar infliximab gains FDA Advisory Committee endorsement

A biosimilar agent to Remicade, the brand-name and reference form of infliximab, stayed on track to become the second biosimilar drug to enter the U.S. market when the Arthritis Advisory Committee of the Food and Drug Administration voted overwhelmingly in... (Source: Skin and Allergy News)

Feb 09, 2016 04:00PM

Response to ?Chemical injuries caused by the hydrofluoric acid leak?

Publication date: Available online 4 February 2016 Source:Burns Author(s): Yuanhai Zhang, Chunmao Han, Xuguang Qiu, Liangfang Ni, Xinxing Mao, Xingang Wang (Source: Burns)

Feb 09, 2016 04:00PM

Tribbles homologue 3 stimulates canonical TGF-{beta} signalling to regulate fibroblast activation and tissue fibrosis

Conclusions The present study characterises TRB3 as a novel profibrotic mediator in SSc. TGF-β induces TRB3, which in turn activates canonical TGF-β/Smad signalling and stimulates the release of collagen, thereby inducing a positive feedback loop that may contribute to aberrant TGF-β signalling in SSc. (Source: Annals of the Rheumatic Diseases)

Feb 09, 2016 04:00PM

Type 2 innate lymphoid cell counts are increased in patients with systemic sclerosis and correlate with the extent of fibrosis

Conclusions ILC2 counts are elevated in patients with SSc and correlate with the extent of skin fibrosis and the presence of interstitial lung disease providing compelling evidence for profibrotic effect of ILC2s in SSc. (Source: Annals of the Rheumatic Diseases)

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Feb 09, 2016 04:00PM

Comparative Transcriptomic Exploration Reveals Unique Molecular Adaptations of Neuropathogenic Trichobilharzia to Invade and Parasitize Its Avian Definitive Host

In conclusion, the present transcriptomic exploration provides new and significant insights into the molecular biology of T. regenti, which should underpin future genomic and proteomic investigations of T. regenti and, importantly, provides a useful starting point for a range of comparative studies of schistosomatids and other trematodes. (Source: PLoS Neglected Tropical Diseases)

Feb 09, 2016 04:00PM

Cutaneous Leishmaniasis: An Overlooked Etiology of Midfacial Destructive Lesions

Conclusion Leishmaniasis may cause MDL especially in endemic areas. PCR is instrumental in confirming the diagnosis. MDL caused by CL showed wide spectrum of clinical and microscopic presentation. (Source: PLoS Neglected Tropical Diseases)

Feb 09, 2016 04:00PM

Calculating the effect of population-level implementation of the Learning Early About Peanut Allergy (LEAP) protocol to prevent peanut allergy

The Learning Early About Peanut Allergy (LEAP) study demonstrated a 70% to 86% relative reduction in the incidence of peanut allergy (PA) in high-risk infants (with severe atopic dermatitis [AD] or egg allergy) if peanut was introduced between 4 and 11 months of age.1 Using data about AD and egg sensitization collected from BASELINE, Ireland's first unselected prospective birth cohort study,2-5 we calculated the effect of implementing the LEAP protocol in our population. (Source: Journal of Allergy and Clinical Immunology)

Feb 09, 2016 04:00PM

Hyperpigmented Plaques of the Alar Crease: An Unusual Presentation of Acanthosis Nigricans

We present the case of an obese 16?year?old African American boy with hyperpigmented plaques along the supra?alar creases of his nose. Clinicians should be aware of this rare manifestation, because newly diagnosed acanthosis nigricans should prompt examination for insulin resistance. (Source: Pediatric Dermatology)

Feb 09, 2016 04:00PM

Water?Holding and Transport Properties of Skin Stratum Corneum of Infants and Toddlers Are Different from Those of Adults: Studies in Three Geographical Regions and Four Ethnic Groups

ConclusionIn general, TEWL and conductance were greater on the upper inner arm than the dorsal forearm. Erythema and scaling were observed most often in subjects from Beijing and most infrequently in subjects from Mumbai. Stratum corneum water barrier properties were different in children and adults. Although there may be differences in these properties between ethnic groups in childhood, TEWL values were similar in adults across the three geographic locations and four ethnicities. (Source: Pediatric Dermatology)

Feb 09, 2016 04:00PM

Radiologic Improvement After Early Medical Intervention in Localised Facial Morphea

We report the case of a young girl who presented with hemiparesis, seizures, and subtle features consistent with a linear form of facial morphea (en coup de sabre). She was treated with pulsed parenteral steroids and oral steroids and started on methotrexate. Magnetic resonance imaging results and neurologic problems improved after 6 months. Switching off inflammation early in the course of disease seemed to reverse some of the central nervous system changes. Assessment of children with unexplained hemiparesis and seizures should include careful examination of the face and scalp, looking for subtle signs of skin change and asymmetry. This is one of the few reported cases of neuroradiologic improvement after immunosuppressive treatment in a child with en coup de sabre. (Source: Pediatric De...

Feb 09, 2016 04:00PM

Palisaded Neutrophilic Granulomatous Dermatitis in a Child with Juvenile Idiopathic Arthritis on Etanercept

We describe a girl with polyarticular juvenile idiopathic arthritis who developed PNGD after administration of etanercept and demonstrated rapid and significant improvement upon treatment with topical triamcinolone 0.1% ointment. (Source: Pediatric Dermatology)

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Feb 09, 2016 04:00PM

Serum Vitamin D Levels Not Associated with Atopic Dermatitis Severity

ConclusionLevels of 25?hydroxyvitamin D were deficient or insufficient in 85% of the children, but serum vitamin D concentrations were not significantly related to AD severity. (Source: Pediatric Dermatology)

Feb 09, 2016 04:00PM

Neurovascular Stains in Two Girls with Neurofibromatosis 1

We report two girls, ages 9 and 17 years, with a clinical diagnosis of neurofibromatosis 1 (NF?1) who presented with ill?defined, blanchable, erythematous patches on the dorsal feet and ankles. We hypothesized that these patches were a rare cutaneous finding in NF?1 that exist on a clinical and histopathologic spectrum with previously described NF?1 vascular lesions including blue?red macules and skin ulceration due to NF?1 vasculopathy. We suggest that these lesions be called neurovascular stains (NVSs) to unify their clinical and histopathologic features. (Source: Pediatric Dermatology)

Feb 09, 2016 04:00PM

High?Potency Topical Steroids: An Effective Therapy for Chronic Scalp Inflammation in Rapp?Hodgkin Ectodermal Dysplasia

We report two cases of Rapp?Hodgkin ED with refractory scalp erosions that markedly improved with the use of potent topical steroids. We also note marked similarities between this scalp inflammation and ?erosive pustular dermatosis of the scalp,? a condition more typically found in elderly individuals with severe scalp sun damage, and speculate about possible shared pathogenetic mechanisms. (Source: Pediatric Dermatology)

Feb 09, 2016 04:00PM

Atrophying tinea versicolor with epidermal atrophy

(Source: JDDG)

Feb 09, 2016 04:00PM

Measurement of health?related quality of life in adult patients with birch pollen?associated food allergy

ConclusionsThe German FAQLQ?AF questionnaire is a reliable and valid tool for measuring HRQL in patients with birch pollen?associated food allergy. (Source: JDDG)

Feb 09, 2016 04:00PM

Issue Information ? TOC

(Source: International Journal of Dermatology)

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Feb 09, 2016 04:00PM

The last bastion of collegiality: the peer?review process in the era of open access

(Source: International Journal of Dermatology)

Feb 09, 2016 04:00PM

Canities subita: sudden blanching of the hair in history and literature

(Source: International Journal of Dermatology)

Feb 09, 2016 04:00PM

Effects of Thermal Treatment on human hair fibers

ConclusionTunisian women hair presented good mechanical properties as shown by a greater breaking stress and higher breaking strain. Both curl type and age are important factors to consider when evaluating the behavior of hairThis article is protected by copyright. All rights reserved. (Source: International Journal of Cosmetic Science)

Feb 09, 2016 04:00PM

Selective CD28 antagonist prevents Aldara?induced skin inflammation in non?human primates

(Source: Experimental Dermatology)

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Feb 09, 2016 04:00PM

Maternal IL?6 can cause T?cell?mediated juvenile alopecia by non?scarring follicular dystrophy in mice

Abstract Aiming to decipher immunological mechanisms of the autoimmune disorder alopecia areata (AA), we hypothesized that interleukin?6 (IL?6) might be associated with juvenile?onset AA, for which there is currently no experimental model. Upon intramuscular transgenesis to overexpress IL?6 in pregnant female C57BL/6 (B6) mice, we found that the offspring displayed an initial normal and complete juvenile hair growth cycle, but developed alopecia around postnatal day 18. This alopecia was patchy and reversible (non?scarring) and was associated with upregulation of Ulbp1 expression, the only mouse homolog of the human AA?associated ULBP3 gene. Alopecia was also associated with inflammatory infiltration of hair follicles by lymphocytes, including alpha?beta T cells, which contri...

Feb 09, 2016 04:00PM

Combination Therapies for Melanoma: A New Standard of Care?

Abstract Recent data have demonstrated improved survival with targeted and immune therapies in patients with advanced melanoma, leading to much excitement amongst the oncology community and the widespread use of these drugs in combination regimens. However, the place of these combination therapies in the treatment of advanced melanoma remains to be fully determined. In this perspectives article, we critically review the available data and outline the rationale for these combinations being adopted as the standard of care for patients with advanced melanoma in the future. (Source: American Journal of Clinical Dermatology)

Feb 09, 2016 04:00PM

Cutaneous T-cell lymphoma (CTCL): Current practices in blood assessment and the utility of T-cell receptor (TCR)-V? chain restriction

Accurate quantification of malignant cells in the peripheral blood of patients with cutaneous T-cell lymphoma is important for early detection, prognosis, and monitoring disease burden. (Source: Journal of the American Academy of Dermatology)

Feb 09, 2016 04:00PM

Fractional carbon-dioxide (CO) laser-assisted topical therapy for the treatment of onychomycosis

Inability of topical medications to penetrate via nail plate brings a great challenge to clinicians in treating onychomycosis. Furthermore, oral medications are not appropriate for all patients because of drug interactions, adverse effects, and contraindications. (Source: Journal of the American Academy of Dermatology)

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Feb 09, 2016 04:00PM

Dermal sheath cells contribute to postnatal hair follicle growth and cycling

The two critical cell types necessary to produce and maintain hair follicles are fibroblasts, which reside in the dermal papilla (DP) and dermal sheath (DS), and keratinocytes, including hair follicle stem cells (HFSCs) and their progeny. Although keratinocytes are the primary constituents of hair follicle that generate the hair structure, the contribution of dermal fibroblasts to hair follicle neogenesis and regeneration are less well defined. Cells within the DP and DS are specialized fibroblasts of mesenchymal origin, collectively forming a dermal microenvironment encircling the epithelial compartment and exhibits hair cycle-associated plasticity. (Source: Journal of Dermatological Science)

Feb 09, 2016 04:00PM

Tender Papules and Plaques in a Patient With Leukemia

A woman with acute myeloid leukemia was admitted with blast crisis and tumor lysis syndrome; flow cytometry showed myeloid blasts, most of which expressed CD13, CD33, CD117, and partial CD11b, and blasts were highly positive for myeloperoxidase. What is your diagnosis? (Source: JAMA Dermatology)

Feb 09, 2016 04:00PM

Cost of Inpatient Care of Patients With Pemphigus in the United States

Pemphigus is an autoimmune blistering disorder that, prior to the use of prednisone, was associated with increased mortality. Even with the availability of steroid-sparing agents, moderate to severe disease can be associated with clinically significant morbidity. In this issue, Hsu et al demonstrate the financial burden of inpatient hospitalization of patients with pemphigus using the National Inpatient Sample (NIS) Database. The NIS is the largest publicly available all-payer hospital inpatient care database in the United States and is used by researchers and policymakers to identify, track, and analyze trends in health care utilization, access, charges, quality, and outcomes. Rare diseases, such as pemphigus, can be difficult to study, but large databases, such as the NIS, allow us a gli...

Feb 09, 2016 04:00PM

Histologic Evidence of Melanocytes Isolated to the Nail Matrix

This analysis examines whether isolated pigmented lesions of the nail bed warrant consideration of causes other than subungual melanoma for their occurrence. (Source: JAMA Dermatology)

Feb 09, 2016 04:00PM

Surveillance of Epidermolysis Bullosa Nevi Malignant Transformation

This case report of a young girl with epidermolysis bullosa (EB) describes melanoma gene expression markers that aid in thorough histopathologic examination of suspicious EB nevi lesions. (Source: JAMA Dermatology)

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Feb 09, 2016 04:00PM

US Hospitalization Costs for Pemphigus

This study examines the incidence of and risk factors for hospitalization for patients with pemphigus and cost of care. (Source: JAMA Dermatology)

Feb 09, 2016 04:00PM

Phenotype Variation and Immature Immunity in Netherton Syndrome

This cohort study evaluates the association of the SPINK5 mutation with the phenotype of Netherton syndrome (NS) and the extent of immunologic deficiencies in Finnish patients with NS. (Source: JAMA Dermatology)

Feb 09, 2016 02:35PM

Obama Releases FY 2017 Budget

(MedPage Today) -- Includes plans to fight the opioid epidemic, eliminate cancer, and expand Medicaid (Source: MedPage Today Dermatology)

Feb 09, 2016 01:00PM

MD Tech Tips: iPad, Wiki, and YouTube

(MedPage Today) -- Help available for chest x-ray interpretation, making medical illustrations, and finding ICD codes (Source: MedPage Today Dermatology)

Feb 09, 2016 12:07PM

Data, new partnerships key to prepping for value-based care

AUSTIN, TEX. ? Gathering data, seeking new partnerships, and showing leadership are the key ways to prepare for value-based medical practice, according to Houston-based health law attorney Ellie Bane. ?We are entering a whole new world... (Source: Skin and Allergy News)

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Feb 09, 2016 12:00PM

When the Doctor Is Not a Doctor

It is now common for patients to arrive in a physician office and never see the physician.... (Source: Cutis: Cutaneous Medicine for the Practitioner)

Feb 09, 2016 12:00PM

A Case of Bloom Syndrome With Uncommon Clinical Manifestations Confirmed on Genetic Testing

Bloom syndrome, also called congenital telangiectatic erythema and stunted growth, was first described by David Bloom in 1954.1 It is a rare autosomal-recessive disorder (Online Mendelian... (Source: Cutis: Cutaneous Medicine for the Practitioner)

Feb 09, 2016 08:49AM

New tanning dependence screening tool ?promising?

The validity of a new screening tool used to identify people who are addicted to indoor tanning has been confirmed in a recent study. In background information to their study, the researchers, led by Jerod L. Stapleton of the Rutgers Cancer Institute of New Jersey, said tools for assessing tanning... (Source: Skin and Allergy News)

Feb 09, 2016 07:20AM

Danish study finds increased glioma risk in a rosacea population

An increased focus on neurologic symptoms in patients with rosacea may be warranted, according to Danish researchers, who found a significantly increased risk of glioma associated with rosacea, in a nationwide study of Danish citizens. The observational study followed 5,484,910 Danish adults... (Source: Skin and Allergy News)

Feb 09, 2016 05:52AM

Dr Sandra Lee slices into PLUM-sized cyst above a woman's breast on video

WARNING GRAPHIC CONTENT: Californian dermatologist Dr Sandra Lee, aka Dr Pimple Popper, squeezes the huge cyst - causing an eruption of yellow fluid to seep from the incision. (Source: the Mail online | Health)

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Feb 09, 2016 05:03AM

SCCA2: Potential biomarker for psoriasis severity and treatment efficacy

The level of serum squamous cell carcinoma antigen 2 ? an isoform of SCCA that is widely used as a tumor marker for SCC ? was significantly higher in both skin and serum of patients with psoriasis, compared with healthy volunteers in a recent study, correlating with psoriasis severity score and... (Source: Skin and Allergy News)

Feb 08, 2016 10:00PM

A novel dermal matrix generated from burned skin as a promising substitute for deep?degree burns therapy.

Authors: Yu G, Ye L, Tan W, Zhu X, Li Y, Jiang D Abstract The extensive skin defects induced by severe burns are dangerous and can be fatal. Currently, the most common therapy is tangential excision to remove the necrotic or denatured areas of skin, followed by skin grafting. Xenogeneic dermal substitutes, such as porcine acellular dermal matrix (ADM), are typically used to cover the burn wounds, and may accelerate wound healing. It is assumed that burned skin that still maintains partial biological activity may be recycled to construct an autologous acellular dermal matrix, termed 'deep?degree burned dermal matrix (DDBDM)'. In theory, DDBDM may avoid the histoincompatibility issues associated with foreign or xenogeneic dermal matrices, and reduce therapy costs by making full use...

Feb 08, 2016 06:05PM

Pet avoidance in allergy cases: Is it possible to implement it?

CONCLUSIONS: High exposure to animals could explain the frequency of sensitization to pets in this population. However, emotional attachment and prevalent indirect exposure to animals among sensitized patients make avoidance recommendations impractical or impossible to achieve. PMID: 26849697 [PubMed - as supplied by publisher] (Source: Biomedica : Revista del Instituto Nacional de Salud)

Feb 08, 2016 04:00PM

Different morphologic formation patterns of dark patches in the black-spotted frog ( Pelophylax nigromaculata ) and the Asiatic toad ( Bufo gargarizans )

Abstract The black-spotted frog (Pelophylax nigromaculata) and Asiatic toad (Bufo gargarizans), two relatively distantly related species, live in different habitats with different adaptive dark patches. To explain the formation of dark patches, the distribution patterns of melanin granules were examined with light microscopy and transmission electron microscopy. Melanin granules were produced and gathered into the ?cap? structures on top of the nuclei in most epidermal cells. The ?cap? structures may play a role in forming the dorsal dark patches coupled with three-layer melanophores, which can give rise to three layers of interconnected melanin networks in the dorsal dermis in P. nigromaculata. Epidermal melanocytes are rare and do not have a definitive role in forming do...

Feb 08, 2016 04:00PM

An Overlook to the Characteristics and Roles Played by Eotaxin Network in the Pathophysiology of Food Allergies: Allergic Asthma and Atopic Dermatitis

Abstract Investigations revealed substantial parts accomplished by chemokines specifically eotaxins and their specific receptors. They are functionally involved in the modulation of the pathologic state of tissue inflammation which is as a result of allergic reactions. Chemokines as small proteins with approximately 8?10 kDa molecular weight are considered and fit in the bigger family of cytokines, containing basic heparin-binding polypeptide mediators. Chemokines actively interfere in the processes of selective, oriented leukocyte (including eosinophil) recruitment. As eminent from their name, more specifically, eotaxins are specialized for eosinophils? oriented locomotion toward allergic inflamed regions. To date, three members are defined for eotaxin subfamily as follows: ...

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Feb 08, 2016 04:00PM

Is Fat From Another Area of Body Safe for Breast Reconstruction?

Research shows this practice doesn't increase risk for new cancers or recurrence (Source: The Doctors Lounge - Oncology)

Feb 08, 2016 04:00PM

Acrodermatitis Dysmetabolica in a Child with Cystic Fibrosis

We present the case of an exclusively breastfed, 2?month?old boy with known cystic fibrosis admitted with failure to thrive and erosive dermatitis. A diagnosis of acrodermatitis dysmetabolica was made when investigations revealed a normal zinc level but low amino acid levels. (Source: Pediatric Dermatology)

Feb 08, 2016 04:00PM

Does Order of Application of Emollient and Topical Corticosteroids Make a Difference in the Severity of Atopic Eczema in Children?

ConclusionThis study suggests that the order of application of emollient and TCS does not matter in the treatment of AE in children and that parents can apply topical medications in whichever order they prefer. (Source: Pediatric Dermatology)

Feb 08, 2016 04:00PM

Correction

Zeitany AE, Bowers EV, Morrell DS. High-dose isotretinoin has lower impact on wallets: A cost analysis of dosing approaches. J Am Acad Dermatol. 2016;74:174-6. (Source: Journal of the American Academy of Dermatology)

Feb 08, 2016 04:00PM

?Ring?within?a?ring? appearance: morphological clue to topical steroid abuse in dermatophytosis

(Source: Journal of the European Academy of Dermatology and Venereology)

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Feb 08, 2016 04:00PM

Usefulness of the Paramedian Forehead Flap in Nasal Reconstructive Surgery: A Retrospective Series of 41 Patients

We describe our experience with the paramedian forehead flap for reconstruction of nasal defects. Methodology We performed a retrospective study of consecutive patients in whom a paramedian forehead flap was used to repair surgical defects of the nose between July 2004 and March 2011. We describe the clinical and epidemiologic characteristics, the surgical technique, complications, secondary procedures, and cosmetic results. Results The series comprised 41 patients with a mean (SD) age of 67 (10.36) years. The majority were men (male to female ratio, 2.4:1). Associated risk factors included diabetes in 27% of patients, cardiovascular risk factors in 49%, and smoking or drinking in 19.5%. The tissue defects were distal in 80% of cases and nonpenetrating in 78%. The mean (SD) diameter was ...

Feb 08, 2016 04:00PM

Hypersensitivity Reactions to Corticosteroids

Publication date: Available online 4 February 2016 Source:Actas Dermo-Sifiliográficas (English Edition) Author(s): L. Berbegal, F.J. DeLeon, J.F. Silvestre Corticosteroids are widely used in clinical practice. In dermatology, their application is generally topical. These substances may act as allergens and produce immediate and delayed hypersensitivity reactions. Allergic contact dermatitis is the most frequent presentation of corticosteroid allergy and it should be studied by patch testing in specific units. The corticosteroids included in the Spanish standard battery are good markers but not ideal. Therefore, if those makers are positive, it is useful to apply a specific battery of corticosteroids and the drugs provided by patients. Immediate reactions are relatively rare but poten...

Feb 08, 2016 04:00PM

e-Dermatology: Social Networks and Other Web Based Tools

Publication date: Available online 4 February 2016 Source:Actas Dermo-Sifiliográficas (English Edition) Author(s): R. Taberner The use by patients of social networking sites and the Internet to look for health related information has already become an everyday phenomenon. If, as dermatologists, we want to be part of this new conversation and provide quality content, we will have to adapt to digital media and find new ways of communicating with both our patients and our colleagues. Dozens of Spanish dermatologists have already ventured into the online space and have begun to provide important content through blogs, which they also disseminate via the social media. However, the use of these new technologies can also pose certain risks from the standpoint of ethics and our codes of practi...

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Feb 08, 2016 04:00PM

Why Is Mohs Micrographic Surgery Underused in the Treatment of Dermatofibrosarcoma Protuberans in Children?

Publication date: Available online 3 February 2016 Source:Actas Dermo-Sifiliográficas (English Edition) Author(s): E. Jubert, L.J. del Pozo, C. Saus, A. Martín-Santiago (Source: Actas Dermo-Sifiliograficas)

Feb 08, 2016 04:00PM

A Rare Case of Glomus Tumor of the Great Toe: An Analysis of Behavior at This Rare Site

Glomus tumor, originally known as an angioneuromyoma, is a benign neoplasm arising from specialized structures called glomus bodies, involved in thermoregulation. Although it has been reported at a number of sites in the body, this rare tumor is most commonly seen in the subungual areas of the digits of the hand. Only a handful of lesions have been reported in the toes. Because most foot conditions are treated by podiatrists and dermatologists, orthopaedic surgeons are generally unaccustomed to making early diagnoses. The purpose of this case report is to alert the attending surgeon regarding the possibility of glomus tumor as a cause of chronic toe pain. Also it has been observed that the behavior of this tumor varies with the site of occurrence—whether digital or extradigital. So w...

Feb 08, 2016 04:00PM

Your NEJM Group Today: Coronary-Artery Vasospasm, Endoscopic Sleeve Gastroplasty, California Dermatology Opportunity (FREE)

By the Editors NEJM Group offers so many valuable resources for practicing clinicians. Here's what we chose for you today:NEJM Clinical Practice Center: Image in Clinical Medicine: ? (Source: Physician's First Watch current issue)

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Feb 08, 2016 04:00PM

Structural characterization of human CRTh2: a combined homology modeling, molecular docking and 3D-QSAR-based in silico approach

In this study, we report the binding site analysis of CRTh2 through molecular docking and quantitative structure?activity relationship (QSAR) studies to explore the interaction of 2-(2-(benzylthio)-1H-benzo[d]imidazol-1-yl) acetic acid derivatives. Various comparative models were generated using the available crystal structure of human delta opioid receptor (4N6H) as the template, and benzylthio acetic acid derivatives were docked into the predicted binding site region of human CRTh2 receptor. Surflex docking studies enabled us to identify that K5.43, Y4.60, N185, Y6.51, Q5.36, E6.58, T7.38 and H6.52 residues were the most crucial amino acids interacting with the ligand. In addition to docking, atom-by-atom matching and structure-based 3D-QSAR method CoMFA was performed. Based on better ...

Feb 08, 2016 04:00PM

Effects of hair removal alexandrite laser on biometric parameters of the skin

Abstract The effects of alexandrite laser (AL) on skin parameters such as melanin content, skin layer depth, elasticity, and density have not been investigated through biometric methods. We aim to assess the effect of AL on the skin parameters through biometric devices to determine whether it has positive effects on treated region. In this pretest-posttest study, we recruited patients who attended Laser Clinic of Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran, from January through December 2014. Patients had to be free of any dermatologic conditions and lesion at the site of treatment or any contraindication to laser therapy. Baseline measurements were performed and patients received four sessions of AL therapy (spot size, 12 mm; fluence, ...

Feb 08, 2016 03:14PM

Average person with atopic dermatitis has no increased risk of actinic keratosis or nonmelanoma skin cancer

People with atopic dermatitis do not appear to be at greater risk for actinic keratosis or basal cell and squamous cell cancer, according to a recent population-based, cross-sectional study. ?This is the first study to examine the association between atopic dermatitis and actinic keratosis [AK].... (Source: Skin and Allergy News)

Feb 08, 2016 02:02PM

Young women who tan indoors are at two- to sixfold increased risk of melanoma

Women under age 50 years who regularly tanned indoors were at a twofold to sixfold increased risk of melanoma, compared with age-matched women who had not engaged in indoor tanning, according to a population-based control study. The 681 individuals with melanoma, drawn from the <a... (Source: Skin and Allergy News)

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Feb 08, 2016 01:00PM

High-dose interferon offered no survival benefit in patients with melanoma and a single tumor?positive sentinel lymph node

Patients with melanoma and a single tumor?positive sentinel lymph node (SLN) had no improvement in overall (OS) or disease-free survival (DFS) with adjuvant high-dose interferon alfa-2b (HDI), and patients with histologically negative, RT-PCR?positive SLNs had no improvement with completion lymph... (Source: Skin and Allergy News)

Feb 08, 2016 10:34AM

Mobile Technology for the Practice of Pathology

Recently, several technological advances have been introduced to mobile phones leading some people to refer to them as ?smartphones.? These changes have led to widespread consumer adoption. A similar adoption has occurred within the medical field and this revolution is changing the practice of medicine, including pathology. Several mobile applications have been published for dermatology, orthopedics, ophthalmology, neurosurgery, and clinical pathology. The applications are wide ranging, including mobile technology to increase patient engagement, self-monitoring by patients, clinical algorithm calculation, facilitation between experts to resource-poor environments. These advances have been received with mixed reviews. For anatomic pathology, mobile technology applications can be broken ...

Feb 08, 2016 08:00AM

Books, text messages increase sun protection behaviors

An intervention consisting of text-message reminders, read-along books, and swim shirts achieved significant improvements in sun protection behaviors in children, compared with information about sun protection alone, according to the results of a randomized controlled trial. The study, published... (Source: Skin and Allergy News)

Feb 08, 2016 05:26AM

Photoletter to the editor: Calcinosis cutis in a burn scar.

We describe the case of a 57-year-old man with dystrophic calcinosis cutis in a burn scar, which developed 42 years after the skin injury. The condition was successfully treated with surgical excision. PMID: 26848324 [PubMed] (Source: Journal of Dermatological Case Reports)

Feb 08, 2016 05:26AM

Photoletter to the editor: Response of linear porokeratosis to photodynamic therapy in an 11-year-old girl.

We report the successful response to photodynamic therapy (PDT) in a pediatric patient diagnosed with linear porokeratosis. PMID: 26848323 [PubMed] (Source: Journal of Dermatological Case Reports)

Feb 08, 2016 05:26AM

Photoletter to the editor: Subcutaneous ciliated Mullerian cyst.

We present a case of a cutaneous ciliated Mullerian cyst arising in the lower leg of a 14-year-old girl, with brief discussion of etiology and diagnosis. This is a rare entity with approximately 50 cases in the literature. PMID: 26848322 [PubMed] (Source: Journal of Dermatological Case Reports)

Feb 08, 2016 05:26AM

A rapidly growing giant cutaneous horn on the chest.

CONCLUSIONS: This is the first known occurrence of a giant cutaneous horn on the chest. While giant cutaneous horns are more commonly associated with malignant lesions, differential diagnosis includes benign lesions such as keratoacanthomas. This differential can be considered in a rapidly growing lesion. Excision and histopathologic review of the base of a cutaneous horn are essential to guide potential further therapy. PMID: 26848321 [PubMed] (Source: Journal of Dermatological Case Reports)

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